Title: Geranylgeranylacetone suppresses noise-induced expression of proinflammatory cytokines in the cochlea.
Journal: Auris, nasus, larynx 20120601
Title: Preventive effects of geranylgeranylacetone on rat ethanol-induced gastritis.
Journal: World journal of gastroenterology 20120514
Title: Geranylgeranylacetone protects mice against morphine-induced hyperlocomotion, rewarding effect, and withdrawal syndrome.
Journal: Free radical biology & medicine 20120401
Title: Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells.
Journal: Journal of gastroenterology 20120201
Title: Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats.
Journal: Molecular medicine reports 20120201
Title: Geranylgeranylacetone attenuates cisplatin-induced reductions in cell viability by suppressing the elevation of intracellular p53 content without heat shock protein induction.
Journal: Nagoya journal of medical science 20120201
Title: Geranylgeranylacetone, heat shock protein 90/AMP-activated protein kinase/endothelial nitric oxide synthase/nitric oxide pathway, and endothelial function in humans.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20120101
Title: Large-scale randomized clinical study on functional dyspepsia treatment with mosapride or teprenone: Japan Mosapride Mega-Study (JMMS).
Journal: Journal of gastroenterology and hepatology 20120101
Title: The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis.
Journal: Journal of biomedicine & biotechnology 20120101
Title: Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS).
Journal: BMC gastroenterology 20120101
Title: Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats.
Journal: The American journal of pathology 20111201
Title: Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes.
Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20111101
Title: Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation.
Journal: Journal of molecular and cellular cardiology 20110901
Title: Anti-ulcer agent teprenone inhibits hepatitis C virus replication: potential treatment for hepatitis C.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20110701
Title: [The correlation between the up-regulation of Hsp90 and drug resistance to cisplatin in lung cancer cell line].
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20110620
Title: Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys.
Journal: American journal of physiology. Endocrinology and metabolism 20110501
Title: [Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501
Title: Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1 cells.
Journal: British journal of pharmacology 20110401
Title: Induction of heat shock protein 70 inhibits ischemic renal injury.
Journal: Kidney international 20110401
Title: Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase.
Journal: The American journal of pathology 20110301
Title: Protective effect of geranylgeranylacetone against loxoprofen sodium-induced small intestinal lesions in rats.
Journal: European journal of pharmacology 20110210
Title: An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice.
Journal: American journal of physiology. Endocrinology and metabolism 20101101
Title: Isoprenoid geranylgeranylacetone inhibits human colon cancer cells through induction of apoptosis and cell cycle arrest.
Journal: Anti-cancer drugs 20101001
Title: Geranylgeranylacetone ameliorates acute cochlear damage caused by 3-nitropropionic acid.
Journal: Neurotoxicology 20100601
Title: The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats.
Journal: Brain research 20100512
Title: Randomized, double-blind, pilot study of geranylgeranylacetone versus placebo in patients taking low-dose enteric-coated aspirin. Low-dose aspirin-induced small bowel damage.
Journal: Scandinavian journal of gastroenterology 20100301
Title: HSP-dependent protection against gastrointestinal diseases.
Journal: Current pharmaceutical design 20100101
Title: Geranylgeranylacetone preconditioning may attenuate heat-induced inflammation and multiorgan dysfunction in rats.
Journal: The Journal of pharmacy and pharmacology 20100101
Title: Induction of heat shock proteins prevents the arrhythmogenic substrate for atrial fibrillation.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20091201
Title: Expression and function of stress (heat shock) proteins in gastrointestinal tract.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20091201
Title: Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20091201
Title: Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis.
Journal: Neuroscience letters 20091025
Title: A role for HSP70 in protecting against indomethacin-induced gastric lesions.
Journal: The Journal of biological chemistry 20090717
Title: Preinduction of HSP70 promotes hypoxic tolerance and facilitates acclimatization to acute hypobaric hypoxia in mouse brain.
Journal: Cell stress & chaperones 20090701
Title: Increased heat-shock protein 90 expression contributes to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rats.
Journal: Journal of gastroenterology and hepatology 20090601
Title: [Effects of biologic therapies on systemic osteoporosis in patients with rheumatoid arthritis].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20090501
Title: [Side effects of non-steroidal anti-inflammatory drugs on gastric mucosa and preventive effects of teprenone].
Journal: Zhonghua yi xue za zhi 20090428
Title: Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20090301
Title: Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GRO1 and induction of heat shock proteins.
Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20090101
Title: Protective effect of geranylgeranylacetone on cisplatin ototoxicity.
Journal: Chemotherapy 20090101
Title: Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.
Journal: PloS one 20090101
Title: Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Journal: Modern rheumatology 20090101
Title: Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model.
Journal: BMC pulmonary medicine 20090101
Title: Lysophosphatidic acid and invasion.
Journal: Cancer treatment and research 20090101
Title: Geranylgeranylacetone protects against diclofenac-induced gastric and small intestinal mucosal injuries in healthy subjects: a prospective randomized placebo-controlled double-blind cross-over study.
Journal: Digestion 20090101
Title: Pharmacological targeting of the Hsp70 chaperone.
Journal: Current topics in medicinal chemistry 20090101
Title: Low-dose sevoflurane inhalation enhances late cardioprotection from the anti-ulcer drug geranylgeranylacetone.
Journal: Anesthesia and analgesia 20080901
Title: HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy.
Journal: American journal of physiology. Renal physiology 20080701
Title: Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, geranylgeranylacetone.
Journal: Brain research 20080530
Title: Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia.
Journal: Cardiovascular research 20080401
Title: [Effects of teprenone on expression of heat shock protein 70 and c-fos in stomach following prednisolone ingestion: experiment with rats].
Journal: Zhonghua yi xue za zhi 20080122
Title: Blunted activation of NF-kappaB and NF-kappaB-dependent gene expression by geranylgeranylacetone: involvement of unfolded protein response.
Journal: Biochemical and biophysical research communications 20080104
Title: Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70.
Journal: Molecular pharmacology 20071101
Title: [Side effects of gastric muco-protective agents].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028
Title: [Role of heat shock protein in gastric mucosal protection].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20071001
Title: Neuroprotective effect of geranylgeranylacetone against ischemia-induced retinal injury.
Journal: Molecular vision 20070907
Title: Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart.
Journal: American journal of physiology. Heart and circulatory physiology 20070901
Title: Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB.
Journal: Digestive diseases and sciences 20070801
Title: HPLC-APCI-MS for the determination of teprenone in human plasma: method and clinical application.
Journal: Journal of pharmaceutical and biomedical analysis 20070727
Title: Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats.
Journal: Acta pharmacologica Sinica 20070701
Title: Geranylgeranylaceton induces heat shock protein 72 in skeletal muscle cells.
Journal: Biochemical and biophysical research communications 20070622
Title: Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20070501
Title: Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo.
Journal: Biochemical and biophysical research communications 20070427
Title: Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions.
Journal: Molecular pharmacology 20070401
Title: Pharmacological induction of heat shock protein exerts neuroprotective effects in experimental intracerebral hemorrhage.
Journal: Brain research 20070302
Title: Effect of geranylgeranylacetone on gentamycin ototoxicity in rat cochlea culture.
Journal: Auris, nasus, larynx 20070301
Title: The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer).
Journal: Biochemical and biophysical research communications 20070209
Title: Hyperthermia ameliorates 2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: the role of heat shock proteins.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20070201
Title: Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice.
Journal: Immunobiology 20070101
Title: [Effect of mucosal protective on the quality of gastric ulcer healing].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070101
Title: Geranylgeranylacetone protects the human gastric mucosa from diclofenac-induced injury via induction of heat shock protein 70.
Journal: Digestion 20070101
Title: Comparison of the effectiveness of geranylgeranylacetone with cimetidine in gastritis patients with dyspeptic symptoms and gastric lesions: a randomized, double-blind trial in Japan.
Journal: Digestion 20070101
Title: Reduction of ethanol-induced injury in portal hypertensive gastric mucosa of rats by induction of heat shock protein 72 by geranylgeranylacetone.
Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20070101
Title: Induction of heat shock response protects the heart against atrial fibrillation.
Journal: Circulation research 20061208
Title: [Non-steroidal anti-inflammatory drug induced gastropathy and preventive effects of teprenone on the gastropathy in rats].
Journal: Zhonghua yi xue za zhi 20061031
Title: Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation.
Journal: Journal of molecular and cellular cardiology 20060901
Title: Role of protein kinase C in neuroprotective effect of geranylgeranylacetone, a noninvasive inducing agent of heat shock protein, on delayed neuronal death caused by transient ischemia in rats.
Journal: Journal of neurotrauma 20060701
Title: Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation.
Journal: Brain research bulletin 20060428
Title: [Preventive effects of teprenone on gastric mucosal lesions induced by Helicobacter pylori in mice].
Journal: Zhonghua yi xue za zhi 20060411
Title: Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats.
Journal: Neuroscience letters 20060403
Title: Protective effects of heat shock protein 70 induced by geranylgeranylacetone on oxidative injury in rat intestinal epithelial cells.
Journal: Scandinavian journal of gastroenterology 20060301
Title: Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70.
Journal: Toxicology 20060215
Title: Protective effect of geranylgeranylacetone on trinitrobenzene sulfonic acid-induced colitis in mice.
Journal: International journal of molecular medicine 20060201
Title: Geranylgeranylacetone, a heat shock protein inducer, prevents acoustic injury in the guinea pig.
Journal: Brain research 20051214
Title: Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats.
Journal: Calcified tissue international 20051201
Title: Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone.
Journal: Digestive diseases and sciences 20051101
Title: Oral administration of geranylgeranylacetone improves survival rate in a rat endotoxin shock model: administration timing and heat shock protein 70 induction.
Journal: Shock (Augusta, Ga.) 20051101
Title: [Protection of gastric mucosa against steroids-induced damage by teprenone].
Journal: Zhonghua yi xue za zhi 20051019
Title: Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs.
Journal: Molecular pharmacology 20051001
Title: An anti-ulcer drug, geranylgeranylacetone, suppresses inducible nitric oxide synthase in cultured vascular smooth muscle cells.
Journal: Journal of hypertension 20051001
Title: Oral administration of geranylgeranylacetone plus local somatothermal stimulation: a simple, effective, safe and operable preconditioning combination for conferring tolerance against ischemia-reperfusion injury in rat livers.
Journal: World journal of gastroenterology 20050928
Title: Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis.
Journal: Scandinavian journal of gastroenterology 20050901
Title: Geranylgeranylacetone limits secondary injury, neuronal death, and progressive necrosis and cavitation after spinal cord injury.
Journal: Brain research 20050816
Title: Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator, in comparison with that of teprenone.
Journal: Biological & pharmaceutical bulletin 20050801
Title: Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats.
Journal: Life sciences 20050708
Title: Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70.
Journal: Kidney international 20050601
Title: Oral administration of geranylgeranylacetone blunts the endothelial dysfunction induced by ischemia and reperfusion in the rat heart.
Journal: Journal of cardiovascular pharmacology 20050601
Title: Upregulation of HSP by geranylgeranylacetone protects the cochlear lateral wall from endotoxin-induced inflammation.
Journal: Hearing research 20050601
Title: [Possible candidates for the compound which is expected to attenuate dioxin toxicity].
Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20050501
Title: Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro.
Journal: Cancer 20050401
Title: Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050302
Title: Prospective randomized trial for optimal prophylactic treatment of the upper gastrointestinal complications after open heart surgery.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20050301
Title: Neuroprotective effect of geranylgeranylacetone, a noninvasive heat shock protein inducer, on cerebral infarction in rats.
Journal: Neuroscience letters 20050221
Title: Neuroprotective effect of a heat shock protein inducer, geranylgeranylacetone in permanent focal cerebral ischemia.
Journal: Brain research 20050125
Title: Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage.
Journal: Circulation 20040928
Title: A single oral dose of geranylgeranylacetone attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus.
Journal: Brain research 20040924
Title: Single oral dose of geranylgeranylacetone for protection against delayed neuronal death induced by transient ischemia.
Journal: Brain research 20040910
Title: Reduction of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice using an antiulcer drug, geranylgeranylacetone.
Journal: Biological & pharmaceutical bulletin 20040901
Title: Teprenone, but not H2-receptor blocker or sucralfate, suppresses corpus Helicobacter pylori colonization and gastritis in humans: teprenone inhibition of H. pylori-induced interleukin-8 in MKN28 gastric epithelial cell lines.
Journal: Helicobacter 20040401
Title: Preventive effect of teprenone on acute gastric mucosal lesion progression in compound 48/80-treated rats.
Journal: European journal of pharmacology 20040308
Title: [Geranylgeranylacetone, an antiulcer drug, potently inhibits formation and function of human osteoclasts in vitro and bone loss in ovariectomized rats].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040201
Title: Geranylgeranylacetone attenuates suppression by Helicobacter pylori extract of human umbilical vein epithelial cell growth.
Journal: Hepato-gastroenterology 20040101
Title: Astroglial activation accompanies heat shock protein upregulation in rat brain following single oral dose of geranylgeranylacetone.
Journal: Brain research 20031121
Title: Geranylgeranylacetone attenuates septic diaphragm dysfunction by induction of heat shock protein 70.
Journal: Critical care medicine 20031101
Title: Proposed mechanism for induction of heat shock protein 70 by geranylgeranyl acetone by prenylation of Ras proteins.
Journal: Critical care medicine 20031101
Title: Protective effect of teprenone against acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats.
Journal: Journal of pharmacological sciences 20031101
Title: Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart.
Journal: Journal of molecular and cellular cardiology 20030701
Title: Cholesteryl glucoside-induced protection against gastric ulcer.
Journal: Cell structure and function 20030601
Title: Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model.
Journal: Investigative ophthalmology & visual science 20030501
Title: [Molecular chaperone inducers in medicine and diseases].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030101
Title: Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model.
Journal: Transactions of the American Ophthalmological Society 20030101
Title: Suppression of Helicobacter pylori-induced interleukin-8 production in gastric cancer cell lines by an anti-ulcer drug, geranylgeranylacetone.
Journal: Journal of gastroenterology and hepatology 20021101
Title: Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons.
Journal: Journal of neuroscience research 20020801
Title: Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced apoptosis.
Journal: Digestive diseases and sciences 20020701
Title: Thioredoxin superfamily and thioredoxin-inducing agents.
Journal: Annals of the New York Academy of Sciences 20020501
Title: Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in rat PC12 cells.
Journal: Neuroscience letters 20020315
Title: [New therapeutic approaches to peptic ulcer using mucosal protective agents].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020201
Title: Geranylgeranylacetone suppresses inflammatory responses and improves survival after massive hepatectomy in rats.
Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20020101
Title: Single oral dose of geranylgeranylacetone induces heat-shock protein 72 and renders protection against ischemia/reperfusion injury in rat heart.
Journal: Circulation 20011009
Title: Geranylgeranylacetone protects human monocytes from mitochondrial membrane depolarization independently of Hsp70 expression.
Journal: Cellular and molecular life sciences : CMLS 20010901
Title: Geranylgeranylacetone protects guinea pig gastric mucosal cells from gastric stressor-induced necrosis by induction of heat-shock proteins.
Journal: Biological & pharmaceutical bulletin 20010801
Title: Geranylgeranylacetone, a heat shock protein inducer, prevents primary graft nonfunction in rat liver transplantation.
Journal: Transplantation 20010727
Title: A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol.
Journal: Journal of hepatology 20010701
Title: Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes.
Journal: Free radical research 20010701
Title: Geranylgeranylacetone induces antiviral gene expression in human hepatoma cells.
Journal: Biochemical and biophysical research communications 20010126
Title: Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues.
Journal: Pharmacological research 20010101
Title: High dose of geranylgeranylacetone accumulate HSP72 mRNA in rat liver.
Journal: Transplantation proceedings 20010101
Title: Geranylgeranylacetone induces apoptosis in HL-60 cells.
Journal: Cell structure and function 19990601
Title: Hirakawa T, et al. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology. 1996 Aug;111(2):345-57.
Title: Caprioli J, et al. Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model. Trans Am Ophthalmol Soc. 2003;101:39-50; discussion 50-1.
Title: Han NK, et al. Geranylgeranylacetone Ameliorates Intestinal Radiation Toxicity by Preventing Endothelial Cell Dysfunction. Int J Mol Sci. 2017 Oct 7;18(10).
