74764-40-2,MFCD00242668
Catalog No.:AA005H7K

74764-40-2 | Bepridil hydrochloride

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5mg
≥98%
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$163.00   $114.00
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10mg
≥98%
in stock  
$234.00   $164.00
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25mg
≥98%
in stock  
$445.00   $312.00
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50mg
≥98%
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100mg
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA005H7K
Chemical Name:
Bepridil hydrochloride
CAS Number:
74764-40-2
Molecular Formula:
C24H35ClN2O
Molecular Weight:
403.0005
MDL Number:
MFCD00242668
SMILES:
CC(COCC(N1CCCC1)CN(c1ccccc1)Cc1ccccc1)C.Cl
NSC Number:
758390
Properties
Computed Properties
 
Complexity:
382  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Stabilization of Kv1.5 channel protein by bepridil through its action as a chemical chaperone.

Journal: European journal of pharmacology 20121205

Title: Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats.

Journal: Journal of cellular and molecular medicine 20121101

Title: Bepridil is effective and improves QOL in multidrug-resistant paroxysmal atrial fibrillation.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20121101

Title: Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.

Journal: Journal of cardiovascular pharmacology 20120801

Title: Effectiveness of amiodarone versus bepridil in achieving conversion to sinus rhythm in patients with persistent atrial fibrillation: a randomised trial.

Journal: Heart (British Cardiac Society) 20120701

Title: Combined effects of up- and downstream therapies on atrial fibrillation in a canine rapid stimulation model.

Journal: International journal of cardiology 20120531

Title: The relationship between the plasma concentration of bepridil and its efficacy in the treatment of atrial fibrillation in Japanese patients.

Journal: Biological & pharmaceutical bulletin 20120101

Title: [Series: Clinical study from Japan and its reflections; J-BAF study].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20110810

Title: Molecular dynamics and docking studies on cardiac troponin C.

Journal: Journal of biomolecular structure & dynamics 20110801

Title: An LC method for quantifying bepridil in human plasma using 1-naphthol as the internal standard.

Journal: Journal of chromatographic science 20110801

Title: In vitro and experimental therapeutic studies of the calcium channel blocker bepridil: detection of viable Leishmania (L.) chagasi by real-time PCR.

Journal: Experimental parasitology 20110601

Title: A computational and experimental approach to investigate bepridil binding with cardiac troponin.

Journal: The journal of physical chemistry. B 20110317

Title: Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110202

Title: Bepridil facilitates early termination of spiral-wave reentry in two-dimensional cardiac muscle through an increase of intercellular electrical coupling.

Journal: Journal of pharmacological sciences 20110101

Title: Clinical outcome in patients with paroxysmal or persistent atrial fibrillation receiving bepridil.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20110101

Title: Repetitive evaluation of fibrillation cycle length predicts the efficacy of bepridil for interruption of long-lasting persistent atrial fibrillation.

Journal: International heart journal 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Efficacy of low-dose bepridil for prevention of ventricular fibrillation in patients with Brugada syndrome with and without SCN5A mutation.

Journal: Journal of cardiovascular pharmacology 20101001

Title: Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog.

Journal: Pacing and clinical electrophysiology : PACE 20100801

Title: Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100711

Title: Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100630

Title: Candesartan decreases type III procollagen-N-peptide levels and inflammatory marker levels and maintains sinus rhythm in patients with atrial fibrillation.

Journal: Journal of cardiovascular pharmacology 20100501

Title: Importance of morphological changes in T-U waves during bepridil therapy as a predictor of ventricular arrhythmic event.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20100501

Title: Effect of bepridil in atrial fibrillation inducibility facilitated by vagal nerve stimulation. - Prevention of vagal nerve activation-induced shortening of the atrial action potential duration -.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20100501

Title: Inhibition of Listeria monocytogenes infection by neurological drugs.

