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863-57-0,MFCD00150466
Catalog No.:AA003QPQ

863-57-0 | Sodium glycocholate

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250mg
95%
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$8.00   $6.00
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25g
95%
in stock  
$119.00   $83.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003QPQ
Chemical Name:
Sodium glycocholate
CAS Number:
863-57-0
Molecular Formula:
C26H42NNaO6
Molecular Weight:
487.6045
MDL Number:
MFCD00150466
SMILES:
O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)NCC(=O)[O-])C)C)O)C.[Na+]
Properties
Properties
 
BP:
692°C at 760 mmHg  
Form:
Solid  
MP:
210-215 °C  
Refractive Index:
30 ° (C=1, H2O)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
766  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  

Literature

Title: Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101

Title: A propofol microemulsion with low free propofol in the aqueous phase: formulation, physicochemical characterization, stability and pharmacokinetics.

Journal: International journal of pharmaceutics 20121015

Title: Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120601

Title: Internal motions and exchange processes in human ileal bile acid binding protein as studied by backbone (15)N nuclear magnetic resonance spectroscopy.

Journal: Biochemistry 20120306

Title: Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription.

Journal: Journal of separation science 20120201

Title: Statistical optimization of insulin-loaded Pluronic F-127 gels for buccal delivery of basal insulin.

Journal: Pharmaceutical development and technology 20120101

Title: Nimodipine-loaded mixed micelles: formulation, compatibility, pharmacokinetics, and vascular irritability study.

Journal: International journal of nanomedicine 20120101

Title: Enhanced transbuccal salmon calcitonin (sCT) delivery: effect of chemical enhancers and electrical assistance on in vitro sCT buccal permeation.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20111001

Title: Oral delivery system for two-pulse colonic release of protein drugs and protease inhibitor/absorption enhancer compounds.

Journal: Journal of pharmaceutical sciences 20110801

Title: Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20110801

Title: Relative acidity scale of glycine- and taurine-conjugated bile acids through ESI-MS measurements.

Journal: Steroids 20110501

Title: [Clinical analysis of fetal death cases in intrahepatic cholestasis of pregnancy].

Journal: Zhonghua fu chan ke za zhi 20110501

Title: Antifungal evaluation of cholic acid and its derivatives on Candida albicans by microcalorimetry and chemometrics.

Journal: Analytica chimica acta 20110318

Title: The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine.

Journal: Biochimica et biophysica acta 20110101

Title: Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting.

Journal: PloS one 20110101

Title: Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation.

Journal: International journal of nanomedicine 20110101

Title: Molecular dynamics simulations of glycocholate-oleic acid mixed micelle assembly.

Journal: Langmuir : the ACS journal of surfaces and colloids 20100406

Title: Protective effects of glycoursodeoxycholic acid in Barrett's esophagus cells.

Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20100201

Title: Bile salt deconjugation and cholesterol removal from media by Lactobacillus strains used as probiotics in chickens.

Journal: Journal of the science of food and agriculture 20100115

Title: The use of liposomes in the study of drug metabolism: a method to incorporate the enzymes of the cytochrome p450 monooxygenase system into phospholipid, bilayer vesicles.

Journal: Methods in molecular biology (Clifton, N.J.) 20100101

Title: Permeation of losartan across human respiratory epithelium: an in vitro study with Calu-3 cells.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20091201

Title: Thermodynamics and structure of inclusion compounds of tauro- and glyco-conjugated bile salts and beta-cyclodextrin.

Journal: Physical chemistry chemical physics : PCCP 20090707

Title: Sodium glycodeoxycholate and glycocholate mixed aggregates in gas and solution phases.

Journal: The journal of physical chemistry. B 20090521

Title: Use of correction factors in mobility shift affinity capillary electrophoresis for weak analyte-ligand interactions.

Journal: Journal of separation science 20090501

Title: Preparation and characterization of spray-dried tobramycin powders containing nanoparticles for pulmonary delivery.

Journal: International journal of pharmaceutics 20090105

Title: Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080902

Title: Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080601

Title: [Study on relationship between expression of familial intrahepatic cholestasis 1 mRNA in placenta and Intrahepatic cholestasis of pregnancy].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080501

Title: Bile salts and glycine as cogerminants for Clostridium difficile spores.

