Home Fluorides 350-92-5
350-92-5,MFCD00068171
Catalog No.:AA003JSH

350-92-5 | 3-Phenyl-1,1,1-trifluoropropan-2-one

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250mg
96%
in stock  
$75.00   $53.00
- +
1g
95%
in stock  
$79.00   $55.00
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5g
95%
in stock  
$134.00   $94.00
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25g
95%
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$660.00   $462.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003JSH
Chemical Name:
3-Phenyl-1,1,1-trifluoropropan-2-one
CAS Number:
350-92-5
Molecular Formula:
C9H7F3O
Molecular Weight:
188.1465
MDL Number:
MFCD00068171
SMILES:
O=C(C(F)(F)F)Cc1ccccc1
NSC Number:
10062
Properties
Properties
 
Form:
Liquid  
Storage:
Room Temperature;Keep in dry area;  

Computed Properties
 
Complexity:
180  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
2.6  

Downstream Synthesis Route

[1]Jagadeesh,RajenahallyV.;Murugesan,Kathiravan;Alshammari,AhmadS.;Neumann,Helfried;Pohl,Marga-Martina;Radnik,Jörg;Beller,Matthias[Science,2017,vol.358,#6361,p.326-332]

[2]Nes;Burger[JournaloftheAmericanChemicalSociety,1950,vol.72,p.5409,5412]

[3]Soloshonok;Soloshonok,VadimA.;Kirilenko;Kirilenko,AlexanderG.;Kukhar;Kukhar,ValeryP.;Resnati;Resnati,Giuseppe[TetrahedronLetters,1994,vol.35,#19,p.3119-3122]

[4]Das,Manas;O'Shea,DonalF.[Tetrahedron,2013,vol.69,#31,p.6448-6460]

[5]Cheng,Guilin;Xia,Bo;Wu,Qi;Lin,Xianfu[RSCAdvances,2013,vol.3,#25,p.9820-9828]

[6]Jiang;Cheng;Yuan[AsianJournalofChemistry,2015,vol.27,#7,p.2406-2408]

[7]Zhang,Xue;Wang,Xin;Gao,Yuelei;Xu,Xianxiu[ChemicalCommunications,2017,vol.53,#16,p.2427-2430]

350-92-5   
α-trifluoromethyl-β-phenylethanol 

[1]Kuroki,Yoshichika;Sakamaki,Yuko;Iseki,Katsuhiko[OrganicLetters,2001,vol.3,#3,p.457-459]

[2]Linderman,RussellJ.;Graves,DavidM.[JournalofOrganicChemistry,1989,vol.54,#3,p.661-668]

[3]Felix,Caroline;Laurent,Andre;Mison,Pierre[JournalofFluorineChemistry,1995,vol.70,#1,p.71-82]

[4]Gais;Jungen;Jadhav[JournalofOrganicChemistry,2001,vol.66,#10,p.3384-3396]

[5]Kawase,Masami;Sakagami,Hiroshi;Kusama,Kaoru;Motohashi,Noboru;Saito,Setsuo[BioorganicandMedicinalChemistryLetters,1999,vol.9,#21,p.3113-3118]

[6]Locationinpatent:bodytextVitale,Paola;Perna,FilippoMaria;Perrone,MariaGrazia;Scilimati,Antonio[TetrahedronAsymmetry,2011,vol.22,#23,p.1985-1993]

[7]Vitale,Paola;Abbinante,VincenzoMirco;Perna,FilippoMaria;Salomone,Antonio;Cardellicchio,Cosimo;Capriati,Vito[AdvancedSynthesisandCatalysis,2017,vol.359,#6,p.1049-1057]

[8]Brüning,Fabian;Nagae,Haruki;Käch,Daniel;Mashima,Kazushi;Togni,Antonio[Chemistry-AEuropeanJournal,2019,vol.25,#46,p.10818-10822]

350-92-5    33513-42-7   
3-chloro-4,4,4-trifluoro-2-phenyl-but-2-enal 

[1]Hale,JeffreyJ.;Lynch,ChristopherL.;Neway,William;Mills,SanderG.;Hajdu,Richard;Keohane,CarolAnn;Rosenbach,MarkJ.;Milligan,JamesA.;Shei,Gan-Ju;Parent,StephenA.;Chrebet,Gary;Bergstrom,James;Card,Deborah;Ferrer,Marc;Hodder,Peter;Strulovici,Berta;Rosen,Hugh;Mandala,Suzanne[JournalofMedicinalChemistry,2004,vol.47,#27,p.6662-6665]

[2]Uno,Hidemitsu;Tanaka,Masanori;Inoue,Takashi;Ono,Noboru[Synthesis,1999,#3,p.471-474]

[3]Laurent;Lesniak[TetrahedronLetters,1992,vol.33,#52,p.8091-8092]

[4]Laurent,AndreJ.;Leniak,Stanislaw[TetrahedronLetters,1992,vol.33,#23,p.3311-3314]

[5]CurrentPatentAssignee:JOHNSON&JOHNSONINC-WO2006/137019,2006,A1Locationinpatent:Page/Pagecolumn18-19

[1]Grunewald,GaryL.;Caldwell,TimothyM.;Li,Qifang;Criscione,KevinR.[JournalofMedicinalChemistry,1999,vol.42,#17,p.3315-3323]

[2]Creary,Xavier[JournalofOrganicChemistry,1987,vol.52,#22,p.5026-5030]

[3]Jiang,Jun;Lu,Wenxin;Lv,Hui;Zhang,Xumu[OrganicLetters,2015,vol.17,#5,p.1154-1156]

[1]Choudhury-Mukherjee,Indrani;Schenck,HilaryA.;Cechova,Sylvia;Pajewski,ThomasN.;Kapur,Jaideep;Ellena,Jeffrey;Cafiso,DavidS.;Brown,MiltonL.[JournalofMedicinalChemistry,2003,vol.46,#12,p.2494-2501]

[2]Schenck,HilaryA.;Lenkowski,PaulW.;Choudhury-Mukherjee,Indrani;Ko,Seong-Hoon;Stables,JamesP.;Patel,ManojK.;Brown,MiltonL.[BioorganicandMedicinalChemistry,2004,vol.12,#5,p.979-993]

Literature

Title: Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.

Journal: Journal of medicinal chemistry 20050324

Title: Trifluoromethyl ketones show culture age-dependent inhibitory effects on low K(+)-induced apoptosis in cerebellar granule neurons.

Journal: In vivo (Athens, Greece) 20020101

Title: Trifluoromethyl ketone-based inhibitors of apoptosis in cerebellar granule neurons.

Journal: Biological & pharmaceutical bulletin 20011101

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Tags:350-92-5 Molecular Formula|350-92-5 MDL|350-92-5 SMILES|350-92-5 3-Phenyl-1,1,1-trifluoropropan-2-one