Catalog No.:AA003KN8

7206-70-4 | 4-Amino-5-chloro-2-methoxybenzoic acid

Name: Name:4-Amino-5-chloro-2-methoxybenzoic acid
Brand: AABLOCKS
SKU: AA003KN8
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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature
Request for Quotation
Download SDS

Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA003KN8

Chemical Name:

4-Amino-5-chloro-2-methoxybenzoic acid

CAS Number:

7206-70-4

Molecular Formula:

C8H8ClNO3

Molecular Weight:

201.6070

MDL Number:

MFCD00038794

SMILES:

COc1cc(N)c(cc1C(=O)O)Cl

Properties

BP:

369.7 °C at 760 mmHg

Form:

Solid

MP:

206 °C (dec.)(lit.)

Refractive Index:

1.5800 (estimate)

Storage:

Room Temperature;

Computed Properties

Complexity:

200

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

2.1

Upstream Synthesis Route

20896-27-9

7206-70-4

[1]Patent:CN105237422,2016,A,.Locationinpatent:Paragraph0018;0022

[2]OrganicPreparationsandProceduresInternational,1992,vol.24,#1,p.64-66

[3]JournalofMolecularStructure,1988,vol.172,p.381-394

4093-31-6

7206-70-4

[1]Patent:US4138492,1979,A,

[2]Patent:US2005/49416,2005,A1,.Locationinpatent:Page/Pagecolumn11

[3]LettersinDrugDesignandDiscovery,2012,vol.9,#5,p.489-493

24201-13-6

7206-70-4

[1]Patent:WO2005/23808,2005,A2,.Locationinpatent:Page/Pagecolumn37-38

65-49-6

7206-70-4

[1]LettersinDrugDesignandDiscovery,2012,vol.9,#5,p.489-493

[2]Patent:CN105237422,2016,A,

27492-84-8

7206-70-4

[1]OrganicPreparationsandProceduresInternational,1992,vol.24,#1,p.64-66

Downstream Synthesis Route

20896-27-9

7206-70-4

[1]Patent:CN105237422,2016,A.Locationinpatent:Paragraph0018;0022

[2]OrganicPreparationsandProceduresInternational,1992,vol.24,p.64-66

[3]JournalofMolecularStructure,1988,vol.172,p.381-394

7206-70-4

40987-24-4

126645-66-7

[1]JournalofMedicinalChemistry,1990,vol.33,p.1406-1413

7206-70-4

110859-47-7

112885-23-1

[1]JournalofMedicinalChemistry,1990,vol.33,p.1406-1413

7206-70-4

1017114-89-4

112885-11-7

[1]Kato;Morie;Kon;Yoshida;Karasawa;Matsumoto[JournalofMedicinalChemistry,1991,vol.34,#2,p.616-624]

7206-70-4

112914-13-3

112885-17-3

[1]JournalofMedicinalChemistry,1991,vol.34,p.616-624

Literature

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Antidepressant-like effects of neferine in the forced swimming test involve the serotonin1A (5-HT1A) receptor in mice.

Journal: European journal of pharmacology 20100525

Title: Involvement of the 5-HT(1A) receptor in the anti-immobility effects of fluvoxamine in the forced swimming test and mouse strain differences in 5-HT(1A) receptor binding.

Journal: European journal of pharmacology 20100310

Title: Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist.

Journal: Chemical & pharmaceutical bulletin 20020701

Title: Endogenous 5-HT tonically inhibits spontaneous firing activity of dorsal hippocampus CA1 pyramidal neurons through stimulation of 5-HT(1A) receptors in quiet awake rats: in vivo electrophysiological evidence.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010201

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SDS