638-23-3,MFCD00002614
Catalog No.:AA003OMI

638-23-3 | (2R)-2-amino-3-[(carboxymethyl)sulfanyl]propanoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
98%
in stock  
$19.00   $14.00
- +
25g
98%
in stock  
$31.00   $22.00
- +
100g
98%
in stock  
$63.00   $44.00
- +
500g
98%
in stock  
$114.00   $80.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003OMI
Chemical Name:
(2R)-2-amino-3-[(carboxymethyl)sulfanyl]propanoic acid
CAS Number:
638-23-3
Molecular Formula:
C5H9NO4S
Molecular Weight:
179.1943
MDL Number:
MFCD00002614
SMILES:
OC(=O)CSC[C@@H](C(=O)O)N
Properties
Properties
 
BP:
393.5°C at 760 mmHg  
Form:
Solid  
MP:
208-213 °C (dec.)  
Refractive Index:
1.5216 (estimate)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
161  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-3.1  

Synonyms
 
  
Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,1956,vol.78,p.4483,4487

[1]BiochemicalJournal,1933,vol.27,p.1142

[2]Patent:US2014/187546,2014,A1.Locationinpatent:Paragraph0120-0122

[1]ArchivderPharmazie,1987,vol.320,p.473-474

[2]JournalofOrganicChemistry,1958,vol.23,p.1251,1956

[3]JournalfurpraktischeChemie(Leipzig1954),1969,vol.311,p.1018-1028

[1]ArchivderPharmazie,1990,vol.323,p.957-965

[2]JournalofBiologicalChemistry,1958,vol.230,p.669,678

[3]JournalofOrganicChemistry,1958,vol.23,p.1251,1956

[4]JournalfurpraktischeChemie(Leipzig1954),1969,vol.311,p.1018-1028

[1]JournaloftheAmericanChemicalSociety,1944,vol.66,p.1757    JournaloftheAmericanChemicalSociety,1945,vol.67,p.2098

[2]Patent:US2537892,1944,

[3]JournaloftheChemicalSociety,1960,p.2906-2914

Literature

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Journal: Chemico-biological interactions 20140905

Title: Oxidative stress and innate immunity responses in cigarette smoke stimulated nasal epithelial cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20140301

Title: Carbocysteine regulates innate immune responses and senescence processes in cigarette smoke stimulated bronchial epithelial cells.

Journal: Toxicology letters 20131125

Title: S-Carboxyethylcysteine (a constituent of Acacia seed) negatively affects casein protein utilization by rats.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20120701

Title: Drug fever due to S-carboxymethyl-L-cystein: demonstration of a causative agent with patch tests.

Journal: The Journal of dermatology 20120601

Title: Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline.

Journal: Frontiers in bioscience (Elite edition) 20120601

Title: An investigation into possible xenobiotic-endobiotic inter-relationships involving the amino acid analogue drug, S-carboxymethyl-L-cysteine and plasma amino acids in humans.

Journal: Amino acids 20120501

Title: S-carboxymethyl-L-cysteine.

Journal: Drug metabolism reviews 20120501

Title: [Notes on syrups and dry syrups of ambroxol hydrochloride and L-carbocysteine].

Journal: Arerugi = [Allergy] 20120501

Title: Carbocisteine promotes phagocytosis of apoptotic cells by alveolar macrophages.

Journal: European journal of pharmacology 20120227

Title: Efficacy of combined treatment with S-carboxymethylcysteine (carbocisteine) and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp.

Journal: Auris, nasus, larynx 20120201

Title: Disulphide linkage in mouse ST6Gal-I: determination of linkage positions and mutant analysis.

Journal: Journal of biochemistry 20120201

Title: l-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells.

Journal: Respiratory physiology & neurobiology 20120115

Title: S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells.

Journal: Journal of medical microbiology 20120101

Title: Carbocisteine reduces the cytotoxicity of oxaliplatin.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20120101

Title: [Expression and role of sugar chains on airway mucus during the exacerbation of airway inflammation].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101

Title: The B°AT1 amino acid transporter from rat kidney reconstituted in liposomes: kinetics and inactivation by methylmercury.

Journal: Biochimica et biophysica acta 20111001

Title: Carbocisteine protects against emphysema induced by cigarette smoke extract in rats.

Journal: Chest 20110501

Title: A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics.

Journal: Biochemical pharmacology 20110415

Title: Recombinant heteromeric phenylalanine monooxygenase and the oxygenation of carbon and sulfur substrates.

Journal: The Journal of pharmacy and pharmacology 20110401

Title: Identification of novel small molecule antimicrobials targeting Mycoplasma bovis.

Journal: The Journal of antimicrobial chemotherapy 20110301

Title: Respiratory paradoxical adverse drug reactions associated with acetylcysteine and carbocysteine systemic use in paediatric patients: a national survey.

Journal: PloS one 20110101

Title: Protein modification by dicarbonyl molecular species in neurodegenerative diseases.

Journal: Journal of amino acids 20110101

Title: Inactivation by Hg2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling.

Journal: Biochemical pharmacology 20101015

Title: Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.

Journal: Biochemical pharmacology 20101001

Title: The effect and mechanism of action of carbocysteine on airway bacterial load in rats chronically exposed to cigarette smoke.

Journal: Respirology (Carlton, Vic.) 20101001

Title: Carbocisteine normalizes the viscous property of mucus through regulation of fucosylated and sialylated sugar chain on airway mucins.

