Home Amines 871307-18-5
871307-18-5,MFCD12405303
Catalog No.:AA004OQN

871307-18-5 | 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$82.00   $57.00
- +
5mg
99% (HPLC)
in stock  
$236.00   $165.00
- +
10mg
99% (HPLC)
in stock  
$354.00   $248.00
- +
25mg
99% (HPLC)
in stock  
$678.00   $474.00
- +
50mg
99% (HPLC)
in stock  
$1,109.00   $777.00
- +
100mg
99% (HPLC)
in stock  
$1,873.00   $1,311.00
- +
500mg
99% (HPLC)
in stock  
$5,905.00   $4,133.00
- +
1000mg
99% (HPLC)
in stock  
$9,410.00   $6,587.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004OQN
Chemical Name:
4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile
CAS Number:
871307-18-5
Molecular Formula:
C21H14ClFN6
Molecular Weight:
404.8275
MDL Number:
MFCD12405303
SMILES:
N#Cc1cnc2c(c1Nc1ccc(c(c1)Cl)F)cc(nc2)NCc1cccnc1
Properties
Properties
 
BP:
616.318 °C at 760 mmHg  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
585  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
4.4  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Identification of new inhibitors of protein kinase R guided by statistical modeling.

Journal: Bioorganic & medicinal chemistry letters 20110701

Title: Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.

Journal: Diabetes 20100101

Title: Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.

Journal: Bioorganic & medicinal chemistry 20071001

Title: Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry letters 20051201

Title: Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59(16):7544-60.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 871307-18-5
Tags:871307-18-5 Molecular Formula|871307-18-5 MDL|871307-18-5 SMILES|871307-18-5 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile