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77671-31-9,MFCD00867130
Catalog No.:AA005GII

77671-31-9 | enoximone

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1mg
≥98%
in stock  
$63.00   $44.00
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5mg
≥98%
in stock  
$205.00   $143.00
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10mg
≥98%
in stock  
$346.00   $242.00
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25mg
97%
in stock  
$679.00   $475.00
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50mg
97%
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$1,184.00   $829.00
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100mg
97%
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$1,963.00   $1,374.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA005GII
Chemical Name:
enoximone
CAS Number:
77671-31-9
Molecular Formula:
C12H12N2O2S
Molecular Weight:
248.3009
MDL Number:
MFCD00867130
SMILES:
CSc1ccc(cc1)C(=O)c1[nH]c(=O)[nH]c1C
Properties
Properties
 
Storage:
2-8℃;Keep in dry area;  

Computed Properties
 
Complexity:
371  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
1.6  

Downstream Synthesis Route

[1]Schnettler;Dage;Grisar[JournalofMedicinalChemistry,1982,vol.25,#12,p.1477-1481]

77671-31-9   
Enoximonesulfoxide 

[1]CurrentPatentAssignee:GILEADSCIENCESINC-WO2005/92333,2005,A1Locationinpatent:Page/Pagecolumn16

[2]CurrentPatentAssignee:GILEADSCIENCESINC-WO2005/92332,2005,A1Locationinpatent:Page/Pagecolumn15-16

[1]CurrentPatentAssignee:SANOFI-US4405635,1983,A

[2]CurrentPatentAssignee:GILEADSCIENCESINC;SANOFI-WO2005/58280,2005,A2Locationinpatent:Page/Pagecolumn19

[1]Bezensek,Jure;Groselj,Uros;Stare,Katarina;Svete,Jurij;Stanovnik,Branko[ARKIVOC,2014,vol.2014,#2,p.294-307]

Literature

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Journal: Inflammation 20120201

Title: The impact of a pulmonary-artery-catheter-based protocol on fluid and catecholamine administration in early sepsis.

Journal: Critical care research and practice 20120101

Title: cGMP Signaling, Phosphodiesterases and Major Depressive Disorder.

Journal: Current neuropharmacology 20111201

Title: Drug use patterns for the prevention of paediatric low cardiac output syndrome in Europe.

Journal: Intensive care medicine 20110801

Title: Retraction Note: Prophylactic use of the phospodiesterase III inhibitor enoximone in elderly cardiac surgery patients: effect on hemodynamics, inflammation, and markers of organ function.

Journal: Intensive care medicine 20110701

Title: The prophylactic use of the beta-blocker esmolol in combination with phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients: Retraction.

Journal: Anesthesia and analgesia 20110501

Title: Case report and mini literature review: anesthetic management for severe peripartum cardiomyopathy complicated with preeclampsia using sufetanil in combined spinal epidural anesthesia.

Journal: Yonsei medical journal 20110101

Title: Prolonged Refractory Hypotension following Combined Amlodipine and Losartan Ingestion Responsive to Metaraminol.

Journal: Case reports in medicine 20110101

Title: Levosimendan and mortality after coronary revascularisation: a meta-analysis of randomised controlled trials.

Journal: Critical care (London, England) 20110101

Title: Patient characteristics in persistent pulmonary hypertension of the newborn.

Journal: Pulmonary medicine 20110101

Title: Effect of short-acting beta blocker on the cardiac recovery after cardiopulmonary bypass.

Journal: Journal of cardiothoracic surgery 20110101

Title: Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema.

Journal: Intensive care medicine 20101101

Title: Blood transfusion in pediatric cardiac surgery.

Journal: Artificial organs 20101101

Title: Inotropic therapy for end-stage heart failure patients.

Journal: Current treatment options in cardiovascular medicine 20101001

Title: Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS.

