Title: Toxicity and related mechanisms of dihydroartemisinin on porcine oocyte maturation in vitro.
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Title: Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner.
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Title: Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle.
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Title: Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120901
Title: The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis.
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Title: Dihydroartemisinin-induced inhibition of proliferation in BEL-7402 cells: an analysis of the mitochondrial proteome.
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Title: Artesunate- and amodiaquine-associated extrapyramidal reactions: a series of 49 cases in VigiBase™.
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Title: In vitro antimalarial activity and drug interactions of fenofibric acid.
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Title: Dihydroartemisinin/Piperaquine: a review of its use in the treatment of uncomplicated Plasmodium falciparum malaria.
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Title: Effect of the in vivo activity of dihydroartemisinin against Schistosoma mansoni infection in mice.
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Title: Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria.
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Title: Drug-drug interaction analysis of pyronaridine/artesunate and ritonavir in healthy volunteers.
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Title: A simplified intravenous artesunate regimen for severe malaria.
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Title: Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line.
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Title: Efficacy and safety of artemisinin-naphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia.
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Title: Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5.
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Title: In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genes.
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Title: Histone deacetylase inhibitors facilitate dihydroartemisinin-induced apoptosis in liver cancer in vitro and in vivo.
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Title: Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India.
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Title: Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1.
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Title: Dihydroartemisinin inhibits angiogenesis in pancreatic cancer by targeting the NF-κB pathway.
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Title: Effects of artemisinin dimers on rat breast cancer cells in vitro and in vivo.
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Title: Highly effective therapy for maternal malaria associated with a lower risk of vertical transmission.
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Title: Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trial.
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Title: Monitoring of artemisinin, dihydroartemisinin, and artemether in environmental matrices using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS).
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Title: Cytotoxicity of ethanolic extracts of Artemisia annua to Molt-4 human leukemia cells.
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Title: Indolone-N-oxide derivatives: in vitro activity against fresh clinical isolates of Plasmodium falciparum, stage specificity and in vitro interactions with established antimalarial drugs.
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Title: A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial.
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Title: Administrative practices of health professionals and use of artesunate-amodiaquine by community members for treating uncomplicated malaria in southern Ghana: implications for artemisinin-based combination therapy deployment.
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Title: Hypoxia modulates the effect of dihydroartemisinin on endothelial cells.
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Title: [Advances in research of dihydroartemisinin against parasitic diseases].
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Title: Dihydroartemisinin induces caspase-8-dependent apoptosis in murine GT1-7 hypothalamic neurons.
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Title: A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue.
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Title: Dihydroartemisinin-praziquantel combinations and multiple doses of dihydroartemisinin in the treatment of Schistosoma japonicum in experimentally infected mice.
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Title: Anti-tumor effects of dihydroartemisinin on human osteosarcoma.
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Title: Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo.
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Title: Anticancer effect of dihydroartemisinin (DHA) in a pancreatic tumor model evaluated by conventional methods and optical imaging.
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Title: Comparative oral bioavailability of non-fixed and fixed combinations of artesunate and amodiaquine in healthy Indian male volunteers.
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Title: The multiple-dosing pharmacokinetics of artemether, artesunate, and their metabolite dihydroartemisinin in rats.
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Title: In-vivo activity of dihydroartemisinin against Schistosoma japonicum.
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Title: Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma.
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Title: Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC.
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Title: Safety and efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Zambian children.
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Title: Cytotoxic activity of artemisinin derivatives against cholangiocarcinoma (CL-6) and hepatocarcinoma (Hep-G2) cell lines.
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Title: Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria.
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Title: Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance.
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Title: Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal.
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Title: Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa.
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Title: Dihydroartemisinin shift the immune response towards Th1, inhibit the tumor growth in vitro and in vivo.
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Title: Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast.
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Title: Similar efficacy and safety of artemether-lumefantrine (Coartem®) in African infants and children with uncomplicated falciparum malaria across different body weight ranges.
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Title: Dihydroartemisinin induces endoplasmic reticulum stress-mediated apoptosis in HepG2 human hepatoma cells.
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Title: [In vitro anti-Trichomonas vaginalis effects of a mixture of dihydroartemisinin and metronidazole].
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Title: A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos.
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Title: A simplified liquid chromatography-mass spectrometry assay for artesunate and dihydroartemisinin, its metabolite, in human plasma.
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Title: Selective toxicity of dihydroartemisinin on human CD34+ erythroid cell differentiation.
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Title: Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared with artemether-lumefantrine for uncomplicated malaria.
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Title: Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity.
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Title: The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells.
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Title: Dihydroartemisinin induces apoptosis by a Bak-dependent intrinsic pathway.
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Title: Dihydroartemisinin loaded nanostructured lipid carriers (DHA-NLC): evaluation of pharmacokinetics and tissue distribution after intravenous administration to rats.
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Title: Effects of artemisinin derivative on the growth metabolism of Tetrahymena thermophila BF5 based on expression of thermokinetics.
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Title: Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo.
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Title: Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.
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Title: Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria.
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Title: The effects of dihydroartemisinin on Giardia lamblia morphology and cell cycle in vitro.
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Title: Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCalpha/Raf/MAPKs and NF-kappaB/AP-1-dependent mechanisms.
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Title: Heme synthesis increases artemisinin-induced radical formation and cytotoxicity that can be suppressed by superoxide scavengers.
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Title: Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-kappaB.
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Title: Dihydroartemisinin-piperaquine versus artemether-lumefantrine, in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan.
Journal: Annals of tropical medicine and parasitology 20100601
Title: Dihydroartemisinin upregulates death receptor 5 expression and cooperates with TRAIL to induce apoptosis in human prostate cancer cells.
Journal: Cancer biology & therapy 20100515
Title: Dihydroartemisinin improves the efficiency of chemotherapeutics in lung carcinomas in vivo and inhibits murine Lewis lung carcinoma cell line growth in vitro.
Journal: Cancer chemotherapy and pharmacology 20100501
Title: Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso.
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Title: Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells.
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Title: Severe congenital malaria acquired in utero.
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Title: [Experimental study of the function and mechanism combining dihydroartemisinin and gemcitabine in treating pancreatic cancer].
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Title: Dihydroartemisinin can inhibit calmodulin, calmodulin-dependent phosphodiesterase activity and stimulate cellular immune responses.
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Title: Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan: too early for too much hope.
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Title: Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda.
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Title: Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial.
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Title: The pharmaceutical death-ride of dihydroartemisinin.
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Title: An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia.
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Title: Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine.
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Title: Development and validation of a high-performance liquid chromatography/tandem mass spectrometry method for the determination of artemether and its active metabolite dihydroartemisinin in human plasma.
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Title: Progress in the development of piperaquine combinations for the treatment of malaria.
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Title: Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children.
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Title: Artemisinin combination therapy for malaria: beyond good efficacy.
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Title: Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.
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Title: Artemisinin-transferrin conjugate retards growth of breast tumors in the rat.
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Title: Comparative study of dihydroartemisinin and artesunate safety in healthy Thai volunteers.
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Title: Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells.
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Title: [In vivo effect of dihydroartemisinin and azithromycin on the ultrastructure of Toxoplasma gondii tachyzoites].
Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20090801
Title: Artemisinin resistance in Plasmodium falciparum malaria.
Journal: The New England journal of medicine 20090730
Title: Artemisinin-based combination therapy for treating uncomplicated malaria.
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Title: Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy.
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Title: Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.
Journal: Experimental parasitology 20090701
Title: Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene.
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Title: [Study on anticancer effect of dihydroartemisinin on pancreatic cancer].
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Title: A randomized, controlled trial of artemisinin-piperaquine vs dihydroartemisinin-piperaquine phosphate in treatment of falciparum malaria.
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Title: Severe idiosyncratic drug reaction (Lyells syndrome) after ingesting dihydroartemisinin.
Journal: Nigerian journal of clinical practice 20090601
Title: Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam.
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Title: A liquid chromatographic-tandem mass spectrometric method for determination of artemether and its metabolite dihydroartemisinin in human plasma.
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Title: Antimalarial therapies in children from Papua New Guinea.
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Title: Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica.
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Title: Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215
Title: Application of a liquid chromatography/tandem mass spectrometry method for the pharmacokinetic study of dihydroartemisinin injectable powder in healthy Chinese subjects.
