Title: Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.
Journal: The Journal of biological chemistry20150424
Title: The role of endoplasmic reticulum Ca2+-independent phospholipase a2γ in oxidant-induced lipid peroxidation, Ca2+ release, and renal cell death.
Journal: Toxicological sciences : an official journal of the Society of Toxicology20120801
Title: Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer.
Journal: Bioorganic & medicinal chemistry letters20120715
Title: Interaction between VEGF and calcium-independent phospholipase A2 in proliferation and migration of retinal pigment epithelium.
Journal: Current eye research20120601
Title: Activation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids.
Journal: The Journal of biological chemistry20120427
Title: Group VIA phospholipase A2 is a target for vasopressin signaling in the thick ascending limb.
Journal: American journal of physiology. Renal physiology20120401
Title: The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction.
Journal: American journal of physiology. Cell physiology20120401
Title: Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling.
Journal: The Journal of biological chemistry20120217
Title: Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels.
Journal: The Journal of pharmacology and experimental therapeutics20111101
Title: GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels.
Journal: Cell calcium20111001
Title: Role of phospholipase A(2) in retrograde transport of ricin.
Journal: Toxins20110901
Title: Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria.
Journal: Toxicology in vitro : an international journal published in association with BIBRA20110801
Title: Combination therapy of an inhibitor of group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development.
Journal: The American journal of pathology20110701
Title: Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance.
Journal: Journal of lipid research20110601
Title: Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.
Journal: Aging20110601
Title: Proinflammatory treatment of astrocytes with lipopolysaccharide results in augmented Ca2+ signaling through increased expression of via phospholipase A2 (iPLA2).
Journal: American journal of physiology. Cell physiology20110301
Title: Role of calcium independent phospholipase A2 in maintaining mitochondrial membrane potential and preventing excessive exocytosis in PC12 cells.
Journal: Neurochemical research20110201
Title: A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking.
Journal: Traffic (Copenhagen, Denmark)20101201
Title: 1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity.
Journal: Journal of medicinal chemistry20100722
Title: Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.
Journal: Oncotarget20100701
Title: Inhibition of calcium-independent phospholipase A2 activates p38 MAPK signaling pathways during cytostasis in prostate cancer cells.
Journal: Biochemical pharmacology20100615
Title: Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain.
Journal: The Journal of pharmacology and experimental therapeutics20100501
Title: Calcium-independent phospholipase A(2) plays a key role in the endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.
Journal: American journal of physiology. Heart and circulatory physiology20100401
Title: The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity.
Journal: Molecular pain20100101
Title: TLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent.
Journal: Biochimica et biophysica acta20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology20091001
Title: Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone.
Journal: Journal of innate immunity20091001
Title: Regulation of store-operated Ca2+ entry in pulmonary artery smooth muscle cells.
Journal: Cell calcium20090801
Title: Calcium-independent phospholipase A2 participates in KCl-induced calcium sensitization of vascular smooth muscle.
Journal: Cell calcium20090701
Title: Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone.
Journal: American journal of physiology. Heart and circulatory physiology20090601
Title: [Expression of iPLA2 in human pancreatic islets and its important role in glucose-stimulated insulin secretion].
Journal: Zhonghua yi xue za zhi20090526
Title: Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium.
Journal: Respiratory physiology & neurobiology20090227
Title: Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.
Journal: Journal of medicinal chemistry20081211
Title: The cytotoxic effect of bromoenol lactone, a calcium-independent phospholipase A2 inhibitor, on rat cortical neurons in culture.
Journal: Cellular and molecular neurobiology20081201
Title: Calcium-independent phospholipase A2 in rabbit ventricular myocytes.
Journal: Lipids20080901
Title: Alterations in phospholipid and fatty acid lipid profiles in primary neocortical cells during oxidant-induced cell injury.
Journal: Chemico-biological interactions20080811
Title: Inhibition of Ca2+-independent phospholipase A2 decreases prostate cancer cell growth by p53-dependent and independent mechanisms.
Journal: The Journal of pharmacology and experimental therapeutics20080701
Title: Complex regulation of store-operated Ca2+ entry pathway by PKC-epsilon in vascular SMCs.
