34580-14-8,MFCD00079394
Catalog No.:AA003R3H

34580-14-8 | (2E)-but-2-enedioic acid; 2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.0^{3,7}]tetradeca-1(10),3(7),4,11,13-pentaen-8-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
95%
in stock  
$16.00   $12.00
- +
1g
95%
in stock  
$75.00   $53.00
- +
5g
95%
in stock  
$170.00   $119.00
- +
10g
95%
in stock  
$266.00   $186.00
- +
25g
95%
in stock  
$464.00 $325.00
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003R3H
Chemical Name:
(2E)-but-2-enedioic acid; 2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.0^{3,7}]tetradeca-1(10),3(7),4,11,13-pentaen-8-one
CAS Number:
34580-14-8
Molecular Formula:
C23H23NO5S
Molecular Weight:
425.4974
MDL Number:
MFCD00079394
SMILES:
CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1.OC(=O)C=CC(=O)O
NSC Number:
757415
Properties
Properties
 
Form:
Solid  
MP:
192 C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
595  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Synonyms
 
  
Downstream Synthesis Route
34580-14-8    84-58-2   
CASUnavailable 

[1]Mostafa,GamalA.E.;Bakheit,Ahmed;Almasoud,Najla;Alrabiah,Haitham[Molecules,2021,vol.26,#7]

34580-14-8    1518-16-7   
C19H19NOS*C4H4O4*C12H4N4 

[1]Mostafa,GamalA.E.;Bakheit,Ahmed;Almasoud,Najla;Alrabiah,Haitham[Molecules,2021,vol.26,#7]

Literature

Title: Anti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20160101

Title: A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.

Journal: Antimicrobial agents and chemotherapy 20130101

Title: In vivo enhancement of transdermal absorption of ketotifen by supersaturation generated by amorphous form of the drug.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120830

Title: Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats.

Journal: Injury 20120801

Title: Delivery of ketotifen fumarate by commercial contact lens materials.

Journal: Optometry and vision science : official publication of the American Academy of Optometry 20120801

Title: Carryover effect on next-day sleepiness and psychomotor performance of nighttime administered antihistaminic drugs: a randomized controlled trial.

Journal: Human psychopharmacology 20120701

Title: Neurogenic airway microvascular leakage induced by toluene inhalation in rats.

Journal: European journal of pharmacology 20120615

Title: First and second generation H₁ histamine receptor antagonists produce different sleep-inducing profiles in rats.

Journal: European journal of pharmacology 20120515

Title: The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120401

Title: Sustained in vivo release from imprinted therapeutic contact lenses.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20120210

Title: In vitro effects of some drugs on human erythrocyte glutathione reductase.

Journal: Journal of enzyme inhibition and medicinal chemistry 20120201

Title: Δ-lactam derivative from thermophilic soil fungus exhibits in vitro anti-allergic activity.

Journal: Natural product research 20120101

Title: The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.

Journal: Biological & pharmaceutical bulletin 20120101

Title: The effects of the c-kit blocker glivec on the contractile response of urinary bladder.

Journal: The Journal of surgical research 20111201

Title: Visceral hypersensitivity in IBS: from bench to bedside.

Journal: Journal of pediatric gastroenterology and nutrition 20111201

Title: Mast cell stabilization: novel medication for obesity and diabetes.

Journal: Diabetes/metabolism research and reviews 20111101

Title: Zaditen (Ketotifen), as mast cell blocker, improves sperm quality, chromatin integrity and pregnancy rate after varicocelectomy.

Journal: International journal of andrology 20111001

Title: Eosinophilic ascites resolution with ketotifen.

Journal: Mayo Clinic proceedings 20111001

Title: Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves.

Journal: Asian Pacific journal of tropical medicine 20110801

Title: Mast cells promote lung vascular remodelling in pulmonary hypertension.

Journal: The European respiratory journal 20110601

Title: Concomitant juvenile xanthogranuloma and cutaneous mastocytosis in a 3-year-old Swedish girl: case report and review of the literature.

Journal: International journal of dermatology 20110501

Title: A nuclear magnetic resonance approach to the comparison of mucoadhesive properties of polysaccharides for ophthalmic uses.

Journal: International journal of pharmaceutics 20110315

Title: Therapeutic potential of ketotifen in irritable bowel syndrome (IBS) may involve changes in mast cells at sites beyond the rectum.

Journal: Gut 20110301

Title: In vitro and in vivo evaluation of ketotifen fumarate-loaded silicone hydrogel contact lenses for ocular drug delivery.

Journal: Drug delivery 20110201

Title: IBS in 2010: advances in pathophysiology, diagnosis and treatment.

Journal: Nature reviews. Gastroenterology & hepatology 20110201

Title: Determination of ketotifen fumarate by capillary electrophoresis with tris(2,2'-bipyridyl) ruthenium(II) electrochemiluminescence detection.

Journal: Luminescence : the journal of biological and chemical luminescence 20110101

Title: Zebrafish mast cells possess an FcɛRI-like receptor and participate in innate and adaptive immune responses.

Journal: Developmental and comparative immunology 20110101

Title: Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro.

Journal: International archives of allergy and immunology 20110101

Title: Alteration in airway microvascular leakage induced by sensorineural stimulation in rats exposed to inhaled formaldehyde.

Journal: Toxicology letters 20101215

Title: Essential oil from Citrus aurantifolia prevents ketotifen-induced weight-gain in mice.

Journal: Phytotherapy research : PTR 20101201

Title: Mast cell degranulation is essential for anastomotic healing in well perfused and poorly perfused rat colon.

Journal: The Journal of surgical research 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome.

Journal: Gut 20100901

Title: Mast cell stabilization decreases cardiomyocyte and LV function in dogs with isolated mitral regurgitation.

Journal: Journal of cardiac failure 20100901

Title: Synergistic interaction between TS-polysaccharide and hyaluronic acid: implications in the formulation of eye drops.

Journal: International journal of pharmaceutics 20100816

Title: [Systemic mastocytosis--definition of an internal disease].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20100801

Title: Mast cell stabilization improves survival by preventing apoptosis in sepsis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20100701

Title: Formulation of ketotifen fumarate fast-melt granulation sublingual tablet.

Journal: AAPS PharmSciTech 20100601

Title: The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures.

Journal: The Journal of bone and joint surgery. American volume 20100601

Title: Antihistamine effects on prefrontal cortex activity during working memory process in preschool children: a near-infrared spectroscopy (NIRS) study.

Journal: Neuroscience research 20100501

Title: Ketotifen versus inhaled budesonide for controlling childhood asthma.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100501

Title: Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation.

Journal: Free radical research 20100201

Title: Mucosal mast cells mediate motor response induced by chronic oral exposure to ovalbumin in the rat gastrointestinal tract.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100101

Title: Childhood autism and eosinophilic colitis.

Journal: Digestion 20100101

Title: Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.

Journal: European journal of ophthalmology 20100101

Title: [Toxicity of topical ocular anti-allergic agents on human corneal epithelial cells in vitro].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20100101

Title: Role of leukotriene B4 in 5-lipoxygenase metabolite- and allergy-induced itch-associated responses in mice.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Characterization of a calcitonin gene-related peptide release assay in rat isolated distal colon.

Journal: Archives of pharmacal research 20091201

Title: Flow injection determination of ketotifen fumarate using PVC membrane selective electrodes.

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20091101

Title: Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: a near-infrared spectroscopy (NIRS) study.

Journal: Psychopharmacology 20091101

Title: Reduced mucosal injury of SPF chickens by mast cell stabilization after infection with very virulent infectious bursal disease virus.

Journal: Veterinary immunology and immunopathology 20091015

Title: Multiple action agents and the eye: do they really stabilize mast cells?

Journal: Current opinion in allergy and clinical immunology 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: The role of mast cell stabilization in treatment of postoperative ileus: a pilot study.

Journal: The American journal of gastroenterology 20090901

Title: Longstanding eosinophilic gastroenteritis of more than 20 years.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20090901

Title: Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial.

Journal: Acta ophthalmologica 20090801

Title: Early intervention with suplatast tosilate for prophylaxis of pediatric atopic asthma: a pilot study.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20090801

Title: Selected polysaccharides at comparison for their mucoadhesiveness and effect on precorneal residence of different drugs in the rabbit model.

Journal: Drug development and industrial pharmacy 20090801

Title: Cyclosporine A eye drops inhibit the early-phase reaction in a type-I allergic conjunctivitis model in mice.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090801

Title: Effect of histamine H4 receptor antagonist on allergic rhinitis in mice.