Journal: European journal of pharmacology 20100901

Title: Inhibitory effects of carbocisteine on type A seasonal influenza virus infection in human airway epithelial cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20100801

Title: Effects of combination therapy with montelukast and carbocysteine in allergen-induced airway hyperresponsiveness and airway inflammation.

Journal: British journal of pharmacology 20100701

Title: [Mucolytic drugs: towards a contraindication in infants].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100601

Title: Post-translational activation of human phenylalanine 4-monooxygenase from an endobiotic to a xenobiotic enzyme by reactive oxygen and reactive nitrogen species.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100501

Title: The pharmacokinetics of orally administered S-carboxymethyl-L-cysteine in the dog, calf and sheep.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100219

Title: Isoprostanes-biomarkers of lipid peroxidation: their utility in evaluating oxidative stress and analysis.

Journal: International journal of molecular sciences 20100101

Title: Association between lung function and exacerbation frequency in patients with COPD.

Journal: International journal of chronic obstructive pulmonary disease 20100101

Title: Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy.

Journal: Experimental diabetes research 20100101

Title: Phenylalanine 4-monooxygenase and the role of endobiotic metabolism enzymes in xenobiotic biotransformation.

Journal: Expert opinion on drug metabolism & toxicology 20091001

Title: Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells.

Journal: Respirology (Carlton, Vic.) 20090901

Title: L-carbocisteine reduces neutrophil elastase-induced mucin production.

Journal: Respiratory physiology & neurobiology 20090630

Title: Carbocysteine: clinical experience and new perspectives in the treatment of chronic inflammatory diseases.

Journal: Expert opinion on pharmacotherapy 20090301

Title: Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease.

Journal: The Cochrane database of systematic reviews 20090121

Title: Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis.

Journal: The Cochrane database of systematic reviews 20090121

Title: The activity of wild type and mutant phenylalanine hydroxylase with respect to the C-oxidation of phenylalanine and the S-oxidation of S-carboxymethyl-L-cysteine.

Journal: Molecular genetics and metabolism 20090101

Title: Human phenylalanine monooxygenase and thioether metabolism.

Journal: The Journal of pharmacy and pharmacology 20090101

Title: Carbocisteine can scavenge reactive oxygen species in vitro.

Journal: Respirology (Carlton, Vic.) 20090101

Title: Mouse recombinant phenylalanine monooxygenase and the S-oxygenation of thioether substrates.

Journal: Journal of biochemical and molecular toxicology 20090101

Title: Sequestration of Alkyltin(IV) compounds in aqueous solution: formation, stability, and empirical relationships for the binding of dimethyltin(IV) cation by N- and O-donor ligands.

Journal: Bioinorganic chemistry and applications 20090101

Title: Measurement of phenylalanine monooxygenase (PAH) activities.

Journal: Current protocols in toxicology 20090101

Title: The role for S-carboxymethylcysteine (carbocisteine) in the management of chronic obstructive pulmonary disease.

Journal: International journal of chronic obstructive pulmonary disease 20081201

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Carbocisteine for acute exacerbations of COPD.

Journal: Lancet (London, England) 20081108

Title: Carbocisteine for acute exacerbations of COPD.

Journal: Lancet (London, England) 20081108

Title: Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080801

Title: A PEACE-ful solution to COPD exacerbations?

Journal: Lancet (London, England) 20080614

Title: Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study.

Journal: Lancet (London, England) 20080614

Title: Glutaraldehyde is an effective cross-linker for production of antibodies against advanced glycation end-products.

Journal: Journal of immunological methods 20080520

Title: s-Carboxymethylcysteine inhibits carbachol-induced constriction of epithelium-denuded rat and human airway preparations.

Journal: Clinical and experimental pharmacology & physiology 20080501

Title: Immunological detection of N omega-(Carboxymethyl)arginine by a specific antibody.

Journal: Annals of the New York Academy of Sciences 20080401

Title: Usefulness of antibodies for evaluating the biological significance of AGEs.

Journal: Annals of the New York Academy of Sciences 20080401

Title: Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody.

Journal: Journal of immunological methods 20080320

Title: [Bitterness of the mixture of clarithromycin dry syrup and carbocisteine preparation--difference between brand name and generic drugs].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080301

Title: Influence of various combinations of mucolytic agent and non-ionic surfactant on intestinal absorption of poorly absorbed hydrophilic compounds.

Journal: International journal of pharmaceutics 20080212

Title: S-CMC-Lys protective effects on human respiratory cells during oxidative stress.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

Title: Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine by human cytosolic fractions.

Journal: Drug metabolism and drug interactions 20080101

Title: Carbocisteine improves quality of life in patients with chronic obstructive pulmonary disease.

Journal: Journal of the American Geriatrics Society 20071101

Title: The suppression of enhanced bitterness intensity of macrolide dry syrup mixed with an acidic powder.

Journal: Chemical & pharmaceutical bulletin 20071001

Title: Mechanisms for the proton mobility-dependent gas-phase fragmentation reactions of S-alkyl cysteine sulfoxide-containing peptide ions.

Journal: Journal of the American Society for Mass Spectrometry 20070901

Title: Bacterial lysate in the prevention of acute exacerbation of COPD and in respiratory recurrent infections.

Journal: International journal of chronic obstructive pulmonary disease 20070901

Title: Plasma protein advanced glycation end products, carboxymethyl cysteine, and carboxyethyl cysteine, are elevated and related to nephropathy in patients with diabetes.

