Home Amines 68401-81-0
68401-81-0,MFCD00072000
Catalog No.:AA003ONO

68401-81-0 | (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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1g
>98.0%(HPLC)
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5g
>98.0%(HPLC)
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003ONO
Chemical Name:
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number:
68401-81-0
Molecular Formula:
C16H17N5O8S
Molecular Weight:
439.3999
MDL Number:
MFCD00072000
SMILES:
CO/N=C(/c1ccco1)\C(=O)N[C@@H]1C(=O)N2[C@H]1SCC(=C2C(=O)O)CO/C(=N/O)/N
Properties
Properties
 
Form:
Solid  
MP:
227° (dec)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
669  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  

Literature

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Title: Concurrent patient-partner treatment in pregnancy: an alternative to expedited partner therapy?

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Title: [Identification of impurity peaks in the HPLC chromatogram by LC-MS and two-dimensional chromatographic correlation spectroscopy].

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Title: Dose escalation of intravenous irinotecan using oral cefpodoxime: a phase I study in pediatric patients with refractory solid tumors.

Journal: Pediatric blood & cancer 20120301

Title: Oral availability of cefadroxil depends on ABCC3 and ABCC4.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120301

Title: Cefpodoxime vs ciprofloxacin for short-course treatment of acute uncomplicated cystitis: a randomized trial.

Journal: JAMA 20120208

Title: Extended-spectrum beta-lactamase-mediated resistance among bacterial isolates recovered from ocular infections.

Journal: Ophthalmic research 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: An efficient one-pot reaction for selective fluorimetric determination of cefpodoxime and its prodrug.

Journal: Talanta 20110930

Title: Quantitative determination of cefetamet in human plasma by liquid chromatography-mass spectrometry.

Journal: Biomedical chromatography : BMC 20110701

Title: Cefpodoxime 10 μg disc screening test for detection of Neisseria gonorrhoeae with mosaic PBP2 and decreased susceptibility to extended-spectrum cephalosporins for public health purposes.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20110601

Title: Pharmacokinetics of cefpodoxime in plasma and subcutaneous fluid following oral administration of cefpodoxime proxetil in male beagle dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20110401

Title: [Comparison of oxacillin, cefoxitin, ceftizoxime, and moxalactam disk diffusion methods for detection of methicillin susceptibility in staphylococci].

Journal: Mikrobiyoloji bulteni 20110401

Title: Synergistic effect of ultrasound and antibiotics against Chlamydia trachomatis-infected human epithelial cells in vitro.

Journal: Ultrasonics sonochemistry 20110101

Title: Is ceftizoxime an appropriate surrogate for amikacin in neonatal sepsis treatment? A randomized clinical trial.

Journal: Acta medica Iranica 20110101

Title: Pharmacokinetics, protein binding, and tissue distribution of orally administered cefpodoxime proxetil and cephalexin in dogs.

Journal: American journal of veterinary research 20101201

Title: Enhancement of bioavailability of cefpodoxime proxetil using different polymeric microparticles.

Journal: AAPS PharmSciTech 20100901

Title: What is your diagnosis? Emphysematous cystitis.

Journal: Journal of the American Veterinary Medical Association 20100715

Title: Physicochemical and pharmacokinetic characterization of a spray-dried cefpodoxime proxetil nanosuspension.

Journal: Chemical & pharmaceutical bulletin 20100701

Title: A novel sensor for cephalosporins based on electrocatalytic oxidation by poly(o-anisidine)/SDS/Ni modified carbon paste electrode.

Journal: Talanta 20100615

Title: Cefpodoxime-induced hyperprolactinemic galactorrhea.

Journal: Annals of internal medicine 20100119

Title: A case of immune hemolytic anemia induced by ceftizoxime and cefobactam (sulbactam/cefoperazone).

Journal: The Korean journal of laboratory medicine 20091201

Title: Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: application to validation and quantification of cefepime, cefixime and cefoperazone.

Journal: Talanta 20091115

Title: Ionic liquids as superior solvents for headspace gas chromatography of residual solvents with very low vapor pressure, relevant for pharmaceutical final dosage forms.

Journal: Journal of chromatography. A 20090807

Title: Extended-spectrum beta-lactamase-producing phenotype signifies a poor prognosis for patients with cefpodoxime-resistant Escherichia coli or Klebsiella pneumoniae bacteremia.

Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20090801

Title: Preparation of cefpodoxime proxetil fine particles using supercritical fluids.

Journal: International journal of pharmaceutics 20090318

Title: Switch therapy in full-term neonates with presumed or proven bacterial infection.

Journal: Journal of chemotherapy (Florence, Italy) 20090201

Title: Cephalosporins with clavulinic acid.

Journal: Indian pediatrics 20090101

Title: Simultaneous spectrophotometric determination of Cefpodoxime proxetil and Potassium clavulanate.

Journal: Hindustan antibiotics bulletin 20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Scintigraphic imaging using technetium-99m-labeled ceftizoxime in an experimental model of acute osteomyelitis in rats.

Journal: Nuclear medicine communications 20080901

Title: In vitro study to compare sensitivity of amoxicillin+clavulanic acid and cefpodoxime+clavulanic acid among beta-lactamase positive clinical isolates of gram-positive and gram-negative pathogens.

Journal: Journal of the Indian Medical Association 20080801

Title: Detection of extended spectrum beta-lactamase production in clinical isolates of Klebsiella spp.