Journal: International immunopharmacology 20090601

Title: Acetoxybenzhydrols as highly active and stable analogues of 1'S-1'-acetoxychavicol, a potent antiallergic principal from Alpinia galanga.

Journal: Bioorganic & medicinal chemistry letters 20090601

Title: Synthesis and structure-activity relationships of phenothiazine carboxylic acids having pyrimidine-dione as novel histamine H(1) antagonists.

Journal: Bioorganic & medicinal chemistry letters 20090515

Title: Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice.

Journal: Psychopharmacology 20090501

Title: Evidence for a role of mast cells in the mucosal injury induced by Newcastle disease virus.

Journal: Poultry science 20090301

Title: Pharmacological analysis of antigen-induced late airway response in rats.

Journal: Biological & pharmaceutical bulletin 20090301

Title: Churg-Strauss syndrome in a child with IgA nephropathy.

Journal: Clinical nephrology 20090301

Title: Prevention of recurrent wheezing in young children by loratadine compared with ketotifen.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20090301

Title: Application of a continuous square-wave potential program for sub nano molar determination of ketotifen.

Journal: Chemical & pharmaceutical bulletin 20090201

Title: Differential effects of topically applied formalin and aromatic compounds on neurogenic-mediated microvascular leakage in rat skin.

Journal: Toxicology 20090108

Title: The effect of levocabastine hydrochloride on human Tenon's capsule fibroblasts: inhibition of proliferation, suppression of DNA synthesis and induction of apoptosis.

Journal: Cutaneous and ocular toxicology 20090101

Title: Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

Journal: Drugs 20090101

Title: Templated hydrogels for combination devices: therapeutic contact lenses.

Journal: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20090101

Title: [Comparison of olopatadin and ketotifen in the treatment of allergic conjunctivitis].

Journal: Revista medica del Instituto Mexicano del Seguro Social 20090101

Title: Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts.

Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM 20090101

Title: Two pharmacological phases in antigen-induced immediate airway response in rats.

Journal: Biological & pharmaceutical bulletin 20081201

Title: Comparison of the conjunctival toxicity of topical ocular antiallergic agents.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081201

Title: [In vitro potentiation of chloroquine activity in Plasmodium falciparum by ketotifen and cyproheptadine].

Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20081030

Title: The sorption of ketotifen fumarate by chitosan.

Journal: AAPS PharmSciTech 20080901

Title: Ketotifen-loaded microspheres prepared by spray-drying poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) polymers: characterization and in vivo evaluation.

Journal: Journal of pharmaceutical sciences 20080801

Title: Development and characterisation of a novel and rapid lung eosinophil influx model in the rat.

Journal: Pulmonary pharmacology & therapeutics 20080801

Title: Transport and structural analysis of molecular imprinted hydrogels for controlled drug delivery.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080801

Title: Mast cell inhibition by ketotifen reduces splanchnic inflammatory response in a portal hypertension model in rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080801

Title: Enhanced affinity of ketotifen toward tamarind seed polysaccharide in comparison with hydroxyethylcellulose and hyaluronic acid: a nuclear magnetic resonance investigation.

Journal: Bioorganic & medicinal chemistry 20080801

Title: Prophylaxis with ketotifen in rats with portal hypertension: involvement of mast cell and eicosanoids.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20080801

Title: Ocular comfort and drying effects of three topical antihistamine/mast cell stabilizers in adults with allergic conjunctivitis: a randomized, double-masked crossover study.

Journal: Clinical therapeutics 20080701

Title: Bioequivalence of two formulations of ketotifen fumarate ophthalmic solution: a single-center, randomized, double-masked conjunctival allergen challenge investigation in allergic conjunctivitis.

Journal: Clinical therapeutics 20080701

Title: Mast cell stabilization improves cardiac contractile function following hemorrhagic shock and resuscitation.

Journal: American journal of physiology. Heart and circulatory physiology 20080601

Title: Effect of mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats.

Journal: Journal of cardiovascular pharmacology 20080601

Title: Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis.

Journal: Experimental eye research 20080501

Title: Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632.

Journal: European journal of pharmacology 20080331

Title: Stimulation of brain mast cells by compound 48/80, a histamine liberator, evokes renin and vasopressin release in dogs.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080301

Title: Ketotifen controlled release from cellulose acetate propionate and cellulose acetate butyrate membranes.

Journal: Journal of materials science. Materials in medicine 20080201

Title: The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red Duroc pigs.

Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20080101

Title: Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats.

Journal: BMC gastroenterology 20080101

Title: Zero-order therapeutic release from imprinted hydrogel contact lenses within in vitro physiological ocular tear flow.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20071220

Title: Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands.

Journal: Bioorganic & medicinal chemistry 20071201

Title: Suppression of plasma matrix metalloproteinase-9 following montelukast treatment in childhood asthma.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20071201

Title: Cardioprotective effects of mast cell modulators in ischemia-reperfusion-induced injury in rats.

Journal: Methods and findings in experimental and clinical pharmacology 20071101

Title: Skin permeation of ketotifen applied from stick-type formulation.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070901

Title: Effects of sedative and non-sedative H1 antagonists on cognitive tasks: behavioral and near-infrared spectroscopy (NIRS) examinations.

Journal: Psychopharmacology 20070901

Title: Immune response and inhibitory effect of ketotifen on the BALB/c and C3H/HeN mice infected with Echinostoma hortense.

Journal: Parasitology research 20070901

Title: The role of mast cells in bacterial enteritis.

Journal: The American journal of pathology 20070801

Title: Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea.

Journal: The American journal of pathology 20070801

Title: Suppressive effects of ketotifen on Th1- and Th2-related chemokines of monocytes.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20070801

Title: Duration of action of topical antiallergy drugs in a Guinea pig model of histamine-induced conjunctival vascular permeability.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070801

Title: Development of a stick-type transdermal eyelid delivery system of ketotifen fumarate for ophthalmic diseases.

Journal: Chemical & pharmaceutical bulletin 20070701

Title: Determination of ketotifen by using calcein as chemiluminescence reagent.

Journal: Analytica chimica acta 20070605

Title: Anti-inflammatory pharmacotherapy for wheezing in preschool children.

Journal: Pediatric pulmonology 20070501

Title: Establishment of an allergic rhinitis model in mice for the evaluation of nasal symptoms.

Journal: Life sciences 20070320

Title: Summing up 100 years of asthma.

Journal: Respiratory medicine 20070301

Title: Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats.

Journal: Biological & pharmaceutical bulletin 20070301

Title: Deformable liposomes and ethosomes as carriers for skin delivery of ketotifen.

Journal: Die Pharmazie 20070201

Title: PAR-2 activating peptide-induced stimulation of pregnant rat myometrium contractile activity partly involves the other membrane receptors.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20070101

Title: Modulatory effect of nitric oxide on mast cells during induction of dextran sulfate sodium colitis.

Journal: Digestive diseases and sciences 20070101

Title: Regulation of stromal cell-derived factor-1 and exhaled nitric oxide in asthmatic children following montelukast and ketotifen treatment.

Journal: Pulmonary pharmacology & therapeutics 20070101

Title: [Peripheral anticholinergic syndrome].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20070101

Title: OTC Products: Alaway and Zaditor.

Journal: Journal of the American Pharmacists Association : JAPhA 20070101

Title: Mast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 20061201

Title: Effect of antihistamine eye drops on the conjunctival provocation test with Japanese cedar pollen allergen.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20061201

Title: Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20061201

Title: Deformable liposomes and ethosomes: mechanism of enhanced skin delivery.

Journal: International journal of pharmaceutics 20060928

Title: Nasal congestion model in Brown Norway rats and the effects of some H1-antagonists.

Journal: International immunopharmacology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Development and validation of a rapid HPLC method for the determination of ketotifen in pharmaceuticals.

Journal: Drug development and industrial pharmacy 20060401

Title: Dense eosinophilic infiltration of the mucosa preceding ulcerative colitis and mimicking eosinophilic colitis: report of two cases.

Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20060301

Title: Ketotifen induced inhibition of histamine release in a non-IgE model of middle ear effusion.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20060201

Title: Brain histamine H receptor occupancy of orally administered antihistamines measured by positron emission tomography with (11)C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen.

Journal: British journal of clinical pharmacology 20060101

Title: Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors.

Journal: Journal of pharmacological sciences 20060101

Title: Ketotifen improves sperm motility and sperm morphology in male patients with leukocytospermia and unexplained infertility.

Journal: Fertility and sterility 20060101

Title: N-octyl-beta-thioglucoside enhances the transdermal permeation of ketotifen.

Journal: Die Pharmazie 20060101

Title: Systemic mast cell disease: a rare cause of osteoporosis.

Journal: Clinical and experimental rheumatology 20060101

Title: Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein.

Journal: Mediators of inflammation 20060101

Title: [Comparative study between 0.025% ketotifen fumarate and 0.1% olopatadine hydrochloride in the treatment of vernal keratoconjunctivitis].

Journal: Arquivos brasileiros de oftalmologia 20060101

Title: Antipruritic and antierythema effects of ascomycete Bulgaria inquinans extract in ICR Mice.

Journal: Biological & pharmaceutical bulletin 20051201

Title: Enhancement of skin permeation of ketotifen by supersaturation generated by amorphous form of the drug.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20051128

Title: Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats.

Journal: Peptides 20050901

Title: Comparison of the effects of ketotifen fumarate 0.025% and olopatadine HCl 0.1% ophthalmic solutions in seasonal allergic conjunctivities: a 30-day, randomized, double-masked, artificial tear substitute-controlled trial.

Journal: Clinical therapeutics 20050901

Title: Ketotifen induces primary necrosis of human eosinophils.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050801

Title: Ketotifen abrogates local and systemic consequences of rat intestinal ischemia-reperfusion injury.

Journal: Journal of gastroenterology and hepatology 20050701

Title: Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20050601

Title: Inhibition of granuloma-associated angiogenesis by controlling mast cell mediator release: role of mast cell protease-5.

Journal: British journal of pharmacology 20050501

Title: [Multiple fibromas in systemic mastocytosis].

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20050501

Title: Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats.

Journal: Acta pharmacologica Sinica 20050301

Title: Coulometric titration of ketotifen in tablets.

Journal: Die Pharmazie 20050301

Title: Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat.

Journal: Ocular immunology and inflammation 20050201

Title: Use of a five-channel multiplexed electrospray quadrupole time-of-flight hybrid mass spectrometer for metabolite identification.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Efficacy and safety of single- and multiple-dose ketotifen fumarate 0.025% ophthalmic solution in a pediatric population.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20041201

Title: Degranulation of mast cells located in median eminence in response to compound 48/80 evokes adrenocortical secretion via histamine and CRF in dogs.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20041001

Title: Induction of premature labor and delivery by allergic reaction and prevention by histamine H1 receptor antagonist.

Journal: American journal of obstetrics and gynecology 20041001

Title: Itch-scratch responses induced by lysophosphatidic acid in mice.

Journal: Pharmacology 20040901

Title: [Ketotifen fumarate (Zaditen) eye drops in the treatment of seasonal allergic conjunctivitis].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20040901

Title: Influence of antazoline and ketotifen on the anticonvulsant activity of conventional antiepileptics against maximal electroshock in mice.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20040801

Title: Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus.

Journal: Pharmacology, biochemistry, and behavior 20040801

Title: Efficacy and comfort of olopatadine versus ketotifen ophthalmic solutions: a double-masked, environmental study of patient preference.

Journal: Current medical research and opinion 20040801

Title: Ketotifen ameliorates development of fibrosis in alkali burns of the esophagus.

Journal: Pediatric surgery international 20040601

Title: Perennial rhinitis in the under 4s: a difficult problem to treat safely and effectively? A comparison of intranasal fluticasone propionate and ketotifen in the treatment of 2-4-year-old children with perennial rhinitis.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20040601

Title: Role of histamine and acid back-diffusion in modulation of gastric microvascular permeability and hemorrhagic ulcers in Salmonella typhimurium-infected rats.

Journal: Life sciences 20040305

Title: Identifying children with persistent asthma from health care administrative records.

Journal: Canadian respiratory journal 20040301

Title: Determination of ketotifen in human plasma by LC-MS.

Journal: Journal of pharmaceutical and biomedical analysis 20040127

Title: Ketotifen alone or as additional medication for long-term control of asthma and wheeze in children.

Journal: The Cochrane database of systematic reviews 20040101

Title: Cold urticaria and infectious mononucleosis in children.

Journal: Allergologia et immunopathologia 20040101

Title: A dramatic response to ketotifen in a case of eosinophilic gastroenteritis mimicking abdominal emergency.

Journal: Digestive diseases and sciences 20040101

Title: [Eosinophilic colitis. A report of two cases with non conventional treatment].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20040101

Title: Efficacy and safety of ketotifen fumarate 0.025% in the conjunctival antigen challenge model of ocular allergic conjunctivitis.

Journal: American journal of ophthalmology 20031201

Title: Release of TNF-alpha during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers.

Journal: Cardiovascular research 20031201

Title: Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201

Title: Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats.

Journal: Brain research 20031121

Title: Effect of ketotifen on the production of reactive oxygen species from human eosinophils primed by eotaxin.

Journal: Pharmacology 20031101

Title: Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20031101

Title: Efficacy and safety of ketotifen eye drops in the treatment of seasonal allergic conjunctivitis.

Journal: The British journal of ophthalmology 20031001

Title: Enhanced skin permeation of cationic drug ketotifen through excised guinea pig dorsal skin by surfactants with different electric charges.

Journal: Chemical & pharmaceutical bulletin 20031001

Title: Coincidental increase of leukotriene B4 between cerebral cortex and lung tissue of sensitized rats.

Journal: Acta pharmacologica Sinica 20031001

Title: Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.

Journal: European journal of pharmacology 20030905

Title: [Effectiveness and impact in the quality of life of ketotifen ophthalmic solution. Results of zeta study in patients with seasonal allergic conjunctivitis].

Journal: Archivos de la Sociedad Espanola de Oftalmologia 20030801

Title: The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030801

Title: Comparison of ketotifen fumarate ophthalmic solution alone, desloratadine alone, and their combination for inhibition of the signs and symptoms of seasonal allergic rhinoconjunctivitis in the conjunctival allergen challenge model: a double-masked, placebo- and active-controlled trial.

Journal: Clinical therapeutics 20030701

Title: A placebo-controlled comparison of ketotifen fumarate and nedocromil sodium ophthalmic solutions for the prevention of ocular itching with the conjunctival allergen challenge model.

Journal: Clinical therapeutics 20030701

Title: Activation of mast cells induced by agonists of proteinase-activated receptors under normal conditions and during acute inflammation in rats.

Journal: European journal of pharmacology 20030620

Title: Ketotifen reverses MDR1-mediated multidrug resistance in human breast cancer cells in vitro and alleviates cardiotoxicity induced by doxorubicin in vivo.

Journal: Cancer chemotherapy and pharmacology 20030501

Title: Efficacy of ketotifen fumarate 0.025% ophthalmic solution compared with placebo in the conjunctival allergen challenge model.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20030501

Title: Inhibitory effects of ketotifen on eotaxin-dependent activation of eosinophils: consequences for allergic eye diseases.

Journal: Allergy 20030501

Title: Effect of dehydroleucodine on histamine and serotonin release from mast cells in the isolated mouse jejunum.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030501

Title: Effects of ketotifen 0.025% and lodoxamide 0.1% on eosinophil infiltration into the guinea pig conjunctiva in a model of allergic conjunctivitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030401

Title: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].

Journal: Journal francais d'ophtalmologie 20030401

Title: Disposition kinetics of ketotifen from liposomal dry powder for inhalation in rat lung.

Journal: Clinical and experimental pharmacology & physiology 20030301

Title: The use of anti-asthmatic medications among pediatric patients in Taiwan.

Journal: Pharmacoepidemiology and drug safety 20030301

Title: The anti-allergic effects of a cromolyn sodium-chlorpheniramine combination compared to ketotifen in the conjunctival allergen challenge model.

Journal: European journal of ophthalmology 20030301

Title: A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.

Journal: Annals of tropical medicine and parasitology 20030301

Title: Alteration of CCK-induced satiety in post-Nippostrongylus brasiliensis-infected rats.

Journal: Brain, behavior, and immunity 20030201

Title: In vitro inhibition of human conjunctival mast-cell degranulation by ketotifen.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030201

Title: The effect of ketotifen on inflammatory markers in allergic conjunctivitis: an open, uncontrolled study.

Journal: BMC ophthalmology 20030101

Title: Effects of second-generation histamine H1 receptor antagonists on the active avoidance response in rats.

Journal: Clinical and experimental pharmacology & physiology 20030101

Title: Ketotifen fumarate and olopatadine hydrochloride in the treatment of allergic conjunctivitis: a real-world comparison of efficacy and ocular comfort.

Journal: Advances in therapy 20030101

Title: Epinastine inhibits eosinophil chemotaxis and adhesion molecules in atopic dermatitis.

Journal: Skin pharmacology and applied skin physiology 20030101

Title: Determination of ketotifen and its conjugated metabolite in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: Efficacy and tolerability of Ketotifen in Nepalese asthmatic children: a clinical study.