Journal: Molecular and cellular biochemistry 20070801

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Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070801

Title: Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20070715

Title: Fluorimetric determination of some sulfur containing compounds through complex formation with terbium (Tb+3) and uranium (U+3).

Journal: Journal of fluorescence 20070501

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Journal: Prescrire international 20070201

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Journal: CSH protocols 20070201

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Journal: Chemical research in toxicology 20061201

Title: Carbocysteine therapy in older people with chronic obstructive pulmonary disease.

Journal: Journal of the American Geriatrics Society 20061101

Title: Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols.

Journal: The Biochemical journal 20060901

Title: Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells.

Journal: The European respiratory journal 20060701

Title: Antioxidant therapeutic targets in COPD.

Journal: Current drug targets 20060601

Title: Ambroxol for the prevention of acute upper respiratory disease.

Journal: Clinical and experimental medicine 20060601

Title: A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060501

Title: A comparative bioavailability study of a generic capsule formulation containing carbocysteine.

Journal: Die Pharmazie 20060501

Title: Efficacy of S-carboxymethyl-L-cysteine for otitis media with effusion.

Journal: Ear, nose, & throat journal 20060501

Title: The sulphoxidation of S-carboxymethyl-L-cysteine in COPD.

Journal: The European respiratory journal 20060401

Title: Cerebral formation in situ of S-carboxymethylcysteine after ifosfamide administration to mice: a further clue to the mechanism of ifosfamide encephalopathy.

Journal: Toxicology letters 20060301

Title: Antioxidant therapies in COPD.

Journal: International journal of chronic obstructive pulmonary disease 20060301

Title: Thiodiglycolic acid and dermatological reactions following S-carboxymethyl-L-cysteine administration.

Journal: The British journal of dermatology 20060201

Title: Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease.

Journal: Journal of the American Geriatrics Society 20060201

Title: Effects of carbocisteine on sialyl-Lewis x expression in an airway carcinoma cell line stimulated with tumor necrosis factor-alpha.

Journal: European journal of pharmacology 20060120

Title: S-CMC-Lys-dependent stimulation of electrogenic glutathione secretion by human respiratory epithelium.

Journal: Journal of molecular medicine (Berlin, Germany) 20060101

Title: Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells.

Journal: BMC infectious diseases 20060101

Title: High-throughput determination of carbocysteine in human plasma by liquid chromatography/tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: An occupational hygiene investigation of exposure to acrylamide and the role for urinary S-carboxyethyl-cysteine (CEC) as a biological marker.

Journal: The Annals of occupational hygiene 20051101

Title: S-carboxymethylcysteine normalises airway responsiveness in sensitised and challenged mice.

Journal: The European respiratory journal 20051001

Title: Evidence for the formation of adducts and S-(carboxymethyl)cysteine on reaction of alpha-dicarbonyl compounds with thiol groups on amino acids, peptides, and proteins.

Journal: Chemical research in toxicology 20050801

Title: Re(CO)(3) complexes synthesized via an improved preparation of aqueous fac-[Re(CO)(3)(H(2)O)(3)](+) as an aid in assessing (99m)Tc imaging agents. Structural characterization and solution behavior of complexes with thioether-bearing amino acids as tridentate ligands.

Journal: Inorganic chemistry 20050725

Title: Thiodiglycolic acid as a possible causative agent of fixed drug eruption provoked only after continuous administration of S-carboxymethyl-L-cysteine: case report and review of reported cases.

Journal: The British journal of dermatology 20050701

Title: Effect of glucose concentration on formation of AGEs in erythrocytes in vitro.

Journal: Annals of the New York Academy of Sciences 20050601

Title: Analysis of plasma amino acids by HPLC with photodiode array and fluorescence detection.

Journal: Clinica chimica acta; international journal of clinical chemistry 20050401

Title: [Fixed drug eruption and carbocysteine].

Journal: Annales de dermatologie et de venereologie 20050401

Title: Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine in HepG2 cells.

Journal: Drug metabolism and drug interactions 20050101

Title: Induction of cysteine dioxygenase activity by oral administration of cysteine analogues to the rat: implications for drug efficacy and safety.

Journal: Drug metabolism and drug interactions 20050101

Title: Phenylalanine hydroxylase: possible involvement in the S-oxidation of S-carboxymethyl-l-cysteine.

Journal: Analytical biochemistry 20041201

Title: Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate (SCMC-Lys).

Journal: European journal of pharmacology 20041128

Title: N-acetylcysteine inhibits Na+ absorption across human nasal epithelial cells.

Journal: Journal of cellular physiology 20041001

Title: Cancer-related anorexia/cachexia syndrome and oxidative stress: an innovative approach beyond current treatment.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20041001

Title: Reduced airway inflammation and remodeling in parallel with mucin 5AC protein expression decreased by s-carboxymethylcysteine, a mucoregulant, in the airways of rats exposed to sulfur dioxide.

Journal: International archives of allergy and immunology 20040801

Title: Lack of congruence between cysteine dioxygenase activity and S-carboxymethyl-L-cysteine S-oxidation activity in rat cytosol.

Journal: The Journal of pharmacy and pharmacology 20040801

Title: Spectrophotometric determination of penicillamine and carbocisteine based on formation of metal complexes.

Journal: Farmaco (Societa chimica italiana : 1989) 20040601

Title: Chemical modification of muscle protein in diabetes.