Journal: Intensive care medicine 20100501

Title: Assessment of residual viability by enoximone echocardiography in patients with previous myocardial infarction correlation with positron emission tomographic studies and functional follow-up.

Journal: Echocardiography (Mount Kisco, N.Y.) 20100501

Title: Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition.

Journal: Basic research in cardiology 20100301

Title: Pulmonary hypertension in cardiac surgery.

Journal: Current cardiology reviews 20100201

Title: Weaning failure of cardiac origin: recent advances.

Journal: Critical care (London, England) 20100101

Title: Enoxaparin, effective dosage for intensive care patients: double-blinded, randomised clinical trial.

Journal: Critical care (London, England) 20100101

Title: Clinical review: practical recommendations on the management of perioperative heart failure in cardiac surgery.

Journal: Critical care (London, England) 20100101

Title: S3 guidelines for intensive care in cardiac surgery patients: hemodynamic monitoring and cardiocirculary system.

Journal: German medical science : GMS e-journal 20100101

Title: Effects of phosphodiesterase (III/IV)-inhibitors and cytokines on mechanical properties of neutrophilic granulocytes in neonates and adults.

Journal: Clinical hemorheology and microcirculation 20100101

Title: Levosimendan as treatment option in severe verapamil intoxication: a case report and review of the literature.

Journal: Case reports in medicine 20100101

Title: Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review.

Journal: Critical care (London, England) 20100101

Title: Levosimendan neither improves nor worsens mortality in patients with cardiogenic shock due to ST-elevation myocardial infarction.

Journal: Vascular health and risk management 20100101

Title: Double-blind placebo-controlled comparison of enoximone and dobutamine infusions in patients with moderate to severe chronic heart failure.

Journal: Congestive heart failure (Greenwich, Conn.) 20100101

Title: Vasodilators in the treatment of acute heart failure: what we know, what we don't.

Journal: Heart failure reviews 20091201

Title: Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials.

Journal: European heart journal 20091201

Title: Inotropic therapy for heart failure: paradise lost.

Journal: European heart journal 20091201

Title: Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond.

Journal: Heart failure reviews 20091201

Title: Cardiorespiratory effects of enoximone in anaesthetised colic horses.

Journal: Equine veterinary journal 20091101

Title: The use of exercise echocardiography in the evaluation of mitral regurgitation.

Journal: Current cardiology reviews 20091101

Title: Investigational positive inotropic agents for acute heart failure.

Journal: Cardiovascular & hematological disorders drug targets 20090901

Title: Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarction.

Journal: Critical care medicine 20090901

Title: Masquerade: fulminant viral myocarditis mimicking a Q-wave anterolateral myocardial infarction.

Journal: The American journal of medicine 20090601

Title: Influence of continuous perioperative beta-blockade in combination with phosphodiesterase inhibition on haemodynamics and myocardial ischaemia in high-risk vascular surgery patients.

Journal: British journal of anaesthesia 20090501

Title: Long-term outcome of coronary artery bypass grafting in patients with left ventricular dysfunction.

Journal: The Annals of thoracic surgery 20090501

Title: Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs.

Journal: Veterinary anaesthesia and analgesia 20090501

Title: Evaluation of 30-day mortality of levosimendan versus enoximone.

Journal: Critical care medicine 20090301

Title: Levosimendan or enoximone in refractory cardiogenic shock?

Journal: Critical care medicine 20090301

Title: Influence of calcium chloride on the cardio-respiratory effects of a bolus of enoximone in isoflurane anaesthetized ponies.

Journal: Veterinary anaesthesia and analgesia 20090301

Title: Inflammatory response to cardiopulmonary bypass with enoximone or steroids in patients undergoing myocardial revascularization: a preliminary report study.

Journal: International journal of clinical pharmacology and therapeutics 20090201

Title: Newer treatments for decompensated heart failure: focus on levosimendan.

