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88426-33-9,MFCD01712789
Catalog No.:AA004EPY

88426-33-9 | Buparvaquone

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50mg
98%
in stock  
$6.00   $4.00
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100mg
98%
in stock  
$8.00   $6.00
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1g
98%
in stock  
$32.00   $22.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA004EPY
Chemical Name:
Buparvaquone
CAS Number:
88426-33-9
Molecular Formula:
C21H26O3
Molecular Weight:
326.4293
MDL Number:
MFCD01712789
SMILES:
OC1=C(CC2CCC(CC2)C(C)(C)C)C(=O)c2c(C1=O)cccc2
Properties
Properties
 
BP:
460.7°C at 760 mmHg  
Form:
Solid  
MP:
178-184˚C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
544  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
5.3  

Downstream Synthesis Route
CASUnavailable 
  88426-33-9 

[1]CurrentPatentAssignee:XINFAPHARMACEUTICALCOLTD-CN110734368,2020,ALocationinpatent:Paragraph0070-0076;0082-0084

[1]CurrentPatentAssignee:CANGZHOUDONGENTECH-CN114956972,2022,ALocationinpatent:Paragraph0095-0098

[2]CurrentPatentAssignee:XINFAPHARMACEUTICALCOLTD-CN110734368,2020,ALocationinpatent:Paragraph0077-0078

[1]CurrentPatentAssignee:XINFAPHARMACEUTICALCOLTD-CN110734368,2020,A

[2]CurrentPatentAssignee:XINFAPHARMACEUTICALCOLTD-CN110734368,2020,A

[1]CurrentPatentAssignee:XINFAPHARMACEUTICALCOLTD-CN110734368,2020,A

[2]CurrentPatentAssignee:XINFAPHARMACEUTICALCOLTD-CN110734368,2020,A

Literature

Title: Drug delivery systems for the topical treatment of cutaneous leishmaniasis.

Journal: Expert opinion on drug delivery 20120901

Title: Point mutations in the Theileria annulata cytochrome b gene is associated with buparvaquone treatment failure.

Journal: Veterinary parasitology 20120706

Title: Effectiveness of liposomal buparvaquone in an experimental hamster model of Leishmania (L.) infantum chagasi.

Journal: Experimental parasitology 20120301

Title: Evaluation and structure-activity relationship study of acute toxicity of naphthoquinones to Photobacterium phosphoreum, Photobacterium T3B.

Journal: Bulletin of environmental contamination and toxicology 20100801

Title: In vitro and in vivo evaluation of self-microemulsifying drug delivery system of buparvaquone.

Journal: Drug development and industrial pharmacy 20100601

Title: Cytoplasmic sequestration of p53 promotes survival in leukocytes transformed by Theileria.

Journal: Oncogene 20100527

Title: In vivo evidence for the resistance of Theileria annulata to buparvaquone.

Journal: Veterinary parasitology 20100511

Title: The protozoan parasite Theileria annulata alters the differentiation state of the infected macrophage and suppresses musculoaponeurotic fibrosarcoma oncogene (MAF) transcription factors.

Journal: International journal for parasitology 20090801

Title: Optimization and validation of RP-HPLC-UV method with solid-phase extraction for determination of buparvaquone in human and rabbit plasma: application to pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20080501

Title: [Therapeutic efficacy of buparvaquone (buparvon) in cattle with theileriosis].

Journal: Turkiye parazitolojii dergisi 20080101

Title: In vivo studies on the antileishmanial activity of buparvaquone and its prodrugs.

Journal: The Journal of antimicrobial chemotherapy 20071001

Title: Clinical, haematological and therapeutic studies on tropical theileriosis in water buffaloes (Bubalus bubalis) in Egypt.

Journal: Veterinary parasitology 20070531

Title: Development and validation of RP-HPLC-UV method for simultaneous determination of buparvaquone, atenolol, propranolol, quinidine and verapamil: a tool for the standardization of rat in situ intestinal permeability studies.

Journal: Journal of pharmaceutical and biomedical analysis 20070312

Title: Topical buparvaquone formulations for the treatment of cutaneous leishmaniasis.

Journal: The Journal of pharmacy and pharmacology 20070101

Title: Clinical efficacy and plasma concentrations of two formulations of buparvaquone in cattle infected with East Coast fever (Theileria parva infection).

Journal: Research in veterinary science 20060801

Title: Evaluation of buparvaquone (BUTA-Kel KELA, Belgium) as a treatment of East Coast fever in cattle, in the peri-urban of Dar Es Salaam city, Tanzania.

Journal: Veterinary parasitology 20060630

Title: Characterization of nebulized buparvaquone nanosuspensions--effect of nebulization technology.

Journal: Journal of drug targeting 20050101

Title: Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041001

Title: Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives.

Journal: Bioorganic & medicinal chemistry 20040701

Title: The effect of dexamethasone and promethazine in combination with buparvaquone in the management of East Coast fever.

Journal: The Onderstepoort journal of veterinary research 20040601

Title: Cerebral theileriosis in a Holstein calf.

Journal: The Veterinary record 20040424

Title: Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone.

Journal: Journal of medicinal chemistry 20040101

Title: In-vivo therapeutic efficacy trial with artemisinin derivative, buparvaquone and imidocarb dipropionate against Babesia equi infection in donkeys.

Journal: The Journal of veterinary medical science 20031101

Title: Theileria parva-transformed T cells show enhanced resistance to Fas/Fas ligand-induced apoptosis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030801

Title: Apoptosis of Theileria-infected lymphocytes induced upon parasite death involves activation of caspases 9 and 3.

Journal: Biochimie 20030801

Title: Transition metal complexes of buparvaquone as potent new antimalarial agents. 1. Synthesis, X-ray crystal-structures, electrochemistry and antimalarial activity against Plasmodium falciparum.

Journal: Journal of inorganic biochemistry 20030701

Title: Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes.

Journal: Blood 20030301

Title: Hijacking of host cell IKK signalosomes by the transforming parasite Theileria.

Journal: Science (New York, N.Y.) 20021101

Title: Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability.

Journal: International journal of pharmaceutics 20020426

Title: Production and characterisation of mucoadhesive nanosuspensions for the formulation of bupravaquone.

Journal: International journal of pharmaceutics 20010219

Title: Müller J, et al. Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. Int J Parasitol Drugs Drug Resist. 2015 Feb 13;5(1):16-25.

Title: Reimão JQ, et al. Effectiveness of liposomal buparvaquone in an experimental hamster model of Leishmania (L.) infantum chagasi. Exp Parasitol. 2012 Mar;130(3):195-9.

Title: Garnier T, et al. In vivo studies on the antileishmanial activity of buparvaquone and its prodrugs. J Antimicrob Chemother. 2007 Oct;60(4):802-10.

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Tags:88426-33-9 Molecular Formula|88426-33-9 MDL|88426-33-9 SMILES|88426-33-9 Buparvaquone