Journal: Archives of biochemistry and biophysics 20040515

Title: Ion-chromatographic determination of carbocisteine in pharmaceuticals based on non-suppressed conductimetric detection.

Journal: Journal of chromatography. A 20040213

Title: The effect of cysteine analogues on the excretion of urinary sulphate in the rat following cysteine administration.

Journal: Drug metabolism and drug interactions 20040101

Title: Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine.

Journal: Drug metabolism and drug interactions 20040101

Title: S-carboxymethylcysteine inhibits the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells.

Journal: Microbial pathogenesis 20030601

Title: Effect of carbocysteine on cough reflex to capsaicin in asthmatic patients.

Journal: British journal of clinical pharmacology 20030601

Title: Thirty-five cases of S-carboxymethylcysteine use in paraquat poisoning.

Journal: Veterinary and human toxicology 20030201

Title: Determination of carbocysteine in human plasma by liquid chromatography/tandem mass spectrometry employing precolumn derivatization.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: Carbocysteine lysine salt monohydrate (SCMC-LYS) is a selective scavenger of reactive oxygen intermediates (ROIs).

Journal: European cytokine network 20030101

Title: Subcutaneous interleukin-2 in combination with medroxyprogesterone acetate and antioxidants in advanced cancer responders to previous chemotherapy: phase II study evaluating clinical, quality of life, and laboratory parameters.

Journal: Journal of experimental therapeutics & oncology 20030101

Title: Neurological toxicity of ifosfamide.

Journal: Oncology 20030101

Title: An investigation into the inter-relationships of sulphur xeno-biotransformation pathways in Parkinson's and motor neurone diseases.

Journal: Drug metabolism and drug interactions 20030101

Title: Degradation to sulphate of S-methyl-L-cysteine sulphoxide and S-carboxymethyl-L-cysteine sulphoxide in man.

Journal: Drug metabolism and drug interactions 20030101

Title: [Mucolytic agents for acute respiratory tract infections in infants: a pharmacoepidemiologic problem?].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20021101

Title: S-carboxymethylcysteine inhibits neutrophil activation mediated by N-formyl-methionyl-leucyl-phenylalanine.

Journal: European journal of pharmacology 20020802

Title: Prolonged survival after experimental paraquat intoxication: role of alternative antioxidants.

Journal: Veterinary and human toxicology 20020201

Title: Study on the inhibition of protein production by L-cysteine derivatives of nucleic acid bases.

Journal: Nucleic acids research. Supplement (2001) 20020101

Title: Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20011201

Title: Antioxidant activity of carbocysteine lysine salt monohydrate.

Journal: Panminerva medica 20010901

Title: Does early detection of otitis media with effusion prevent delayed language development?

Journal: Archives of disease in childhood 20010801

Title: Effect of fudosteine, a cysteine derivative, on blood flow of tracheal microvasculature increased by airway inflammation.

Journal: Environmental toxicology and pharmacology 20010701

Title: Effects of carbocysteine on antigen-induced increases in cough sensitivity and bronchial responsiveness in guinea pigs.

Journal: The Journal of pharmacology and experimental therapeutics 20010601

Title: Direct determination of s-carboxymethyl-l-cysteine in syrups by reversed-phase high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20010401

Title: Modulating effects of mucoregulating drugs on the attachment of Haemophilus influenzae.

Journal: Microbial pathogenesis 20010301

Title: [Comparative study of effects of anti-infective and respiratory system agents on endogeneous glucocorticoids with macrolides].

Journal: The Japanese journal of antibiotics 20010201

Title: [Effects of carbocisteine on airway inflammation and related events in SO2-exposed rats].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20010101

Title: Chemical and biochemical issues related to X-ray crystallography of the ligand-binding domain of estrogen receptor alpha.

Journal: Bioconjugate chemistry 20010101

Title: A review of xenobiotic metabolism enzymes in Parkinson's disease and motor neuron disease.

Journal: Drug metabolism and drug interactions 20010101

Title: S-carboxymethylcysteine in the treatment of glue ear: quantitative systematic review.

Journal: BMC family practice 20010101

Title: Study about the inhibition of L-cysteine derivatives of nucleic acid bases in protein production.

Journal: Nucleic acids research. Supplement (2001) 20010101

Title: Transfection of fluorescent probed antisense compounds: L-cysteine derivatives of nucleic acid bases.

Journal: Nucleic acids research. Supplement (2001) 20010101

Title: A proposed mechanism for chlorpromazine jaundice--defective hepatic sulphoxidation combined with rapid hydroxylation.

Journal: Journal of hepatology 19880801

Title: Paola Rogliani, et al. Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine. Respir Res. 2019 May 27;20(1):104.

