68767-14-6,MFCD00864331
Catalog No.:AA003RAE

68767-14-6 | 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid

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100mg
97%
in stock  
$6.00   $4.00
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250mg
97%
in stock  
$8.00   $6.00
- +
1g
97%
in stock  
$11.00   $8.00
- +
5g
97%
in stock  
$17.00   $12.00
- +
25g
97%
in stock  
$38.00   $27.00
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100g
97%
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$116.00   $82.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003RAE
Chemical Name:
2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
CAS Number:
68767-14-6
Molecular Formula:
C15H18O3
Molecular Weight:
246.3016
MDL Number:
MFCD00864331
SMILES:
OC(=O)C(c1ccc(cc1)CC1CCCC1=O)C
Properties
Properties
 
BP:
417.9°C at 760 mmHg  
Form:
Solid  
MP:
108.5-111°  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
316  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
2  
XLogP3:
2.4  

Upstream Synthesis Route

[1]Patent:US4161538,1979,A,

[1]Patent:US2016/151506,2016,A1,.Locationinpatent:Paragraph0416-0420

[1]SyntheticCommunications,1984,vol.14,#14,p.1365-1372

[1]SyntheticCommunications,1984,vol.14,#14,p.1365-1372

[1]SyntheticCommunications,1984,vol.14,#14,p.1365-1372

Downstream Synthesis Route

[1]Chemicalandpharmaceuticalbulletin,1983,vol.31,p.4286-4294

[2]Chemicalandpharmaceuticalbulletin,1983,vol.31,p.4286-4294

[1]JournalofMedicinalChemistry,1984,vol.27,p.212-216

[1]JournalofMedicinalChemistry,1984,vol.27,p.212-216

[1]ChemicalandPharmaceuticalBulletin,1983,vol.31,p.4319-4323

[2]BiochemicalPharmacology,1995,vol.50,p.221-227

[1]ChemicalandPharmaceuticalBulletin,1983,vol.31,p.4319-4323

Literature

Title: Assessing the cardiovascular risk between celecoxib and nonselective nonsteroidal antiinflammatory drugs in patients with rheumatoid arthritis and osteoarthritis.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20140101

Title: Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomy in elderly patients.

Journal: Japanese journal of clinical oncology 20121101

Title: Chiral amines as reagents for HPLC-MS enantioseparation of chiral carboxylic acids.

Journal: Journal of separation science 20120701

Title: Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity.

Journal: Journal of medicinal chemistry 20120614

Title: Simultaneous determination of non-steroidal anti-inflammatory drugs in river water by gas chromatography-mass spectrometry.

Journal: Journal of separation science 20120201

Title: Cyclooxygenase inhibitor improved an exudative lesion of choroidal neovascularization in age-related macular degeneration.

Journal: European journal of ophthalmology 20120101

Title: Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion.

Journal: Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT 20120101

Title: New therapeutic strategy for amino acid medicine: prophylactic and healing promoting effect of monosodium glutamate against NSAID-induced enteropathy.

Journal: Journal of pharmacological sciences 20120101

Title: Chronic mandibular osteomyelitis with suspected underlying synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: a case report.

Journal: Journal of inflammation research 20120101

Title: Complete remission of human parvovirus b19 associated symptoms by loxoprofen in patients with atopic predispositions.

Journal: Case reports in medicine 20120101

Title: Adverse events in patients with blood loss: a pooled analysis of 51 clinical studies from the celecoxib clinical trial database.

Journal: The open rheumatology journal 20120101

Title: Heart failure assocated with pregabalin.

Journal: Pain physician 20120101

Title: [Correlation study on effects of electroacupuncture on the muscle condition and MNCV in rabbits with lumbar nerve root compression].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20111101

Title: Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20110901

Title: Synthesis and biological evaluation of loxoprofen derivatives.

Journal: Bioorganic & medicinal chemistry 20110601

Title: Prescription pattern of NSAIDs and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients in clinical practice in Korea.

Journal: Journal of Korean medical science 20110401

Title: Long-term effect of loxoprofen sodium on nocturia in patients with benign prostatic hyperplasia.

Journal: Korean journal of urology 20110401

Title: [Japanese SUNCT patient responsive to gabapentin].

Journal: Rinsho shinkeigaku = Clinical neurology 20110401

Title: Protective effect of geranylgeranylacetone against loxoprofen sodium-induced small intestinal lesions in rats.

Journal: European journal of pharmacology 20110210

Title: Efficacy and safety of the selective cyclooxygenase-2 inhibitor celecoxib in the treatment of rheumatoid arthritis and osteoarthritis in Japan.

Journal: Digestion 20110101

Title: A case of chlorpheniramine maleate-induced hypersensitivity with aspirin intolerance.

Journal: Allergy, asthma & immunology research 20110101

Title: Unilateral eyelid angioedema with congestion of the right bulbar conjunctiva due to loxoprofen sodium.

