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Home Thiazoles 74772-78-4
74772-78-4,MFCD00754499
Catalog No.:AA003M37

74772-78-4 | 5-(4-Hydroxybenzyl)-2,4-thiazolidinedione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$87.00   $61.00
- +
1g
95%
in stock  
$170.00   $119.00
- +
5g
95%
in stock  
$544.00   $381.00
- +
10g
95%
in stock  
$976.00   $683.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003M37
Chemical Name:
5-(4-Hydroxybenzyl)-2,4-thiazolidinedione
CAS Number:
74772-78-4
Molecular Formula:
C10H9NO3S
Molecular Weight:
223.2484
MDL Number:
MFCD00754499
SMILES:
O=C1NC(=O)SC1Cc1ccc(cc1)O
Properties
Properties
 
BP:
471.516°C at 760 mmHg  
Form:
Solid  
MP:
145-147°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
274  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-US4725610,1988,A

[2]Sohda;Mizuno;Momose;Ikeda;Fujita;Meguro[JournalofMedicinalChemistry,1992,vol.35,#14,p.2617-2626]

[1]JournalofMedicinalChemistry,1992,vol.35,p.2617-2626

[1]Sohda;Mizuno;Momose;Ikeda;Fujita;Meguro[JournalofMedicinalChemistry,1992,vol.35,#14,p.2617-2626]

30458-68-5    74772-78-4   
5-4-(3-methyl-3<i>H</i>-imidazo4,5-<i>b</i>pyridin-2-yloxy)-benzyl-thiazolidine-2,4-dione 

[1]JournalofMedicinalChemistry,2000,vol.43,p.3052-3066

[1]CurrentPatentAssignee:THERACOSINC-US2003/181494,2003,A1

[2]Fan,Yun-Hua;Chen,Han;Natarajan,Amarnath;Guo,Yuhong;Harbinski,Fred;Iyasere,Julia;Christ,William;Aktas,Huseyin;Halperin,JoseA.[BioorganicandMedicinalChemistryLetters,2004,vol.14,#10,p.2547-2550]

[3]CurrentPatentAssignee:HYUNDAIPHARM.CO.,LTD-WO2013/105753,2013,A1Locationinpatent:Paragraph137;138;139;140;141

Literature

Title: Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity.

Journal: Journal of medicinal chemistry 20121011

Title: A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.

Journal: Bioorganic & medicinal chemistry letters 20110815

Title: Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium.

Journal: Bioorganic & medicinal chemistry letters 20040517

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SDS
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