Journal: Kathmandu University medical journal (KUMJ) 20030101

Title: The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021201

Title: Pharmacokinetics of ketotifen fumarate after intravenous, intranasal, oral and rectal administration in rabbits.

Journal: Biological & pharmaceutical bulletin 20021201

Title: Levothyroxine versus ketotifen in the treatment of patients with chronic urticaria and thyroid autoimmunity.

Journal: The Journal of dermatological treatment 20021201

Title: Ketotifen fumarate treatment of superior limbic keratoconjunctivitis.

Journal: Cornea 20021101

Title: A comparison of the relative clinical efficacy of a single dose of ketotifen fumarate 0.025% ophthalmic solution versus placebo in inhibiting the signs and symptoms of allergic rhinoconjunctivitis as induced by the conjunctival allergen challenge model.

Journal: Clinical therapeutics 20021101

Title: Sensitivity of myeloid leukemia cells to calcium influx blockade: application to bone marrow purging.

Journal: Experimental hematology 20021001

Title: Absolute stereostructures of three new sesquiterpenes from the fruit of Alpinia oxyphylla with inhibitory effects on nitric oxide production and degranulation in RBL-2H3 cells.

Journal: Journal of natural products 20021001

Title: Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment.

Journal: International journal of dermatology 20020701

Title: The pharmacological profile of ovalbumin-induced paw oedema in rats.

Journal: Mediators of inflammation 20020601

Title: [Anti-allergic drugs inhibit the proliferation of human Tenon's capsule fibroblast and maintain the experimental filtering blebs on rabbit eyes].

Journal: Nippon Ganka Gakkai zasshi 20020601

Title: Delineation of the protective action of zinc sulfate on ulcerative colitis in rats.

Journal: European journal of pharmacology 20020517

Title: Oral administration of ketotifen in a patient with eosinophilic colitis and severe osteoporosis.

Journal: The American journal of gastroenterology 20020401

Title: Purging of contaminating breast cancer cells from hematopoietic progenitor cell preparations using activation enhanced cell death.

Journal: Breast cancer research and treatment 20020401

Title: Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs.

Journal: Japanese journal of pharmacology 20020301

Title: Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model.

Journal: Clinical therapeutics 20020301

Title: Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.

Journal: European journal of pharmacology 20020125

Title: Ocular tolerability and safety of ketotifen fumarate ophthalmic solution.

Journal: Advances in therapy 20020101

Title: Single dose of ketotifen fumarate .025% vs 2 weeks of cromolyn sodium 4% for allergic conjunctivitis.

Journal: Advances in therapy 20020101

Title: [Correction with zaditen of impaired activity of pancreatic digestive enzymes in sensitization and anaphylactic shock].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20020101

Title: Role of histamine in aggravation of gastric acid back-diffusion and vascular permeability in septic rats.

Journal: The Chinese journal of physiology 20011231

Title: [Sodium cromoglycate in the treatment of food hypersensitivity in children under 3 years of age].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20010901

Title: Antiallergic/antiasthmatic effect of novel antiallergic hexapeptide-95/220 in various experimental models.

Journal: Indian journal of experimental biology 20010901

Title: [Anti-allergic drugs inhibit the proliferation of bovine lens epithelial cells in culture].

Journal: Nippon Ganka Gakkai zasshi 20010801

Title: Dry powder inhalation of liposomal Ketotifen fumarate: formulation and characterization.

Journal: International journal of pharmaceutics 20010731

Title: Mast cells are involved in the gastric hyperemic response to acid back diffusion via release of histamine.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010601

Title: VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities.

Journal: Japanese journal of pharmacology 20010501

Title: Eosinophilic cystitis.

Journal: Archives of disease in childhood 20010401

Title: [Anti-allergy therapy in children].

Journal: Allergie et immunologie 20010301

Title: Adsorption of allopurinol and ketotifen by chitosan.

Journal: AAPS PharmSciTech 20010118

Title: [Changes in biochemical inflammation markers in evaluation of the effectiveness of basic chemotherapy in bronchial asthma].

Journal: Terapevticheskii arkhiv 20010101

Title: Effect of hydrophobic permeation enhancers on the release and skin permeation kinetics from matrix type transdermal drug delivery system of ketotifen fumarate.

Journal: Acta poloniae pharmaceutica 20010101

Title: Urticaria pigmentosa associated with Wilms tumor.

Journal: Pediatric dermatology 20010101

Title: Reduction of colonic mucus by repeated short-term stress enhances experimental colitis in rats.

Journal: Journal of physiology, Paris 20010101

Title: Influence of chronic treatment with H1 receptor antagonists on the anticonvulsant activity of antiepileptic drugs.

Journal: Polish journal of pharmacology 20010101

Title: Effects of mast-cell stabilization in cerulein-induced acute pancreatitis in rats.

Journal: International journal of pancreatology : official journal of the International Association of Pancreatology 20010101

Title: The mucosal mast cell and IgA plasma cell responses to primary Trichinelia spiralis infection in BALB/c mice treated with ketotifen.

Journal: Wiadomosci parazytologiczne 20010101

Title: A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.

Journal: Immunopharmacology 20000601

Title: Substance P may attenuate gastric hyperemia by a mast cell-dependent mechanism in the damaged gastric mucosa.

Journal: The American journal of physiology 19991101

Title: Ketotifen and cardiovascular effects of xamoterol following single and chronic dosing in healthy volunteers.

Journal: British journal of clinical pharmacology 19990101

Title: Infantile spasms associated with a histamine H1 antagonist.

Journal: Neuropediatrics 19981201

Title: [Effect of mast cell activation on microcirculation of intestinal mucosa in inflamed small intestine of the rat].

Journal: Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress 19980101

Title: The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 19960101

Title: Ketotifen therapy in chronic graft-versus-host disease (cGVHD): effect on mast cells and fibroblasts.

Journal: Clinical and experimental immunology 19950601

Title: The effect of antihistamines on the immediate allergic response: a comparative review.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 19930601

Title: Proconvulsant effect of ketotifen, a histamine H1 antagonist, confirmed by the use of d-chlorpheniramine with monitoring electroencephalography.

Journal: Methods and findings in experimental and clinical pharmacology 19930401

Title: [Drug induced cystitis due to ketotifen fumarate--a case report].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 19921101

Title: Pharmacological modulation of the antigen-induced expression of the low-affinity IgE receptor (Fc epsilon RII/CD23) on rat alveolar macrophages.

Journal: International archives of allergy and applied immunology 19910101

Title: Inhibition profiles of picumast and ketotifen on the in vitro release of prostanoids, slow-reacting substance of anaphylaxis, histamine and enzyme from human leukocytes and rat alveolar macrophages.

Journal: International archives of allergy and applied immunology 19870101

Title: Prevention of mast-cell degranulation by ketotifen in patients with physical urticarias.

Journal: Annals of internal medicine 19860401

Title: Klooker TK, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010 Sep;59(9):1213-21.

Title: Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35(1):1322-1330.

Title: Kiani P, et al. In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2. Viruses. 2021 Mar 26;13(4):558.

Title: Enkirch T, et al. Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs With Broad Anti-influenza A Activity. Front Immunol. 2019 Jun 5;10:1097.

Title: Pinke KH, et al. Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy? Neurotherapeutics. 2020 Jan;17(1):218-234.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:34580-14-8 Molecular Formula|34580-14-8 MDL|34580-14-8 SMILES|34580-14-8 (2E)-but-2-enedioic acid; 2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.0^{3,7}]tetradeca-1(10),3(7),4,11,13-pentaen-8-one
Catalog No.: AA003R3H
34580-14-8,MFCD00079394
34580-14-8 | (2E)-but-2-enedioic acid; 2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.0^{3,7}]tetradeca-1(10),3(7),4,11,13-pentaen-8-one
Pack Size: 100mg
Purity: 95%
in stock
$16.00 $12.00
Pack Size: 1g
Purity: 95%
in stock
$75.00 $53.00
Pack Size: 5g
Purity: 95%
in stock
$170.00 $119.00
Pack Size: 10g
Purity: 95%
in stock
$266.00 $186.00
Pack Size: 25g
Purity: 95%
in stock
$464.00 $325.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003R3H
Chemical Name: (2E)-but-2-enedioic acid; 2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.0^{3,7}]tetradeca-1(10),3(7),4,11,13-pentaen-8-one
CAS Number: 34580-14-8
Molecular Formula: C23H23NO5S
Molecular Weight: 425.4974
MDL Number: MFCD00079394
SMILES: CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1.OC(=O)C=CC(=O)O
NSC Number: 757415
Properties
Form: Solid  
MP: 192 C  
Storage: Inert atmosphere;Room Temperature;  
Complexity: 595  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 30  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
115:   
Downstream Synthesis Route
34580-14-8    84-58-2   
CASUnavailable 

[1]Mostafa,GamalA.E.;Bakheit,Ahmed;Almasoud,Najla;Alrabiah,Haitham[Molecules,2021,vol.26,#7]

34580-14-8    1518-16-7   
C19H19NOS*C4H4O4*C12H4N4 

[1]Mostafa,GamalA.E.;Bakheit,Ahmed;Almasoud,Najla;Alrabiah,Haitham[Molecules,2021,vol.26,#7]

Literature fold

Title: Anti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology20160101

Title: A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.