Journal: Cutis 20110101

Title: Influence of nonsteroidal anti-inflammatory drugs on the antiplatelet effects of aspirin in rats.

Journal: Biological & pharmaceutical bulletin 20110101

Title: Antipyretic and analgesic effects of zaltoprofen for the treatment of acute upper respiratory tract infection: verification of a noninferiority hypothesis using loxoprofen sodium.

Journal: Pharmacology 20110101

Title: Review of allergic and photoallergic contact dermatitis from an ingredient in a medicament vehicle consisting of a compress, poultice, plaster, and tape.

Journal: Journal of allergy 20110101

Title: Prostacyclin: an inflammatory paradox.

Journal: Frontiers in pharmacology 20110101

Title: Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in an Upper Limb Suggesting Pain Alleviation through Neural Plasticity within the Central Nervous System: A Case Report.

Journal: Anesthesiology research and practice 20110101

Title: Epiploic appendagitis in a 27-year-old man.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20110101

Title: Percutaneous cryoablation of pulmonary metastases from colorectal cancer.

Journal: PloS one 20110101

Title: Vulnerable sites and changes in mucin in the rat small intestine after non-steroidal anti-inflammatory drugs administration.

Journal: Digestive diseases and sciences 20101201

Title: [Case of food-dependent exercise-induced anaphylaxis diagnosed by the provocation test with cuttlefish after the pretreatment with 1.5 g of aspirin].

Journal: Arerugi = [Allergy] 20101201

Title: Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities.

Journal: Journal of medicinal chemistry 20101111

Title: High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis.

Journal: Modern rheumatology 20101001

Title: Lafutidine prevents low-dose aspirin and loxoprofen induced gastric injury: a randomized, double-blinded, placebo controlled study.

Journal: Journal of gastroenterology and hepatology 20101001

Title: [Experience of ultrasound-guided popliteal sciatic nerve block and femoral nerve perineural catheter placement in a morbidly obese patient undergoing total knee arthroplasty].

Journal: Masui. The Japanese journal of anesthesiology 20101001

Title: Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation.

Journal: Journal of clinical biochemistry and nutrition 20100901

Title: Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats.

Journal: Journal of gastroenterology and hepatology 20100501

Title: Evaluation of correlation between dissolution rates of loxoprofen tablets and their surface morphology observed by scanning electron microscope and atomic force microscope.

Journal: Chemical & pharmaceutical bulletin 20100101

Title: Low direct cytotoxicity of loxoprofen on gastric mucosal cells.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Case of Chlamydia-associated arthritis.

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20091201

Title: Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan.

Journal: World journal of gastroenterology 20091028

Title: [Tendencies of prescriptions for neuralgic pain in National Suruga Sanatorium (leprosy), Japan during last 11 years].

Journal: Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association 20090901

Title: Liquid chromatography-tandem mass spectrometry method of loxoprofen in human plasma.

Journal: Biomedical chromatography : BMC 20090701

Title: The importance of brain PGE2 inhibition versus paw PGE2 inhibition as a mechanism for the separation of analgesic and antipyretic effects of lornoxicam in rats with paw inflammation.

Journal: The Journal of pharmacy and pharmacology 20090501

Title: Overexpression of protein kinase C-delta plays a crucial role in interleukin-6-producing pheochromocytoma presenting with acute inflammatory syndrome: a case report.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090401

Title: Synthesis of the active form of loxoprofen by using allylic substitutions in two steps.

Journal: Organic letters 20090305

Title: Effects of non-steroidal anti-inflammatory drugs (NSAIDs) on serum allergen levels after wheat ingestion.

Journal: Journal of dermatological science 20090301

Title: Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice.

Journal: European journal of pain (London, England) 20090101

Title: A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in East Asian countries in 2007.

Journal: Digestion 20090101

Title: Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.

Journal: Drug metabolism and pharmacokinetics 20090101

Title: A novel approach to management of nocturia in patients with benign prostatic hyperplasia.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20090101

Title: Clinical, radiological, and biochemical characteristics in patients with diseases mimicking polymyalgia rheumatica.

Journal: Clinical interventions in aging 20090101

Title: A clinical investigation of the mechanism of loxoprofen, a non-steroidal anti-inflammatory drug, for patients with nocturia.

Journal: Acta medica Okayama 20081201

Title: Prolonged intrahepatic cholestasis after exposure to loxoprofen.

Journal: Clinical therapeutics 20081201

Title: Identification of degradation products in loxoprofen sodium adhesive tapes by liquid chromatography-mass spectrometry and dynamic pressurized liquid extraction-solid-phase extraction coupled to liquid chromatography-nuclear magnetic resonance spectroscopy.

Journal: Journal of chromatography. A 20081024

Title: Long-lasting breaches in the bladder epithelium lead to storage dysfunction with increase in bladder PGE2 levels in the rat.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080801

Title: Loxoprofen sodium treatment for elderly men with refractory nocturia: effect on night-time urine production.

Journal: International journal of urology : official journal of the Japanese Urological Association 20080501

Title: Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.

Journal: BMC musculoskeletal disorders 20080101

Title: NSAID loxoprofen inhibits high threshold or wide dynamic range neuronal responses in the rat at different time-courses.

Journal: Pharmacological reports : PR 20080101

Title: Periodontal tissue regeneration using fibroblast growth factor-2: randomized controlled phase II clinical trial.

Journal: PloS one 20080101

Title: Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats.

Journal: Journal of bone and mineral metabolism 20080101

Title: Short-term effect of COX-2 selective inhibitor as an adjunct for the treatment of periodontal disease: a clinical double-blind study in humans.

Journal: Brazilian dental journal 20080101

Title: Massive myelinolytic leukoencephalopathy in a patient medicated with low-dose oral methotrexate for rheumatoid arthritis: an autopsy report.

Journal: Acta neuropathologica 20071001

Title: [Case of loxoprofen sodium-induced eosinophilic pneumonia that occurred ipsilaterally after VATS lobectomy for lung cancer].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20071001

Title: Education and Imaging. Gastrointestinal: ileal ulcers induced by non-steroidal anti-inflammatory drugs.

Journal: Journal of gastroenterology and hepatology 20070801

Title: Up-to-date information on gastric mucosal lesions from long-term NSAID therapy in orthopedic outpatients: a study using logistic regression analysis.

Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20070701

Title: Safety of selective cyclooxygenase-2 inhibitors and a basic non-steroidal anti-inflammatory drug (NSAID) in Japanese patients with NSAID-induced urticaria and/or angioedema: Comparison of meloxicam, etodolac and tiaramide.

Journal: The Journal of dermatology 20070301

Title: Skin irritation in transdermal drug delivery systems: a strategy for its reduction.

Journal: Pharmaceutical research 20070201

Title: Risk of cardiovascular events in patients receiving celecoxib: a meta-analysis of randomized clinical trials.

Journal: The American journal of cardiology 20070101

Title: Influence of loxoprofen use on recovery from naturally acquired upper respiratory tract infections: a randomized controlled trial.

Journal: Internal medicine (Tokyo, Japan) 20070101

Title: Pharmacokinetics and bioequivalence study of two brands of loxoprofen tablets in healthy volunteers.

Journal: Arzneimittel-Forschung 20070101

Title: Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan.

Journal: European journal of clinical pharmacology 20060901

Title: [Epidural infusion of low dose bupivacaine after combined spinal-epidural anesthesia using needle through needle method provided no analgesic effect on postoperative pain after caesarian section].

Journal: Masui. The Japanese journal of anesthesiology 20060801

Title: Study on the mechanism of photosensitive dermatitis caused by ketoprofen in the guinea pig.

Journal: Archives of toxicology 20060701

Title: Premedication with cyclooxygenase-2 inhibitor meloxicam reduced postoperative pain in patients after oral surgery.

Journal: International journal of oral and maxillofacial surgery 20060701

Title: [Cluster like headache in a patient with the Maffucci's syndrome].

Journal: No to shinkei = Brain and nerve 20060601

Title: Direct and simultaneous analysis of loxoprofen and its diastereometric alcohol metabolites in human serum by on-line column switching liquid chromatography and its application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060501

Title: NSAID zaltoprofen possesses novel anti-nociceptive mechanism through blockage of B2-type bradykinin receptor in nerve endings.

Journal: Neuroscience letters 20060424

Title: Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors.

Journal: Neuroscience research 20060401

Title: Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary bladder inflammation in rats.

Journal: Biomedical research (Tokyo, Japan) 20060401

Title: Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.

Journal: Biological & pharmaceutical bulletin 20060301

Title: [A case of takotsubo cardiomyopathy provoked by taking a new quinolone antibiotic drug and a non-steroidal anti-inflammatory drug].

Journal: Kaku igaku. The Japanese journal of nuclear medicine 20060201

Title: Pseudogout attack induced during etidronate disodium therapy.

Journal: Modern rheumatology 20060101

Title: Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites.

Journal: Biological & pharmaceutical bulletin 20051101

Title: Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration of loxoprofen in rats: evidence for extrahepatic metabolism.

Journal: Journal of pharmaceutical sciences 20051001

Title: Effectiveness of an anti-inflammatory drug, loxoprofen, for patients with nocturia.

Journal: International journal of urology : official journal of the Japanese Urological Association 20050801

Title: Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells.

Journal: Neuropharmacology 20050601

Title: Retroperitoneal fibrosis with periaortic and pericardial involvement.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20050601

Title: Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat.

