Home Other Building Blocks 42189-56-0
42189-56-0,MFCD00049301
Catalog No.:AA003S4T

42189-56-0 | N-(1-Pyrenyl)maleimide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
98%
in stock  
$43.00   $30.00
- +
250mg
98%
in stock  
$66.00   $47.00
- +
1g
95%
in stock  
$178.00   $125.00
- +
5g
95%
in stock  
$760.00   $532.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003S4T
Chemical Name:
N-(1-Pyrenyl)maleimide
CAS Number:
42189-56-0
Molecular Formula:
C20H11NO2
Molecular Weight:
297.3068
MDL Number:
MFCD00049301
SMILES:
O=C1C=CC(=O)N1c1ccc2c3c1ccc1c3c(cc2)ccc1
Properties
Properties
 
BP:
438.82°C (rough estimate)  
Form:
Solid  
MP:
235-237 °C(lit.)  
Refractive Index:
1.5180 (estimate)  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
550  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
4.1  

Downstream Synthesis Route

[1]Reddy,PaidiYella;Kondo,Satoru;Fujita,Satoshi;Toru,Takeshi[Synthesis,1998,#7,p.999-1002]

42189-56-0   
5'-d(T(7-vinyl-7-deazaguanine)GACGTCA)-3' 
 
C101H113N30O48P7 

[1]Okamoto,Akimitsu;Taiji,Toshiji;Tainaka,Kazuki;Saito,Isao[Bioorganicandmedicinalchemistryletters,2002,vol.12,#15,p.1895-1896]

42189-56-0    155773-72-1   
C102H92N14O12 

[1]Wang,Bing-Bing;Zhang,Xin;Jia,Xin-Ru;Li,Zi-Chen;Ji,Yan;Yang,Ling;Wei,Yen[JournaloftheAmericanChemicalSociety,2004,vol.126,#46,p.15180-15194]

42189-56-0    78-81-9   
N-(N'-1-pyrenylsuccinimido)isobutylamine 

[1]Wang,Bing-Bing;Zhang,Xin;Jia,Xin-Ru;Li,Zi-Chen;Ji,Yan;Yang,Ling;Wei,Yen[JournaloftheAmericanChemicalSociety,2004,vol.126,#46,p.15180-15194]

Literature

Title: N-(1-Pyrenyl) maleimide inhibits telomerase activity in a cell free system and induces apoptosis in Jurkat cells.

Journal: Molecular biology reports 20120901

Title: The extent of pyrene excimer fluorescence emission is a reflector of distance and flexibility: analysis of the segment linking the LDL receptor-binding and tetramerization domains of apolipoprotein E3.

Journal: Biochemistry 20120807

Title: Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4.

Journal: Biochemistry 20120717

Title: [Determination of homocysteine in plasma by precolumn derivatization-high performance liquid chromatography with fluorescence detection].

Journal: Se pu = Chinese journal of chromatography 20120601

Title: High-energy radiation monitoring based on radio-fluorogenic co-polymerization II: fixed fluorescent images of collimated x-ray beams using an RFCP gel.

Journal: Physics in medicine and biology 20110307

Title: Anion exchanger and the resistance against thermal haemolysis.

Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20110101

Title: A pyrene maleimide with a flexible linker for sampling of longer inter-thiol distances by excimer formation.

Journal: PloS one 20110101

Title: Pyrene fluorescence analysis offers new insights into the conformation of the lipoprotein-binding domain of human apolipoprotein E.

Journal: Biochemistry 20100302

Title: Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation.

Journal: The Journal of biological chemistry 20090717

Title: Highly selective and simple method for determination of polythiols based on liquid chromatography with postcolumn excimer fluorescence derivatization.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20090601

Title: Determination of glutathione disulfide levels in biological samples using thiol-disulfide exchanging agent, dithiothreitol.

Journal: Biomedical chromatography : BMC 20090201

Title: Dynamic fluctuations of protein-carbohydrate interactions promote protein aggregation.

Journal: PloS one 20090101

Title: Conformational flexibility of the N-terminal domain of apolipoprotein a-I bound to spherical lipid particles.

Journal: Biochemistry 20081028

Title: The N-terminal domain of annexin 2 serves as a secondary binding site during membrane bridging.

Journal: The Journal of biological chemistry 20080808

Title: [Determination of tiopronin in rat plasma by HPLC following fluorescent derivatization].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080701

Title: Different conformational switches underlie the calmodulin-dependent modulation of calcium pumps and channels.

Journal: Biochemistry 20080212

Title: Insight into the location and dynamics of the annexin A2 N-terminal domain during Ca(2+)-induced membrane bridging.

Journal: Biochimica et biophysica acta 20080201

Title: Lipoperoxidation and protein oxidative damage exhibit different kinetics during septic shock.

Journal: Mediators of inflammation 20080101

Title: Calcium occupancy of N-terminal sites within calmodulin induces inhibition of the ryanodine receptor calcium release channel.

Journal: Biochemistry 20070918

Title: Disruption of interdomain interactions via partial calcium occupancy of calmodulin.

Journal: Biochemistry 20070417

Title: Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ.

Journal: Biochemistry 20070410

Title: Dynacortin facilitates polarization of chemotaxing cells.

Journal: BMC biology 20070101

Title: High performance liquid chromatography analysis of 2-mercaptoethylamine (cysteamine) in biological samples by derivatization with N-(1-pyrenyl) maleimide (NPM) using fluorescence detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061020

Title: Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5.

Journal: Molecular bioSystems 20061001

Title: Effects of ligand binding and oxidation on hinge-bending motions in S-adenosyl-L-homocysteine hydrolase.

Journal: Biochemistry 20060627

Title: Separation and quantification of N-acetyl-l-cysteine and N-acetyl-cysteine-amide by HPLC with fluorescence detection.

Journal: Biomedical chromatography : BMC 20060501

Title: Fluorescent labeling of RAFT-generated poly(N-isopropylacrylamide) via a facile maleimide-thiol coupling reaction.

Journal: Biomacromolecules 20060501

Title: Fluorescence energy transfer studies of human deoxycytidine kinase: role of cysteine 185 in the conformational changes that occur upon substrate binding.

Journal: Biochemistry 20060321

Title: Differential interaction of cardiac, skeletal muscle, and yeast tropomyosins with fluorescent (pyrene235) yeast actin.

Journal: Biophysical journal 20060215

Title: Pyrene excimer fluorescence of yeast alcohol dehydrogenase: a sensitive probe to investigate ligand binding and unfolding pathway of the enzyme.

Journal: Photochemistry and photobiology 20060101

Title: Unfolding pathways of human serum albumin: evidence for sequential unfolding and folding of its three domains.

Journal: International journal of biological macromolecules 20051215

Title: Characterization of a dimeric unfolding intermediate of bovine serum albumin under mildly acidic condition.

Journal: Biochimica et biophysica acta 20050810

Title: Examination of lipid-bound conformation of apolipoprotein E4 by pyrene excimer fluorescence.

Journal: The Journal of biological chemistry 20050415

Title: Lead-induced changes in human erythrocytes and lymphocytes.

Journal: Journal of applied toxicology : JAT 20050101

Title: The mitochondrial tricarboxylate carrier of silver eel: chemical modification by sulfhydryl reagents.

Journal: Journal of biochemistry and molecular biology 20040930

Title: Conformational changes within the cytosolic portion of phospholamban upon release of Ca-ATPase inhibition.

Journal: Biochemistry 20040406

Title: Local conformational changes in the Vibrio Na+/galactose cotransporter.

Journal: Biochemistry 20040330

Title: Phospholamban binds in a compact and ordered conformation to the Ca-ATPase.

Journal: Biochemistry 20040120

Title: A fluorescent probe-labeled Escherichia coli aspartate transcarbamoylase that monitors the allosteric conformational state.

Journal: The Journal of biological chemistry 20040109

Title: Structural and functional roles of Cys-238 and Cys-295 in Escherichia coli phosphofructokinase-2.

Journal: The Biochemical journal 20031115

Title: Phosphorylation by cAMP-dependent protein kinase modulates the structural coupling between the transmembrane and cytosolic domains of phospholamban.

Journal: Biochemistry 20030916

Title: Vacuolar accumulation and extracellular extrusion of electrophilic compounds by wild-type and glutathione-deficient mutants of the methylotrophic yeast Hansenula polymorpha.

Journal: Cell biology international 20030101

Title: Lipid-triggered conformational switch of apolipophorin III helix bundle to an extended helix organization.

Journal: Journal of molecular biology 20020809

Title: Effect of polymerization on the subdomain 3/4 loop of yeast actin.

Journal: The Journal of biological chemistry 20020621

Title: Fluorescence resonance energy transfer between coumarin-derived mitochondrial F(1)-ATPase gamma subunit and pyrenylmaleimide-labelled fragments of IF(1) and c subunit.

Journal: The Biochemical journal 20020215

Title: Free sulfhydryl in recombinant monoclonal antibodies.

Journal: Biotechnology progress 20020101

Title: Electron spin resonance and fluorescence studies of the bound-state conformation of a model protein substrate to the chaperone SecB.

Journal: The Journal of biological chemistry 20010907

Title: Characterization of mutants of beta histidine91, beta aspartate213, and beta asparagine222, possible components of the energy transduction pathway of the proton-translocating pyridine nucleotide transhydrogenase of Escherichia coli.

Journal: Archives of biochemistry and biophysics 20010415

Title: Determination of biological thiols by high-performance liquid chromatography following derivatization by ThioGlo maleimide reagents.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010405

Title: Resonance energy transfer between tryptophan 57 in the epsilon subunit and pyrene maleimide labeled gamma subunit of the chloroplast ATP synthase.

Journal: Biochemistry 20010213

Title: Nucleotide binding to the chaperonin GroEL: non-cooperative binding of ATP analogs and ADP, and cooperative effect of ATP.

Journal: Biochimica et biophysica acta 20010209

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:42189-56-0 Molecular Formula|42189-56-0 MDL|42189-56-0 SMILES|42189-56-0 N-(1-Pyrenyl)maleimide |Organic_Building_Blocks