Home Amines 13035-19-3
13035-19-3,MFCD02179399
Catalog No.:AA003KP6

13035-19-3 | Piperidin-4-amine

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5g
95%
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$18.00   $13.00
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25g
95%
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$85.00   $59.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003KP6
Chemical Name:
Piperidin-4-amine
CAS Number:
13035-19-3
Molecular Formula:
C5H12N2
Molecular Weight:
100.1622
MDL Number:
MFCD02179399
SMILES:
NC1CCNCC1
Properties
Properties
 
BP:
65°C at 760 mmHg  
Form:
Liquid  
Refractive Index:
n20/D 1.4910(lit.)  
Stability:
Hygroscopic  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
48  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
XLogP3:
-0.6  

Literature

Title: Preparation and spectral characterization of fluorescence probes based on 4-N,N-dimethylamino benzoic acid and sterically hindered amines.

Journal: Journal of fluorescence 20120901

Title: Variation of the intercalating proline in artificial peptides mimicking the DNA binding and bending IHF protein.

Journal: Amino acids 20120701

Title: Hippocampus versus entorhinal cortex decoupling by an NR2 subunit-specific block of NMDA receptors in a rat in vitro model of temporal lobe epilepsy.

Journal: Epilepsia 20120501

Title: Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.

Journal: Nature neuroscience 20120205

Title: Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study.

Journal: Alimentary pharmacology & therapeutics 20120201

Title: Exploring Left-Hand-Side substitutions in the benzoxazinone series of 4-amino-piperidine bacterial type IIa topoisomerase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: Abnormal presynaptic short-term plasticity and information processing in a mouse model of fragile X syndrome.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110727

Title: Studies of tricyclic piperazine/piperidine furnished molecules as novel integrin αvβ3/αIIbβ3 dual antagonists using 3D-QSAR and molecular docking.

Journal: Journal of molecular graphics & modelling 20110201

Title: Oligo(4-aminopiperidine-4-carboxylic acid): an unusual basic oligopeptide with an acid-induced helical conformation.

Journal: Journal of the American Chemical Society 20100929

Title: Piperidinyl-nicotinamides as potent and selective somatostatin receptor subtype 5 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20100315

Title: Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt).

Journal: Journal of medicinal chemistry 20100311

Title: Inhibition requirements of the human apical sodium-dependent bile acid transporter (hASBT) using aminopiperidine conjugates of glutamyl-bile acids.

Journal: Pharmaceutical research 20090701

Title: The effects of oxaliplatin, an anticancer drug, on potassium channels of the peripheral myelinated nerve fibres of the adult rat.

Journal: Neurotoxicology 20081101

Title: Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation.

Journal: Bioorganic & medicinal chemistry 20080815

Title: C101, a novel 4-amino-piperidine derivative selectively blocks N-type calcium channels.

Journal: European journal of pharmacology 20080610

Title: Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.

Journal: Journal of medicinal chemistry 20080410

Title: Palladium-mediated N-arylation of heterocyclic diamines: insights into the origin of an unusual chemoselectivity.

Journal: The Journal of organic chemistry 20070316

Title: Opposing inward and outward conductances regulate rebound discharges in olfactory mitral cells.

Journal: Journal of neurophysiology 20070301

Title: Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease.

Journal: Journal of neurochemistry 20070101

Title: Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity.

Journal: Bioorganic & medicinal chemistry letters 20061015

Title: Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part III: synthesis of potent antagonists with alpha(v)beta3/alpha(IIb)beta3 dual activity and improved water solubility.

Journal: Bioorganic & medicinal chemistry 20060401

Title: Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part 2: synthesis of potent alpha(v)beta3/alpha(IIb)beta3 dual antagonists.

Journal: Bioorganic & medicinal chemistry 20060401

Title: Potent 4-aminopiperidine based antimalarial agents.

Journal: Bioorganic & medicinal chemistry letters 20050117

Title: Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain.

Journal: Journal of medicinal chemistry 20041118

Title: [The mechanisms of short-term forms of synaptic plasticity].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20040801

Title: Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20040716

Title: Stereocontrolled dopamine receptor binding and subtype selectivity of clebopride analogues synthesized from aspartic acid.

Journal: Bioorganic & medicinal chemistry letters 20031006

Title: 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.

Journal: Bioorganic & medicinal chemistry letters 20030721

Title: New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.

Journal: Journal of medicinal chemistry 20021107

Title: A new series of M3 muscarinic antagonists based on the 4-amino-piperidine scaffold.

Journal: Bioorganic & medicinal chemistry letters 20020916

Title: The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency.

Journal: European journal of medicinal chemistry 20020601

Title: 4-Aminopiperidine ureas as potent selective agonists of the human beta(3)-adrenergic receptor.

Journal: Bioorganic & medicinal chemistry letters 20011217

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Tags:13035-19-3 Molecular Formula|13035-19-3 MDL|13035-19-3 SMILES|13035-19-3 Piperidin-4-amine |Organic_Building_Blocks