Catalog No.:AA003MRL

4382-54-1 | 5-Methoxyindole-2-carboxylic acid

Name: Name:5-Methoxyindole-2-carboxylic acid
Brand: AABLOCKS
SKU: AA003MRL
Availability: InStock
Rating: 90 (10 reviews)

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250mg

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in stock

$7.00 $5.00

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97%

in stock

$11.00 $8.00

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97%

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$26.00 $18.00

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10g

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$44.00 $31.00

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25g

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100g

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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature
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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA003MRL

Chemical Name:

5-Methoxyindole-2-carboxylic acid

CAS Number:

4382-54-1

Molecular Formula:

C10H9NO3

Molecular Weight:

191.1834

MDL Number:

MFCD00005614

SMILES:

COc1ccc2c(c1)cc([nH]2)C(=O)O

NSC Number:

30927

Properties

BP:

447.6°C at 760 mmHg

Form:

Solid

MP:

199-201 °C

Refractive Index:

1.5310 (estimate)

Storage:

Keep in dry area;Room Temperature;

Computed Properties

Complexity:

231

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

2.3

Upstream Synthesis Route

4382-54-1

10601-19-1

[1]JournalofMedicinalChemistry,2004,vol.47,#25,p.6270-6282

124-38-9

169383-96-4

4382-54-1

[1]Molecules,2017,vol.22,#11,

4792-58-9

4382-54-1

[1]EuropeanJournalofMedicinalChemistry,1990,vol.25,#3,p.257-265

[2]AdvancedSynthesisandCatalysis,2016,vol.358,#24,p.3938-3942

[3]GazzettaChimicaItaliana,1958,vol.88,p.574,589

[4]GazzettaChimicaItaliana,1955,vol.85,p.1445,1447

[5]OrganicProcessResearchandDevelopment,1998,vol.2,#4,p.214-220

67929-86-6

4382-54-1

[1]JournalofMedicinalChemistry,2004,vol.47,#25,p.6270-6282

[2]Chemistry-AEuropeanJournal,2012,vol.18,#16,p.4859-4865

[3]BioorganicandMedicinalChemistryLetters,2016,vol.26,#3,p.950-954

104-94-9

4382-54-1

[1]OrganicProcessResearchandDevelopment,1998,vol.2,#4,p.214-220

[2]OrganicProcessResearchandDevelopment,1998,vol.2,#4,p.214-220

[3]OrganicProcessResearchandDevelopment,1998,vol.2,#4,p.214-220

[4]AngewandteChemie-InternationalEdition,2016,vol.55,#6,p.2243-2247

[5]BioorganicandMedicinalChemistryLetters,2016,vol.26,#3,p.950-954

Downstream Synthesis Route

4792-58-9

4382-54-1

[1]EuropeanJournalofMedicinalChemistry,1990,vol.25,p.257-265

[2]AdvancedSynthesisandCatalysis,2016,vol.358,p.3938-3942

[3]GazzettaChimicaItaliana,1958,vol.88,p.574,589

[4]OrganicProcessResearchandDevelopment,1998,vol.2,p.214-220

[5]Patent:CN109320448,2019,A.Locationinpatent:Paragraph0043;0050-0053

[6]EuropeanJournalofMedicinalChemistry,2019,vol.173,p.15-31

2055-46-1

4382-54-1

55107-72-7

[1]Nagarajan,K.;Arya,V.P.;Parthasarathy,T.N.;Shenoy,S.J.;Shah,R.K.;Kulkarni,Y.S.[IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1981,vol.20,#8,p.672-679]

108-86-1

4382-54-1

104961-45-7

[1]Patent:US4675332,1987,A

[2]JournalofHeterocyclicChemistry,1987,vol.24,p.811-815

4382-54-1

64-17-5

4792-58-9

[1]Tetrahedron,2013,vol.69,p.3039-3044

[2]ChemicalCommunications,2011,vol.47,p.7500-7502

[3]JournalofMedicinalChemistry,2007,vol.50,p.6436-6440

[4]JournalofMedicinalChemistry,1987,vol.30,p.2074-2080

[5]JournalofMedicinalChemistry,2015,vol.58,p.2489-2512

[6]Patent:US2007/149602,2007,A1.Locationinpatent:Page/Pagecolumn5

[7]JournalofMedicinalChemistry,2008,vol.51,p.3414-3421

[8]Patent:CN103992326,2016,B.Locationinpatent:Paragraph0090-0091

[9]JournalofEnzymeInhibitionandMedicinalChemistry,2018,vol.33,p.1225-1238

[10]Patent:US2008/188460,2008,A1.Locationinpatent:Page/Pagecolumn8

[11]JournalofMedicinalChemistry,2020

4382-54-1

62099-65-4

[1]Molecules,2011,vol.16,p.8292-8304

[2]EuropeanJournalofMedicinalChemistry,1990,vol.25,p.257-265

[3]JournalofMedicinalChemistry,1980,vol.23,p.1330-1335

[4]JournaloftheAmericanChemicalSociety,1992,vol.114,p.3346-3355

[5]ActaCrystallographica,SectionC:CrystalStructureCommunications,1995,vol.51,p.1341-1345

[6]BioorganicandMedicinalChemistryLetters,2004,vol.14,p.3345-3349

[7]BioorganicandMedicinalChemistryLetters,2005,vol.15,p.5439-5441

[8]MedicinalChemistryResearch,2010,vol.19,p.1141-1152

[9]EuropeanJournalofMedicinalChemistry,2012,vol.56,p.263-270

[10]BioorganicandMedicinalChemistryLetters,2018,vol.28,p.1127-1131

[11]JournaloftheAmericanChemicalSociety,2019,vol.141,p.981-989

[12]JournalofOrganicChemistry,2019,vol.84,p.5886-5892

Literature

Title: Association of lactate, intracellular pH, and intracellular calcium during capacitation and acrosome reaction: contribution of hamster sperm dihydrolipoamide dehydrogenase, the E3 subunit of pyruvate dehydrogenase complex.

Journal: Journal of andrology 20120101

Title: New spectrofluorimetric methods for determination of melatonin in the presence of N-{2-[1-({3-[2-(acetylamino)ethyl]-5-methoxy-1H-indol-2-yl}methyl)-5-methoxy-1H-indol-3-yl]- ethyl}acetamide: a contaminant in commercial melatonin preparations.

Journal: Chemistry Central journal 20120101

Title: 1,3-Dinitrobenzene-induced metabolic impairment through selective inactivation of the pyruvate dehydrogenase complex.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110801

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Vibrational spectroscopic studies of indolecarboxylic acids and their metal complexes part VIII. 5-methoxyindole-2-carboxylic acid and its Zn(II) complex.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090301

Title: Hamster sperm capacitation: role of pyruvate dehydrogenase A and dihydrolipoamide dehydrogenase.

Journal: Biology of reproduction 20080801

Title: Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.

Journal: Journal of medicinal chemistry 20040506

Title: Novel tyrosine-phosphorylated post-pyruvate metabolic enzyme, dihydrolipoamide dehydrogenase, involved in capacitation of hamster spermatozoa.

Journal: Biology of reproduction 20040401

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