Journal: International journal of antimicrobial agents 20100301

Title: [Best strategy for the treatment of atrial fibrillation: reconsideration after randomized multicenter clinical trials in Japan].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20100201

Title: Pharmacological cardioversion preceding left atrial ablation: bepridil predicts the clinical outcome following ablation in patients with persistent atrial fibrillation.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20091201

Title: Opposing effects of bepridil on ventricular repolarization in humans. Inhomogeneous prolongation of the action potential duration vs flattening of its restitution kinetics.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20090901

Title: Two patients with bepridil-induced interstitial pneumonia.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20090701

Title: Predicting the efficacy of antiarrhythmic agents for interrupting persistent atrial fibrillation according to spectral analysis of the fibrillation waves on the surface ECG.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20090701

Title: Dose-response effects of bepridil in patients with persistent atrial fibrillation monitored with transtelephonic electrocardiograms: a multicenter, randomized, placebo-controlled,double-blind study (J-BAF Study).

Journal: Circulation journal : official journal of the Japanese Circulation Society 20090601

Title: Bepridil up-regulates cardiac Na+ channels as a long-term effect by blunting proteasome signals through inhibition of calmodulin activity.

Journal: British journal of pharmacology 20090601

Title: Does bepridil create a paradigm shift in the treatment of persistent atrial fibrillation?

Journal: Circulation journal : official journal of the Japanese Circulation Society 20090601

Title: Effect of compound plate composition on measurement of hERG current IC(50) using PatchXpress.

Journal: Journal of pharmacological and toxicological methods 20090101

Title: Gradual progression of interstitial pneumonia induced by bepridil.

Journal: Internal medicine (Tokyo, Japan) 20090101

Title: Beat-to-beat variability of repolarization differentiates the extent of torsadogenic potential of multi ion channel-blockers bepridil and amiodarone.

Journal: European journal of pharmacology 20081031

Title: Comparison of electropharmacological effects of bepridil and sotalol in halothane-anesthetized dogs.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20080601

Title: Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20080501

Title: [Role of apoptosis in the kidney after reperfusion].

Journal: Orvosi hetilap 20080217

Title: Inhomogenic effect of bepridil on atrial electrical remodeling in a canine rapid atrial stimulation model.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20080201

Title: Combination therapy of renin angiotensin system inhibitors and bepridil is useful for maintaining sinus rhythm in patients with atrial fibrillation.

Journal: Journal of cardiology 20071201

Title: Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation.

Journal: Journal of cardiovascular pharmacology 20070901

Title: Neuronal preconditioning with the antianginal drug, bepridil.

Journal: Journal of neurochemistry 20070801

Title: Efficacy and safety of the additional bepridil treatment in patients with atrial fibrillation refractory to class I antiarrhythmic drugs.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20070801

Title: Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia.

Journal: Journal of cardiovascular electrophysiology 20070701

Title: Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons.

Journal: Neuroscience 20070425

Title: Na+/Ca2+ exchanger inhibitors modify the accumulation of tumor-diagnostic PET tracers in cancer cells.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070101

Title: Bepridil for drug-refractory ventricular tachyarrhythmias.

Journal: Internal medicine (Tokyo, Japan) 20070101

Title: Bepridil produces prominent bradycardia-dependent QT prolongation in patients with structural heart disease.

Journal: Journal of electrocardiology 20070101

Title: Proarrhythmic potential of reverse use-dependent drugs.

Journal: Journal of electrocardiology 20070101

Title: Elevation of intracellular ca(2+) concentration induced by hypoxia in retinal ganglion cells.

Journal: Japanese journal of ophthalmology 20070101

Title: Evaluation of the guinea pig monophasic action potential (MAP) assay in predicting drug-induced delay of ventricular repolarisation using 12 clinically documented drugs.

Journal: Journal of pharmacological and toxicological methods 20070101

Title: [Cardioversion of amiodarone-insensitive atrial fibrillation by bepridil in heart failure: two case reports].

Journal: Journal of cardiology 20061201

Title: The influence of sodium-calcium exchange inhibitors on rabbit lens ion balance and transparency.

Journal: Experimental eye research 20061101

Title: Studies of the effect of ionomycin on the KCNQ4 channel expressed in Xenopus oocytes.

Journal: Biochemical and biophysical research communications 20060915

Title: Pharmacological activation and inhibition of Slack (Slo2.2) channels.

Journal: Neuropharmacology 20060901

Title: Pharmacological cardioversion of persistent atrial fibrillation with and without a history of drug-resistant paroxysmal atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20060901

Title: Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization.