Journal: American journal of physiology. Cell physiology20080601
Title: The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes.
Journal: Journal of leukocyte biology20080401
Title: On the importance of plasmalogen status in stimulated arachidonic acid release in the macrophage cell line RAW 264.7.
Journal: Biochimica et biophysica acta20080401
Title: Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL).
Journal: Journal of hepatology20080301
Title: Inhibition of calcium-independent phospholipase A impairs agonist-induced calcium entry in keratinocytes.
Journal: The British journal of dermatology20080101
Title: Role of calcium-independent phospholipase A2 in cortex striatum thalamus cortex circuitry-enzyme inhibition causes vacuous chewing movements in rats.
Journal: Psychopharmacology20071201
Title: The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR.
Journal: Journal of cell science20071201
Title: Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants.
Journal: American journal of physiology. Cell physiology20071101
Title: Arachidonic acid signaling is involved in the mechanism of imidazoline-induced KATP channel-independent stimulation of insulin secretion.
Journal: Cellular and molecular life sciences : CMLS20071101
Title: Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells.
Journal: The Biochemical journal20070915
Title: Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells.
Journal: The Journal of biological chemistry20070831
Title: A novel role of group VIB calcium-independent phospholipase A2 (iPLA2gamma) in the inducible expression of group IIA secretory PLA2 in rat fibroblastic cells.
Journal: The Journal of biological chemistry20070713
Title: The transfer of VLDL-associated phospholipids to activated platelets depends upon cytosolic phospholipase A2 activity.
Journal: Journal of lipid research20070701
Title: Activation and inactivation of the volume-sensitive taurine leak pathway in NIH3T3 fibroblasts and Ehrlich Lettre ascites cells.
Journal: American journal of physiology. Cell physiology20070701
Title: Agonist-induced calcium entry correlates with STIM1 translocation.
Journal: Journal of cellular physiology20070601
Title: Role of Ca2+-independent phospholipase A2gamma in Ca2+-induced mitochondrial permeability transition.
Journal: The Journal of pharmacology and experimental therapeutics20070501
Title: Bromoenol lactone, an inhibitor of Group V1A calcium-independent phospholipase A2 inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx.
Journal: Cell calcium20070201
Title: Identification of calcium-independent phospholipase A2gamma in mitochondria and its role in mitochondrial oxidative stress.
Journal: American journal of physiology. Renal physiology20070201
Title: Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells.
Journal: Toxicology20070105
Title: Calcium-independent phospholipase A2-catalyzed plasmalogen hydrolysis in hypoxic human coronary artery endothelial cells.
Journal: American journal of physiology. Cell physiology20070101
Title: Phospholipase A2-catalyzed hydrolysis of plasmalogen phospholipids in thrombin-stimulated human platelets.
Journal: Thrombosis research20070101
Title: Inhibition of phospholipase A2 reduces neurite outgrowth and neuronal viability.
Journal: Prostaglandins, leukotrienes, and essential fatty acids20070101
Title: Calcium-independent phospholipase A(2) influences AMPA-mediated toxicity of hippocampal slices by regulating the GluR1 subunit in synaptic membranes.
Journal: Hippocampus20070101
Title: Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells.
Journal: International journal of toxicology20070101
Title: Roles of phospholipase A2 isoforms in swelling- and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts.
Journal: American journal of physiology. Cell physiology20061201
Title: Group VIA calcium-independent phospholipase A2 mediates endothelial cell S phase progression.
Journal: The Journal of biological chemistry20061124
Title: Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent.
Journal: The Journal of biological chemistry20061103
Title: Prostacyclin production in tryptase and thrombin stimulated human bladder endothelial cells: effect of pretreatment with phospholipase A2 and cyclooxygenase inhibitors.
Journal: The Journal of urology20061001
Title: Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibers.
Journal: Journal of cell science20060915
Title: Neuroprotection of rat hippocampal slices exposed to oxygen-glucose deprivation by enrichment with docosahexaenoic acid and by inhibition of hydrolysis of docosahexaenoic acid-containing phospholipids by calcium independent phospholipase A2.
