Home Amines 56741-95-8
56741-95-8,MFCD00813905
Catalog No.:AA003GDP

56741-95-8 | 2-Amino-5-bromo-4-hydroxy-6-phenylpyrimidine

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5mg
≥95%
in stock  
$46.00   $32.00
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10mg
≥95%
in stock  
$82.00   $57.00
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250mg
≥98%(HPLC)
in stock  
$165.00   $115.00
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1g
≥98%(HPLC)
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$324.00   $227.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003GDP
Chemical Name:
2-Amino-5-bromo-4-hydroxy-6-phenylpyrimidine
CAS Number:
56741-95-8
Molecular Formula:
C10H8BrN3O
Molecular Weight:
266.0940
MDL Number:
MFCD00813905
SMILES:
O=c1nc(N)[nH]c(c1Br)c1ccccc1
NSC Number:
149027
Properties
Properties
 
BP:
389.7°C at 760 mmHg  
Form:
Solid  
MP:
268 - 270 °C  
Refractive Index:
1.6520 (estimate)  
Solubility:
DMSO: ≥5mg/mL (warm DMSO)  
Storage:
Light sensitive;Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
343  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
1.2  

Literature

Title: The expression and functions of toll-like receptors in atherosclerosis.

Journal: Mediators of inflammation 20100101

Title: Toll-like receptors: role in dermatological disease.

Journal: Mediators of inflammation 20100101

Title: Intravesical hyperthermia and mitomycin-C for carcinoma in situ of the urinary bladder: experience of the European Synergo working party.

Journal: World journal of urology 20090601

Title: A phase II clinical trial of oral bropirimine in combination with intravesical bacillus Calmette-Guérin for carcinoma in situ of the bladder: a Southwest Oncology Group Study.

Journal: Urologic oncology 20050101

Title: Current state of immunotherapy for bladder cancer.

Journal: Expert review of anticancer therapy 20041201

Title: Current and new strategies in immunotherapy for superficial bladder cancer.

Journal: Urology 20040901

Title: Superficial bladder cancer therapy.

Journal: TheScientificWorldJournal 20040101

Title: Characterization of bropirimine O-glucuronidation in human liver microsomes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20031001

Title: Recognition of pathogen-associated molecular patterns by TLR family.

Journal: Immunology letters 20030122

Title: In vitro antitumor activity of bropirimine against urinary bladder tumor cells.

Journal: Anticancer research 20020101

Title: The limits of bacillus Calmette-Guerin for carcinoma in situ of the bladder.

Journal: The Journal of urology 20010301

Title: Immunotherapy for bladder cancer.

Journal: Current urology reports 20010201

Title: Lack of interaction between bropirimine and 5-fluorouracil on human dihydropyrimidine dehydrogenase.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20010101

Title: Antiviral and immunomodulating inhibitors of experimentally-induced Punta Toro virus infections.

Journal: Antiviral research 19941001

Title: Protection from carcinogen-induced murine bladder carcinoma by interferons and an oral interferon-inducing pyrimidinone, bropirimine.

Journal: Cancer research 19900215

Title: Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents.

Journal: Journal of medicinal chemistry 19851201

Title: Antiviral and other bioactivities of pyrimidinones.

Journal: Pharmacology & therapeutics 19850101

Title: 5-substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents.

Journal: Journal of medicinal chemistry 19800301

Title: Suzuki H, et al. Bropirimine inhibits osteoclast differentiation through production of interferon-β. Biochem Biophys Res Commun. 2015;467(1):146‐151.

Title: Sarosdy MF, et al. Oral bropirimine immunotherapy of bladder carcinoma in situ after prior intravesical bacille Calmette-Guérin. Urology. 1998;51(2):226‐231.

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