Name: Name:N-Hydroxy-benzamidine
Brand: AABLOCKS
SKU: AA003NXR
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA003NXR

Chemical Name: N-Hydroxy-benzamidine

CAS Number: 613-92-3

Molecular Formula: C7H8N2O

Molecular Weight: 136.1512

MDL Number: MFCD00031485

SMILES: O/N=C(/c1ccccc1)\N

NSC Number: 13999

Properties

BP: 307.4°C at 760 mmHg

Form: Solid

MP: 77 °C

Storage: Inert atmosphere;Room Temperature;

Complexity: 128

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 1

Formal Charge: 0

Heavy Atom Count: 10

Hydrogen Bond Acceptor Count: 2

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 1

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.1

Literature fold

Title: The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues.

Journal: Chemical research in toxicology20121119

Title: Insight into technetium amidoxime complex: oxo technetium(V) complex of N-substituted benzamidoxime as new basic structure for molecular imaging.

Journal: Inorganic chemistry20110207

Title: Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC).

Journal: The Biochemical journal20110115

Title: Convenient synthesis and biological profile of 5-amino-substituted 1,2,4-oxadiazole derivatives.

Journal: European journal of medicinal chemistry20101201

Title: A novel and specific fluorescence reaction for uracil.

Journal: Analytica chimica acta20100803

Title: The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs.

Journal: Journal of medicinal chemistry20081225

Title: Involvement of stearoyl-CoA desaturase in the reduction of amidoxime prodrugs.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20080901

Title: N,N'-dihydroxyamidines: a new prodrug principle to improve the oral bioavailability of amidines.

Journal: Journal of medicinal chemistry20071227

Title: Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme.

Journal: The Journal of biological chemistry20061117

Title: Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro 48-3656 ([[1-[(2s)-2-[[4-[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-acetic acid).

Journal: Drug metabolism and disposition: the biological fate of chemicals20051101

Title: Characterization and partial purification of the rat and human enzyme systems active in the reduction of N-hydroxymelagatran and benzamidoxime.

Journal: Drug metabolism and disposition: the biological fate of chemicals20050401

Title: Metabolism of benzamidoxime (N-hydroxyamidine) in human hepatocytes and role of UDP-glucuronosyltransferases.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20050101

Title: N-Aryl N'-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: structure-activity relationship.

Journal: Journal of medicinal chemistry20020214

Title: Phase 2 metabolites of N-hydroxylated amidines (amidoximes): synthesis, in vitro formation by pig hepatocytes, and mutagenicity testing.

Journal: Chemical research in toxicology20010301

613-92-3 | N-Hydroxy-benzamidine