Journal: European journal of pharmacology 20060807

Title: Clinical evaluation of adverse effects during bepridil administration for atrial fibrillation and flutter.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Chronic hypoxia inhibits Na+/Ca2+ exchanger expression in cortical astrocytes.

Journal: Neuroreport 20060424

Title: [Strategy for cardiac arrhythmias in acute coronary syndrome].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060401

Title: Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias.

Journal: Biological & pharmaceutical bulletin 20060301

Title: [Present status in and prospects for anti-arrhythmic drug therapy: How to use type III anti-arrhythmic agents].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20060210

Title: [Clinical care for patients with possible Brugada syndrome].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20060210

Title: Role of the Na+/Ca2+ exchanger in calcium homeostasis and human sperm motility regulation.

Journal: Cell motility and the cytoskeleton 20060201

Title: Bepridil inhibits sub-acute phase of atrial electrical remodeling in canine rapid atrial stimulation model.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20060201

Title: Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection.

Journal: The Journal of pharmacology and experimental therapeutics 20060101

Title: [A case of drug-induced pneumonitis due to bepridil].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20060101

Title: Recurrence of atrial fibrillation after internal cardioversion of persistent atrial fibrillation: prognostic importance of electrophysiologic parameters.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20051201

Title: Involvement of Na+-Ca2+ exchanger in intracellular Ca2+ increase and neuronal injury induced by polychlorinated biphenyls in human neuroblastoma SH-SY5Y cells.

Journal: The Journal of pharmacology and experimental therapeutics 20051001

Title: Practical application of guinea pig telemetry system for QT evaluation.

Journal: The Journal of toxicological sciences 20050801

Title: Voltage-dependent and frequency-independent inhibition of recombinant Cav3.2 T-type Ca2+ channel by bepridil.

Journal: Pharmacology 20050701

Title: Repolarization dynamics in patients with idiopathic ventricular fibrillation: pharmacological therapy with bepridil and disopyramide.

Journal: Journal of cardiovascular pharmacology 20050601

Title: Fibrillation cycle length and fibrillatory rate obtained from peak frequency of fibrillation waves.

Journal: The American journal of cardiology 20050415

Title: Conversion and maintenance of sinus rhythm by bepridil in patients with persistent atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20050101

Title: Effects of Na+-Ca2+ exchanger activity on the alpha-amino-3-hydroxy-5-methyl-4-isoxazolone-propionate-induced Ca2+ influx in cerebellar Purkinje neurons.

Journal: Neuroscience 20050101

Title: Influence of different calcic antagonists on the Caco-2 cell monolayer integrity or 'TEER, a measurement of toxicity?'.

Journal: European journal of drug metabolism and pharmacokinetics 20050101

Title: Drug-induced changes in fibrillation cycle length and organization index can predict chemical cardioversion of long-lasting atrial fibrillation with bepridil alone or in combination with aprindine.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20041201

Title: Effects of blockers of Ca2+ channels and other ion channels on in vitro excystment of Paragonimus ohirai metacercariae induced by sodium cholate.

Journal: Parasitology research 20041101

Title: Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis.

Journal: Experimental neurology 20040901

Title: Maintenance of sinus rhythm and recovery of atrial mechanical function after cardioversion with bepridil or in combination with aprindine in long-lasting persistent atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20040901

Title: Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists.

Journal: Bioorganic & medicinal chemistry letters 20040716

Title: Atrial fibrillatory frequency, atrial fibrillatory rate, or atrial cycle length--does it matter?

Journal: The American journal of cardiology 20040701

Title: Evidence for a protective role played by the Na+/Ca2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats.

Journal: Neuropharmacology 20040301

Title: Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.

Journal: European journal of pharmacology 20040220

Title: Bepridil block of recombinant human cardiac IKs current shows a time-dependent unblock.

Journal: Journal of cardiovascular pharmacology 20040201

Title: A case of bepridil induced interstitial pneumonitis.

Journal: Heart (British Cardiac Society) 20031201

Title: Sodium-calcium exchange influences the response to endothelin-1 in lens epithelium.