Journal: European journal of pharmacology 20050425

Title: [Cranial subdural hematoma after inadvertent dural puncture at epidural anesthesia].

Journal: Masui. The Japanese journal of anesthesiology 20050401

Title: Loxoprofen inhibits facilitated micturition reflex induced by acetic acid urinary bladder infusion of the rats.

Journal: Biomedical research (Tokyo, Japan) 20050201

Title: Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports.

Journal: Arthritis research & therapy 20050101

Title: Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.

Journal: Osteoarthritis and cartilage 20041101

Title: Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3.

Journal: Drug metabolism and pharmacokinetics 20041001

Title: Parvovirus B19 infection and myofasciitis.

Journal: Clinical rheumatology 20040401

Title: Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.

Journal: Bioorganic & medicinal chemistry letters 20040308

Title: Loxoprofen sodium and survival in older people with advanced non-small cell lung cancer.

Journal: Journal of the American Geriatrics Society 20040301

Title: Effectiveness of a nonsteroidal anti-inflammatory drug for nocturia on patients with benign prostatic hyperplasia: a prospective non-randomized study of loxoprofen sodium 60 mg once daily before sleeping.

Journal: Acta medica Okayama 20040201

Title: A case of complex regional pain syndrome type II after transradial coronary intervention.

Journal: Journal of anesthesia 20040101

Title: [A case of loxoprofen sodium-induced bronchiolitis obliterans organizing pneumonia (BOOP)].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20031201

Title: Effects of orally administered OP-1206 alpha-CD with loxoprofen-Na on walking dysfunction in the rat neuropathic intermittent claudication model.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20031001

Title: [The analysis of prescription frequency and the factors on adverse reactions of NSAIDs for post-operative pain in orthopedic patients].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20030701

Title: Evaluation of gastric acid secretion in two patients (each aged over 90 years) with Helicobacter pylori-negative nonsteroidal anti-inflammatory drug-caused duodenal ulcers.

Journal: Journal of gastroenterology 20030101

Title: Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor.

Journal: Acta oncologica (Stockholm, Sweden) 20030101

Title: [A study of logotherapy for chronic low back pain patients].

Journal: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20030101

Title: [A case of sarcoidosis overlapping with rheumatoid arthritis].

Journal: Nihon Jinzo Gakkai shi 20030101

Title: Anti-U1RNP antibody and aseptic meningitis in connective tissue diseases.

Journal: Scandinavian journal of rheumatology 20030101

Title: Cognitive decline in administration of the nonsteroidal antiinflammatory drug loxoprofen with misoprostol in a 91-year-old Japanese woman.

Journal: Journal of the American Geriatrics Society 20021001

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Altered metabolism of orally administered loxoprofen in human subjects after an oral administration of loxoprofen for three consecutive days followed by a seven-day washout.

Journal: Journal of pharmaceutical sciences 20020401

Title: Stereospecific analysis of loxoprofen in plasma by chiral column liquid chromatography with a circular dichroism-based detector.

Journal: Journal of chromatography. A 20020301

Title: [A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20020201

Title: The combination therapy of Ephedra herb and Loxoprofen caused gastric lesions in mice.

Journal: The American journal of Chinese medicine 20020101

Title: Anti-inflammatory, analgesic and antipyretic activities of loxoprofen sodium given intramuscularly in animals.

Journal: Archives of pharmacal research 20011201

Title: Simultaneous determination of loxoprofen and its diastereomeric alcohol metabolites in human plasma and urine by a simple HPLC-UV detection method.

Journal: Journal of pharmaceutical and biomedical analysis 20010601

Title: An autopsy case of giant cell myocarditis probably due to a non-steroidal anti-inflammatory drug.

Journal: Pathology international 20010201

Title: Direct superoxide scavenging activity of nonsteroidal anti-inflammatory drugs: determination by electron spin resonance using the spin trap method.

Journal: Headache 20010201

Title: NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.

Journal: General pharmacology 19930101

Title: Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds.

Journal: Journal of medicinal chemistry 19840201

Title: Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201-1203.

Title: Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11(9):479. Published 2019 Sep 16.

Title: Hamaguchi M, et al. Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation. J Clin Biochem Nutr. 2010 Sep;47(2):138-47.

Title: Kanda A, et al. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor. Acta Oncol. 2003;42(1):62-70.

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Tags:68767-14-6 Molecular Formula|68767-14-6 MDL|68767-14-6 SMILES|68767-14-6 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
Catalog No.: AA003RAE
68767-14-6,MFCD00864331
68767-14-6 | 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
Pack Size: 100mg
Purity: 97%
in stock
$6.00 $4.00
Pack Size: 250mg
Purity: 97%
in stock
$8.00 $6.00
Pack Size: 1g
Purity: 97%
in stock
$11.00 $8.00
Pack Size: 5g
Purity: 97%
in stock
$17.00 $12.00
Pack Size: 25g
Purity: 97%
in stock
$38.00 $27.00
Pack Size: 100g
Purity: 97%
in stock
$116.00 $82.00
Quantity
- +
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Technical Information
Catalog Number: AA003RAE
Chemical Name: 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
CAS Number: 68767-14-6
Molecular Formula: C15H18O3
Molecular Weight: 246.3016
MDL Number: MFCD00864331
SMILES: OC(=O)C(c1ccc(cc1)CC1CCCC1=O)C
Properties
BP: 417.9°C at 760 mmHg  
Form: Solid  
MP: 108.5-111°  
Storage: Keep in dry area;Room Temperature;  
Complexity: 316  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 18  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 2  
XLogP3: 2.4  
Upstream Synthesis Route
68767-26-0    68767-14-6 

[1]Patent:US4161538,1979,A,

80382-23-6    68767-14-6 

[1]Patent:US2016/151506,2016,A1,.Locationinpatent:Paragraph0416-0420

2867-63-2    68767-14-6 

[1]SyntheticCommunications,1984,vol.14,#14,p.1365-1372

96824-28-1    68767-14-6 

[1]SyntheticCommunications,1984,vol.14,#14,p.1365-1372

96824-29-2    68767-14-6 

[1]SyntheticCommunications,1984,vol.14,#14,p.1365-1372

Downstream Synthesis Route
2627-86-3    68767-14-6    83599-41-1    83599-41-1 

[1]Chemicalandpharmaceuticalbulletin,1983,vol.31,p.4286-4294

[2]Chemicalandpharmaceuticalbulletin,1983,vol.31,p.4286-4294

68767-14-6    68266-50-2 

[1]JournalofMedicinalChemistry,1984,vol.27,p.212-216

68767-14-6    68767-19-1 

[1]JournalofMedicinalChemistry,1984,vol.27,p.212-216

68767-14-6    83599-40-0    83599-40-0 

[1]ChemicalandPharmaceuticalBulletin,1983,vol.31,p.4319-4323

[2]BiochemicalPharmacology,1995,vol.50,p.221-227

68767-14-6    83599-40-0 

[1]ChemicalandPharmaceuticalBulletin,1983,vol.31,p.4319-4323

Literature fold

Title: Assessing the cardiovascular risk between celecoxib and nonselective nonsteroidal antiinflammatory drugs in patients with rheumatoid arthritis and osteoarthritis.

Journal: Circulation journal : official journal of the Japanese Circulation Society20140101

Title: Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomy in elderly patients.

Journal: Japanese journal of clinical oncology20121101

Title: Chiral amines as reagents for HPLC-MS enantioseparation of chiral carboxylic acids.

Journal: Journal of separation science20120701

Title: Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity.

Journal: Journal of medicinal chemistry20120614

Title: Simultaneous determination of non-steroidal anti-inflammatory drugs in river water by gas chromatography-mass spectrometry.

Journal: Journal of separation science20120201

Title: Cyclooxygenase inhibitor improved an exudative lesion of choroidal neovascularization in age-related macular degeneration.

Journal: European journal of ophthalmology20120101

Title: Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion.

Journal: Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT20120101

Title: New therapeutic strategy for amino acid medicine: prophylactic and healing promoting effect of monosodium glutamate against NSAID-induced enteropathy.

Journal: Journal of pharmacological sciences20120101

Title: Chronic mandibular osteomyelitis with suspected underlying synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: a case report.

Journal: Journal of inflammation research20120101

Title: Complete remission of human parvovirus b19 associated symptoms by loxoprofen in patients with atopic predispositions.

Journal: Case reports in medicine20120101

Title: Adverse events in patients with blood loss: a pooled analysis of 51 clinical studies from the celecoxib clinical trial database.

Journal: The open rheumatology journal20120101

Title: Heart failure assocated with pregabalin.

Journal: Pain physician20120101

Title: [Correlation study on effects of electroacupuncture on the muscle condition and MNCV in rabbits with lumbar nerve root compression].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion20111101

Title: Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.

Journal: The Journal of pharmacology and experimental therapeutics20110901

Title: Synthesis and biological evaluation of loxoprofen derivatives.

Journal: Bioorganic & medicinal chemistry20110601

Title: Prescription pattern of NSAIDs and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients in clinical practice in Korea.

Journal: Journal of Korean medical science20110401

Title: Long-term effect of loxoprofen sodium on nocturia in patients with benign prostatic hyperplasia.

Journal: Korean journal of urology20110401

Title: [Japanese SUNCT patient responsive to gabapentin].

Journal: Rinsho shinkeigaku = Clinical neurology20110401

Title: Protective effect of geranylgeranylacetone against loxoprofen sodium-induced small intestinal lesions in rats.

