Home Amines 83578-21-6
83578-21-6,MFCD01863453
Catalog No.:AA004UCQ

83578-21-6 | 2-(Pyridin-2-yldisulfanyl)ethanamine

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100mg
≥97%
in stock  
$482.00   $338.00
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1g
95%
in stock  
$721.00   $505.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA004UCQ
Chemical Name:
2-(Pyridin-2-yldisulfanyl)ethanamine
CAS Number:
83578-21-6
Molecular Formula:
C7H10N2S2
Molecular Weight:
186.2977
MDL Number:
MFCD01863453
SMILES:
NCCSSc1ccccn1
Properties
Properties
 
BP:
305.4°C at 760 mmHg  
Form:
Solid  
MP:
124-126℃  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
100  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
0.8  

Downstream Synthesis Route

[1]Gademann,Karl;Shchelik,IngaS.[ACSMedicinalChemistryLetters,2021,vol.12,#12,p.1898-1904]

[2]CurrentPatentAssignee:CATABASISPHARMACEUTICALS,INC.-WO2016/86103,2016,A1Locationinpatent:Paragraph00226

[3]Vu,ChiB.;Bridges,RobertJ.;Pena-Rasgado,Cecilia;Lacerda,AntonioE.;Bordwell,Curtis;Sewell,Abby;Nichols,AndrewJ.;Chandran,Sachin;Lonkar,Pallavi;Picarella,Dominic;Ting,Amal;Wensley,Allison;Yeager,Maisy;Liu,Feng[JournalofMedicinalChemistry,2017,vol.60,#1,p.458-473]

[4]CurrentPatentAssignee:NANTONGUNIVERSITY-CN104829671,2017,BLocationinpatent:Paragraph0083;0088;0089

[5]CurrentPatentAssignee:FUDANUNIVERSITY-CN109985006,2019,ALocationinpatent:Paragraph0078-0081

[6]Cui,Zhiyong;Sun,Lele;Zhang,Biliang[BioorganicandMedicinalChemistry,2004,vol.12,#5,p.927-933]

[7]Sugahara;Uragami;Yan;Regen[JournaloftheAmericanChemicalSociety,2001,vol.123,#32,p.7939-7940]

[8]CurrentPatentAssignee:NATIONALYANGMINGCHIAOTUNGUNIVERSITY-US2011/92672,2011,A1Locationinpatent:Page/Pagecolumn4

[9]Locationinpatent:schemeortableDuvall,CraigL.;Convertine,AnthonyJ.;Benoit,DanielleS.W.;Hoffman,AllanS.;Stayton,PatrickS.[MolecularPharmaceutics,2010,vol.7,#2,p.468-476]

[10]Vivero-Escoto,JuanL.;Rieter,WilliamJ.;Lau,Honam;Huxford-Phillips,RachelC.;Lin,Wenbin[Small,2013,vol.9,#20,p.3523-3531]

[11]Ghorbani,Marjan;Hamishehkar,Hamed;Hajipour,Hamed;Arsalani,Naser;Entezami,AliAkbar[NewJournalofChemistry,2016,vol.40,#4,p.3561-3570]

[12]CurrentPatentAssignee:BICYCLETHERAPEUTICSLIMITED-WO2019/34866,2019,A1Locationinpatent:Paragraph00422

83578-21-6    1070-70-8   
C-PDApolymer,Mw=4000,polydispersity=1.35;monomer(s):2-(pyridyldithio)-ethylamine;1,4-butanedioldiacrylate 

[1]JournaloftheAmericanChemicalSociety,2006,vol.128,p.12726-12734

83578-21-6    2223-82-7   
F-PDApolymer,Mw=4400,polydispersity=1.40;monomer(s):2-(pyridyldithio)-ethylamine;neopentylglycoldiacrylate 

[1]Zugates,GregoryT.;Anderson,DanielG.;Little,StevenR.;Lawhorn,IngridE.B.;Langer,Robert[JournaloftheAmericanChemicalSociety,2006,vol.128,#39,p.12726-12734]

[1]CurrentPatentAssignee:CATABASISPHARMACEUTICALS,INC.-WO2016/86136,2016,A1Locationinpatent:Paragraph00196;00208

[2]CurrentPatentAssignee:IMMUNOGENINC-WO2010/91150,2010,A1Locationinpatent:Page/Pagecolumn152-153

[3]Suzuki,Takayoshi;Hisakawa,Shinya;Itoh,Yukihiro;Suzuki,Nobuaki;Takahashi,Katsumasa;Kawahata,Masatoshi;Yamaguchi,Kentaro;Nakagawa,Hidehiko;Miyata,Naoki[BioorganicandMedicinalChemistryLetters,2007,vol.17,#15,p.4208-4212]

[1]Gauthier,Florian;Malher,Astrid;Vasseur,Jean-Jacques;Dupouy,Christelle;Debart,Françoise[EuropeanJournalofOrganicChemistry,2019,vol.2019,#33,p.5636-5645]

[2]CurrentPatentAssignee:IMMUNOGENINC-WO2014/194030,2014,A2Locationinpatent:Paragraph235

[3]CurrentPatentAssignee:IMMUNOGENINC-WO2010/91150,2010,A1Locationinpatent:Page/Pagecolumn134

[4]CurrentPatentAssignee:LUMOSPHARMAINC-US2013/196946,2013,A1Locationinpatent:Paragraph1666

[5]Bird,GregoryH.;Cohen,DanielT.;Dhe-Paganon,Sirano;Engen,JohnR.;Guerra,RachelM.;Harvey,EdwardP.;Hauseman,ZacharyJ.;Huhn,AnnissaJ.;Lee,Susan;Luccarelli,James;Newman,CatherineE.;Rettenmaier,T.Justin;Seo,Hyuk-Soo;Walensky,LorenD.;Wales,ThomasE.;Wells,JamesA.[CellChemicalBiology,2020,vol.27,#6,p.647-656]

Literature

Title: Fabrication of biodegradable micelles with reduction-triggered release of 6-mercaptopurine profile based on disulfide-linked graft copolymer conjugate.

Journal: Colloids and surfaces. B, Biointerfaces 20121201

Title: Targeted RGD nanoparticles for highly sensitive in vivo integrin receptor imaging.

Journal: Contrast media & molecular imaging 20120101

Title: Real-Time Analysis of Specific Protein-DNA Interactions with Surface Plasmon Resonance.

Journal: Journal of amino acids 20120101

Title: Langmuir-Blodgett films of pyridyldithio-modified multiwalled carbon nanotubes as a support to immobilize hydrogenase.

Journal: Langmuir : the ACS journal of surfaces and colloids 20100615

Title: Intracellular delivery of the reactive oxygen species generating agent D-penicillamine upon conjugation to poly-L-glutamic acid.

Journal: Molecular pharmaceutics 20100607

Title: Characterisation of peptide microarrays for studying antibody-antigen binding using surface plasmon resonance imagery.

Journal: PloS one 20100101

Title: Peptide aptamers in label-free protein detection: 2. Chemical optimization and detection of distinct protein isoforms.

Journal: Analytical chemistry 20090501

Title: Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59.

Journal: Molecular immunology 20090401

Title: The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells.

Journal: PloS one 20090101

Title: Selective release of DNA from the surface of indium-tin oxide thin electrode films using thiol-disulfide exchange chemistry.

Journal: Analytical chemistry 20070301

Title: Synthesis of poly(beta-amino ester)s with thiol-reactive side chains for DNA delivery.

Journal: Journal of the American Chemical Society 20061004

Title: Sulphydryl modifications alter scramblase activity in murine sickle cell disease.

Journal: British journal of haematology 20060501

Title: Electron beam-induced graft polymerization of acrylic acid and immobilization of arginine-glycine-aspartic acid-containing peptide onto nanopatterned polycaprolactone.

Journal: Biomacromolecules 20040101

Title: Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A(2): role of negatively charged phospholipids as potential membrane binding sites.

Journal: Archives of biochemistry and biophysics 20010701

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Tags:83578-21-6 Molecular Formula|83578-21-6 MDL|83578-21-6 SMILES|83578-21-6 2-(Pyridin-2-yldisulfanyl)ethanamine