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SDS
Tags:638-23-3 Molecular Formula|638-23-3 MDL|638-23-3 SMILES|638-23-3 (2R)-2-amino-3-[(carboxymethyl)sulfanyl]propanoic acid
Catalog No.: AA003OMI
638-23-3,MFCD00002614
638-23-3 | (2R)-2-amino-3-[(carboxymethyl)sulfanyl]propanoic acid
Pack Size: 5g
Purity: 98%
in stock
$19.00 $14.00
Pack Size: 25g
Purity: 98%
in stock
$31.00 $22.00
Pack Size: 100g
Purity: 98%
in stock
$63.00 $44.00
Pack Size: 500g
Purity: 98%
in stock
$114.00 $80.00
Quantity
- +
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Technical Information
Catalog Number: AA003OMI
Chemical Name: (2R)-2-amino-3-[(carboxymethyl)sulfanyl]propanoic acid
CAS Number: 638-23-3
Molecular Formula: C5H9NO4S
Molecular Weight: 179.1943
MDL Number: MFCD00002614
SMILES: OC(=O)CSC[C@@H](C(=O)O)N
Properties
BP: 393.5°C at 760 mmHg  
Form: Solid  
MP: 208-213 °C (dec.)  
Refractive Index: 1.5216 (estimate)  
Storage: Inert atmosphere;2-8℃;  
Complexity: 161  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 11  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -3.1  
153:   
Downstream Synthesis Route
67-56-1    638-23-3    24815-26-7 

[1]JournaloftheAmericanChemicalSociety,1956,vol.78,p.4483,4487

52-90-4    64-69-7    638-23-3 

[1]BiochemicalJournal,1933,vol.27,p.1142

[2]Patent:US2014/187546,2014,A1.Locationinpatent:Paragraph0120-0122

638-23-3    5439-87-2 

[1]ArchivderPharmazie,1987,vol.320,p.473-474

[2]JournalofOrganicChemistry,1958,vol.23,p.1251,1956

[3]JournalfurpraktischeChemie(Leipzig1954),1969,vol.311,p.1018-1028

638-23-3    25515-73-5 

[1]ArchivderPharmazie,1990,vol.323,p.957-965

[2]JournalofBiologicalChemistry,1958,vol.230,p.669,678

[3]JournalofOrganicChemistry,1958,vol.23,p.1251,1956

[4]JournalfurpraktischeChemie(Leipzig1954),1969,vol.311,p.1018-1028

638-23-3    98-88-4    6332-29-2 

[1]JournaloftheAmericanChemicalSociety,1944,vol.66,p.1757    JournaloftheAmericanChemicalSociety,1945,vol.67,p.2098

[2]Patent:US2537892,1944,

[3]JournaloftheChemicalSociety,1960,p.2906-2914

Literature fold

Title: Synthesis, chemical identification, antioxidant capacities and immunological evaluation studies of a novel silver(I) carbocysteine complex.

Journal: Chemico-biological interactions20140905

Title: Oxidative stress and innate immunity responses in cigarette smoke stimulated nasal epithelial cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20140301

Title: Carbocysteine regulates innate immune responses and senescence processes in cigarette smoke stimulated bronchial epithelial cells.

Journal: Toxicology letters20131125

Title: S-Carboxyethylcysteine (a constituent of Acacia seed) negatively affects casein protein utilization by rats.

Journal: Nutrition (Burbank, Los Angeles County, Calif.)20120701

Title: Drug fever due to S-carboxymethyl-L-cystein: demonstration of a causative agent with patch tests.

Journal: The Journal of dermatology20120601

Title: Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline.

Journal: Frontiers in bioscience (Elite edition)20120601

Title: An investigation into possible xenobiotic-endobiotic inter-relationships involving the amino acid analogue drug, S-carboxymethyl-L-cysteine and plasma amino acids in humans.

Journal: Amino acids20120501

Title: S-carboxymethyl-L-cysteine.

Journal: Drug metabolism reviews20120501

Title: [Notes on syrups and dry syrups of ambroxol hydrochloride and L-carbocysteine].

Journal: Arerugi = [Allergy]20120501

Title: Carbocisteine promotes phagocytosis of apoptotic cells by alveolar macrophages.

Journal: European journal of pharmacology20120227

Title: Efficacy of combined treatment with S-carboxymethylcysteine (carbocisteine) and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp.

Journal: Auris, nasus, larynx20120201

Title: Disulphide linkage in mouse ST6Gal-I: determination of linkage positions and mutant analysis.

Journal: Journal of biochemistry20120201

Title: l-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells.

Journal: Respiratory physiology & neurobiology20120115

Title: S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells.

Journal: Journal of medical microbiology20120101

Title: Carbocisteine reduces the cytotoxicity of oxaliplatin.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20120101

Title: [Expression and role of sugar chains on airway mucus during the exacerbation of airway inflammation].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20120101

Title: The B°AT1 amino acid transporter from rat kidney reconstituted in liposomes: kinetics and inactivation by methylmercury.

Journal: Biochimica et biophysica acta20111001

Title: Carbocisteine protects against emphysema induced by cigarette smoke extract in rats.

Journal: Chest20110501

Title: A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics.

Journal: Biochemical pharmacology20110415

Title: Recombinant heteromeric phenylalanine monooxygenase and the oxygenation of carbon and sulfur substrates.

Journal: The Journal of pharmacy and pharmacology20110401

Title: Identification of novel small molecule antimicrobials targeting Mycoplasma bovis.

Journal: The Journal of antimicrobial chemotherapy20110301

Title: Respiratory paradoxical adverse drug reactions associated with acetylcysteine and carbocysteine systemic use in paediatric patients: a national survey.

Journal: PloS one20110101

Title: Protein modification by dicarbonyl molecular species in neurodegenerative diseases.

Journal: Journal of amino acids20110101

Title: Inactivation by Hg2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling.

Journal: Biochemical pharmacology20101015

Title: Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.

Journal: Biochemical pharmacology20101001

Title: The effect and mechanism of action of carbocysteine on airway bacterial load in rats chronically exposed to cigarette smoke.