Journal: European journal of pharmacology20110210

Title: Efficacy and safety of the selective cyclooxygenase-2 inhibitor celecoxib in the treatment of rheumatoid arthritis and osteoarthritis in Japan.

Journal: Digestion20110101

Title: A case of chlorpheniramine maleate-induced hypersensitivity with aspirin intolerance.

Journal: Allergy, asthma & immunology research20110101

Title: Unilateral eyelid angioedema with congestion of the right bulbar conjunctiva due to loxoprofen sodium.

Journal: Cutis20110101

Title: Influence of nonsteroidal anti-inflammatory drugs on the antiplatelet effects of aspirin in rats.

Journal: Biological & pharmaceutical bulletin20110101

Title: Antipyretic and analgesic effects of zaltoprofen for the treatment of acute upper respiratory tract infection: verification of a noninferiority hypothesis using loxoprofen sodium.

Journal: Pharmacology20110101

Title: Review of allergic and photoallergic contact dermatitis from an ingredient in a medicament vehicle consisting of a compress, poultice, plaster, and tape.

Journal: Journal of allergy20110101

Title: Prostacyclin: an inflammatory paradox.

Journal: Frontiers in pharmacology20110101

Title: Oral Local Anesthesia Successfully Ameliorated Neuropathic Pain in an Upper Limb Suggesting Pain Alleviation through Neural Plasticity within the Central Nervous System: A Case Report.

Journal: Anesthesiology research and practice20110101

Title: Epiploic appendagitis in a 27-year-old man.

Journal: Medical science monitor : international medical journal of experimental and clinical research20110101

Title: Percutaneous cryoablation of pulmonary metastases from colorectal cancer.

Journal: PloS one20110101

Title: Vulnerable sites and changes in mucin in the rat small intestine after non-steroidal anti-inflammatory drugs administration.

Journal: Digestive diseases and sciences20101201

Title: [Case of food-dependent exercise-induced anaphylaxis diagnosed by the provocation test with cuttlefish after the pretreatment with 1.5 g of aspirin].

Journal: Arerugi = [Allergy]20101201

Title: Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities.

Journal: Journal of medicinal chemistry20101111

Title: High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis.

Journal: Modern rheumatology20101001

Title: Lafutidine prevents low-dose aspirin and loxoprofen induced gastric injury: a randomized, double-blinded, placebo controlled study.

Journal: Journal of gastroenterology and hepatology20101001

Title: [Experience of ultrasound-guided popliteal sciatic nerve block and femoral nerve perineural catheter placement in a morbidly obese patient undergoing total knee arthroplasty].

Journal: Masui. The Japanese journal of anesthesiology20101001

Title: Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation.

Journal: Journal of clinical biochemistry and nutrition20100901

Title: Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats.

Journal: Journal of gastroenterology and hepatology20100501

Title: Evaluation of correlation between dissolution rates of loxoprofen tablets and their surface morphology observed by scanning electron microscope and atomic force microscope.

Journal: Chemical & pharmaceutical bulletin20100101

Title: Low direct cytotoxicity of loxoprofen on gastric mucosal cells.

Journal: Biological & pharmaceutical bulletin20100101

Title: Case of Chlamydia-associated arthritis.

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology20091201

Title: Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan.

Journal: World journal of gastroenterology20091028

Title: [Tendencies of prescriptions for neuralgic pain in National Suruga Sanatorium (leprosy), Japan during last 11 years].

Journal: Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association20090901

Title: Liquid chromatography-tandem mass spectrometry method of loxoprofen in human plasma.

Journal: Biomedical chromatography : BMC20090701

Title: The importance of brain PGE2 inhibition versus paw PGE2 inhibition as a mechanism for the separation of analgesic and antipyretic effects of lornoxicam in rats with paw inflammation.

Journal: The Journal of pharmacy and pharmacology20090501

Title: Overexpression of protein kinase C-delta plays a crucial role in interleukin-6-producing pheochromocytoma presenting with acute inflammatory syndrome: a case report.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20090401

Title: Synthesis of the active form of loxoprofen by using allylic substitutions in two steps.

Journal: Organic letters20090305

Title: Effects of non-steroidal anti-inflammatory drugs (NSAIDs) on serum allergen levels after wheat ingestion.

Journal: Journal of dermatological science20090301

Title: Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice.

Journal: European journal of pain (London, England)20090101

Title: A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in East Asian countries in 2007.

Journal: Digestion20090101

Title: Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.

Journal: Drug metabolism and pharmacokinetics20090101

Title: A novel approach to management of nocturia in patients with benign prostatic hyperplasia.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India20090101

Title: Clinical, radiological, and biochemical characteristics in patients with diseases mimicking polymyalgia rheumatica.

Journal: Clinical interventions in aging20090101

Title: A clinical investigation of the mechanism of loxoprofen, a non-steroidal anti-inflammatory drug, for patients with nocturia.