Journal: Drug design, development and therapy 20090101

Title: Left ventricular diastolic dysfunction of the cardiac surgery patient; a point of view for the cardiac surgeon and cardio-anesthesiologist.

Journal: Journal of cardiothoracic surgery 20090101

Title: Apart from the other members of PDE inhibitors' family, enoximone does not enhance renal ischemic reperfusion injury: the effects of enoximone on renal ischemia reperfusion.

Journal: Renal failure 20090101

Title: Is there a role for carvedilol in the management of pediatric heart failure? A meta analysis and e-mail survey of expert opinion.

Journal: Annals of pediatric cardiology 20090101

Title: ABCD of the phosphodiesterase family: interaction and differential activity in COPD.

Journal: International journal of chronic obstructive pulmonary disease 20081201

Title: Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarction.

Journal: Critical care medicine 20080801

Title: Levosimendan in cardiogenic shock: better than enoximone!

Journal: Critical care medicine 20080801

Title: Effects of dobutamine on cardiovascular function and respiratory gas exchange after enoximone in isoflurane-anaesthetized ponies.

Journal: Veterinary anaesthesia and analgesia 20080701

Title: Recovery of heart function in children with acute severe heart failure.

Journal: Transplantation 20080415

Title: [Continuous beta-block with esmolol in combination with enoximone: influence on cardiac function in high risk patients undergoing vascular surgery].

Journal: Der Anaesthesist 20080301

Title: Effects of enoximone on peripheral and central chemoreflex responses in humans.

Journal: American journal of physiology. Heart and circulatory physiology 20080101

Title: Understanding cardiac output.

Journal: Critical care (London, England) 20080101

Title: Spontaneous perforation of the cystic duct in streptococcal toxic shock syndrome: a case report.

Journal: Journal of medical case reports 20080101

Title: [Potentialitis of phosphodiesterase inhibitors in management of patients with chronic heart failure complicating cardiac ischemia].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20080101

Title: Cardiovascular effects of enoximone in isoflurane anaesthetized ponies.

Journal: Veterinary anaesthesia and analgesia 20071101

Title: [Rational use of catecholamines and inotropes].

Journal: Pneumologie (Stuttgart, Germany) 20071101

Title: Low-dose oral enoximone enhances the ability to wean patients with ultra-advanced heart failure from intravenous inotropic support: results of the oral enoximone in intravenous inotrope-dependent subjects trial.

Journal: American heart journal 20071101

Title: [Pleural effusion following coronary bypass surgery].

Journal: Harefuah 20071101

Title: Peripartum cardiomyopathy: review of the literature.

Journal: Yonsei medical journal 20071031

Title: Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone.

Journal: Expert opinion on pharmacotherapy 20070901

Title: Effects of preemptive enoximone on left ventricular diastolic function after valve replacement for aortic stenosis.

Journal: Journal of cardiothoracic and vascular anesthesia 20070601

Title: Current practice of hemodynamic monitoring and vasopressor and inotropic therapy in post-operative cardiac surgery patients in Germany: results from a postal survey.

Journal: Acta anaesthesiologica Scandinavica 20070301

Title: Factors influencing the outcome of paediatric cardiac surgical patients during extracorporeal circulatory support.

Journal: Journal of cardiothoracic surgery 20070101

Title: The metabolic and renal effects of adrenaline and milrinone in patients with myocardial dysfunction after coronary artery bypass grafting.

Journal: Critical care (London, England) 20070101

Title: Metabolic effects of phosphodiesterase III inhibitors: another reason to promote their use?

Journal: Critical care (London, England) 20070101

Title: Acute heart failure: inotropic agents and their clinical uses.

Journal: Expert opinion on pharmacotherapy 20061101

Title: Intraaortic balloon pumping during cardioplegic arrest preserves lung function in patients with chronic obstructive pulmonary disease.

Journal: The Annals of thoracic surgery 20060701

Title: Enoximone in cardiac arrest caused by propranolol: two case reports.