Journal: Antimicrobial agents and chemotherapy20130101

Title: In vivo enhancement of transdermal absorption of ketotifen by supersaturation generated by amorphous form of the drug.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20120830

Title: Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats.

Journal: Injury20120801

Title: Delivery of ketotifen fumarate by commercial contact lens materials.

Journal: Optometry and vision science : official publication of the American Academy of Optometry20120801

Title: Carryover effect on next-day sleepiness and psychomotor performance of nighttime administered antihistaminic drugs: a randomized controlled trial.

Journal: Human psychopharmacology20120701

Title: Neurogenic airway microvascular leakage induced by toluene inhalation in rats.

Journal: European journal of pharmacology20120615

Title: First and second generation H₁ histamine receptor antagonists produce different sleep-inducing profiles in rats.

Journal: European journal of pharmacology20120515

Title: The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20120401

Title: Sustained in vivo release from imprinted therapeutic contact lenses.

Journal: Journal of controlled release : official journal of the Controlled Release Society20120210

Title: In vitro effects of some drugs on human erythrocyte glutathione reductase.

Journal: Journal of enzyme inhibition and medicinal chemistry20120201

Title: Δ-lactam derivative from thermophilic soil fungus exhibits in vitro anti-allergic activity.

Journal: Natural product research20120101

Title: The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.

Journal: Biological & pharmaceutical bulletin20120101

Title: The effects of the c-kit blocker glivec on the contractile response of urinary bladder.

Journal: The Journal of surgical research20111201

Title: Visceral hypersensitivity in IBS: from bench to bedside.

Journal: Journal of pediatric gastroenterology and nutrition20111201

Title: Mast cell stabilization: novel medication for obesity and diabetes.

Journal: Diabetes/metabolism research and reviews20111101

Title: Zaditen (Ketotifen), as mast cell blocker, improves sperm quality, chromatin integrity and pregnancy rate after varicocelectomy.

Journal: International journal of andrology20111001

Title: Eosinophilic ascites resolution with ketotifen.

Journal: Mayo Clinic proceedings20111001

Title: Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves.

Journal: Asian Pacific journal of tropical medicine20110801

Title: Mast cells promote lung vascular remodelling in pulmonary hypertension.

Journal: The European respiratory journal20110601

Title: Concomitant juvenile xanthogranuloma and cutaneous mastocytosis in a 3-year-old Swedish girl: case report and review of the literature.

Journal: International journal of dermatology20110501

Title: A nuclear magnetic resonance approach to the comparison of mucoadhesive properties of polysaccharides for ophthalmic uses.

Journal: International journal of pharmaceutics20110315

Title: Therapeutic potential of ketotifen in irritable bowel syndrome (IBS) may involve changes in mast cells at sites beyond the rectum.

Journal: Gut20110301

Title: In vitro and in vivo evaluation of ketotifen fumarate-loaded silicone hydrogel contact lenses for ocular drug delivery.

Journal: Drug delivery20110201

Title: IBS in 2010: advances in pathophysiology, diagnosis and treatment.

Journal: Nature reviews. Gastroenterology & hepatology20110201

Title: Determination of ketotifen fumarate by capillary electrophoresis with tris(2,2'-bipyridyl) ruthenium(II) electrochemiluminescence detection.

Journal: Luminescence : the journal of biological and chemical luminescence20110101

Title: Zebrafish mast cells possess an FcɛRI-like receptor and participate in innate and adaptive immune responses.

Journal: Developmental and comparative immunology20110101

Title: Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro.

Journal: International archives of allergy and immunology20110101

Title: Alteration in airway microvascular leakage induced by sensorineural stimulation in rats exposed to inhaled formaldehyde.

Journal: Toxicology letters20101215

Title: Essential oil from Citrus aurantifolia prevents ketotifen-induced weight-gain in mice.

Journal: Phytotherapy research : PTR20101201

Title: Mast cell degranulation is essential for anastomotic healing in well perfused and poorly perfused rat colon.

Journal: The Journal of surgical research20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome.

Journal: Gut20100901

Title: Mast cell stabilization decreases cardiomyocyte and LV function in dogs with isolated mitral regurgitation.

Journal: Journal of cardiac failure20100901

Title: Synergistic interaction between TS-polysaccharide and hyaluronic acid: implications in the formulation of eye drops.

Journal: International journal of pharmaceutics20100816

Title: [Systemic mastocytosis--definition of an internal disease].

Journal: Medizinische Klinik (Munich, Germany : 1983)20100801

Title: Mast cell stabilization improves survival by preventing apoptosis in sepsis.

Journal: Journal of immunology (Baltimore, Md. : 1950)20100701

Title: Formulation of ketotifen fumarate fast-melt granulation sublingual tablet.

Journal: AAPS PharmSciTech20100601

Title: The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures.

Journal: The Journal of bone and joint surgery. American volume20100601

Title: Antihistamine effects on prefrontal cortex activity during working memory process in preschool children: a near-infrared spectroscopy (NIRS) study.

Journal: Neuroscience research20100501

Title: Ketotifen versus inhaled budesonide for controlling childhood asthma.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet20100501

Title: Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation.

Journal: Free radical research20100201

Title: Mucosal mast cells mediate motor response induced by chronic oral exposure to ovalbumin in the rat gastrointestinal tract.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20100101

Title: Childhood autism and eosinophilic colitis.

Journal: Digestion20100101

Title: Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.

Journal: European journal of ophthalmology20100101

Title: [Toxicity of topical ocular anti-allergic agents on human corneal epithelial cells in vitro].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology20100101

Title: Role of leukotriene B4 in 5-lipoxygenase metabolite- and allergy-induced itch-associated responses in mice.

Journal: Biological & pharmaceutical bulletin20100101

Title: Characterization of a calcitonin gene-related peptide release assay in rat isolated distal colon.

Journal: Archives of pharmacal research20091201

Title: Flow injection determination of ketotifen fumarate using PVC membrane selective electrodes.

Journal: Bioelectrochemistry (Amsterdam, Netherlands)20091101

Title: Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: a near-infrared spectroscopy (NIRS) study.

Journal: Psychopharmacology20091101

Title: Reduced mucosal injury of SPF chickens by mast cell stabilization after infection with very virulent infectious bursal disease virus.

Journal: Veterinary immunology and immunopathology20091015

Title: Multiple action agents and the eye: do they really stabilize mast cells?

Journal: Current opinion in allergy and clinical immunology20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: The role of mast cell stabilization in treatment of postoperative ileus: a pilot study.

Journal: The American journal of gastroenterology20090901

Title: Longstanding eosinophilic gastroenteritis of more than 20 years.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie20090901

Title: Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial.

Journal: Acta ophthalmologica20090801

Title: Early intervention with suplatast tosilate for prophylaxis of pediatric atopic asthma: a pilot study.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology20090801

Title: Selected polysaccharides at comparison for their mucoadhesiveness and effect on precorneal residence of different drugs in the rabbit model.

Journal: Drug development and industrial pharmacy20090801

Title: Cyclosporine A eye drops inhibit the early-phase reaction in a type-I allergic conjunctivitis model in mice.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20090801

Title: Effect of histamine H4 receptor antagonist on allergic rhinitis in mice.

Journal: International immunopharmacology20090601

Title: Acetoxybenzhydrols as highly active and stable analogues of 1'S-1'-acetoxychavicol, a potent antiallergic principal from Alpinia galanga.

Journal: Bioorganic & medicinal chemistry letters20090601

Title: Synthesis and structure-activity relationships of phenothiazine carboxylic acids having pyrimidine-dione as novel histamine H(1) antagonists.

Journal: Bioorganic & medicinal chemistry letters20090515

Title: Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice.

Journal: Psychopharmacology20090501

Title: Evidence for a role of mast cells in the mucosal injury induced by Newcastle disease virus.