Journal: Neuroscience20060630
Title: Gestation age-related increase in 50-kDa rat uterine calcium-independent phospholipase A2 expression influences uterine sensitivity to polychlorinated biphenyl stimulation.
Journal: Biology of reproduction20060501
Title: Disruption of G1-phase phospholipid turnover by inhibition of Ca2+-independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase.
Journal: Journal of cell science20060315
Title: Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells.
Journal: Cancer research20060315
Title: Calcium-independent phospholipase A2 modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cells.
Journal: Journal of applied physiology (Bethesda, Md. : 1985)20060201
Title: A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols.
Journal: Biochemistry20060124
Title: A small-molecule FRET probe to monitor phospholipase A2 activity in cells and organisms.
Journal: Angewandte Chemie (International ed. in English)20060109
Title: A novel role for calcium-independent phospholipase A in alpha-amino-3-hydroxy-5-methylisoxazole-propionate receptor regulation during long-term potentiation.
Journal: The European journal of neuroscience20060101
Title: Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium.
Journal: American journal of physiology. Cell physiology20051201
Title: Modulation of phospholipase A2 activity in primary cultures of rat cortical neurons.
Journal: Journal of neural transmission (Vienna, Austria : 1996)20051001
Title: Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory.
Journal: Psychopharmacology20050901
Title: The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.
Journal: Journal of medicinal chemistry20050811
Title: Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by macrophages.
Journal: The Journal of biological chemistry20050729
Title: Ca(2+)-independent phospholipase A2 participates in the vesicular transport of milk proteins.
Journal: Biochimica et biophysica acta20050415
Title: Identification and distribution of endoplasmic reticulum iPLA2.
Journal: Biochemical and biophysical research communications20050204
Title: Inhibition of Ca2+-independent phospholipase A2 results in insufficient insulin secretion and impaired glucose tolerance.
Journal: Molecular endocrinology (Baltimore, Md.)20050201
Title: Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.
Journal: The Journal of biological chemistry20041119
Title: Contribution of lipid second messengers to the regulation of phosphatidylcholine synthesis during cell cycle re-entry.
Journal: Biochimica et biophysica acta20041108
Title: Amyloid beta(1-42) and its beta(25-35) fragment induce activation and membrane translocation of cytosolic phospholipase A2 in bovine retina capillary pericytes.
Journal: Biochimica et biophysica acta20041108
Title: Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2.
Journal: Toxicon : official journal of the International Society on Toxinology20041001
Title: Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility.
Journal: The Journal of biological chemistry20040910
Title: Differing caspase-1 activation states in monocyte versus macrophage models of IL-1beta processing and release.
Journal: Journal of leukocyte biology20040901
Title: Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells.
Journal: Circulation20040831
Title: Inactivation of endoplasmic reticulum bound Ca2+-independent phospholipase A2 in renal cells during oxidative stress.
Journal: Journal of the American Society of Nephrology : JASN20040601
Title: Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release.
Journal: American journal of physiology. Cell physiology20040501
Title: Mercury- and copper-induced lysosomal membrane destabilisation depends on [Ca2+]i dependent phospholipase A2 activation.
Journal: Aquatic toxicology (Amsterdam, Netherlands)20040210
Title: Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.
Journal: Biochemistry20040203
Title: Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells.
Journal: Cytokine20040107
Title: Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission.
Journal: Hippocampus20040101
Title: Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript.
Journal: Biochemistry20031202
Title: Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20031201
Title: Bromoenol lactone promotes cell death by a mechanism involving phosphatidate phosphohydrolase-1 rather than calcium-independent phospholipase A2.
Journal: The Journal of biological chemistry20031107
Title: A requirement for calcium-independent phospholipase A2 in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells.
Journal: The Journal of biological chemistry20031031
Title: Dopamine D1 receptor-dependent inhibition of NaCl transport in the rat thick ascending limb: mechanism of action.
Journal: European journal of pharmacology20030725
Title: Ca2+-independent phospholipase A2 is a novel determinant of store-operated Ca2+ entry.
Journal: The Journal of biological chemistry20030404
Title: Phospholipase A2 modulates respiratory burst developed by neutrophils in patients with rheumatoid arthritis.
Journal: Journal of cellular and molecular medicine20030101
Title: Phospholipid metabolite production in human urothelial cells after protease-activated receptor cleavage.
Journal: American journal of physiology. Renal physiology20021101
Title: Essential role of Ca2+ -dependent phospholipase A2 in estradiol-induced lysosome activation.
Journal: American journal of physiology. Cell physiology20021101
Title: Novel role for calcium-independent phospholipase A(2) in the macrophage antiviral response of inducible nitric-oxide synthase expression.
Journal: The Journal of biological chemistry20021011
Title: Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s.
Journal: The Journal of biological chemistry20020906
Title: Role of an endoplasmic reticulum Ca(2+)-independent phospholipase A(2) in oxidant-induced renal cell death.
Journal: American journal of physiology. Renal physiology20020901
Title: Pore formation and uncoupling initiate a Ca2+-independent degradation of mitochondrial phospholipids.
Journal: Biochemistry20020618
Title: Roles of various phospholipases A2 in providing lysophospholipid acceptors for fatty acid phospholipid incorporation and remodelling.
Journal: The Biochemical journal20020615
Title: Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent.
Journal: Biochemical pharmacology20020615
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry20020419
Title: PTH and DA regulate Na-K ATPase through divergent pathways.
Journal: American journal of physiology. Renal physiology20020301
Title: Identification of the phospholipase A(2) isoforms that contribute to arachidonic acid release in hypoxic endothelial cells: limits of phospholipase A(2) inhibitors.
Journal: Biochemical pharmacology20020115
Title: A calcium-independent phospholipase activity insensitive to bromoenol lactone mediates arachidonic acid release by lindane in rat myometrial cells.
Journal: Life sciences20011214
Title: Endothelial cell PAF synthesis following thrombin stimulation utilizes Ca(2+)-independent phospholipase A(2).
Journal: Biochemistry20011211
Title: Proliferative and morphological effects of endothelins in Schwann cells: roles of p38 mitogen-activated protein kinase and Ca(2+)-independent phospholipase A2.
Journal: Journal of neurochemistry20011201
Title: Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1.
Journal: Journal of immunology (Baltimore, Md. : 1950)20010915
Title: Calcium-independent phospholipase A(2) mediates CREB phosphorylation and c-fos expression during ischemia.
Journal: American journal of physiology. Heart and circulatory physiology20010701
Title: Anti-CD3 and concanavalin A-induced human T cell proliferation is associated with an increased rate of arachidonate-phospholipid remodeling. Lack of involvement of group IV and group VI phospholipase A2 in remodeling and increased susceptibility of proliferating T cells to CoA-independent transacyclase inhibitor-induced apoptosis.
Journal: The Journal of biological chemistry20010518
Title: Clinical concentrations of doxorubicin inhibit activity of myocardial membrane-associated, calcium-independent phospholipase A(2).
Journal: Cancer research20010515
Title: The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway.
Journal: The Journal of biological chemistry20010427
Title: Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2beta.
Journal: The Journal of biological chemistry20010420
Title: Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices.
Journal: British journal of pharmacology20010401
Title: Arachidonyltrifluoromethy ketone, a phospholipase A(2) antagonist, induces dispersal of both Golgi stack- and trans Golgi network-resident proteins throughout the cytoplasm.
Journal: Biochemical and biophysical research communications20010223
Title: Oxidant-induced inhibition of myocardial calcium-independent phospholipase A2.
Journal: Cardiovascular toxicology20010101
Title: Fensome-Green A, et al. Bromoenol lactone, an inhibitor of Group V1A calcium-independent phospholipase A2 inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. Cell Calcium. 2007 Feb;41(2):145-53.
Title: Takuma T, et al. Role of Ca2+-independent phospholipase A2 in exocytosis of amylase from parotid acinar cells. J Biochem. 1997 Jun;121(6):1018-24.
