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135-09-1,MFCD00057316
Catalog No.:AA003QVX

135-09-1 | 6-(Trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

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50mg
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100mg
≥98%
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003QVX
Chemical Name:
6-(Trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
CAS Number:
135-09-1
Molecular Formula:
C8H8F3N3O4S2
Molecular Weight:
331.2920
MDL Number:
MFCD00057316
SMILES:
FC(c1cc2NCNS(=O)(=O)c2cc1S(=O)(=O)N)(F)F
Properties
Properties
 
BP:
531.6 °C at 760 mmHg  
Form:
Solid  
MP:
265-268°C (dec.)  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
578  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
0.4  

Downstream Synthesis Route

[1]Holdregeetal.[JournaloftheAmericanChemicalSociety,1959,vol.81,p.4807,4808]

[2]Novello,F.C.etal.[JournalofOrganicChemistry,1960,vol.25,p.970-981]

[3]Close,W.J.etal.[JournaloftheAmericanChemicalSociety,1960,vol.82,p.1132-1135]

[4]Yale,H.L.etal.[JournaloftheAmericanChemicalSociety,1960,vol.82,p.2042-2046]

[5]Klosa,J.;Voigt,H.[JournalfurpraktischeChemie(Leipzig1954),1962,vol.16,p.264-276]

Literature

Title: Performance scores in general practice: a comparison between the clinical versus medication-based approach to identify target populations.

Journal: PloS one 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.

Journal: Analytical and bioanalytical chemistry 20100401

Title: Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors.

Journal: Journal of medicinal chemistry 20100311

Title: Interfacing on-line solid phase extraction with monolithic column multisyringe chromatography and chemiluminescence detection: An effective tool for fast, sensitive and selective determination of thiazide diuretics.

Journal: Talanta 20100115

Title: Fifty years of thiazide diuretic therapy for hypertension.

Journal: Archives of internal medicine 20091109

Title: Rapid determination of losartan and losartan acid in human plasma by multiplexed LC-MS/MS.

Journal: Journal of separation science 20091001

Title: Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?

Journal: Organic & biomolecular chemistry 20080721

Title: Chloro-thia-zide-pyridine (1/3).

Journal: Acta crystallographica. Section E, Structure reports online 20080601

Title: Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides.

Journal: Current pharmaceutical design 20080101

Title: Fast gas chromatographic/mass spectrometric determination of diuretics and masking agents in human urine: Development and validation of a productive screening protocol for antidoping analysis.

Journal: Journal of chromatography. A 20061201

Title: High-speed gas chromatography in doping control: fast-GC and fast-GC/MS determination of beta-adrenoceptor ligands and diuretics.

Journal: Journal of separation science 20061201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Physicochemical evaluation of PVP-thiazide diuretic interactions in co-spray-dried composites--analysis of glass transition composition relationships.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050401

Title: FI-chemiluminometric study of thiazides by on-line photochemical reaction.

Journal: Journal of pharmaceutical and biomedical analysis 20041119

Title: Indexing powder patterns in physical form screening: instrumentation and data quality.

Journal: Journal of pharmaceutical sciences 20030901

Title: Tumor estrogen content and clinico-morphological and endocrine features of endometrial cancer.

Journal: Journal of cancer research and clinical oncology 20030401

Title: Gas-phase behaviour of negative ions produced from thiazidic diuretics under electrospray conditions.

Journal: Journal of mass spectrometry : JMS 20020901

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Tags:135-09-1 Molecular Formula|135-09-1 MDL|135-09-1 SMILES|135-09-1 6-(Trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide