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847559-80-2,MFCD18251568
Catalog No.:AA004RTA

847559-80-2 | Nvp-bep800

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$112.00   $78.00
- +
5mg
in stock  
$254.00   $178.00
- +
10mg
in stock  
$397.00   $278.00
- +
25mg
in stock  
$790.00   $553.00
- +
100mg
in stock  
$1,772.00   $1,240.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA004RTA
Chemical Name:
Nvp-bep800
CAS Number:
847559-80-2
Molecular Formula:
C21H23Cl2N5O2S
Molecular Weight:
480.4106
MDL Number:
MFCD18251568
SMILES:
CCNC(=O)c1sc2c(c1)c(nc(n2)N)c1cc(OCCN2CCCC2)c(cc1Cl)Cl
Properties
Properties
 
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
614  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
4.6  

Literature

Title: Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction.

Journal: British journal of cancer 20100525

Title: Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.

Journal: Molecular cancer therapeutics 20100401

Title: Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.

Journal: Journal of medicinal chemistry 20090813

Title: Massey AJ, et al. Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800. Mol Cancer Ther. 2010 Apr;9(4):906-19.

Title: Niewidok N, et al. Hsp90 Inhibitors NVP-AUY922 and NVP-BEP800 May Exert a Significant Radiosensitization on Tumor Cells along with a Cell Type-Specific Cytotoxicity. Transl Oncol. 2012 Oct;5(5):356-69. Epub 2012 Oct 1.

Title: Wu J, et al. Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70. Exp Ther Med. 2014 Sep;8(3):893-898. Epub 2014 Jun 23.

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Tags:847559-80-2 Molecular Formula|847559-80-2 MDL|847559-80-2 SMILES|847559-80-2 Nvp-bep800
Catalog No.: AA004RTA
847559-80-2,MFCD18251568
847559-80-2 | Nvp-bep800
Pack Size： 1mg
Purity： ≥98%
in stock
$112.00 $78.00
Pack Size： 5mg
Purity：
in stock
$254.00 $178.00
Pack Size： 10mg
Purity：
in stock
$397.00 $278.00
Pack Size： 25mg
Purity：
in stock
$790.00 $553.00
Pack Size： 100mg
Purity：
in stock
$1,772.00 $1,240.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA004RTA
Chemical Name: Nvp-bep800
CAS Number: 847559-80-2
Molecular Formula: C21H23Cl2N5O2S
Molecular Weight: 480.4106
MDL Number: MFCD18251568
SMILES: CCNC(=O)c1sc2c(c1)c(nc(n2)N)c1cc(OCCN2CCCC2)c(cc1Cl)Cl
Properties
Storage: -20 ℃;  
Complexity: 614  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 7  
XLogP3: 4.6  
Literature fold

Title: Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.

Journal: Bioorganic & medicinal chemistry20121115

Title: Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction.

Journal: British journal of cancer20100525

Title: Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.

Journal: Molecular cancer therapeutics20100401

Title: Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.

Journal: Journal of medicinal chemistry20090813

Title: Massey AJ, et al. Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800. Mol Cancer Ther. 2010 Apr;9(4):906-19.

Title: Niewidok N, et al. Hsp90 Inhibitors NVP-AUY922 and NVP-BEP800 May Exert a Significant Radiosensitization on Tumor Cells along with a Cell Type-Specific Cytotoxicity. Transl Oncol. 2012 Oct;5(5):356-69. Epub 2012 Oct 1.

Title: Wu J, et al. Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70. Exp Ther Med. 2014 Sep;8(3):893-898. Epub 2014 Jun 23.

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