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Title: Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo.
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Title: Dihydroartemisinin-cyclodextrin complexation: solubility and stability.
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Title: Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells.
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Title: Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats.
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Title: Dihydroartemisinin pharmacokinetics in patients with malaria after multiple doses--assembling clues and perspectives.
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Title: Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis.
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Title: Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children.
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Title: Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial.
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Title: Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children.
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Title: Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects.
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Title: Pharmacokinetics and pharmacodynamics of a new ACT formulation: Artesunate/Amodiaquine (TRIMALACT) following oral administration in African malaria patients.
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Title: A trial of combination antimalarial therapies in children from Papua New Guinea.
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Title: A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma.
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Title: On-column epimerization of dihydroartemisinin: an effective analytical approach to overcome the shortcomings of the International Pharmacopoeia monograph.
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Title: Development and validation of a liquid chromatography-mass spectrometry method for the simultaneous quantification of artesunate and dihydroartemisinin in human plasma.
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Title: Absence of time-dependent artesunate pharmacokinetics in healthy subjects during 5-day oral administration.
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Title: Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum calcium adenosine triphosphatase activity.
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Title: Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action.
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Title: [Effects of dihydroartiminisin on proliferation and phosphorylation of mitogen-activated protein kinase in epithelial ovarian cancer cell lines].
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Title: Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX).
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Title: The influence of food on the pharmacokinetics of piperaquine in healthy Vietnamese volunteers.
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Title: Embryotoxicity of artesunate in animal species related to drug tissue distribution and toxicokinetic profiles.
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Title: Artesunate: developmental toxicity and toxicokinetics in monkeys.
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Title: Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species.
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Title: [Dihydroartemisinin down-regulates the expression of transferrin receptor in myeloid leukemia cells].
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Title: Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemic.
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Title: The role of calcium, P38 MAPK in dihydroartemisinin-induced apoptosis of lung cancer PC-14 cells.
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Title: Plasmodium berghei: parasite clearance after treatment with dihydroartemisinin in an asplenic murine malaria model.
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Title: Orally active esters of dihydroartemisinin: Synthesis and antimalarial activity against multidrug-resistant Plasmodium yoelii in mice.
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Journal: International journal for parasitology 20071201
Title: Pharmacodynamics of doxycycline in a murine malaria model.
Journal: Antimicrobial agents and chemotherapy 20071201
Title: A new decomposition product of dihydroartemisinin.
Journal: Die Pharmazie 20071201
Title: Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone: implications for embryotoxicity.
Journal: Toxicology 20071120
Title: Evaluation of the safety and relative bioavailability of a new dihydroartemisinin tablet formulation in healthy Thai volunteers.
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20071001
Title: Artesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug.
Journal: ChemMedChem 20071001
Title: An analytical method with a single extraction procedure and two separate high performance liquid chromatographic systems for the determination of artesunate, dihydroartemisinin and mefloquine in human plasma for application in clinical pharmacological studies of the drug combination.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001
Title: Antimalarial drug quality in Africa.
Journal: Journal of clinical pharmacy and therapeutics 20071001
Title: Efficacy and safety of dihydroartemisinin-piperaquine.
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20070901
Title: Assessment of in vitro antimalarial interactions between dihydroartemisinin and fosmidomycin.
Journal: The Southeast Asian journal of tropical medicine and public health 20070901
Title: Dihydroartemisinin is an inhibitor of ovarian cancer cell growth.
Journal: Acta pharmacologica Sinica 20070701
Title: Clinical efficacy of high dose monotherapy of oral dihydroartemisinin in uncomplicated falciparum malaria in viet nam.
Journal: Japanese journal of infectious diseases 20070701
Title: Rectal administration of artemisinin derivatives for the treatment of malaria.
Journal: JAMA 20070606
Title: Liquid chromatography-tandem mass spectrometry assay for the quantitation of beta-dihydroartemisinin in rat plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601
Title: Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1alpha activation in C6 glioma cells.
Journal: The Journal of pharmacy and pharmacology 20070601
Title: CD4 count, viral load and parasite density of HIV positive individuals undergoing malaria treatment with dihydroartemisinin in Benin City, Edo state, Nigeria.