Journal: Acta anaesthesiologica Scandinavica 20060701

Title: A comparison of three phosphodiesterase type III inhibitors on mechanical and metabolic function in guinea pig isolated hearts.

Journal: Anesthesia and analgesia 20060601

Title: Effect of combining phosphodiesterase III inhibitors with St Thomas Hospital's solution used as transplantation preservative solution in isolated rat hearts.

Journal: Transplantation proceedings 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Levosimendan may improve survival in patients requiring mechanical assist devices for post-cardiotomy heart failure.

Journal: Critical care (London, England) 20060101

Title: The impact of an hematocrit of 20% during normothermic cardiopulmonary bypass for elective low risk coronary artery bypass graft surgery on oxygen delivery and clinical outcome--a randomized controlled study [ISRCTN35655335].

Journal: Critical care (London, England) 20060101

Title: Arginine-vasopressin in catecholamine-refractory septic versus non-septic shock in extremely low birth weight infants with acute renal injury.

Journal: Critical care (London, England) 20060101

Title: Bench-to-bedside review: hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers.

Journal: Critical care (London, England) 20060101

Title: The year in heart failure.

Journal: Journal of the American College of Cardiology 20051206

Title: Rationale and design of the enoximone clinical trials program.

Journal: Journal of cardiac failure 20051201

Title: Clinical trials update from the European Society of Cardiology meeting 2005: CARE-HF extension study, ESSENTIAL, CIBIS-III, S-ICD, ISSUE-2, STRIDE-2, SOFA, IMAGINE, PREAMI, SIRIUS-II and ACTIVE.

Journal: European journal of heart failure 20051001

Title: Two inotropes with different mechanisms of action: contractile, PDE-inhibitory and direct myofibrillar effects of levosimendan and enoximone.

Journal: Journal of cardiovascular pharmacology 20050901

Title: Natriuretic peptides and E-selectin as predictors of acute deterioration in patients with inotrope-dependent heart failure.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20050501

Title: Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine.

Journal: European journal of anaesthesiology 20050401

Title: Determinants and prognosis of myocardial damage after coronary artery bypass grafting.

Journal: The Annals of thoracic surgery 20050301

Title: Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, on myocyte calcium cycling and contractility.

Journal: The Journal of pharmacology and experimental therapeutics 20050201

Title: Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery -- a systematic literature review.

Journal: Critical care (London, England) 20050101

Title: Time course of endothelial damage in septic shock: prediction of outcome.

Journal: Critical care (London, England) 20050101

Title: [Treatment of cardiogenic shock with the Ca2+ sensitizer levosimendan].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20041215

Title: Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD.

Journal: European journal of heart failure 20041201

Title: The prophylactic use of the beta-blocker esmolol in combination with phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients.

Journal: Anesthesia and analgesia 20041001

Title: Effect of activators and the phosphodiesterase inhibitors pentoxifylline and enoximone on the deformability of neutrophils in neonates and adults.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20041001

Title: Perioperative enoximone infusion improves cardiac enzyme release after CABG.

Journal: Journal of cardiothoracic and vascular anesthesia 20040801

Title: Successful treatment with enoximone for severe poisoning with atenolol and verapamil: a case report.

Journal: Acta anaesthesiologica Scandinavica 20040701

Title: New strategies to control the inflammatory response in cardiac surgery.

Journal: Current opinion in anaesthesiology 20040201

Title: Pharmacokinetics and pharmacodynamics of intravenous inotropic agents.

Journal: Clinical pharmacokinetics 20040101

Title: Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock.

Journal: Critical care (London, England) 20040101

Title: Stress echocardiography in heart failure.

Journal: Cardiovascular ultrasound 20040101

Title: Na(+)-channel modulation, a new principle of inotropic intervention: effects on hemodynamic and myocardial energetics in the immature rabbit heart.