Journal: Cell calcium 20030901

Title: A case of sick sinus syndrome that developed torsades de pointes, pacing failure and sensing failure during administration of bepridil.

Journal: Japanese heart journal 20030901

Title: Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm.

Journal: The American journal of cardiology 20030815

Title: Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration.

Journal: Annals of neurology 20030201

Title: Evaluation of the effect of bepridil on paroxysmal atrial fibrillation: relationship between efficacy and the f-f interval in surface ECG recordings.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20030101

Title: Bepridil prevents paroxysmal atrial fibrillation by a class III antiarrhythmic drug effect.

Journal: Pacing and clinical electrophysiology : PACE 20030101

Title: Transepithelial transport of bepridil in the human intestinal cell line, Caco-2, using a 'dynamic model'.

Journal: European journal of drug metabolism and pharmacokinetics 20030101

Title: Beta-blocker decreases the increase in QT dispersion and transmural dispersion of repolarization induced by bepridil.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20021101

Title: Na+/Ca2+ exchanger in Na+ efflux-Ca2+ influx mode of operation exerts a neuroprotective role in cellular models of in vitro anoxia and in vivo cerebral ischemia.

Journal: Annals of the New York Academy of Sciences 20021101

Title: Na(+)/Ca(2+) exchanger in porcine oocytes.

Journal: Biology of reproduction 20021001

Title: Possible role of calcium ions, calcium channels and calmodulin in excystation and metacystic development of Entamoeba invadens.

Journal: Parasitology research 20020901

Title: [Successful hybrid therapy combined with oral bepridil and ICD in a patient with amiodarone refractory life-threatening ventricular tachyarrhythmia associated with ischemic cardiomyopathy].

Journal: Journal of UOEH 20020901

Title: Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil.

Journal: The Journal of biological chemistry 20020823

Title: Assessment of pro-oxidant activity of foods by kinetic analysis of crocin bleaching.

Journal: Journal of agricultural and food chemistry 20020508

Title: Identification of radical scavengers in sweet grass (Hierochloe odorata).

Journal: Journal of agricultural and food chemistry 20020508

Title: On-line HPLC-DPPH screening method for evaluation of radical scavenging phenols extracted from apples (Malus domestica L.).

Journal: Journal of agricultural and food chemistry 20020424

Title: Antioxidant functions of selected allium thiosulfinates and S-alk(en)yl-L-cysteine sulfoxides.

Journal: Journal of agricultural and food chemistry 20020424

Title: Antioxidative activity and safety of the 50 ethanolic extract from red bean fermented by Bacillus subtilis IMR-NK1.

Journal: Journal of agricultural and food chemistry 20020410

Title: Comparison of radical scavenging effect, inhibition of microsomal oxygen free radical generation, and serum lipoprotein oxidation of several natural antioxidants.

Journal: Journal of agricultural and food chemistry 20020410

Title: Antioxidant properties of ferulic acid and its related compounds.

Journal: Journal of agricultural and food chemistry 20020327

Title: Free radical studies of ellagic acid, a natural phenolic antioxidant.

Journal: Journal of agricultural and food chemistry 20020327

Title: Free radical scavenging activity of red ginseng aqueous extracts.

Journal: Toxicology 20020320

Title: Free radical scavenging properties of wheat extracts.

Journal: Journal of agricultural and food chemistry 20020313

Title: Antioxidants from the bark of Burkea africana, an African medicinal plant.

Journal: Phytotherapy research : PTR 20020301

Title: Antioxidant capacities of ten edible North American plants.

Journal: Phytotherapy research : PTR 20020201

Title: Antioxidant enzymes and DPPH-radical scavenging activity in chilled and heat-shocked rice (Oryza sativa L.) seedlings radicles.

Journal: Journal of agricultural and food chemistry 20020130

Title: Antioxidant effects of 1,5-anhydro-D-fructose, a new natural sugar, in vitro.

Journal: Planta medica 20020101

Title: Role of Na(+)-Ca(2+) exchanger after traumatic or hypoxic/ischemic injury to spinal cord white matter.

Journal: The spine journal : official journal of the North American Spine Society 20020101

Title: A quinolone alkaloid with antioxidant activity from the aleurone layer of anthocyanin-pigmented rice.

