Home Amines 171179-06-9
171179-06-9,MFCD00942160
Catalog No.:AA003SLA

171179-06-9 | N4-(3-Bromophenyl)-n6-methylpyrido[3,4-d]pyrimidine-4,6-diamine

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Purity
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1mg
98%
in stock  
$27.00   $19.00
- +
5mg
≥98%
in stock  
$129.00   $90.00
- +
10mg
≥98%
in stock  
$230.00   $161.00
- +
25mg
98% by HPLC
in stock  
$473.00   $331.00
- +
50mg
98% by HPLC
in stock  
$761.00   $533.00
- +
100mg
98% by HPLC
in stock  
$1,270.00   $889.00
- +
500mg
98% by HPLC
in stock  
$3,958.00   $2,771.00
- +
1000mg
98% by HPLC
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA003SLA
Chemical Name:
N4-(3-Bromophenyl)-n6-methylpyrido[3,4-d]pyrimidine-4,6-diamine
CAS Number:
171179-06-9
Molecular Formula:
C14H12BrN5
Molecular Weight:
330.1826
MDL Number:
MFCD00942160
SMILES:
CNc1ncc2c(c1)c(ncn2)Nc1cccc(c1)Br
Properties
Properties
 
BP:
499.6°C at 760 mmHg  
Form:
Solid  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
316  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.4  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20121003

Title: Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.

Journal: ChemMedChem 20120401

Title: Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons.

Journal: Nature neuroscience 20111211

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

Journal: Journal of medicinal chemistry 20100923

Title: Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential.

Journal: Toxicology and applied pharmacology 20070515

Title: Pharmacology of epidermal growth factor inhibitors.

Journal: The International journal of biological markers 20070101

Title: Constitutive activation of neuregulin/ERBB3 signaling pathway in clear cell sarcoma of soft tissue.

Journal: Neoplasia (New York, N.Y.) 20060701

Title: Heparin-binding epidermal growth factor-like growth factor stimulates cell proliferation in cerebral cortical cultures through phosphatidylinositol 3'-kinase and mitogen-activated protein kinase.

Journal: Journal of neuroscience research 20050815

Title: Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050518

Title: Src family kinase inhibitors block amphiregulin-mediated autocrine ErbB signaling in normal human keratinocytes.

Journal: Molecular pharmacology 20050401

Title: G1 cell cycle arrest due to the inhibition of erbB family receptor tyrosine kinases does not require the retinoblastoma protein.

Journal: Experimental cell research 20050201

Title: Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 1. Comparison with conventional ELISA.

Journal: Journal of medicinal chemistry 20041007

Title: Extracellular oxidation by taurine chloramine activates ERK via the epidermal growth factor receptor.

Journal: The Journal of biological chemistry 20040730

Title: Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line.

Journal: Glia 20030801

Title: Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells.

Journal: Journal of cellular physiology 20030301

Title: Neuregulin-1beta modulates in vivo entorhinal-hippocampal synaptic transmission in adult rats.

Journal: Neuroscience 20030101

Title: Metalloproteinases stimulate ErbB-dependent ERK signaling in human skin organ culture.

Journal: The Journal of biological chemistry 20020726

Title: Effect of tyrosine kinase inhibitors on clathrin-coated pit recruitment and internalization of epidermal growth factor receptor.

Journal: The Journal of biological chemistry 20020726

Title: Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis.

Journal: Biochemical and biophysical research communications 20020712

Title: N-acetylcysteine inhibits angiotensin ii-mediated activation of extracellular signal-regulated kinase and epidermal growth factor receptor.

Journal: Biochemical and biophysical research communications 20010202

Title: Tyrosine kinase inhibitors. 12. Synthesis and structure-activity relationships for 6-substituted 4-(phenylamino)pyrimido[5,4-d]pyrimidines designed as inhibitors of the epidermal growth factor receptor.

Journal: Journal of medicinal chemistry 19970606

Title: Fry DW, et al. Biochemical and antiproliferative properties of 4-[ar(alk)ylaminopyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor. Biochem Pharmacol. 1997 Oct 15;54(8):877-87.

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Tags:171179-06-9 Molecular Formula|171179-06-9 MDL|171179-06-9 SMILES|171179-06-9 N4-(3-Bromophenyl)-n6-methylpyrido[3,4-d]pyrimidine-4,6-diamine