Journal: Pediatric research 20031201

Title: Cardiac rescue with enoximone in volume and catecholamine refractory septic shock.

Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20031001

Title: Neonatal flecainide toxicity following supraventricular tachycardia treatment.

Journal: The Annals of pharmacotherapy 20030901

Title: Enoximone very low-dose dobutamine stress echocardiography: a new test for detecting viability in severe myocardial dysfunction after acute myocardial infarction.

Journal: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20030901

Title: [Sex, erectile dysfunction, and the heart: a growing problem].

Journal: Herz 20030601

Title: In vitro and in vivo effects of the phosphodiesterase-III inhibitor enoximone on malignant hyperthermia-susceptible swine.

Journal: Anesthesiology 20030401

Title: Role of nonglycosidic inotropic agents: indications, ethics, and limitations.

Journal: The Medical clinics of North America 20030301

Title: Enoximone echocardiography: a novel test to evaluate left ventricular contractile reserve in patients with heart failure on chronic beta-blocker therapy.

Journal: Cardiovascular ultrasound 20030101

Title: Beta-blocker therapy influences the hemodynamic response to inotropic agents in patients with heart failure: a randomized comparison of dobutamine and enoximone before and after chronic treatment with metoprolol or carvedilol.

Journal: Journal of the American College of Cardiology 20021002

Title: Prophylactic use of the phospodiesterase III inhibitor enoximone in elderly cardiac surgery patients: effect on hemodynamics, inflammation, and markers of organ function.

Journal: Intensive care medicine 20021001

Title: [Therapy of verapamil poisoning with noradrenaline and the phosphodiesterase inhibitor enoximone].

Journal: Deutsche medizinische Wochenschrift (1946) 20020927

Title: Incidence and risk calculation of inotropic support in patients undergoing cardiac surgery with cardiopulmonary bypass using an automated anaesthesia record-keeping system.

Journal: British journal of anaesthesia 20020901

Title: The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta-regression analysis.

Journal: European journal of heart failure 20020801

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: [Twin-twin transfusion syndrome: report of two cases with hemodynamic complications].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20020401

Title: Coronary artery bypass grafting in patients with severe left ventricular dysfunction: a prospective randomized study on the timing of perioperative intraaortic balloon pump support.

Journal: The International journal of artificial organs 20020201

Title: Severe reperfusion lung injury after double lung transplantation.

Journal: Critical care (London, England) 20020101

Title: Clinical review: splanchnic ischaemia.

Journal: Critical care (London, England) 20020101

Title: Comparison of enoximone, amrinone, or levosimendan enriched St. Thomas' hospital cardioplegic solutions used for myocardial preservation in isolated guinea pig hearts.

Journal: Acta medica (Hradec Kralove) 20020101

Title: Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients.

Journal: Critical care medicine 20010801

Title: Inotropes and beta-blockers: is there a need for new guidelines?

Journal: Journal of cardiac failure 20010601

Title: Rhabdomyolysis following cardiopulmonary bypass and treatment with enoximone in a patient susceptible to malignant hyperthermia.

Journal: Anesthesiology 20010201

Title: Enoximone maintains intestinal villus blood flow during endotoxemia.

Journal: International journal of surgical investigation 20010101

Title: [Use of enoximone in patients with acute and subacute heart failure in the intensive care unit].

Journal: Zeitschrift fur Kardiologie 19940101

Title: [Neurohumoral and hemodynamic effects in combination therapy of enoximone and dopamine].

Journal: Zeitschrift fur Kardiologie 19940101

Title: Low-dose enoximone therapy in pre-transplant patients: hemodynamic, echocardiographic, and neurohumoral findings.

Journal: Zeitschrift fur Kardiologie 19940101

Title: [Treatment of low cardiac output syndrome in newborn infants and children].

Journal: Zeitschrift fur Kardiologie 19940101

Title: Effect of enoximone alone and in combination with metoprolol on myocardial function and energetics in severe congestive heart failure: improvement in hemodynamic and metabolic profile.

Journal: Cardiovascular drugs and therapy 19930601

Title: Intravenous enoximone or dobutamine for severe heart failure after acute myocardial infarction: a randomized double-blind trial.

Journal: European heart journal 19930501

Title: The influence of clinical intervention on pressure-volume relationships--the conductance (volume) technique.

Journal: European heart journal 19921101

Title: Improved heart failure protection by FK664, a novel positive inotropic agent, in dog heart-lung preparations.

Journal: Life sciences 19920101

Title: Clinical pharmacology of intravenous enoximone: pharmacodynamics and pharmacokinetics in patients with heart failure.

Journal: American heart journal 19910901

Title: [Use of a new inotropic agent, enoximone, in heart surgery].

Journal: Revista espanola de anestesiologia y reanimacion 19910101

Title: [Vasodilatation and positive inotropic effect of the phosphodiesterase inhibitor enoximone].

Journal: Zeitschrift fur Kardiologie 19910101

Title: Enoximone: true inotropic effects? Do they cause ischemia? Analysis of end-systolic pressure-volume relations using the conductance (volume) catheter technique.

Journal: Cardiovascular drugs and therapy 19901001

Title: Effects of enoximone in patients with heart failure uncontrolled by captopril and diuretics.

Journal: International journal of cardiology 19900701

Title: Convulsions induced by enoximone administered as a continuous intravenous infusion.

Journal: BMJ (Clinical research ed.) 19900303

Title: Augmentation of diastolic function with phosphodiesterase inhibition in congestive heart failure.

Journal: The Journal of laboratory and clinical medicine 19890901

Title: Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.

Journal: Journal of medicinal chemistry 19890201

Title: A dose-response study of intravenous enoximone in congestive heart failure.

Journal: The American journal of cardiology 19870814

Title: Long-term oral enoximone therapy in chronic cardiac failure.

Journal: The American journal of cardiology 19870814

Title: Inotropic effect of enoximone in patients with severe heart failure: demonstration by left ventricular end-systolic pressure-volume analysis.

Journal: Journal of the American College of Cardiology 19870501

Title: Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).

Journal: Journal of medicinal chemistry 19870201

Title: Comparison of acute hemodynamic response to dobutamine and intravenous MDL 17,043 (enoximone) in severe congestive heart failure secondary to ischemic cardiomyopathy or idiopathic dilated cardiomyopathy.

Journal: The American journal of cardiology 19860601

Title: Enoximone (MDL 17,043), a phosphodiesterase inhibitor, in the treatment of advanced, unstable chronic heart failure.

Journal: The Journal of heart transplantation 19860101

Title: Comparative hemodynamic effects of intravenous dobutamine and MDL-17,043, a new cardioactive drug, in severe congestive heart failure.

Journal: American heart journal 19850101

Title: The new inotropic phosphodiesterase inhibitors.

Journal: Archives internationales de physiologie et de biochimie 19841101

Title: Cardiovascular properties of a new cardiotonic agent: MDL 17,043 (1.3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazol-2-one).

Journal: Journal of cardiovascular pharmacology 19820101

Title: Characterization of the cardiovascular activities of a new cardiotonic agent, MDL 17043 (1,3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazole-2-one).

Journal: Journal of cardiovascular pharmacology 19820101

Title: Jan Beute, et al. A Pathophysiological Role of PDE3 in Allergic Airway Inflammation. JCI Insight. 2018 Jan 25;3(2):e94888.

Title: R C Dage, et al. Pharmacology and Pharmacokinetics of Enoximone. Cardiology. 1990;77 Suppl 3:2-13; discussion 27-33.

Title: M B Vroom, et al. Effect of Phosphodiesterase Inhibitors on Human Arteries in Vitro. Br J Anaesth. 1996 Jan;76(1):122-9.

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