Journal: Journal of natural products 20011201

Title: Inhibitory effect of bepridil on hKv1.5 channel current: comparison with amiodarone and E-4031.

Journal: European journal of pharmacology 20011102

Title: Antioxidant properties of methanolic extracts from several ear mushrooms.

Journal: Journal of agricultural and food chemistry 20011101

Title: Synthesis and in vitro studies of pyrone derivatives as scavengers of active oxygen species.

Journal: Arzneimittel-Forschung 20011101

Title: Scavenging of reactive oxygen species by chlorophyllin: an ESR study.

Journal: Free radical research 20011101

Title: Vasorelaxing and antioxidant constituents from Hernandia nymphaeifolia.

Journal: Planta medica 20011001

Title: Identification and antioxidant activity of novel chlorogenic acid derivatives from bamboo (Phyllostachys edulis).

Journal: Journal of agricultural and food chemistry 20011001

Title: Antioxidant activities of dioscorin, the storage protein of yam (Dioscorea batatas Decne) tuber.

Journal: Journal of agricultural and food chemistry 20011001

Title: Scavenging of free radicals, antimicrobial, and cytotoxic activities of the Maillard reaction products of beta-lactoglobulin glycated with several sugars.

Journal: Journal of agricultural and food chemistry 20011001

Title: DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity of flavonoids obtained from some medicinal plants.

Journal: Biological & pharmaceutical bulletin 20011001

Title: Antioxidative components from the aerial parts of Lactuca scariola L.

Journal: Archives of pharmacal research 20011001

Title: Superoxide- and 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activities of soyasaponin beta g related to gallic acid.

Journal: Bioscience, biotechnology, and biochemistry 20011001

Title: Sorbicillinol, a key intermediate of bisorbicillinoid biosynthesis in Trichoderma sp. USF-2690.

Journal: Bioscience, biotechnology, and biochemistry 20011001

Title: Interaction of bepridil with the cardiac troponin C/troponin I complex.

Journal: FEBS letters 20010928

Title: Antiradical and antilipoperoxidative effects of some plant extracts used by Sri Lankan traditional medical practitioners for cardioprotection.

Journal: Phytotherapy research : PTR 20010901

Title: Two new diterpenoids from Plectranthus nummularius Briq.

Journal: Chemical & pharmaceutical bulletin 20010901

Title: Inhibition of Na+/Ca2+ exchange with KB-R7943 or bepridil diminished mineral deposition by osteoblasts.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010801

Title: Phenolic constituents and antioxidant activity of an extract of Anthuriumversicolor leaves.

Journal: Journal of natural products 20010801

Title: Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia.

Journal: Journal of natural products 20010801

Title: Antioxidant principles from Bauhinia tarapotensis.

Journal: Journal of natural products 20010701

Title: [Bepridil inhibition on the delayed rectifier K+ currents in thyroxine induced hypertrophied guinea pig ventricular myocytes].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010701

Title: Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata.

Journal: Bioorganic & medicinal chemistry letters 20010618

Title: 2,2-Diphenyl-1-picrylhydrazyl hydrate, a stable free radical, is an alpha-glucosidase inhibitor.

Journal: Biological & pharmaceutical bulletin 20010601

Title: Alkaloids and flavonoids from peanut skins.

Journal: Planta medica 20010601

Title: Isolation and antioxidant activity of galloyl flavonol glycosides from the seashore plant, Pemphis acidula.

Journal: Bioscience, biotechnology, and biochemistry 20010601

Title: Effect of the antianginal drug bepridil on intracellular Ca2+ release and extracellular Ca2+ influx in human neutrophils.

Journal: International immunopharmacology 20010501

Title: A novel series of thromboxane A2 synthetase inhibitors with free radical scavenging and anti-peroxidative activities.

Journal: Chemical & pharmaceutical bulletin 20010501

Title: Radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl of ascorbic acid 2-glucoside (AA-2G) and 6-acyl-AA-2G.

Journal: Chemical & pharmaceutical bulletin 20010501

Title: Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages.