Journal: Poultry science20090301

Title: Pharmacological analysis of antigen-induced late airway response in rats.

Journal: Biological & pharmaceutical bulletin20090301

Title: Churg-Strauss syndrome in a child with IgA nephropathy.

Journal: Clinical nephrology20090301

Title: Prevention of recurrent wheezing in young children by loratadine compared with ketotifen.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet20090301

Title: Application of a continuous square-wave potential program for sub nano molar determination of ketotifen.

Journal: Chemical & pharmaceutical bulletin20090201

Title: Differential effects of topically applied formalin and aromatic compounds on neurogenic-mediated microvascular leakage in rat skin.

Journal: Toxicology20090108

Title: The effect of levocabastine hydrochloride on human Tenon's capsule fibroblasts: inhibition of proliferation, suppression of DNA synthesis and induction of apoptosis.

Journal: Cutaneous and ocular toxicology20090101

Title: Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

Journal: Drugs20090101

Title: Templated hydrogels for combination devices: therapeutic contact lenses.

Journal: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference20090101

Title: [Comparison of olopatadin and ketotifen in the treatment of allergic conjunctivitis].

Journal: Revista medica del Instituto Mexicano del Seguro Social20090101

Title: Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts.

Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM20090101

Title: Two pharmacological phases in antigen-induced immediate airway response in rats.

Journal: Biological & pharmaceutical bulletin20081201

Title: Comparison of the conjunctival toxicity of topical ocular antiallergic agents.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20081201

Title: [In vitro potentiation of chloroquine activity in Plasmodium falciparum by ketotifen and cyproheptadine].

Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases20081030

Title: The sorption of ketotifen fumarate by chitosan.

Journal: AAPS PharmSciTech20080901

Title: Ketotifen-loaded microspheres prepared by spray-drying poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) polymers: characterization and in vivo evaluation.

Journal: Journal of pharmaceutical sciences20080801

Title: Development and characterisation of a novel and rapid lung eosinophil influx model in the rat.

Journal: Pulmonary pharmacology & therapeutics20080801

Title: Transport and structural analysis of molecular imprinted hydrogels for controlled drug delivery.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20080801

Title: Mast cell inhibition by ketotifen reduces splanchnic inflammatory response in a portal hypertension model in rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie20080801

Title: Enhanced affinity of ketotifen toward tamarind seed polysaccharide in comparison with hydroxyethylcellulose and hyaluronic acid: a nuclear magnetic resonance investigation.

Journal: Bioorganic & medicinal chemistry20080801

Title: Prophylaxis with ketotifen in rats with portal hypertension: involvement of mast cell and eicosanoids.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT20080801

Title: Ocular comfort and drying effects of three topical antihistamine/mast cell stabilizers in adults with allergic conjunctivitis: a randomized, double-masked crossover study.

Journal: Clinical therapeutics20080701

Title: Bioequivalence of two formulations of ketotifen fumarate ophthalmic solution: a single-center, randomized, double-masked conjunctival allergen challenge investigation in allergic conjunctivitis.

Journal: Clinical therapeutics20080701

Title: Mast cell stabilization improves cardiac contractile function following hemorrhagic shock and resuscitation.

Journal: American journal of physiology. Heart and circulatory physiology20080601

Title: Effect of mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats.

Journal: Journal of cardiovascular pharmacology20080601

Title: Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis.

Journal: Experimental eye research20080501

Title: Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632.

Journal: European journal of pharmacology20080331

Title: Stimulation of brain mast cells by compound 48/80, a histamine liberator, evokes renin and vasopressin release in dogs.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20080301

Title: Ketotifen controlled release from cellulose acetate propionate and cellulose acetate butyrate membranes.

Journal: Journal of materials science. Materials in medicine20080201

Title: The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red Duroc pigs.

Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society20080101

Title: Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats.

Journal: BMC gastroenterology20080101

Title: Zero-order therapeutic release from imprinted hydrogel contact lenses within in vitro physiological ocular tear flow.

Journal: Journal of controlled release : official journal of the Controlled Release Society20071220

Title: Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands.

Journal: Bioorganic & medicinal chemistry20071201

Title: Suppression of plasma matrix metalloproteinase-9 following montelukast treatment in childhood asthma.

Journal: Pediatrics international : official journal of the Japan Pediatric Society20071201

Title: Cardioprotective effects of mast cell modulators in ischemia-reperfusion-induced injury in rats.

Journal: Methods and findings in experimental and clinical pharmacology20071101

Title: Skin permeation of ketotifen applied from stick-type formulation.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20070901

Title: Effects of sedative and non-sedative H1 antagonists on cognitive tasks: behavioral and near-infrared spectroscopy (NIRS) examinations.

Journal: Psychopharmacology20070901

Title: Immune response and inhibitory effect of ketotifen on the BALB/c and C3H/HeN mice infected with Echinostoma hortense.

Journal: Parasitology research20070901

Title: The role of mast cells in bacterial enteritis.

Journal: The American journal of pathology20070801

Title: Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea.

Journal: The American journal of pathology20070801

Title: Suppressive effects of ketotifen on Th1- and Th2-related chemokines of monocytes.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology20070801

Title: Duration of action of topical antiallergy drugs in a Guinea pig model of histamine-induced conjunctival vascular permeability.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20070801

Title: Development of a stick-type transdermal eyelid delivery system of ketotifen fumarate for ophthalmic diseases.

Journal: Chemical & pharmaceutical bulletin20070701

Title: Determination of ketotifen by using calcein as chemiluminescence reagent.

Journal: Analytica chimica acta20070605

Title: Anti-inflammatory pharmacotherapy for wheezing in preschool children.

Journal: Pediatric pulmonology20070501

Title: Establishment of an allergic rhinitis model in mice for the evaluation of nasal symptoms.

Journal: Life sciences20070320

Title: Summing up 100 years of asthma.

Journal: Respiratory medicine20070301

Title: Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats.

Journal: Biological & pharmaceutical bulletin20070301

Title: Deformable liposomes and ethosomes as carriers for skin delivery of ketotifen.

Journal: Die Pharmazie20070201

Title: PAR-2 activating peptide-induced stimulation of pregnant rat myometrium contractile activity partly involves the other membrane receptors.

Journal: European journal of obstetrics, gynecology, and reproductive biology20070101

Title: Modulatory effect of nitric oxide on mast cells during induction of dextran sulfate sodium colitis.

Journal: Digestive diseases and sciences20070101

Title: Regulation of stromal cell-derived factor-1 and exhaled nitric oxide in asthmatic children following montelukast and ketotifen treatment.

Journal: Pulmonary pharmacology & therapeutics20070101

Title: [Peripheral anticholinergic syndrome].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)20070101

Title: OTC Products: Alaway and Zaditor.

Journal: Journal of the American Pharmacists Association : JAPhA20070101

Title: Mast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat.

Journal: The Journal of pharmacology and experimental therapeutics20061201

Title: Effect of antihistamine eye drops on the conjunctival provocation test with Japanese cedar pollen allergen.

Journal: Allergology international : official journal of the Japanese Society of Allergology20061201

Title: Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.

Journal: Allergology international : official journal of the Japanese Society of Allergology20061201

Title: Deformable liposomes and ethosomes: mechanism of enhanced skin delivery.

Journal: International journal of pharmaceutics20060928

Title: Nasal congestion model in Brown Norway rats and the effects of some H1-antagonists.

Journal: International immunopharmacology20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Development and validation of a rapid HPLC method for the determination of ketotifen in pharmaceuticals.

Journal: Drug development and industrial pharmacy20060401

Title: Dense eosinophilic infiltration of the mucosa preceding ulcerative colitis and mimicking eosinophilic colitis: report of two cases.

Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology20060301

Title: Ketotifen induced inhibition of histamine release in a non-IgE model of middle ear effusion.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology20060201

Title: Brain histamine H receptor occupancy of orally administered antihistamines measured by positron emission tomography with (11)C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen.

Journal: British journal of clinical pharmacology20060101

Title: Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors.

Journal: Journal of pharmacological sciences20060101

Title: Ketotifen improves sperm motility and sperm morphology in male patients with leukocytospermia and unexplained infertility.

Journal: Fertility and sterility20060101

Title: N-octyl-beta-thioglucoside enhances the transdermal permeation of ketotifen.

Journal: Die Pharmazie20060101

Title: Systemic mast cell disease: a rare cause of osteoporosis.

Journal: Clinical and experimental rheumatology20060101

Title: Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein.

Journal: Mediators of inflammation20060101

Title: [Comparative study between 0.025% ketotifen fumarate and 0.1% olopatadine hydrochloride in the treatment of vernal keratoconjunctivitis].

