Title: XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells.
Journal: Environmental toxicology 20171101
Title: Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors.
Journal: The Journal of pharmacology and experimental therapeutics 20140501
Title: Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.
Journal: PloS one 20140101
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry 20121115
Title: Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes.
Journal: Journal of diabetes 20120901
Title: Combination therapy of antiandrogen and XIAP inhibitor for treating advanced prostate cancer.
Journal: Pharmaceutical research 20120801
Title: Inhibition of UVB-induced oxidative damage and apoptotic biochemical changes in human lymphocytes by 2,5-dihydroxy-3-undecyl-1,4-benzoquinone (embelin).
Journal: International journal of radiation biology 20120801
Title: PEG-derivatized embelin as a dual functional carrier for the delivery of paclitaxel.
Journal: Bioconjugate chemistry 20120718
Title: XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells.
Journal: Molecular cancer therapeutics 20120701
Title: Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma.
Journal: The American journal of pathology 20120501
Title: Preventive effect of embelin from embelia ribes on lipid metabolism and oxidative stress in high-fat diet-induced obesity in rats.
Journal: Planta medica 20120501
Title: Inhibition of X-linked inhibitor of apoptosis with embelin differentially affects male versus female behavioral outcome following neonatal hypoxia-ischemia in rats.
Journal: Developmental neuroscience 20120301
Title: Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells.
Journal: Medical oncology (Northwood, London, England) 20111201
Title: Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats.
Journal: Neurotoxicity research 20111101
Title: Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.
Journal: Cancer letters 20110901
Title: Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice.
Journal: European journal of pharmacology 20110715
Title: Embelin ameliorates dextran sodium sulfate-induced colitis in mice.
Journal: International immunopharmacology 20110601
Title: RP-HPLC-DAD method for the estimation of embelin as marker in Embelia ribes and its polyherbal formulations.
Journal: Biomedical chromatography : BMC 20110501
Title: Protective effect of embelin against acetic acid induced ulcerative colitis in rats.
Journal: European journal of pharmacology 20110301
Title: Anticonvulsant activity of embelin isolated from Embelia ribes.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110115
Title: Synthesis and evaluation of analgesic and anti-inflammatory activities of most active free radical scavenging derivatives of embelin-A structure-activity relationship.
Journal: Chemical & pharmaceutical bulletin 20110101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Synthesis and characterization of amphiphilic lipopolymers for micellar drug delivery.
Journal: Biomacromolecules 20101011
Title: Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.
Journal: The Journal of pathology 20101001
Title: Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway.
Journal: Molecular cancer research : MCR 20101001
Title: Activation of endothelial nitric oxide synthase by the pro-apoptotic drug embelin: Striking discrepancy between nitric oxide-mediated cyclic GMP accumulation and L-citrulline formation.
Journal: Nitric oxide : biology and chemistry 20100515
Title: X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor.
Journal: Molecular cancer therapeutics 20100501
Title: Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis.
Journal: Molecular carcinogenesis 20100401
Title: XIAP-mediated protection of H460 lung cancer cells against cisplatin.
Journal: European journal of pharmacology 20100210
Title: Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver.
Journal: Asian Pacific journal of cancer prevention : APJCP 20100101
Title: The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP.
Journal: Neurochemistry international 20091101
Title: Effects of embelin on lipid peroxidation and free radical scavenging activity against liver damage in rats.
Journal: Basic & clinical pharmacology & toxicology 20091001
Title: Micellar delivery of bicalutamide and embelin for treating prostate cancer.
Journal: Pharmaceutical research 20090901
Title: Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis.
Journal: Cancer research 20090601
Title: Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease.
Journal: Phytotherapy research : PTR 20090401
Title: Triterpenes from Cynomorium songaricium--analysis of HCV protease inhibitory activity, quantification, and content change under the influence of heating.
Journal: Journal of natural medicines 20090101
Title: Cell-penetrating peptide-conjugated XIAP-inhibitory cyclic hexapeptides enter into Jurkat cells and inhibit cell proliferation.
Journal: The FEBS journal 20081201
Title: Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
Journal: Journal of agricultural and food chemistry 20080611
Title: Protein-protein recognition as a first step towards the inhibition of XIAP and Survivin anti-apoptotic proteins.
Journal: Journal of molecular recognition : JMR 20080101
Title: Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells.
Journal: The Journal of surgical research 20071001
Title: Free radical scavenging reactions and antioxidant activity of embelin: biochemical and pulse radiolytic studies.
Journal: Chemico-biological interactions 20070425
Title: Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm.
Journal: Journal of ethnopharmacology 20070212
Title: Microwave-assisted extraction of embelin from Embelia ribes.
Journal: Biotechnology letters 20070201
Title: Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products.
Journal: Molecular pharmacology 20070101
Title: Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein.
Journal: Bioorganic & medicinal chemistry letters 20061115
Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
Journal: Journal of molecular graphics & modelling 20061101
Title: A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
Journal: Journal of natural products 20061101
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Journal: Molecular and cellular biochemistry 20060301
Title: Cell death in pancreatitis: caspases protect from necrotizing pancreatitis.
Journal: The Journal of biological chemistry 20060210
Title: Embelin derivatives and their anticancer activity through microtubule disassembly.
Journal: Planta medica 20051001
Title: Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Journal: Fitoterapia 20050901
Title: Cytotoxic activity of embelin from Lysimachia punctata.
Journal: Fitoterapia 20050601
Title: Anti-fertility effects of embelin in female Sprague-Dawley rats may be due to suppression of ovarian function.
Journal: Acta biologica Hungarica 20050101
Title: Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
Journal: Journal of medicinal chemistry 20040506
Title: Bioactive alkyl phenols and embelin from Oxalis erythrorhiza.
Journal: Journal of ethnopharmacology 20031001
Title: Electrochemically synthesized polymer of the plant substance embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone).
Journal: Applied biochemistry and biotechnology 20010101
Title: Inhibitory effects of sudanese medicinal plant extracts on hepatitis C virus (HCV) protease.
Journal: Phytotherapy research : PTR 20001101
Title: Steroid hormone activity of flavonoids and related compounds.
Journal: Breast cancer research and treatment 20000701
Title: Nikolovska-Coleska Z, et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004;47(10):2430-2440.
Title: Ahn KS, et al. Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol. 2007;71(1):209-219.
Title: Lee YJ, et al. XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells. Environ Toxicol. 2017;32(11):2371-2378.