Journal: Biochemical pharmacology 20010415

Title: KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology.

Journal: American journal of physiology. Cell physiology 20010401

Title: Ionic mechanisms of aglycemic axon injury in mammalian central white matter.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010401

Title: A new antioxidant monoterpene glycoside, alpha-benzoyloxypaeoniflorin from Paeonia suffruticosa.

Journal: Archives of pharmacal research 20010401

Title: Blocking effect of bepridil on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes.

Journal: Japanese journal of pharmacology 20010401

Title: 1,1-Diphenyl-2-picrylhydrazyl radical-scavenging active compounds from greater cardamom (Amomum subulatum Roxb.).

Journal: Journal of nutritional science and vitaminology 20010401

Title: Expression and functional behavior of troponin C in soleus muscle fibers of rat after hindlimb unloading.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20010301

Title: Relationship between effects of phenolic compounds on the generation of free radicals from lactoperoxidase-catalyzed oxidation of NAD(P)H or GSH and their DPPH scavenging ability.

Journal: Chemical & pharmaceutical bulletin 20010301

Title: Antioxidant activities of buckwheat hull extract toward various oxidative stress in vitro and in vivo.

Journal: Biological & pharmaceutical bulletin 20010301

Title: The antioxidant activity of the essential oils of Artemisia afra, Artemisia abyssinica and Juniperus procera.

Journal: Phytotherapy research : PTR 20010301

Title: Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method.

Journal: Phytotherapy research : PTR 20010301

Title: Activation of Na(+), K(+), Cl(-)-cotransport mediates intracellular Ca(2+) increase and apoptosis induced by Pinacidil in HepG2 human hepatoblastoma cells.

Journal: Biochemical and biophysical research communications 20010223

Title: In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G.

Journal: Life sciences 20010209

Title: New bis-catechols 5-lipoxygenase inhibitors.

Journal: Bioorganic & medicinal chemistry 20010201

Title: Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits.

Journal: Atherosclerosis 20010101

Title: Antioxidant benzoylated flavan-3-ol glycoside from Celastrus orbiculatus.

Journal: Journal of natural products 20010101

Title: Effect of nilvadipine in weak acidic medium by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.

Journal: Arzneimittel-Forschung 20010101

Title: Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone.

Journal: Journal of Asian natural products research 20010101

Title: Screening of chemiluminescence constituents of cereals and DPPH radical scavenging activity of gamma-oryzanol.

Journal: Luminescence : the journal of biological and chemical luminescence 20010101

Title: Antioxidant activity of 5-alkoxymethyl-6-chromanols.

Journal: Redox report : communications in free radical research 20010101

Title: Assessment of antioxidant activity of some antileprotic drugs.

Journal: Arzneimittel-Forschung 20010101

Title: Electron spin resonance assessment of the antioxidant potential of medicinal plants. Part I. Contribution of anthocyanosides and flavonoids to the radical scavenging ability of fruit and herbal teas.

Journal: Acta poloniae pharmaceutica 20010101

Title: Evaluation of the absorption, excretion, and metabolism of the antihypertensive agent RWJ-26899 in male and female CR Wistar rats and Beagle dogs.

Journal: European journal of drug metabolism and pharmacokinetics 20010101

Title: Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities.

Journal: Anticancer research 20010101

Title: [Bepridil: importance of serum level in treatment surveillance].

Journal: Presse medicale (Paris, France : 1983) 20000401

Title: Propranolol and bepridil attenuating levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation.

Journal: Zhongguo yao li xue bao = Acta pharmacologica Sinica 19961101

Title: Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs.

Journal: JAMA 19931201

Title: Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance.

Journal: Arzneimittel-Forschung 19930301

Title: Safety profile of bepridil determined from clinical trials in chronic stable angina in the United States.

Journal: The American journal of cardiology 19920409

Title: Evaluation of bepridil efficacy by electrophysiologic testing in patients with recurrent ventricular tachycardia: comparison of two regimens.

Journal: Cardiovascular drugs and therapy 19920401

Title: Effects of bepridil and CERM 4205 (ORG 30701) on the relation between cardiac cycle length and QT duration in healthy volunteers.

