Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Journal: Chemical research in toxicology 20170515
Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101
Title: Glucocorticoid-dependent expression of O(6)-methylguanine-DNA methyltransferase gene modulates dacarbazine-induced hepatotoxicity in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20100601
Title: Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.
Journal: Molecular cancer research : MCR 20090601
Title: Cerebellar dysfunction caused by procarbazine and consumption of excessive amount of bananas.
Journal: Pediatric blood & cancer 20080601
Title: Meta-analysis of ifosfamide-based combination chemotherapy in advanced soft tissue sarcoma.
Journal: Cancer treatment reviews 20080601
Title: Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080501
Title: The 'old drug' dacarbazine as a second/third line chemotherapy in advanced soft tissue sarcomas.
Journal: Investigational new drugs 20080401
Title: Influence of therapy on the antioxidant status in patients with melanoma.
Journal: Journal of clinical pharmacy and therapeutics 20080401
Title: Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies.
Journal: Cancer chemotherapy and pharmacology 20080301
Title: Plitidepsin has a dual effect inhibiting cell cycle and inducing apoptosis via Rac1/c-Jun NH2-terminal kinase activation in human melanoma cells.
Journal: The Journal of pharmacology and experimental therapeutics 20080301
Title: Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080220
Title: Multicenter phase II study of chemoimmunotherapy in the treatment of metastatic melanoma.
Journal: Anti-cancer drugs 20080201
Title: Hodgkin lymphoma presenting with various immunologic abnormalities, including autoimmune hepatitis, Hashimoto's thyroiditis, autoimmune hemolytic anemia, and immune thrombocytopenia.
Journal: Clinical lymphoma & myeloma 20080201
Title: Unexpected clinical outcome in a patient with liver and brain metastasis from melanoma.
Journal: Anticancer research 20080101
Title: The management of desmoids in patients with familial adenomatous polyposis (FAP).
Journal: Acta chirurgica Iugoslavica 20080101
Title: CD69 on CD56+ NK cells and response to chemoimmunotherapy in metastatic melanoma.
Journal: European journal of clinical investigation 20071101
Title: Comparison of a treatment strategy combining CCI-779 plus DTIC versus DTIC monotreatment in human melanoma in SCID mice.
Journal: The Journal of investigative dermatology 20071001
Title: Results of a multicenter randomized study to evaluate the safety and efficacy of combined immunotherapy with interleukin-2, interferon-{alpha}2b and histamine dihydrochloride versus dacarbazine in patients with stage IV melanoma.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20071001
Title: Biochemotherapy of metastatic melanoma in patients with or without recently diagnosed brain metastases.
Journal: Cancer 20070915
Title: Durable complete responses with high-dose bolus interleukin-2 in patients with metastatic melanoma who have experienced progression after biochemotherapy.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070901
Title: Chemoimmunotherapy for cutaneous melanoma with dacarbazine and epifocal contact sensitizers: results of a nationwide survey of the German Dermatologic Co-operative Oncology Group.
Journal: Journal of cancer research and clinical oncology 20070701
Title: Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines.
Journal: The journal of gene medicine 20070601
Title: Hemorrhagic cystitis in a patient receiving conventional doses of dacarbazine for metastatic malignant melanoma: case report and review of the literature.
Journal: Clinical therapeutics 20070601
Title: Single-agent interleukin-2 in the treatment of metastatic melanoma.
Journal: Current oncology (Toronto, Ont.) 20070201
Title: Resection in the popliteal fossa for metastatic melanoma.
Journal: World journal of surgical oncology 20070101
Title: Serum VEGF-C is associated with metastatic site in patients with malignant melanoma.
Journal: Acta oncologica (Stockholm, Sweden) 20070101
Title: Adjuvant chemotherapy with doxorubicin and dacarbazine has no effect in recurrence-free survival of malignant phyllodes tumors of the breast.
Journal: The breast journal 20070101
Title: Interleukin-2-based biochemotherapy for patients with stage IV melanoma: long-term survivors outside a clinical trial setting.
Journal: Oncology 20070101
Title: Alkylating benzamides with melanoma cytotoxicity: experimental chemotherapy in a mouse melanoma model.
Journal: Melanoma research 20061201
Title: Chemoimmunotherapy with dacarbazine, cisplatin, interferon-alpha2b and interleukin-2 versus two cycles of dacarbazine followed by chemoimmunotherapy in patients with metastatic melanoma: a randomised phase II study of the European Organization for Research and Treatment of Cancer Melanoma Group.
Journal: European journal of cancer (Oxford, England : 1990) 20061101
Title: Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061010
Title: Intralesional therapy of metastatic spreading melanoma with beta-interferon.
Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20060901
Title: Phase II multicenter study of neoadjuvant biochemotherapy for patients with stage III malignant melanoma.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060701
Title: [Hypersensitivity to dacarbazine in patients with metastatic malignant melanoma].
Journal: Annales de dermatologie et de venereologie 20060201
Title: Long-term survival benefit after adjuvant treatment of cutaneous melanoma with dacarbazine and low dose natural interferon alpha: A controlled, randomised multicentre trial.
Journal: Acta oncologica (Stockholm, Sweden) 20060101
Title: Long-term survival in metastatic melanoma patients treated with sequential biochemotherapy: report of a Phase II study.
Journal: Cancer investigation 20060101
Title: Artesunate in the treatment of metastatic uveal melanoma--first experiences.
Journal: Oncology reports 20051201
Title: Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.
Journal: Molecular cancer therapeutics 20051201
Title: Organ- and treatment-specific local response rates to systemic and local treatment modalities in stage IV melanoma.
Journal: The British journal of dermatology 20051101
Title: A retrospective study of biochemotherapy for metastatic melanoma: the importance of dose intensity.
Journal: Cancer biotherapy & radiopharmaceuticals 20051001
Title: Dacarbazine, cisplatin, and interferon-alfa-2b with or without interleukin-2 in metastatic melanoma: a randomized phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050920
Title: Sarcomatoid renal cell carcinoma with a chromophobe component producing beta-human chorionic gonadotropin.
Journal: International journal of urology : official journal of the Japanese Urological Association 20050901
Title: Randomized trial of dacarbazine versus bleomycin, vincristine, lomustine and dacarbazine (BOLD) chemotherapy combined with natural or recombinant interferon-alpha in patients with advanced melanoma.
Journal: Melanoma research 20050801
Title: Phase II/III study of doxorubicin with fluorouracil compared with streptozocin with fluorouracil or dacarbazine in the treatment of advanced carcinoid tumors: Eastern Cooperative Oncology Group Study E1281.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050801
Title: Thalidomide enhances the anti-tumor activity of standard chemotherapy in a human melanoma xenotransplatation model.
Journal: The Journal of investigative dermatology 20050801
Title: Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest.
Journal: International journal of oncology 20050601
Title: Combined chemoimmunotherapy of metastatic melanoma: a single institution experience.
Journal: Melanoma research 20050601
Title: Clusterin regulates drug-resistance in melanoma cells.
Journal: The Journal of investigative dermatology 20050601
Title: Amelanotic malignant melanoma of the esophagus: report of a patient with recurrence successfully treated with chemoendocrine therapy.
Journal: International journal of clinical oncology 20050601
Title: Functional erythropoietin autocrine loop in melanoma.
Journal: The American journal of pathology 20050301
Title: Isolated limb infusion with fotemustine after dacarbazine chemosensitisation for inoperable loco-regional melanoma recurrence.
Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 20041201
Title: The prognostic role of CD4+ and CD8+ lymphocytes during chemoimmunotherapy in metastatic melanoma.
Journal: Melanoma research 20041201
Title: Biochemotherapy in patients with advanced vulvovaginal mucosal melanoma.
Journal: Melanoma research 20041201
Title: Serum bcl-2 and survivin levels in melanoma.
Journal: Melanoma research 20041201
Title: A humanized monoclonal antibody to carcinoembryonic antigen, labetuzumab, inhibits tumor growth and sensitizes human medullary thyroid cancer xenografts to dacarbazine chemotherapy.
Journal: Molecular cancer therapeutics 20041201
Title: Exposure of melanoma cells to dacarbazine results in enhanced tumor growth and metastasis in vivo.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040601
Title: Activity of irinotecan, cisplatin and dacarbazine (CPD) combination in previously treated patients with advanced colorectal carcinoma.
Journal: Experimental oncology 20040601
Title: Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells: effects of Mgmt and Mlh1 mutations.
Journal: DNA repair 20040401
Title: Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040315
Title: Correspondence re: DC Lev et al., Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy. Mol Cancer Ther, 2003;2(8):753-63.
Journal: Molecular cancer therapeutics 20040301
Title: [Chemoimmunotherapy with dacarbazine and aranose combined with interferon-alpha in disseminated cutaneous melanoma].
Journal: Voprosy onkologii 20040101
Title: O6-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma.
Journal: British journal of cancer 20031020
Title: On the effect of biochemotherapy in metastatic malignant melanoma: an immunopathological evaluation.
Journal: Melanoma research 20030801
Title: Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy.
Journal: Molecular cancer therapeutics 20030801
Title: Second-line chemotherapy with dacarbazine and fotemustine in nitrosourea-pretreated patients with recurrent glioblastoma multiforme.
