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52353-35-2,MFCD00793683
Catalog No.:AA003KZQ

52353-35-2 | 4-Chloro-2-(trifluoromethyl)quinazoline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%
in stock  
$22.00   $15.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003KZQ
Chemical Name:
4-Chloro-2-(trifluoromethyl)quinazoline
CAS Number:
52353-35-2
Molecular Formula:
C9H4ClF3N2
Molecular Weight:
232.5897
MDL Number:
MFCD00793683
SMILES:
Clc1nc(nc2c1cccc2)C(F)(F)F
Properties
Properties
 
BP:
171.2±40.0°C at 760 mmHg  
Form:
Solid  
MP:
65-68 °C  
Storage:
Inert atmosphere;2-8℃;Light sensitive;  

Computed Properties
 
Complexity:
234  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
5  
XLogP3:
3.7  

Downstream Synthesis Route
6859-99-0    52353-35-2   
1-(2-trifluoromethyl-quinazolin-4-yl)-piperidin-3-ol 

[1]Sielecki,ThaisM.;Johnson,TriciaL.;Liu,Jie;Muckelbauer,JodiK.;Grafstrom,RobertH.;Cox,Sarah;Boylan,John;Burton,CatherineR.;Chen,Haiying;Smallwood,Angela;Chang,Chong-Hwan;Boisclair,Michael;Benfield,PamelaA.;Trainor,GeorgeL.;Seitz,StevenP.[BioorganicandMedicinalChemistryLetters,2001,vol.11,#9,p.1157-1160]

124-68-5    52353-35-2   
2-methyl-2-(2-trifluoromethyl-quinazolin-4-ylamino)-propan-1-ol 

[1]Sielecki,ThaisM.;Johnson,TriciaL.;Liu,Jie;Muckelbauer,JodiK.;Grafstrom,RobertH.;Cox,Sarah;Boylan,John;Burton,CatherineR.;Chen,Haiying;Smallwood,Angela;Chang,Chong-Hwan;Boisclair,Michael;Benfield,PamelaA.;Trainor,GeorgeL.;Seitz,StevenP.[BioorganicandMedicinalChemistryLetters,2001,vol.11,#9,p.1157-1160]

75-64-9    52353-35-2   
<i>tert</i>-butyl-(2-trifluoromethyl-quinazolin-4-yl)-amine 

[1]Sielecki,ThaisM.;Johnson,TriciaL.;Liu,Jie;Muckelbauer,JodiK.;Grafstrom,RobertH.;Cox,Sarah;Boylan,John;Burton,CatherineR.;Chen,Haiying;Smallwood,Angela;Chang,Chong-Hwan;Boisclair,Michael;Benfield,PamelaA.;Trainor,GeorgeL.;Seitz,StevenP.[BioorganicandMedicinalChemistryLetters,2001,vol.11,#9,p.1157-1160]

625-30-9    52353-35-2   
(1-methyl-butyl)-(2-trifluoromethyl-quinazolin-4-yl)-amine 

[1]Sielecki,ThaisM.;Johnson,TriciaL.;Liu,Jie;Muckelbauer,JodiK.;Grafstrom,RobertH.;Cox,Sarah;Boylan,John;Burton,CatherineR.;Chen,Haiying;Smallwood,Angela;Chang,Chong-Hwan;Boisclair,Michael;Benfield,PamelaA.;Trainor,GeorgeL.;Seitz,StevenP.[BioorganicandMedicinalChemistryLetters,2001,vol.11,#9,p.1157-1160]

Literature

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

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