Journal: Journal of vector borne diseases 20070601
Title: [Dihydroartemisinin inhibits proliferation and induces apoptosis of rat glioma C6 cells].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070501
Title: Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070415
Title: Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison.
Journal: Lancet (London, England) 20070303
Title: Pharmacokinetics of mefloquine with dihydroartemisinin as 2-day regimens in patients with uncomplicated falciparum malaria.
Journal: The Southeast Asian journal of tropical medicine and public health 20070301
Title: [Effect of dihydroartemisinin on the ultrastructure of Trichomonas vaginalis trophozoites in vitro].
Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20070227
Title: In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).
Journal: The American journal of tropical medicine and hygiene 20070201
Title: A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia.
Journal: Tropical medicine & international health : TM & IH 20070201
Title: Quality control of active ingredients in artemisinin-derivative antimalarials within Kenya and DR Congo.
Journal: Tropical medicine & international health : TM & IH 20070101
Title: Dihydroartemisinin suppository in moderately severe malaria: comparative efficacy of dihydroartemisinin suppository versus intramuscular artemeter followed by oral sulfadoxine-pyrimethamine in the management of moderately severe malaria in Nigerian children.
Journal: The American journal of tropical medicine and hygiene 20070101
Title: Calcium and survivin are involved in the induction of apoptosis by dihydroartemisinin in human lung cancer SPC-A-1 cells.
Journal: Methods and findings in experimental and clinical pharmacology 20070101
Title: Induction of apoptosis and inhibition of cell migration and tube-like formation by dihydroartemisinin in murine lymphatic endothelial cells.
Journal: Pharmacology 20070101
Title: Neurotoxicity and toxicokinetics of artelinic acid following repeated oral administration in rats.
Journal: International journal of toxicology 20070101
Title: A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru.
Journal: PloS one 20070101
Title: In vitro interaction of dihydroartemisin and lumefantrine in clinical field isolates from Bangladesh.
Journal: Wiener klinische Wochenschrift 20070101
Title: [In vitro interaction studies of azithromycin and dihydroartemisinin in Plasmodium falciparum isolates from Bangladesh].
Journal: Wiener klinische Wochenschrift 20070101
Title: Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20061201
Title: Treatment of malaria in a mouse model by intranasal drug administration.
Journal: International journal for parasitology 20061201
Title: Characterization of human urinary metabolites of the antimalarial piperaquine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20061201
Title: The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.
Journal: European journal of clinical pharmacology 20061201
Title: The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria.
Journal: European journal of clinical pharmacology 20061201
Title: In vivo and in vitro investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20061101
Title: Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients.
Journal: PLoS medicine 20061101
Title: Resistance to dihydroartemisinin.
Journal: Emerging infectious diseases 20061101
Title: Artesunate and a major metabolite, dihydroartemisinin, diminish mitogen-induced lymphocyte proliferation and activation.
Journal: The Southeast Asian journal of tropical medicine and public health 20060901
Title: Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation.
Journal: International immunopharmacology 20060801
Title: An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos).
Journal: Tropical medicine & international health : TM & IH 20060801
Title: Dihydroartemisinin inhibits angiogenesis induced by multiple myeloma RPMI8226 cells under hypoxic conditions via downregulation of vascular endothelial growth factor expression and suppression of vascular endothelial growth factor secretion.
Journal: Anti-cancer drugs 20060801
Title: Artemisinin combination therapies.
Journal: Lancet (London, England) 20060624
Title: Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison.
Journal: Lancet (London, England) 20060624
Title: In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20060601
Title: Artesunate and artemether are effective fasciolicides in the rat model and in vitro.
Journal: The Journal of antimicrobial chemotherapy 20060601
Title: Manslaughter by fake artesunate in Asia--will Africa be next?
Journal: PLoS medicine 20060601
Title: Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.
Journal: European journal of clinical pharmacology 20060501
Title: Pharmacokinetics of piperaquine after repeated oral administration of the antimalarial combination CV8 in 12 healthy male subjects.
Journal: European journal of clinical pharmacology 20060501
Title: A dimer of alpha- and beta-dihydroartemisinin: bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether.