Journal: Acta medica Okayama20081201

Title: Prolonged intrahepatic cholestasis after exposure to loxoprofen.

Journal: Clinical therapeutics20081201

Title: Identification of degradation products in loxoprofen sodium adhesive tapes by liquid chromatography-mass spectrometry and dynamic pressurized liquid extraction-solid-phase extraction coupled to liquid chromatography-nuclear magnetic resonance spectroscopy.

Journal: Journal of chromatography. A20081024

Title: Long-lasting breaches in the bladder epithelium lead to storage dysfunction with increase in bladder PGE2 levels in the rat.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20080801

Title: Loxoprofen sodium treatment for elderly men with refractory nocturia: effect on night-time urine production.

Journal: International journal of urology : official journal of the Japanese Urological Association20080501

Title: Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.

Journal: BMC musculoskeletal disorders20080101

Title: NSAID loxoprofen inhibits high threshold or wide dynamic range neuronal responses in the rat at different time-courses.

Journal: Pharmacological reports : PR20080101

Title: Periodontal tissue regeneration using fibroblast growth factor-2: randomized controlled phase II clinical trial.

Journal: PloS one20080101

Title: Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats.

Journal: Journal of bone and mineral metabolism20080101

Title: Short-term effect of COX-2 selective inhibitor as an adjunct for the treatment of periodontal disease: a clinical double-blind study in humans.

Journal: Brazilian dental journal20080101

Title: Massive myelinolytic leukoencephalopathy in a patient medicated with low-dose oral methotrexate for rheumatoid arthritis: an autopsy report.

Journal: Acta neuropathologica20071001

Title: [Case of loxoprofen sodium-induced eosinophilic pneumonia that occurred ipsilaterally after VATS lobectomy for lung cancer].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20071001

Title: Education and Imaging. Gastrointestinal: ileal ulcers induced by non-steroidal anti-inflammatory drugs.

Journal: Journal of gastroenterology and hepatology20070801

Title: Up-to-date information on gastric mucosal lesions from long-term NSAID therapy in orthopedic outpatients: a study using logistic regression analysis.

Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association20070701

Title: Safety of selective cyclooxygenase-2 inhibitors and a basic non-steroidal anti-inflammatory drug (NSAID) in Japanese patients with NSAID-induced urticaria and/or angioedema: Comparison of meloxicam, etodolac and tiaramide.

Journal: The Journal of dermatology20070301

Title: Skin irritation in transdermal drug delivery systems: a strategy for its reduction.

Journal: Pharmaceutical research20070201

Title: Risk of cardiovascular events in patients receiving celecoxib: a meta-analysis of randomized clinical trials.

Journal: The American journal of cardiology20070101

Title: Influence of loxoprofen use on recovery from naturally acquired upper respiratory tract infections: a randomized controlled trial.

Journal: Internal medicine (Tokyo, Japan)20070101

Title: Pharmacokinetics and bioequivalence study of two brands of loxoprofen tablets in healthy volunteers.

Journal: Arzneimittel-Forschung20070101

Title: Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan.

Journal: European journal of clinical pharmacology20060901

Title: [Epidural infusion of low dose bupivacaine after combined spinal-epidural anesthesia using needle through needle method provided no analgesic effect on postoperative pain after caesarian section].

Journal: Masui. The Japanese journal of anesthesiology20060801

Title: Study on the mechanism of photosensitive dermatitis caused by ketoprofen in the guinea pig.

Journal: Archives of toxicology20060701

Title: Premedication with cyclooxygenase-2 inhibitor meloxicam reduced postoperative pain in patients after oral surgery.

Journal: International journal of oral and maxillofacial surgery20060701

Title: [Cluster like headache in a patient with the Maffucci's syndrome].

Journal: No to shinkei = Brain and nerve20060601

Title: Direct and simultaneous analysis of loxoprofen and its diastereometric alcohol metabolites in human serum by on-line column switching liquid chromatography and its application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20060501

Title: NSAID zaltoprofen possesses novel anti-nociceptive mechanism through blockage of B2-type bradykinin receptor in nerve endings.

Journal: Neuroscience letters20060424

Title: Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors.

Journal: Neuroscience research20060401

Title: Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary bladder inflammation in rats.

Journal: Biomedical research (Tokyo, Japan)20060401

Title: Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.

Journal: Biological & pharmaceutical bulletin20060301

Title: [A case of takotsubo cardiomyopathy provoked by taking a new quinolone antibiotic drug and a non-steroidal anti-inflammatory drug].

Journal: Kaku igaku. The Japanese journal of nuclear medicine20060201

Title: Pseudogout attack induced during etidronate disodium therapy.

Journal: Modern rheumatology20060101

Title: Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites.

Journal: Biological & pharmaceutical bulletin20051101

Title: Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration of loxoprofen in rats: evidence for extrahepatic metabolism.