Journal: Respirology (Carlton, Vic.)20101001

Title: Carbocisteine normalizes the viscous property of mucus through regulation of fucosylated and sialylated sugar chain on airway mucins.

Journal: European journal of pharmacology20100901

Title: Inhibitory effects of carbocisteine on type A seasonal influenza virus infection in human airway epithelial cells.

Journal: American journal of physiology. Lung cellular and molecular physiology20100801

Title: Effects of combination therapy with montelukast and carbocysteine in allergen-induced airway hyperresponsiveness and airway inflammation.

Journal: British journal of pharmacology20100701

Title: [Mucolytic drugs: towards a contraindication in infants].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie20100601

Title: Post-translational activation of human phenylalanine 4-monooxygenase from an endobiotic to a xenobiotic enzyme by reactive oxygen and reactive nitrogen species.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20100501

Title: The pharmacokinetics of orally administered S-carboxymethyl-L-cysteine in the dog, calf and sheep.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20100219

Title: Isoprostanes-biomarkers of lipid peroxidation: their utility in evaluating oxidative stress and analysis.

Journal: International journal of molecular sciences20100101

Title: Association between lung function and exacerbation frequency in patients with COPD.

Journal: International journal of chronic obstructive pulmonary disease20100101

Title: Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy.

Journal: Experimental diabetes research20100101

Title: Phenylalanine 4-monooxygenase and the role of endobiotic metabolism enzymes in xenobiotic biotransformation.

Journal: Expert opinion on drug metabolism & toxicology20091001

Title: Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells.

Journal: Respirology (Carlton, Vic.)20090901

Title: L-carbocisteine reduces neutrophil elastase-induced mucin production.

Journal: Respiratory physiology & neurobiology20090630

Title: Carbocysteine: clinical experience and new perspectives in the treatment of chronic inflammatory diseases.

Journal: Expert opinion on pharmacotherapy20090301

Title: Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease.

Journal: The Cochrane database of systematic reviews20090121

Title: Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis.

Journal: The Cochrane database of systematic reviews20090121

Title: The activity of wild type and mutant phenylalanine hydroxylase with respect to the C-oxidation of phenylalanine and the S-oxidation of S-carboxymethyl-L-cysteine.

Journal: Molecular genetics and metabolism20090101

Title: Human phenylalanine monooxygenase and thioether metabolism.

Journal: The Journal of pharmacy and pharmacology20090101

Title: Carbocisteine can scavenge reactive oxygen species in vitro.

Journal: Respirology (Carlton, Vic.)20090101

Title: Mouse recombinant phenylalanine monooxygenase and the S-oxygenation of thioether substrates.

Journal: Journal of biochemical and molecular toxicology20090101

Title: Sequestration of Alkyltin(IV) compounds in aqueous solution: formation, stability, and empirical relationships for the binding of dimethyltin(IV) cation by N- and O-donor ligands.

Journal: Bioinorganic chemistry and applications20090101

Title: Measurement of phenylalanine monooxygenase (PAH) activities.

Journal: Current protocols in toxicology20090101

Title: The role for S-carboxymethylcysteine (carbocisteine) in the management of chronic obstructive pulmonary disease.

Journal: International journal of chronic obstructive pulmonary disease20081201

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry20081113

Title: Carbocisteine for acute exacerbations of COPD.

Journal: Lancet (London, England)20081108

Title: Carbocisteine for acute exacerbations of COPD.

Journal: Lancet (London, England)20081108

Title: Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy20080801

Title: A PEACE-ful solution to COPD exacerbations?

Journal: Lancet (London, England)20080614

Title: Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study.

Journal: Lancet (London, England)20080614

Title: Glutaraldehyde is an effective cross-linker for production of antibodies against advanced glycation end-products.

Journal: Journal of immunological methods20080520

Title: s-Carboxymethylcysteine inhibits carbachol-induced constriction of epithelium-denuded rat and human airway preparations.

Journal: Clinical and experimental pharmacology & physiology20080501

Title: Immunological detection of N omega-(Carboxymethyl)arginine by a specific antibody.

Journal: Annals of the New York Academy of Sciences20080401

Title: Usefulness of antibodies for evaluating the biological significance of AGEs.

Journal: Annals of the New York Academy of Sciences20080401

Title: Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody.

Journal: Journal of immunological methods20080320

Title: [Bitterness of the mixture of clarithromycin dry syrup and carbocisteine preparation--difference between brand name and generic drugs].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20080301

Title: Influence of various combinations of mucolytic agent and non-ionic surfactant on intestinal absorption of poorly absorbed hydrophilic compounds.

Journal: International journal of pharmaceutics20080212

Title: S-CMC-Lys protective effects on human respiratory cells during oxidative stress.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology20080101

Title: Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine by human cytosolic fractions.

Journal: Drug metabolism and drug interactions20080101

Title: Carbocisteine improves quality of life in patients with chronic obstructive pulmonary disease.

Journal: Journal of the American Geriatrics Society20071101

Title: The suppression of enhanced bitterness intensity of macrolide dry syrup mixed with an acidic powder.

Journal: Chemical & pharmaceutical bulletin20071001

Title: Mechanisms for the proton mobility-dependent gas-phase fragmentation reactions of S-alkyl cysteine sulfoxide-containing peptide ions.