Journal: Anti-cancer drugs 20030701
Title: Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model.
Journal: The Journal of investigative dermatology 20030601
Title: Metastatic melanoma presenting as cardiac mass and hemobilia.
Journal: The American journal of the medical sciences 20030301
Title: Survival with dacarbazine and fotemustine in newly diagnosed glioblastoma multiforme.
Journal: British journal of cancer 20030224
Title: Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer.
Journal: International journal of cancer 20030220
Title: Effect of a novel somatostatin analogue combined with cytotoxic drugs on human tumour xenografts and metastasis of B16 melanoma.
Journal: British journal of cancer 20030113
Title: Farnesyl thiosalicylic acid chemosensitizes human melanoma in vivo.
Journal: The Journal of investigative dermatology 20030101
Title: IL-2-mediated augmentation of NK-cell activity and activation antigen expression on NK- and T-cell subsets in patients with metastatic melanoma treated with interferon-alpha and DTIC.
Journal: Clinical & experimental metastasis 20030101
Title: Phase I/II study of sequential chemoimmunotherapy (SCIT) for metastatic melanoma: outpatient treatment with dacarbazine, granulocyte-macrophage colony-stimulating factor, low-dose interleukin-2, and interferon-alpha.
Journal: Cancer immunology, immunotherapy : CII 20021201
Title: Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response.
Journal: Cancer immunology, immunotherapy : CII 20021001
Title: Chemoimmunohormonal therapy with carmustine, dacarbazine, cisplatin, tamoxifen, and interferon for metastatic melanoma: a prospective phase II study.
Journal: American journal of clinical oncology 20021001
Title: Analysis of O(6)-methylguanine-DNA methyltransferase in melanoma tumours in patients treated with dacarbazine-based chemotherapy.
Journal: Melanoma research 20020801
Title: Successful palliation of stenosing anorectal melanoma by intratumoral injections with natural interferon-beta.
Journal: Melanoma research 20020801
Title: The role of glucocorticoids in the treatment of fulminant hepatitis induced by dacarbazine.
Journal: Anti-cancer drugs 20020201
Title: Combining radioimmunotherapy and chemotherapy for treatment of medullary thyroid carcinoma: effectiveness of dacarbazine.
Journal: Cancer 20020101
Title: Phase II trial of Paclitaxel and Dacarbazine with filgrastim administration in advanced malignant melanoma.
Journal: Cancer investigation 20020101
Title: Docetaxel in combination with dacarbazine in patients with advanced melanoma.
Journal: Oncology 20020101
Title: [Correlation between functional capability and phenotypic characteristics of peripheral blood lymphocytes in patients with malignant melanoma].
Journal: Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka 20020101
Title: Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
Title: Phase II trial of dacarbazine (DTIC) in advanced pancreatic islet cell carcinoma. Study of the Eastern Cooperative Oncology Group-E6282.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010801
Title: Dacarbazine-induced carotid artery and deep venous thrombosis in a patient with leiomyosarcoma: case report.
Journal: Journal of chemotherapy (Florence, Italy) 20010401
Title: Single-agent DTIC versus combination chemotherapy with or without immunotherapy in metastatic melanoma: a meta-analysis of 3273 patients from 20 randomized trials.
Journal: Melanoma research 20010201
Title: Therapeutic implications of the kinetics of immunomodulation during single or combined treatment of melanoma patients with dacarbazine and interferon-alpha.
Journal: Neoplasma 20010101
Title: Dacarbazine DTIC and carboplatin as an outpatient treatment for disseminated malignant melanoma.
Journal: Anticancer research 20010101
Title: Inhibition of melanoma growth and metastasis by combination with (-)-epigallocatechin-3-gallate and dacarbazine in mice.
Journal: Journal of cellular biochemistry 20010101
Title: Cisplatin, dacarbazine, and fotemustine plus interferon alpha in patients with advanced malignant melanoma. A multicenter phase II study of the Italian Cooperative Oncology Group.
Journal: Cancer 20001215
Title: Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase.
Journal: Carcinogenesis 20001001
Title: Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O(6)-methylguanine-DNA methyltransferase.
Journal: Mutation research 20000214
Title: Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20000101
Title: Chemotherapy for desmoid tumors in association with familial adenomatous polyposis.
Journal: Diseases of the colon and rectum 19970701
Title: Phase I trial of dacarbazine with cyclophosphamide, carmustine, etoposide, and autologous stem-cell transplantation in patients with lymphoma and multiple myeloma.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19940901
Title: FIVB plus GM-CSF in metastatic colorectal cancer.
Journal: Investigational new drugs 19940101
Title: A phase I clinical and pharmacological profile of dacarbazine with autologous bone marrow transplantation in patients with solid tumors.