Journal: The American journal of cardiology 19900901

Title: Effects of calcium entry blockers on blood pressure and heart rate in neurogenic hypertensive dogs.

Journal: Fundamental & clinical pharmacology 19870101

Title: Alterations in contrast medium-induced coronary reactive hyperemia after bepridil in patients with coronary artery disease.

Journal: American heart journal 19850201

Title: Bepridil for recurrent sustained ventricular tachycardias: assessment using electrophysiologic testing.

Journal: The American journal of cardiology 19840901

Title: Studies on the bradycardia induced by bepridil.

Journal: British journal of pharmacology 19820201

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Tags:74764-40-2 Molecular Formula|74764-40-2 MDL|74764-40-2 SMILES|74764-40-2 Bepridil hydrochloride
Catalog No.: AA005H7K
74764-40-2,MFCD00242668
74764-40-2 | Bepridil hydrochloride
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Technical Information
Catalog Number: AA005H7K
Chemical Name: Bepridil hydrochloride
CAS Number: 74764-40-2
Molecular Formula: C24H35ClN2O
Molecular Weight: 403.0005
MDL Number: MFCD00242668
SMILES: CC(COCC(N1CCCC1)CN(c1ccccc1)Cc1ccccc1)C.Cl
NSC Number: 758390
Properties
Complexity: 382  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 28  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 10  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Stabilization of Kv1.5 channel protein by bepridil through its action as a chemical chaperone.

Journal: European journal of pharmacology20121205

Title: Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats.

Journal: Journal of cellular and molecular medicine20121101

Title: Bepridil is effective and improves QOL in multidrug-resistant paroxysmal atrial fibrillation.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.)20121101

Title: Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.

Journal: Journal of cardiovascular pharmacology20120801

Title: Effectiveness of amiodarone versus bepridil in achieving conversion to sinus rhythm in patients with persistent atrial fibrillation: a randomised trial.

Journal: Heart (British Cardiac Society)20120701

Title: Combined effects of up- and downstream therapies on atrial fibrillation in a canine rapid stimulation model.

Journal: International journal of cardiology20120531

Title: The relationship between the plasma concentration of bepridil and its efficacy in the treatment of atrial fibrillation in Japanese patients.

Journal: Biological & pharmaceutical bulletin20120101

Title: [Series: Clinical study from Japan and its reflections; J-BAF study].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine20110810

Title: Molecular dynamics and docking studies on cardiac troponin C.

Journal: Journal of biomolecular structure & dynamics20110801

Title: An LC method for quantifying bepridil in human plasma using 1-naphthol as the internal standard.

Journal: Journal of chromatographic science20110801

Title: In vitro and experimental therapeutic studies of the calcium channel blocker bepridil: detection of viable Leishmania (L.) chagasi by real-time PCR.

Journal: Experimental parasitology20110601

Title: A computational and experimental approach to investigate bepridil binding with cardiac troponin.

Journal: The journal of physical chemistry. B20110317

Title: Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110202

Title: Bepridil facilitates early termination of spiral-wave reentry in two-dimensional cardiac muscle through an increase of intercellular electrical coupling.

Journal: Journal of pharmacological sciences20110101

Title: Clinical outcome in patients with paroxysmal or persistent atrial fibrillation receiving bepridil.

Journal: Circulation journal : official journal of the Japanese Circulation Society20110101

Title: Repetitive evaluation of fibrillation cycle length predicts the efficacy of bepridil for interruption of long-lasting persistent atrial fibrillation.

Journal: International heart journal20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Efficacy of low-dose bepridil for prevention of ventricular fibrillation in patients with Brugada syndrome with and without SCN5A mutation.

Journal: Journal of cardiovascular pharmacology20101001

Title: Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog.

Journal: Pacing and clinical electrophysiology : PACE20100801

Title: Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20100711

Title: Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20100630

Title: Candesartan decreases type III procollagen-N-peptide levels and inflammatory marker levels and maintains sinus rhythm in patients with atrial fibrillation.

Journal: Journal of cardiovascular pharmacology20100501

Title: Importance of morphological changes in T-U waves during bepridil therapy as a predictor of ventricular arrhythmic event.