Journal: Arquivos brasileiros de oftalmologia20060101

Title: Antipruritic and antierythema effects of ascomycete Bulgaria inquinans extract in ICR Mice.

Journal: Biological & pharmaceutical bulletin20051201

Title: Enhancement of skin permeation of ketotifen by supersaturation generated by amorphous form of the drug.

Journal: Journal of controlled release : official journal of the Controlled Release Society20051128

Title: Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats.

Journal: Peptides20050901

Title: Comparison of the effects of ketotifen fumarate 0.025% and olopatadine HCl 0.1% ophthalmic solutions in seasonal allergic conjunctivities: a 30-day, randomized, double-masked, artificial tear substitute-controlled trial.

Journal: Clinical therapeutics20050901

Title: Ketotifen induces primary necrosis of human eosinophils.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20050801

Title: Ketotifen abrogates local and systemic consequences of rat intestinal ischemia-reperfusion injury.

Journal: Journal of gastroenterology and hepatology20050701

Title: Discrepant clinical responses and blood chemokine profiles between two non-steroidal anti-inflammatory medications for children with mild persistent asthma.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology20050601

Title: Inhibition of granuloma-associated angiogenesis by controlling mast cell mediator release: role of mast cell protease-5.

Journal: British journal of pharmacology20050501

Title: [Multiple fibromas in systemic mastocytosis].

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG20050501

Title: Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats.

Journal: Acta pharmacologica Sinica20050301

Title: Coulometric titration of ketotifen in tablets.

Journal: Die Pharmazie20050301

Title: Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat.

Journal: Ocular immunology and inflammation20050201

Title: Use of a five-channel multiplexed electrospray quadrupole time-of-flight hybrid mass spectrometer for metabolite identification.

Journal: Rapid communications in mass spectrometry : RCM20050101

Title: Efficacy and safety of single- and multiple-dose ketotifen fumarate 0.025% ophthalmic solution in a pediatric population.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology20041201

Title: Degranulation of mast cells located in median eminence in response to compound 48/80 evokes adrenocortical secretion via histamine and CRF in dogs.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20041001

Title: Induction of premature labor and delivery by allergic reaction and prevention by histamine H1 receptor antagonist.

Journal: American journal of obstetrics and gynecology20041001

Title: Itch-scratch responses induced by lysophosphatidic acid in mice.

Journal: Pharmacology20040901

Title: [Ketotifen fumarate (Zaditen) eye drops in the treatment of seasonal allergic conjunctivitis].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti20040901

Title: Influence of antazoline and ketotifen on the anticonvulsant activity of conventional antiepileptics against maximal electroshock in mice.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20040801

Title: Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus.

Journal: Pharmacology, biochemistry, and behavior20040801

Title: Efficacy and comfort of olopatadine versus ketotifen ophthalmic solutions: a double-masked, environmental study of patient preference.

Journal: Current medical research and opinion20040801

Title: Ketotifen ameliorates development of fibrosis in alkali burns of the esophagus.

Journal: Pediatric surgery international20040601

Title: Perennial rhinitis in the under 4s: a difficult problem to treat safely and effectively? A comparison of intranasal fluticasone propionate and ketotifen in the treatment of 2-4-year-old children with perennial rhinitis.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology20040601

Title: Role of histamine and acid back-diffusion in modulation of gastric microvascular permeability and hemorrhagic ulcers in Salmonella typhimurium-infected rats.

Journal: Life sciences20040305

Title: Identifying children with persistent asthma from health care administrative records.

Journal: Canadian respiratory journal20040301

Title: Determination of ketotifen in human plasma by LC-MS.

Journal: Journal of pharmaceutical and biomedical analysis20040127

Title: Ketotifen alone or as additional medication for long-term control of asthma and wheeze in children.

Journal: The Cochrane database of systematic reviews20040101

Title: Cold urticaria and infectious mononucleosis in children.

Journal: Allergologia et immunopathologia20040101

Title: A dramatic response to ketotifen in a case of eosinophilic gastroenteritis mimicking abdominal emergency.

Journal: Digestive diseases and sciences20040101

Title: [Eosinophilic colitis. A report of two cases with non conventional treatment].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)20040101

Title: Efficacy and safety of ketotifen fumarate 0.025% in the conjunctival antigen challenge model of ocular allergic conjunctivitis.

Journal: American journal of ophthalmology20031201

Title: Release of TNF-alpha during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers.

Journal: Cardiovascular research20031201

Title: Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20031201

Title: Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats.

Journal: Brain research20031121

Title: Effect of ketotifen on the production of reactive oxygen species from human eosinophils primed by eotaxin.

Journal: Pharmacology20031101

Title: Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology20031101

Title: Efficacy and safety of ketotifen eye drops in the treatment of seasonal allergic conjunctivitis.

Journal: The British journal of ophthalmology20031001

Title: Enhanced skin permeation of cationic drug ketotifen through excised guinea pig dorsal skin by surfactants with different electric charges.

Journal: Chemical & pharmaceutical bulletin20031001

Title: Coincidental increase of leukotriene B4 between cerebral cortex and lung tissue of sensitized rats.

Journal: Acta pharmacologica Sinica20031001

Title: Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.

Journal: European journal of pharmacology20030905

Title: [Effectiveness and impact in the quality of life of ketotifen ophthalmic solution. Results of zeta study in patients with seasonal allergic conjunctivitis].

Journal: Archivos de la Sociedad Espanola de Oftalmologia20030801

Title: The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20030801

Title: Comparison of ketotifen fumarate ophthalmic solution alone, desloratadine alone, and their combination for inhibition of the signs and symptoms of seasonal allergic rhinoconjunctivitis in the conjunctival allergen challenge model: a double-masked, placebo- and active-controlled trial.

Journal: Clinical therapeutics20030701

Title: A placebo-controlled comparison of ketotifen fumarate and nedocromil sodium ophthalmic solutions for the prevention of ocular itching with the conjunctival allergen challenge model.

Journal: Clinical therapeutics20030701

Title: Activation of mast cells induced by agonists of proteinase-activated receptors under normal conditions and during acute inflammation in rats.

Journal: European journal of pharmacology20030620

Title: Ketotifen reverses MDR1-mediated multidrug resistance in human breast cancer cells in vitro and alleviates cardiotoxicity induced by doxorubicin in vivo.

Journal: Cancer chemotherapy and pharmacology20030501

Title: Efficacy of ketotifen fumarate 0.025% ophthalmic solution compared with placebo in the conjunctival allergen challenge model.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960)20030501

Title: Inhibitory effects of ketotifen on eotaxin-dependent activation of eosinophils: consequences for allergic eye diseases.

Journal: Allergy20030501

Title: Effect of dehydroleucodine on histamine and serotonin release from mast cells in the isolated mouse jejunum.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20030501

Title: Effects of ketotifen 0.025% and lodoxamide 0.1% on eosinophil infiltration into the guinea pig conjunctiva in a model of allergic conjunctivitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20030401

Title: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].

Journal: Journal francais d'ophtalmologie20030401

Title: Disposition kinetics of ketotifen from liposomal dry powder for inhalation in rat lung.

Journal: Clinical and experimental pharmacology & physiology20030301

Title: The use of anti-asthmatic medications among pediatric patients in Taiwan.

Journal: Pharmacoepidemiology and drug safety20030301

Title: The anti-allergic effects of a cromolyn sodium-chlorpheniramine combination compared to ketotifen in the conjunctival allergen challenge model.

Journal: European journal of ophthalmology20030301

Title: A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.

Journal: Annals of tropical medicine and parasitology20030301

Title: Alteration of CCK-induced satiety in post-Nippostrongylus brasiliensis-infected rats.

Journal: Brain, behavior, and immunity20030201

Title: In vitro inhibition of human conjunctival mast-cell degranulation by ketotifen.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20030201

Title: The effect of ketotifen on inflammatory markers in allergic conjunctivitis: an open, uncontrolled study.

Journal: BMC ophthalmology20030101

Title: Effects of second-generation histamine H1 receptor antagonists on the active avoidance response in rats.

Journal: Clinical and experimental pharmacology & physiology20030101

Title: Ketotifen fumarate and olopatadine hydrochloride in the treatment of allergic conjunctivitis: a real-world comparison of efficacy and ocular comfort.

Journal: Advances in therapy20030101

Title: Epinastine inhibits eosinophil chemotaxis and adhesion molecules in atopic dermatitis.

Journal: Skin pharmacology and applied skin physiology20030101

Title: Determination of ketotifen and its conjugated metabolite in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study.

