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7554-12-3,MFCD00048556
Catalog No.:AA003PDT

7554-12-3 | Diethyl malate

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25g
>98.0%(GC)
in stock  
$35.00   $24.00
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500g
>98.0%(GC)
in stock  
$325.00   $228.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003PDT
Chemical Name:
Diethyl malate
CAS Number:
7554-12-3
Molecular Formula:
C8H14O5
Molecular Weight:
190.1938
MDL Number:
MFCD00048556
SMILES:
CCOC(=O)CC(C(=O)OCC)O
FEMA Number:
2374
Properties
Properties
 
BP:
281.6°C at 760 mmHg  
Form:
Liquid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
177  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  
XLogP3:
0.1  

Downstream Synthesis Route

[1]Gopinath,Pushparathinam;Nilaya,Surapaneni;Muraleedharan,KannothManheri[OrganicLetters,2011,vol.13,#8,p.1932-1935]

[2]Kumar;Kumar;Parmar[SyntheticCommunications,1992,vol.22,#7,p.1087-1094]

[3]Morietal.[NipponKagakuZasshi,1956,vol.77,p.459,461,462][Chem.Abstr.,1958,p.7858]

[4]Holy,A.[CollectionofCzechoslovakChemicalCommunications,1978,vol.43,p.3444-3465]

[5]Cohen;Neuwirth;Weinstein[JournaloftheAmericanChemicalSociety,1966,vol.88,#22,p.5306-5315]

[6]Houston,ToddA.;Wilkinson,BrendanL.;Blanchfield,JoanneT.[OrganicLetters,2004,vol.6,#5,p.679-681]

[7]Fedorov;Bogdanov;Fadeev;Lagodzinskaya[RussianChemicalBulletin,2014,vol.63,#5,p.1119-1125][Russ.Chem.Bull.,2014,vol.63,#5,p.1119-1125,7]

[8]Portnova;Yamshchikova,Yu.F.;Krasnykh[RussianJournalofPhysicalChemistry,2019,vol.93,#3,p.577-583][Zh.Fiz.Khim.,2019,vol.93,#3,p.464-470,7]

7554-12-3    19734-51-1   
sulfooxy-succinicacidbis-(2-ethyl-hexyl)-methyl-amide 

[1]CurrentPatentAssignee:DUPONTDENEMOURSINC-US2192906,1937,A

[1]Ingold[JournaloftheChemicalSociety,1921,vol.119,p.339][JournaloftheChemicalSociety,1925,vol.127,p.475]

[1]JournaloftheAmericanChemicalSociety,1948,vol.70,p.3121

[2]JournaloftheAmericanChemicalSociety,1948,vol.70,p.3121

[1]Darzens[ComptesRendusHebdomadairesdesSeancesdel'AcademiedesSciences,1911,vol.152,p.1603]

[2]McKenzie;Barrow[JournaloftheChemicalSociety,1911,vol.99,p.1923,1924]

[3]Gurarii,L.I.;Mukmenev,E.T.[BulletinoftheAcademyofSciencesoftheUSSRDivisionofChemicalScience,1975,vol.24,p.2450-2453][IzvestiyaAkademiiNaukSSSR,SeriyaKhimicheskaya,1975,vol.24,p.2563-2568]

Literature

Title: Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.

Journal: PLoS genetics 20160501

Title: Diethyl maleate inhibits MCA+TPA transformed cell growth via modulation of GSH, MAPK, and cancer pathways.

Journal: Chemico-biological interactions 20140805

Title: Role of glutathione in lung retention of 99mTc-hexamethylpropyleneamine oxime in two unique rat models of hyperoxic lung injury.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20120815

Title: Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells.

Journal: Archives of biochemistry and biophysics 20120301

Title: Effectiveness of high-throughput miniaturized sorbent- and solid phase microextraction techniques combined with gas chromatography-mass spectrometry analysis for a rapid screening of volatile and semi-volatile composition of wines--a comparative study.

Journal: Talanta 20120115

Title: Na-K-ATPase in rat cerebellar granule cells is redox sensitive.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060401

Title: Acute depletion of reduced glutathione causes extensive carbonylation of rat brain proteins.

Journal: Journal of neuroscience research 20060301

Title: Cadmium-induced astroglial death proceeds via glutathione depletion.

Journal: Journal of neuroscience research 20060201

Title: Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.

Journal: Journal of cellular physiology 20050601

Title: Altered differentiation in rat and rabbit limb bud micromass cultures by glutathione modulating agents.

Journal: Free radical biology & medicine 20011215

Title: Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway.

Journal: The Journal of biological chemistry 19991008

Title: Malathion degradation by Trichoderma viride and a Pseudomonas species.

Journal: Science (New York, N.Y.) 19660909

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