Journal: Journal of pharmaceutical sciences20051001

Title: Effectiveness of an anti-inflammatory drug, loxoprofen, for patients with nocturia.

Journal: International journal of urology : official journal of the Japanese Urological Association20050801

Title: Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells.

Journal: Neuropharmacology20050601

Title: Retroperitoneal fibrosis with periaortic and pericardial involvement.

Journal: Circulation journal : official journal of the Japanese Circulation Society20050601

Title: Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat.

Journal: European journal of pharmacology20050425

Title: [Cranial subdural hematoma after inadvertent dural puncture at epidural anesthesia].

Journal: Masui. The Japanese journal of anesthesiology20050401

Title: Loxoprofen inhibits facilitated micturition reflex induced by acetic acid urinary bladder infusion of the rats.

Journal: Biomedical research (Tokyo, Japan)20050201

Title: Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports.

Journal: Arthritis research & therapy20050101

Title: Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.

Journal: Osteoarthritis and cartilage20041101

Title: Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3.

Journal: Drug metabolism and pharmacokinetics20041001

Title: Parvovirus B19 infection and myofasciitis.

Journal: Clinical rheumatology20040401

Title: Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.

Journal: Bioorganic & medicinal chemistry letters20040308

Title: Loxoprofen sodium and survival in older people with advanced non-small cell lung cancer.

Journal: Journal of the American Geriatrics Society20040301

Title: Effectiveness of a nonsteroidal anti-inflammatory drug for nocturia on patients with benign prostatic hyperplasia: a prospective non-randomized study of loxoprofen sodium 60 mg once daily before sleeping.

Journal: Acta medica Okayama20040201

Title: A case of complex regional pain syndrome type II after transradial coronary intervention.

Journal: Journal of anesthesia20040101

Title: [A case of loxoprofen sodium-induced bronchiolitis obliterans organizing pneumonia (BOOP)].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20031201

Title: Effects of orally administered OP-1206 alpha-CD with loxoprofen-Na on walking dysfunction in the rat neuropathic intermittent claudication model.

Journal: Prostaglandins, leukotrienes, and essential fatty acids20031001

Title: [The analysis of prescription frequency and the factors on adverse reactions of NSAIDs for post-operative pain in orthopedic patients].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20030701

Title: Evaluation of gastric acid secretion in two patients (each aged over 90 years) with Helicobacter pylori-negative nonsteroidal anti-inflammatory drug-caused duodenal ulcers.

Journal: Journal of gastroenterology20030101

Title: Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor.

Journal: Acta oncologica (Stockholm, Sweden)20030101

Title: [A study of logotherapy for chronic low back pain patients].

Journal: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica20030101

Title: [A case of sarcoidosis overlapping with rheumatoid arthritis].

Journal: Nihon Jinzo Gakkai shi20030101

Title: Anti-U1RNP antibody and aseptic meningitis in connective tissue diseases.

Journal: Scandinavian journal of rheumatology20030101

Title: Cognitive decline in administration of the nonsteroidal antiinflammatory drug loxoprofen with misoprostol in a 91-year-old Japanese woman.

Journal: Journal of the American Geriatrics Society20021001

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Altered metabolism of orally administered loxoprofen in human subjects after an oral administration of loxoprofen for three consecutive days followed by a seven-day washout.

Journal: Journal of pharmaceutical sciences20020401

Title: Stereospecific analysis of loxoprofen in plasma by chiral column liquid chromatography with a circular dichroism-based detector.

Journal: Journal of chromatography. A20020301

Title: [A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20020201

Title: The combination therapy of Ephedra herb and Loxoprofen caused gastric lesions in mice.

Journal: The American journal of Chinese medicine20020101

Title: Anti-inflammatory, analgesic and antipyretic activities of loxoprofen sodium given intramuscularly in animals.

Journal: Archives of pharmacal research20011201

Title: Simultaneous determination of loxoprofen and its diastereomeric alcohol metabolites in human plasma and urine by a simple HPLC-UV detection method.

Journal: Journal of pharmaceutical and biomedical analysis20010601

Title: An autopsy case of giant cell myocarditis probably due to a non-steroidal anti-inflammatory drug.

Journal: Pathology international20010201

Title: Direct superoxide scavenging activity of nonsteroidal anti-inflammatory drugs: determination by electron spin resonance using the spin trap method.

Journal: Headache20010201

Title: NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.

Journal: General pharmacology19930101

Title: Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds.

Journal: Journal of medicinal chemistry19840201

Title: Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201-1203.

Title: Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11(9):479. Published 2019 Sep 16.

Title: Hamaguchi M, et al. Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation. J Clin Biochem Nutr. 2010 Sep;47(2):138-47.

Title: Kanda A, et al. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor. Acta Oncol. 2003;42(1):62-70.

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