Journal: Rapid communications in mass spectrometry : RCM20030101

Title: Efficacy and tolerability of Ketotifen in Nepalese asthmatic children: a clinical study.

Journal: Kathmandu University medical journal (KUMJ)20030101

Title: The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology20021201

Title: Pharmacokinetics of ketotifen fumarate after intravenous, intranasal, oral and rectal administration in rabbits.

Journal: Biological & pharmaceutical bulletin20021201

Title: Levothyroxine versus ketotifen in the treatment of patients with chronic urticaria and thyroid autoimmunity.

Journal: The Journal of dermatological treatment20021201

Title: Ketotifen fumarate treatment of superior limbic keratoconjunctivitis.

Journal: Cornea20021101

Title: A comparison of the relative clinical efficacy of a single dose of ketotifen fumarate 0.025% ophthalmic solution versus placebo in inhibiting the signs and symptoms of allergic rhinoconjunctivitis as induced by the conjunctival allergen challenge model.

Journal: Clinical therapeutics20021101

Title: Sensitivity of myeloid leukemia cells to calcium influx blockade: application to bone marrow purging.

Journal: Experimental hematology20021001

Title: Absolute stereostructures of three new sesquiterpenes from the fruit of Alpinia oxyphylla with inhibitory effects on nitric oxide production and degranulation in RBL-2H3 cells.

Journal: Journal of natural products20021001

Title: Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment.

Journal: International journal of dermatology20020701

Title: The pharmacological profile of ovalbumin-induced paw oedema in rats.

Journal: Mediators of inflammation20020601

Title: [Anti-allergic drugs inhibit the proliferation of human Tenon's capsule fibroblast and maintain the experimental filtering blebs on rabbit eyes].

Journal: Nippon Ganka Gakkai zasshi20020601

Title: Delineation of the protective action of zinc sulfate on ulcerative colitis in rats.

Journal: European journal of pharmacology20020517

Title: Oral administration of ketotifen in a patient with eosinophilic colitis and severe osteoporosis.

Journal: The American journal of gastroenterology20020401

Title: Purging of contaminating breast cancer cells from hematopoietic progenitor cell preparations using activation enhanced cell death.

Journal: Breast cancer research and treatment20020401

Title: Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs.

Journal: Japanese journal of pharmacology20020301

Title: Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model.

Journal: Clinical therapeutics20020301

Title: Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.

Journal: European journal of pharmacology20020125

Title: Ocular tolerability and safety of ketotifen fumarate ophthalmic solution.

Journal: Advances in therapy20020101

Title: Single dose of ketotifen fumarate .025% vs 2 weeks of cromolyn sodium 4% for allergic conjunctivitis.

Journal: Advances in therapy20020101

Title: [Correction with zaditen of impaired activity of pancreatic digestive enzymes in sensitization and anaphylactic shock].

Journal: Eksperimental'naia i klinicheskaia farmakologiia20020101

Title: Role of histamine in aggravation of gastric acid back-diffusion and vascular permeability in septic rats.

Journal: The Chinese journal of physiology20011231

Title: [Sodium cromoglycate in the treatment of food hypersensitivity in children under 3 years of age].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego20010901

Title: Antiallergic/antiasthmatic effect of novel antiallergic hexapeptide-95/220 in various experimental models.

Journal: Indian journal of experimental biology20010901

Title: [Anti-allergic drugs inhibit the proliferation of bovine lens epithelial cells in culture].

Journal: Nippon Ganka Gakkai zasshi20010801

Title: Dry powder inhalation of liposomal Ketotifen fumarate: formulation and characterization.

Journal: International journal of pharmaceutics20010731

Title: Mast cells are involved in the gastric hyperemic response to acid back diffusion via release of histamine.

Journal: American journal of physiology. Gastrointestinal and liver physiology20010601

Title: VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities.

Journal: Japanese journal of pharmacology20010501

Title: Eosinophilic cystitis.

Journal: Archives of disease in childhood20010401

Title: [Anti-allergy therapy in children].

Journal: Allergie et immunologie20010301

Title: Adsorption of allopurinol and ketotifen by chitosan.

Journal: AAPS PharmSciTech20010118

Title: [Changes in biochemical inflammation markers in evaluation of the effectiveness of basic chemotherapy in bronchial asthma].

Journal: Terapevticheskii arkhiv20010101

Title: Effect of hydrophobic permeation enhancers on the release and skin permeation kinetics from matrix type transdermal drug delivery system of ketotifen fumarate.

Journal: Acta poloniae pharmaceutica20010101

Title: Urticaria pigmentosa associated with Wilms tumor.

Journal: Pediatric dermatology20010101

Title: Reduction of colonic mucus by repeated short-term stress enhances experimental colitis in rats.

Journal: Journal of physiology, Paris20010101

Title: Influence of chronic treatment with H1 receptor antagonists on the anticonvulsant activity of antiepileptic drugs.

Journal: Polish journal of pharmacology20010101

Title: Effects of mast-cell stabilization in cerulein-induced acute pancreatitis in rats.

Journal: International journal of pancreatology : official journal of the International Association of Pancreatology20010101

Title: The mucosal mast cell and IgA plasma cell responses to primary Trichinelia spiralis infection in BALB/c mice treated with ketotifen.

Journal: Wiadomosci parazytologiczne20010101

Title: A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.

Journal: Immunopharmacology20000601

Title: Substance P may attenuate gastric hyperemia by a mast cell-dependent mechanism in the damaged gastric mucosa.

Journal: The American journal of physiology19991101

Title: Ketotifen and cardiovascular effects of xamoterol following single and chronic dosing in healthy volunteers.

Journal: British journal of clinical pharmacology19990101

Title: Infantile spasms associated with a histamine H1 antagonist.

Journal: Neuropediatrics19981201

Title: [Effect of mast cell activation on microcirculation of intestinal mucosa in inflamed small intestine of the rat].

Journal: Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress19980101

Title: The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics19960101

Title: Ketotifen therapy in chronic graft-versus-host disease (cGVHD): effect on mast cells and fibroblasts.

Journal: Clinical and experimental immunology19950601

Title: The effect of antihistamines on the immediate allergic response: a comparative review.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery19930601

Title: Proconvulsant effect of ketotifen, a histamine H1 antagonist, confirmed by the use of d-chlorpheniramine with monitoring electroencephalography.

Journal: Methods and findings in experimental and clinical pharmacology19930401

Title: [Drug induced cystitis due to ketotifen fumarate--a case report].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology19921101

Title: Pharmacological modulation of the antigen-induced expression of the low-affinity IgE receptor (Fc epsilon RII/CD23) on rat alveolar macrophages.

Journal: International archives of allergy and applied immunology19910101

Title: Inhibition profiles of picumast and ketotifen on the in vitro release of prostanoids, slow-reacting substance of anaphylaxis, histamine and enzyme from human leukocytes and rat alveolar macrophages.

Journal: International archives of allergy and applied immunology19870101

Title: Prevention of mast-cell degranulation by ketotifen in patients with physical urticarias.

Journal: Annals of internal medicine19860401

Title: Klooker TK, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010 Sep;59(9):1213-21.

Title: Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35(1):1322-1330.

Title: Kiani P, et al. In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2. Viruses. 2021 Mar 26;13(4):558.

Title: Enkirch T, et al. Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs With Broad Anti-influenza A Activity. Front Immunol. 2019 Jun 5;10:1097.

Title: Pinke KH, et al. Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy? Neurotherapeutics. 2020 Jan;17(1):218-234.

Building Blocks More >
6108-23-2
6108-23-2
Lithium formate hydrate
AA003R8J | MFCD00150507
595-33-5
595-33-5
Megestryl acetate
AA003RDY | MFCD00056470
639091-75-1
639091-75-1
Methyl 2-(Boc-amino)isonicotinate
AA003RI9 | MFCD11504796
22621-41-6
22621-41-6
Methyl 2-hydroxy-3-nitrobenzoate
AA003RLA | MFCD00272263
377734-27-5
377734-27-5
Methyl 3-bromo-5-formylbenzoate
AA003ROR | MFCD22381229
688357-19-9
688357-19-9
Methyl 4-chloro-5-azaindole-2-carboxylate
AA003RS6 | MFCD09870065
73781-91-6
73781-91-6
Methyl 6-chloronicotinate
AA003RVN | MFCD00023420
51502-45-5
51502-45-5
Methyl perfluorononanoate
AA003RZ6 | MFCD00153213
589-68-4
589-68-4
Monomyristin
AA003S31 | MFCD00046760
544-31-0
544-31-0
Palmitoylethanolamide
AA003S6V | MFCD00020562
Submit
© 2017 AA BLOCKS, INC. All rights reserved.