Journal: Journal of the American Society for Mass Spectrometry20070901

Title: Bacterial lysate in the prevention of acute exacerbation of COPD and in respiratory recurrent infections.

Journal: International journal of chronic obstructive pulmonary disease20070901

Title: Plasma protein advanced glycation end products, carboxymethyl cysteine, and carboxyethyl cysteine, are elevated and related to nephropathy in patients with diabetes.

Journal: Molecular and cellular biochemistry20070801

Title: [A possible case of drug-induced pneumonia due to L-carbocisteine].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20070801

Title: Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.

Journal: Bioorganic & medicinal chemistry letters20070715

Title: Fluorimetric determination of some sulfur containing compounds through complex formation with terbium (Tb+3) and uranium (U+3).

Journal: Journal of fluorescence20070501

Title: Carbocisteine: frequent cutaneous adverse effects.

Journal: Prescrire international20070201

Title: Reduction and s-carboxymethylation of proteins: large-scale method.

Journal: CSH protocols20070201

Title: Protein and low molecular mass thiols as targets and inhibitors of glycation reactions.

Journal: Chemical research in toxicology20061201

Title: Carbocysteine therapy in older people with chronic obstructive pulmonary disease.

Journal: Journal of the American Geriatrics Society20061101

Title: Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols.

Journal: The Biochemical journal20060901

Title: Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells.

Journal: The European respiratory journal20060701

Title: Antioxidant therapeutic targets in COPD.

Journal: Current drug targets20060601

Title: Ambroxol for the prevention of acute upper respiratory disease.

Journal: Clinical and experimental medicine20060601

Title: A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology20060501

Title: A comparative bioavailability study of a generic capsule formulation containing carbocysteine.

Journal: Die Pharmazie20060501

Title: Efficacy of S-carboxymethyl-L-cysteine for otitis media with effusion.

Journal: Ear, nose, & throat journal20060501

Title: The sulphoxidation of S-carboxymethyl-L-cysteine in COPD.

Journal: The European respiratory journal20060401

Title: Cerebral formation in situ of S-carboxymethylcysteine after ifosfamide administration to mice: a further clue to the mechanism of ifosfamide encephalopathy.

Journal: Toxicology letters20060301

Title: Antioxidant therapies in COPD.

Journal: International journal of chronic obstructive pulmonary disease20060301

Title: Thiodiglycolic acid and dermatological reactions following S-carboxymethyl-L-cysteine administration.

Journal: The British journal of dermatology20060201

Title: Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease.

Journal: Journal of the American Geriatrics Society20060201

Title: Effects of carbocisteine on sialyl-Lewis x expression in an airway carcinoma cell line stimulated with tumor necrosis factor-alpha.

Journal: European journal of pharmacology20060120

Title: S-CMC-Lys-dependent stimulation of electrogenic glutathione secretion by human respiratory epithelium.

Journal: Journal of molecular medicine (Berlin, Germany)20060101

Title: Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells.

Journal: BMC infectious diseases20060101

Title: High-throughput determination of carbocysteine in human plasma by liquid chromatography/tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers.

Journal: Rapid communications in mass spectrometry : RCM20060101

Title: An occupational hygiene investigation of exposure to acrylamide and the role for urinary S-carboxyethyl-cysteine (CEC) as a biological marker.

Journal: The Annals of occupational hygiene20051101

Title: S-carboxymethylcysteine normalises airway responsiveness in sensitised and challenged mice.

Journal: The European respiratory journal20051001

Title: Evidence for the formation of adducts and S-(carboxymethyl)cysteine on reaction of alpha-dicarbonyl compounds with thiol groups on amino acids, peptides, and proteins.

Journal: Chemical research in toxicology20050801

Title: Re(CO)(3) complexes synthesized via an improved preparation of aqueous fac-[Re(CO)(3)(H(2)O)(3)](+) as an aid in assessing (99m)Tc imaging agents. Structural characterization and solution behavior of complexes with thioether-bearing amino acids as tridentate ligands.

Journal: Inorganic chemistry20050725

Title: Thiodiglycolic acid as a possible causative agent of fixed drug eruption provoked only after continuous administration of S-carboxymethyl-L-cysteine: case report and review of reported cases.

Journal: The British journal of dermatology20050701

Title: Effect of glucose concentration on formation of AGEs in erythrocytes in vitro.

Journal: Annals of the New York Academy of Sciences20050601

Title: Analysis of plasma amino acids by HPLC with photodiode array and fluorescence detection.

Journal: Clinica chimica acta; international journal of clinical chemistry20050401

Title: [Fixed drug eruption and carbocysteine].

Journal: Annales de dermatologie et de venereologie20050401

Title: Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine in HepG2 cells.

Journal: Drug metabolism and drug interactions20050101

Title: Induction of cysteine dioxygenase activity by oral administration of cysteine analogues to the rat: implications for drug efficacy and safety.

Journal: Drug metabolism and drug interactions20050101

Title: Phenylalanine hydroxylase: possible involvement in the S-oxidation of S-carboxymethyl-l-cysteine.

Journal: Analytical biochemistry20041201

Title: Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate (SCMC-Lys).

Journal: European journal of pharmacology20041128

Title: N-acetylcysteine inhibits Na+ absorption across human nasal epithelial cells.

Journal: Journal of cellular physiology20041001

Title: Cancer-related anorexia/cachexia syndrome and oxidative stress: an innovative approach beyond current treatment.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology20041001

Title: Reduced airway inflammation and remodeling in parallel with mucin 5AC protein expression decreased by s-carboxymethylcysteine, a mucoregulant, in the airways of rats exposed to sulfur dioxide.