Journal: Journal of bacteriology 20080401

Title: Blending effects on adsorption and micellization of different membrane protein solubilizers II. A thermodynamic study on a mixed system of CHAPS with a bile salt in pH 7.4 phosphate buffer solution.

Journal: Colloids and surfaces. B, Biointerfaces 20080315

Title: Long-term biokinetics and radiation exposure of patients undergoing 14C-glycocholic acid and 14C-xylose breath tests.

Journal: Cancer biotherapy & radiopharmaceuticals 20071201

Title: Structure-interaction relationships between the bile acid GCA and pharmaceuticals using multivariate data analysis and capillary electrophoresis.

Journal: Journal of pharmaceutical sciences 20070801

Title: Kinetic mechanism of ligand binding in human ileal bile acid binding protein as determined by stopped-flow fluorescence analysis.

Journal: Biochemistry 20070508

Title: Influence of sodium glycocholate on production of conjugated linoleic acid by cells of Lactobacillus reuteri ATCC 55739.

Journal: Journal of food science 20070501

Title: Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake.

Journal: Bioorganic & medicinal chemistry 20070315

Title: Biosynthesis of bile acids in a variety of marine bacterial taxa.

Journal: Journal of microbiology and biotechnology 20070301

Title: Luminal stimuli acutely sensitize visceromotor responses to distension of the rat stomach.

Journal: Digestive diseases and sciences 20070201

Title: Bile acid salt binding with colesevelam HCl is not affected by suspension in common beverages.

Journal: Journal of pharmaceutical sciences 20061201

Title: [Bile salts induce differentiation in cultured human normal esophageal mucosal epithelial cells].

Journal: Zhonghua yi xue za zhi 20060912

Title: Effects of choleretics on bile compositions drained from patients with pigment gallstone.

Journal: Chinese journal of integrative medicine 20060601

Title: Excellent absorption enhancing characteristics of NO donors for improving the intestinal absorption of poorly absorbable compound compared with conventional absorption enhancers.

Journal: Drug metabolism and pharmacokinetics 20060601

Title: Single-step analysis of individual conjugated bile acids in human bile using 1H NMR spectroscopy.

Journal: Lipids 20060601

Title: Repeated administration of a vitamin preparation containing glycocholic acid in patients with hepatobiliary disease.

Journal: Alimentary pharmacology & therapeutics 20060501

Title: [Clinical and experimental study on wuling pill in treating gestation period intrahepatic cholestasis].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060201

Title: Effects of absorption promoters on insulin absorption through colon-targeted delivery.

Journal: International journal of pharmaceutics 20060113

Title: Effect of tamoxifen and raloxifene on the conjugation of bile acids with taurine and glycine in ovariectomized rats.

Journal: Pharmacological reports : PR 20060101

Title: Adsorption of bile acid by chitosan salts prepared with cinnamic acid and analogue compounds.

Journal: Journal of biomaterials science. Polymer edition 20060101

Title: Small-angle X-ray scattering and light scattering on lysozyme and sodium glycocholate micelles.

Journal: The journal of physical chemistry. B 20051222

Title: Alternative delivery of insulin via eye drops.

Journal: Diabetes technology & therapeutics 20051001

Title: Development of a 13C-glycocholic acid blood test to assess bacterial metabolic activity of the small intestine in canines.

Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20051001

Title: [Cholyl glycine (CG)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20050801

Title: High-speed digital imaging method for ciliary beat frequency measurement.

Journal: The Journal of pharmacy and pharmacology 20050401

Title: Stable ciliary activity in human nasal epithelial cells grown in a perfusion system.

Journal: International journal of pharmaceutics 20050323

Title: Micellar electrokinetic chromatography of bilirubin, related compounds, and selected drugs with mixtures of binary bile salts.

Journal: Electrophoresis 20050201

Title: Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model.

Journal: The Journal of pharmacy and pharmacology 20050201

Title: The influence of the ionic medium on the behaviour of sodium glycocholate and cholate aqueous solutions.

Journal: Annali di chimica 20050101

Title: Composition of aqueous solutions containing sodium glycocholate and glycodeoxycholate.

Journal: Annali di chimica 20050101

Title: Noninvasive methods to determine the critical micelle concentration of some bile acid salts.

Journal: Analytical biochemistry 20041101

Title: Evaluation of different toxicity assays applied to proliferating cells and to stratified epithelium in relation to permeability enhancement with glycocholate.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20041001

Title: Functional assessment of bacterial colonization in patients with ileal pouch-anal anastomosis and Brooke ileostomy.

Journal: Diseases of the colon and rectum 20040801

Title: [Study on relationship between serum cholylglycine and placental apoptosis in patients with intrahepatic cholestasis of pregnancy].

Journal: Zhonghua fu chan ke za zhi 20040701

Title: Sensitization of mechanosensitive gastric vagal afferent fibers in the rat by thermal and chemical stimuli and gastric ulcers.

Journal: Journal of neurophysiology 20040501

Title: Metabolism and absorption enhancement of methionine enkephalin in human nasal epithelium.

Journal: Peptides 20040401

Title: [Effects of protease inhibitors on intestinal absorption of insulin].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040201

Title: Poly(N,N,N-trimethylammoniumalkyl acrylamide chloride) based hydrogels for serum cholesterol reduction.

Journal: Biomacromolecules 20040101

Title: Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor.

Journal: Hepatology (Baltimore, Md.) 20031001

Title: Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties.

Journal: Bioorganic & medicinal chemistry 20030515

Title: Effect of ursodeoxycholic acid on the impairment induced by maternal cholestasis in the rat placenta-maternal liver tandem excretory pathway.

Journal: The Journal of pharmacology and experimental therapeutics 20030501

Title: Sensitivity of bile acid transport by organic anion-transporting polypeptides to intracellular pH.

Journal: Biochimica et biophysica acta 20030401

Title: Effect of sodium glycocholate on development of tolerance to Parthenium hysterophorus extracts.

Journal: Indian journal of experimental biology 20030401

Title: Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats.

Journal: Hepatology (Baltimore, Md.) 20030301

Title: Differential effects of metformin on bile salt absorption from the jejunum and ileum.

Journal: Diabetes, obesity & metabolism 20030301

Title: Sodium glycocholate transport across Caco-2 cell monolayers, and the enhancement of mannitol transport relative to transepithelial electrical resistance.

Journal: International journal of pharmaceutics 20030218

Title: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).

Journal: Molecular pharmacology 20030201

Title: Maldigestion and malabsorption of dietary lipid during severe childhood malnutrition.

Journal: Archives of disease in childhood 20021201

Title: A monoclonal antibody-based enzyme-linked immunosorbent assay of glycolithocholic acid sulfate in human urine for liver function test.

Journal: Steroids 20020901

Title: Buccal transport of flecainide and sotalol: effect of a bile salt and ionization state.

Journal: International journal of pharmaceutics 20020708

Title: Drug metabolic activity of cultured hepatocytes can synchronize with bile acid concentration in the medium.

Journal: Cell biochemistry and function 20020301

Title: [Observation on effect of danxiaoling in supplementary treatment of intrahepatic cholestasis in pregnancy].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20020201

Title: On lead(II) glycocholate solubility.

Journal: Annali di chimica 20020101

Title: Absorption of water-soluble compounds with different molecular weights and.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20011019

Title: Beneficial effects of glycocholic acid (GCA) on gut mucosal damage in bile duct ligated rats.

Journal: Inflammation 20011001

Title: Nasal bioavailability of peptide T in rabbits: absorption enhancement by sodium glycocholate and glycofurol.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010801

Title: Gastrointestinal handling and metabolic disposal of 13C-labelled tripalmitin during rehabilitation from childhood malnutrition.

Journal: The British journal of nutrition 20010601

Title: Penetration of verapamil hydrochloride in the presence of sodium glycocholate as penetration enhancer through mucous membrane.

Journal: Die Pharmazie 20010101

Title: Cyclosporin A-mediated cholestasis in patients with chronic hepatitis after heart transplantation.

Journal: European journal of gastroenterology & hepatology 19960301

Title: Inhibition of amphotericin B (Fungizone) toxicity to cells by egg lecithin-glycocholic acid mixed micelles.

Journal: Antimicrobial agents and chemotherapy 19901201

Title: Biliary permeability during ethinyl estradiol-induced cholestasis studied by segmented retrograde intrabiliary injections in rats.

Journal: Journal of hepatology 19850101

Title: Substrate specificity of cholylglycine hydrolase for the hydrolysis of bile acid conjugates.

Journal: The Journal of biological chemistry 19841225

Title: Hepatic handling of bile salts and protein in the rat during intrahepatic cholestasis.

Journal: Gastroenterology 19830501

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