Journal: Investigational new drugs 19930101
Title: Dana-Farber Cancer Institute studies in advanced sarcoma.
Journal: Seminars in oncology 19900201
Title: [Hepatic veno-occlusive disease caused by Deticene: a cause of acute hypovolemic shock].
Journal: Annales francaises d'anesthesie et de reanimation 19900101
Title: Hepatic vascular toxicity of dacarbazine (DTIC): not a rare complication.
Journal: Hepatology (Baltimore, Md.) 19890501
Title: Fatal hepatic vascular toxicity of DTIC. Is it really a rare event?
Journal: Cancer 19880515
Title: [Ifosfamide treatment for children with malignant tumor].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 19871201
Title: Allergy-induced hepatic toxicity associated with dacarbazine.
Journal: Cancer treatment reports 19870201
Title: Peripheral DTIC neurotoxicity: a case report.
Journal: Cancer chemotherapy and pharmacology 19870101
Title: [DTIC: effect on fibrinolysis and thrombocyte function].
Journal: Onkologie 19861001
Title: Pathophysiological aspects of dacarbazine-induced human liver damage.
Journal: Hepato-gastroenterology 19851201
Title: [Budd-Chiari syndrome following dacarbazine therapy of malignant melanoma--an avoidable complication?].
Journal: Zeitschrift fur Hautkrankheiten 19850615
Title: Single-dose dacarbazine and dactinomycin in advanced malignant melanoma.
Journal: Cancer treatment reports 19850101
Title: Veno-occlusive liver disease after dacarbazine therapy (DTIC) for melanoma.
Journal: Journal of surgical oncology 19841201
Title: Phase I trial of intermittent high-dose dacarbazine.
Journal: Cancer treatment reports 19840301
Title: Acute liver dystrophy with thrombosis of hepatic veins: a fatal complication of dacarbazine treatment.
Journal: Cancer treatment reports 19830901
Title: Mitomycin-associated renal failure. Case report and review.
Journal: Archives of internal medicine 19830401
Title: [Dacarbazine in malignant melanoma. Rare, severe side-effect: Budd-Chiari-syndrome (author's transl)].
Journal: Zeitschrift fur Hautkrankheiten 19820701
Title: [Budd-Chiari syndrome in DTIC therapy].
Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 19820101
Title: Hepatic vascular lesions associated with dacarbazine treatment.
Journal: British medical journal (Clinical research ed.) 19810530
Title: [Veno-occlusive syndrome with acute liver dystrophy following decarbazine therapy of malignant melanoma (author's transl)].
Journal: Klinische Wochenschrift 19810302
Title: Symptoms of occult brain metastases initiated by systemic Dacarbazine (DTIC-DOME) therapy in melanoma patients.
Journal: Clinical oncology 19801201
Title: [Dacarbazine (DTIC) therapy and the Budd-Chiari syndrome].
Journal: MMW, Munchener medizinische Wochenschrift 19800523
Title: Hepatic veno-occlusive disease due to DTIC.
Journal: Cancer 19800515
Title: [Budd-Chiari syndrome during treatment with dacarbazine (DTIC) (author's transl)].
Journal: Deutsche medizinische Wochenschrift (1946) 19800215
Title: Acute hepatic vein thrombosis occurring during therapy for Hodgkin's disease: a case report.
Journal: Cancer 19791201
Title: Hepatic failure in a patient treated with dacarbazine (DTIC) for malignant melanoma.
Journal: Journal of cancer research and clinical oncology 19790101
Title: High incidence of cardiomyopathy in children treated with adriamycin and DTIC in combination chemotherapy.
Journal: Cancer treatment reports 19771201
Title: Neuraxonal dystrophy of the brain in patients receiving antineoplastic chemotherapy.
Journal: Acta neuropathologica 19770331
Title: Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.
Journal: Cancer 19751101
Title: Carcinogenicity of the antineoplastic agent, 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide, and its metabolites in rats.
Journal: Journal of the National Cancer Institute 19750401
Title: Central nervous system complications after combination treatment with adriamycin (NSC-123127) and 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388).
Journal: Cancer chemotherapy reports 19740101
Title: Al-Badr AA, et al. Dacarbazine. Profiles Drug Subst Excip Relat Methodol. 2016;41:323-77.
Title: Rojo JM, et al. Inhibition of T and B lymphoblastic response by mithramycin, dacarbazine, prospidium chloride and peptichemio. Chemotherapy. 1983;29(5):345-51.
Title: Serrone, L., et al., Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year experience overview. J Exp Clin Cancer Res, 2000. 19(1): p. 21-34.