Journal: International archives of allergy and immunology20040801

Title: Lack of congruence between cysteine dioxygenase activity and S-carboxymethyl-L-cysteine S-oxidation activity in rat cytosol.

Journal: The Journal of pharmacy and pharmacology20040801

Title: Spectrophotometric determination of penicillamine and carbocisteine based on formation of metal complexes.

Journal: Farmaco (Societa chimica italiana : 1989)20040601

Title: Chemical modification of muscle protein in diabetes.

Journal: Archives of biochemistry and biophysics20040515

Title: Ion-chromatographic determination of carbocisteine in pharmaceuticals based on non-suppressed conductimetric detection.

Journal: Journal of chromatography. A20040213

Title: The effect of cysteine analogues on the excretion of urinary sulphate in the rat following cysteine administration.

Journal: Drug metabolism and drug interactions20040101

Title: Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine.

Journal: Drug metabolism and drug interactions20040101

Title: S-carboxymethylcysteine inhibits the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells.

Journal: Microbial pathogenesis20030601

Title: Effect of carbocysteine on cough reflex to capsaicin in asthmatic patients.

Journal: British journal of clinical pharmacology20030601

Title: Thirty-five cases of S-carboxymethylcysteine use in paraquat poisoning.

Journal: Veterinary and human toxicology20030201

Title: Determination of carbocysteine in human plasma by liquid chromatography/tandem mass spectrometry employing precolumn derivatization.

Journal: Rapid communications in mass spectrometry : RCM20030101

Title: Carbocysteine lysine salt monohydrate (SCMC-LYS) is a selective scavenger of reactive oxygen intermediates (ROIs).

Journal: European cytokine network20030101

Title: Subcutaneous interleukin-2 in combination with medroxyprogesterone acetate and antioxidants in advanced cancer responders to previous chemotherapy: phase II study evaluating clinical, quality of life, and laboratory parameters.

Journal: Journal of experimental therapeutics & oncology20030101

Title: Neurological toxicity of ifosfamide.

Journal: Oncology20030101

Title: An investigation into the inter-relationships of sulphur xeno-biotransformation pathways in Parkinson's and motor neurone diseases.

Journal: Drug metabolism and drug interactions20030101

Title: Degradation to sulphate of S-methyl-L-cysteine sulphoxide and S-carboxymethyl-L-cysteine sulphoxide in man.

Journal: Drug metabolism and drug interactions20030101

Title: [Mucolytic agents for acute respiratory tract infections in infants: a pharmacoepidemiologic problem?].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie20021101

Title: S-carboxymethylcysteine inhibits neutrophil activation mediated by N-formyl-methionyl-leucyl-phenylalanine.

Journal: European journal of pharmacology20020802

Title: Prolonged survival after experimental paraquat intoxication: role of alternative antioxidants.

Journal: Veterinary and human toxicology20020201

Title: Study on the inhibition of protein production by L-cysteine derivatives of nucleic acid bases.

Journal: Nucleic acids research. Supplement (2001)20020101

Title: Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons.

Journal: The Journal of pharmacology and experimental therapeutics20011201

Title: Antioxidant activity of carbocysteine lysine salt monohydrate.

Journal: Panminerva medica20010901

Title: Does early detection of otitis media with effusion prevent delayed language development?

Journal: Archives of disease in childhood20010801

Title: Effect of fudosteine, a cysteine derivative, on blood flow of tracheal microvasculature increased by airway inflammation.

Journal: Environmental toxicology and pharmacology20010701

Title: Effects of carbocysteine on antigen-induced increases in cough sensitivity and bronchial responsiveness in guinea pigs.

Journal: The Journal of pharmacology and experimental therapeutics20010601

Title: Direct determination of s-carboxymethyl-l-cysteine in syrups by reversed-phase high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis20010401

Title: Modulating effects of mucoregulating drugs on the attachment of Haemophilus influenzae.

Journal: Microbial pathogenesis20010301

Title: [Comparative study of effects of anti-infective and respiratory system agents on endogeneous glucocorticoids with macrolides].

Journal: The Japanese journal of antibiotics20010201

Title: [Effects of carbocisteine on airway inflammation and related events in SO2-exposed rats].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20010101

Title: Chemical and biochemical issues related to X-ray crystallography of the ligand-binding domain of estrogen receptor alpha.

Journal: Bioconjugate chemistry20010101

Title: A review of xenobiotic metabolism enzymes in Parkinson's disease and motor neuron disease.

Journal: Drug metabolism and drug interactions20010101

Title: S-carboxymethylcysteine in the treatment of glue ear: quantitative systematic review.

Journal: BMC family practice20010101

Title: Study about the inhibition of L-cysteine derivatives of nucleic acid bases in protein production.

Journal: Nucleic acids research. Supplement (2001)20010101

Title: Transfection of fluorescent probed antisense compounds: L-cysteine derivatives of nucleic acid bases.

Journal: Nucleic acids research. Supplement (2001)20010101

Title: A proposed mechanism for chlorpromazine jaundice--defective hepatic sulphoxidation combined with rapid hydroxylation.

Journal: Journal of hepatology19880801

Title: Paola Rogliani, et al. Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine. Respir Res. 2019 May 27;20(1):104.

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