Journal: The Indian journal of medical research 20080401

Title: Gastro-retentive dosage form for improving bioavailability of Cefpodoxime proxetil in rats.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080301

Title: Preparation & characterization of solid inclusion complex of cefpodoxime proxetil with beta-cyclodextrin.

Journal: Current drug delivery 20080101

Title: Detection of ESBL bacteria from clinical specimens: evaluation of a new selective medium.

Journal: British journal of biomedical science 20080101

Title: Cefpodoxime proxetil compared with cefixime for treatment of typhoid fever in children.

Journal: Indian pediatrics 20071101

Title: The comparative plasma pharmacokinetics of intravenous cefpodoxime sodium and oral cefpodoxime proxetil in beagle dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20070801

Title: Aminopenicillin-induced exanthema allows treatment with certain cephalosporins or phenoxymethyl penicillin.

Journal: The Journal of antimicrobial chemotherapy 20070701

Title: Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney.

Journal: Molecular pharmacology 20070601

Title: Pharmacodynamics of simulated total versus free-drug serum concentrations of a low versus a high protein bound third-generation oral cephalosporin (Cefpodoxime versus cefditoren) against Streptococcus pneumoniae.

Journal: Journal of chemotherapy (Florence, Italy) 20070601

Title: Inhibitors of bacterial virulence identified in a surrogate host model.

Journal: Cellular microbiology 20070501

Title: Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil.

Journal: International journal of pharmaceutics 20070201

Title: Structural identification and characterization of impurities in ceftizoxime sodium.

Journal: Journal of pharmaceutical and biomedical analysis 20070117

Title: Simultaneous determination of cefazolin or ceftizoxime in presence of ascorbic acid from pharmaceutical formulation and human serum by RP-HPLC.

Journal: Pakistan journal of pharmaceutical sciences 20070101

Title: [Antibiotic susceptibility of Enterobacter sakazakii isolated from powdered formula for infant and young children].

Journal: Wei sheng yan jiu = Journal of hygiene research 20070101

Title: Cefotaxime-ciprofloxacin combination therapy for nontyphoid Salmonella bacteremia and paravertebral abscess after failure of monotherapy.

Journal: Pharmacotherapy 20061101

Title: Application of high-performance liquid chromatography hyphenated techniques for identification of degradation products of cefpodoxime proxetil.

Journal: Journal of chromatography. A 20061006

Title: Investigation on physicochemical and biological differences of cefpodoxime proxetil enantiomers.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061001

Title: Verification of cefmetazole and cefpodoxime proxetil contamination to other pharmaceuticals by liquid chromatography-tandem mass spectrometry.

Journal: Chemical & pharmaceutical bulletin 20061001

Title: Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: a technical note.

Journal: AAPS PharmSciTech 20060901

Title: Urinary tract infection caused by fluoroquinolone- and cephem-resistant Enterobacteriaceae.

Journal: International journal of antimicrobial agents 20060801

Title: Investigation of factors responsible for low oral bioavailability of cefpodoxime proxetil.

Journal: International journal of pharmaceutics 20060724

Title: LC/MS/MS method for the determination of trace amounts of cefmetazole and cefpodoxime proxetil contaminants in pharmaceutical manufacturing environments.

Journal: Journal of pharmaceutical and biomedical analysis 20060616

Title: Superior discriminative performance of ceftizoxime disk diffusion test for detecting meticillin-resistant Staphylococcus aureus.

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Title: [Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2004). I. Susceptibility distribution].

Journal: The Japanese journal of antibiotics 20060601

Title: Development and validation of isomer specific RP-HPLC method for quantification of cefpodoxime proxetil.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060501

Title: [Activity of cefpodoxime and other oral beta-lactams against Haemophilus influenzae and Streptococcus pneumoniae with different susceptibilities to penicillin].

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20060301

Title: AmpC beta-lactamase-mediated cefpodoxime-resistant Escherichia coli isolated from faecal samples of healthy volunteers.

Journal: The Journal of antimicrobial chemotherapy 20060201

Title: [Treatment of acute maxillary sinusitis in adults. Comparison of cefpodoxime-proxetil and amoxicillin-clavulanic acid].

Journal: Presse medicale (Paris, France : 1983) 20060101

Title: Laboratory diagnosis of bloodstream infections caused by extended-spectrum beta-lactamase-producing E. coli and Klebsiella species.

Journal: British journal of biomedical science 20060101

Title: Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1.

Journal: Biochemical pharmacology 20051001

Title: Acidity constants of cefetamet, cefotaxime and ceftriaxone; the effect of the substituent at C3 position.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

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Title: [Activity of cefpodoxime against pathogens causing respiratory, urinary or soft tissue infections].

Journal: Revista medica de Chile 20050801

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Journal: The Journal of antimicrobial chemotherapy 20050401

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Journal: International journal of antimicrobial agents 20050201

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Journal: The Journal of antimicrobial chemotherapy 20050101

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Journal: American journal of veterinary research 20050101

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Journal: Oral microbiology and immunology 20021001

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Journal: The Journal of antimicrobial chemotherapy 20020701

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Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20020201

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Journal: British journal of pharmacology 20020101

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Journal: Acta poloniae pharmaceutica 20020101

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Journal: International journal of antimicrobial agents 20011101

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Journal: International journal of antimicrobial agents 20011101

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SDS
Tags:68401-81-0 Molecular Formula|68401-81-0 MDL|68401-81-0 SMILES|68401-81-0 (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid