Home Fluorides 75059-22-2
75059-22-2,MFCD20134043
Catalog No.:AA005EIX

75059-22-2 | 3'-Deoxy-3'-fluoroadenosine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
1 week  
$92.00   $64.00
- +
10mg
95%
1 week  
$116.00   $81.00
- +
25mg
95%
1 week  
$179.00   $125.00
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50mg
98%
1 week  
$243.00   $171.00
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100mg
95%
1 week  
$374.00   $262.00
- +
250mg
98%
1 week  
$913.00   $639.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA005EIX
Chemical Name:
3'-Deoxy-3'-fluoroadenosine
CAS Number:
75059-22-2
Molecular Formula:
C10H12FN5O3
Molecular Weight:
269.2324
MDL Number:
MFCD20134043
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1F)O)n1cnc2c1ncnc2N
Properties
Properties
 
BP:
628.6°C at 760 mmHg  
Form:
Solid  
MP:
211-212℃  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
338  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-0.6  

Downstream Synthesis Route

[1]Synthesis,1990,vol.1,p.900-905

[1]JournalofMedicinalChemistry,1991,vol.34,p.2195-2202

[2]ZeitschriftfurChemie,1989,vol.29,p.209-210

[3]BioorganicandMedicinalChemistry,2004,vol.12,p.475-487

[1]JournalofOrganicChemistry,1992,vol.57,p.7315-7321

[2]ChemBioChem,2015,vol.16,p.477-486

[1]BulletinoftheChemicalSocietyofJapan,1989,vol.62,p.2119-2120

[1]RecueildesTravauxChimiquesdesPays-Bas,1995,vol.114,p.43-50

Literature

Title: S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine.

Journal: Bioorganic & medicinal chemistry letters 20120615

Title: Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.

Journal: Journal of medicinal chemistry 20040422

Title: Phosphoramidate protides of 2',3'-dideoxy-3'-fluoroadenosine and related nucleosides with potent activity against HIV and HBV.

Journal: Nucleosides, nucleotides & nucleic acids 20031001

Title: Selective inhibition of arthropod-borne and arenaviruses in vitro by 3'-fluoro-3'-deoxyadenosine.

Journal: Antiviral research 19920601

Title: Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases.

Journal: Journal of medicinal chemistry 19910701

Title: Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine.

Journal: Antiviral research 19891001

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SDS
Tags:75059-22-2 Molecular Formula|75059-22-2 MDL|75059-22-2 SMILES|75059-22-2 3'-Deoxy-3'-fluoroadenosine