Journal: Acta crystallographica. Section C, Crystal structure communications 20060501
Title: Dihydroartemisinin enhances radiosensitivity of human glioma cells in vitro.
Journal: Journal of cancer research and clinical oncology 20060201
Title: Effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20060101
Title: Dihydroartemisinin downregulates vascular endothelial growth factor expression and induces apoptosis in chronic myeloid leukemia K562 cells.
Journal: Cancer chemotherapy and pharmacology 20060101
Title: Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo.
Journal: Cancer research 20051201
Title: In vitro interactions of Aspilia africana (Pers.) C.D. Adams, a traditional antimalarial medicinal plant, with artemisinin against Plasmodium falciparum.
Journal: Journal of ethnopharmacology 20051114
Title: [Dihydroartemisinin inhibits the expression of vascular endothelial growth factor in K562 cells].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20051101
Title: [Effect of dihydroartemisinin on ultrastructure of Giardia lamblia in vitro].
Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20051030
Title: Pharmacokinetics of the diastereomers of arteether, a potent antimalarial drug, in rats.
Journal: Biopharmaceutics & drug disposition 20050901
Title: An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria.
Journal: The Southeast Asian journal of tropical medicine and public health 20050901
Title: A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815
Title: Once-daily combination therapy for uncomplicated malaria: is this the way forward?
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815
Title: Efficacy comparison between anti-malarial drugs in Africans presenting with mild malaria in the Central Republic of Africa: a preliminary study.
Journal: Parasite (Paris, France) 20050301
Title: Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225
Title: [Effects of combined artemether and dihydroarteamisinin in treatment of children with falciparum malaria].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20050101
Title: Pharmacokinetics of the four combination regimens of dihydroartemisinin/mefloquine in acute uncomplicated falciparum malaria.
Journal: The Southeast Asian journal of tropical medicine and public health 20050101
Title: Investigation of bioavailability, pharmacokinetics and safety of new pediatric formulations of artesunate and mefloquine.
Journal: The Southeast Asian journal of tropical medicine and public health 20050101
Title: In vitro antimalarial drug susceptibility in Thai border areas from 1998-2003.
Journal: Malaria journal 20050101
Title: Toxicokinetics and hydrolysis of artelinate and artesunate in malaria-infected rats.
Journal: International journal of toxicology 20050101
Title: Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells.
Journal: Anticancer research 20050101
Title: Comparison of the bioequivalence of three oral formulations of dihydroartemisinin based on ex vivo blood schizontocidal activities against Plasmodium falciparum.
Journal: The American journal of tropical medicine and hygiene 20041201
Title: Pharmacokinetic investigation on the therapeutic potential of artemotil (beta-arteether) in Thai patients with severe Plasmodium falciparum malaria.
Journal: The American journal of tropical medicine and hygiene 20041201
Title: Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand.
Journal: The Journal of infectious diseases 20041115
Title: The pharmacokinetics of oral dihydroartemisinin and artesunate in healthy Thai volunteers.
Journal: The Southeast Asian journal of tropical medicine and public health 20040901
Title: Activity of dihydroartemisinin against Leishmania donovani both in vitro and vivo.
Journal: Chinese medical journal 20040801
Title: Antimalarial dihydroartemisinin also inhibits angiogenesis.
Journal: Cancer chemotherapy and pharmacology 20040501
Title: Synthesis of O-aminodihydroartemisinin via TMS triflate catalyzed C-O coupling reaction.
Journal: The Journal of organic chemistry 20040430
Title: Design of a dissolution system for the evaluation of the release rate characteristics of artemether and dihydroartemisinin from tablets.
Journal: International journal of pharmaceutics 20040415
Title: Protein binding and alpha : beta anomer ratio of dihydroartemisinin in vivo.
Journal: British journal of clinical pharmacology 20040401
Title: Population pharmacokinetics of artemether and dihydroartemisinin following single intramuscular dosing of artemether in African children with severe falciparum malaria.
Journal: British journal of clinical pharmacology 20040201
Title: CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.
Journal: Tropical medicine & international health : TM & IH 20040201
Title: Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial.
Journal: Lancet (London, England) 20040103
Title: Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria.
Journal: British journal of clinical pharmacology 20040101
Title: Artemisinin induces apoptosis in human cancer cells.
Journal: Anticancer research 20040101
Title: Effect of dihydroartemisinin on the antioxidant capacity of P. falciparum-infected erythrocytes.
Journal: The Southeast Asian journal of tropical medicine and public health 20031201
Title: Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro.
Journal: Pharmacological research 20030901
Title: Comparison of bioassay and high performance liquid chromatographic assay of artesunate and dihydroartemisinin in plasma.
Journal: Acta tropica 20030801
Title: A sensitive and selective liquid chromatographic/electrospray ionization tandem mass spectrometric assay for the simultaneous quantification of alpha-,beta-arteether and its metabolite dihydroartemisinin in plasma, useful for pharmacokinetic studies.
Journal: Journal of mass spectrometry : JMS 20030701
Title: Comparative clinical trial of two-fixed combinations dihydroartemisinin-napthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand.
Journal: The Southeast Asian journal of tropical medicine and public health 20030601
Title: Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021215
Title: Modulation of multidrug resistance by artemisinin, artesunate and dihydroartemisinin in K562/adr and GLC4/adr resistant cell lines.
Journal: Biological & pharmaceutical bulletin 20021201
Title: Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020901
Title: An open randomized clinical trial of Artecom vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.
Journal: The Southeast Asian journal of tropical medicine and public health 20020901
Title: A comparative clinical trial of combinations of dihydroartemisinin plus azithromycin and dihydroartemisinin plus mefloquine for treatment of multidrug resistant falciparum malaria.
Journal: The Southeast Asian journal of tropical medicine and public health 20020901
Title: Development and validation of a high-performance liquid chromatography-mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020715
Title: Membrane heme as a host factor in reducing effectiveness of dihydroartemisinin.
Journal: Biochemical pharmacology 20020701
Title: Relative bioavailability of artesunate and dihydroartemisinin: investigations in the isolated perfused rat liver and in healthy Caucasian volunteers.
Journal: The American journal of tropical medicine and hygiene 20020201
Title: The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria.
Journal: British journal of clinical pharmacology 20020101
Title: Assessment of the neurotoxicity of oral dihydroartemisinin in mice.
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20020101
Title: [Pharmacokinetic studies on artemether under conditions simulated in vivo].
Journal: Se pu = Chinese journal of chromatography 20020101
Title: [Therapeutic effect of dihydroartemisinin combined with naphthoquine phosphate in patients with falciparum malaria].
Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20020101
Title: [Study on treatment of multi-drug resistant falciparum malaria by using a combination of dihydroartemisinin and pyronaridine].
Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20020101
Title: The effect of 10 alpha-trifluoromethylhydroartemisinin on Plasmodium berghei infection and its toxicity in experimental animals.
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20020101
Title: Authentication of artemether, artesunate and dihydroartemisinin antimalarial tablets using a simple colorimetric method.
Journal: Tropical medicine & international health : TM & IH 20011201
Title: Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria.
Journal: The American journal of tropical medicine and hygiene 20011201
Title: Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells.
Journal: Life sciences 20011121
Title: Multiple dose study of interactions between artesunate and artemisinin in healthy volunteers.
Journal: British journal of clinical pharmacology 20011001
Title: Ammunition against malaria.
Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20010904
Title: Antimalarial activity of azithromycin, artemisinin and dihydroartemisinin in fresh isolates of Plasmodium falciparum in Thailand.
Journal: Acta tropica 20010901
Title: Oral bioavailability of dihydroartemisinin in Vietnamese volunteers and in patients with falciparum malaria.
Journal: British journal of clinical pharmacology 20010601
Title: Efficacy of dihydroartemisinin-mefloquine on acute uncomplicated falciparum malaria.
Journal: Chinese medical journal 20010601
Title: Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.
Journal: Journal of medicinal chemistry 20010426
Title: [In vitro study of the anti-pneumocystis carinii effect of arteminsin derivatives].
Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20010301
Title: The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro.
Journal: Biochemical pharmacology 20010215
Title: Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.
Journal: Journal of medicinal chemistry 20010104
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