Journal: Circulation journal : official journal of the Japanese Circulation Society20100501

Title: Effect of bepridil in atrial fibrillation inducibility facilitated by vagal nerve stimulation. - Prevention of vagal nerve activation-induced shortening of the atrial action potential duration -.

Journal: Circulation journal : official journal of the Japanese Circulation Society20100501

Title: Inhibition of Listeria monocytogenes infection by neurological drugs.

Journal: International journal of antimicrobial agents20100301

Title: [Best strategy for the treatment of atrial fibrillation: reconsideration after randomized multicenter clinical trials in Japan].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica20100201

Title: Pharmacological cardioversion preceding left atrial ablation: bepridil predicts the clinical outcome following ablation in patients with persistent atrial fibrillation.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology20091201

Title: Opposing effects of bepridil on ventricular repolarization in humans. Inhomogeneous prolongation of the action potential duration vs flattening of its restitution kinetics.

Journal: Circulation journal : official journal of the Japanese Circulation Society20090901

Title: Two patients with bepridil-induced interstitial pneumonia.

Journal: Circulation journal : official journal of the Japanese Circulation Society20090701

Title: Predicting the efficacy of antiarrhythmic agents for interrupting persistent atrial fibrillation according to spectral analysis of the fibrillation waves on the surface ECG.

Journal: Circulation journal : official journal of the Japanese Circulation Society20090701

Title: Dose-response effects of bepridil in patients with persistent atrial fibrillation monitored with transtelephonic electrocardiograms: a multicenter, randomized, placebo-controlled,double-blind study (J-BAF Study).

Journal: Circulation journal : official journal of the Japanese Circulation Society20090601

Title: Bepridil up-regulates cardiac Na+ channels as a long-term effect by blunting proteasome signals through inhibition of calmodulin activity.

Journal: British journal of pharmacology20090601

Title: Does bepridil create a paradigm shift in the treatment of persistent atrial fibrillation?

Journal: Circulation journal : official journal of the Japanese Circulation Society20090601

Title: Effect of compound plate composition on measurement of hERG current IC(50) using PatchXpress.

Journal: Journal of pharmacological and toxicological methods20090101

Title: Gradual progression of interstitial pneumonia induced by bepridil.

Journal: Internal medicine (Tokyo, Japan)20090101

Title: Beat-to-beat variability of repolarization differentiates the extent of torsadogenic potential of multi ion channel-blockers bepridil and amiodarone.

Journal: European journal of pharmacology20081031

Title: Comparison of electropharmacological effects of bepridil and sotalol in halothane-anesthetized dogs.

Journal: Circulation journal : official journal of the Japanese Circulation Society20080601

Title: Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm.

Journal: Circulation journal : official journal of the Japanese Circulation Society20080501

Title: [Role of apoptosis in the kidney after reperfusion].

Journal: Orvosi hetilap20080217

Title: Inhomogenic effect of bepridil on atrial electrical remodeling in a canine rapid atrial stimulation model.

Journal: Circulation journal : official journal of the Japanese Circulation Society20080201

Title: Combination therapy of renin angiotensin system inhibitors and bepridil is useful for maintaining sinus rhythm in patients with atrial fibrillation.

Journal: Journal of cardiology20071201

Title: Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation.

Journal: Journal of cardiovascular pharmacology20070901

Title: Neuronal preconditioning with the antianginal drug, bepridil.

Journal: Journal of neurochemistry20070801

Title: Efficacy and safety of the additional bepridil treatment in patients with atrial fibrillation refractory to class I antiarrhythmic drugs.

Journal: Circulation journal : official journal of the Japanese Circulation Society20070801

Title: Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia.

Journal: Journal of cardiovascular electrophysiology20070701

Title: Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons.

Journal: Neuroscience20070425

Title: Na+/Ca2+ exchanger inhibitors modify the accumulation of tumor-diagnostic PET tracers in cancer cells.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20070101

Title: Bepridil for drug-refractory ventricular tachyarrhythmias.

Journal: Internal medicine (Tokyo, Japan)20070101

Title: Bepridil produces prominent bradycardia-dependent QT prolongation in patients with structural heart disease.

Journal: Journal of electrocardiology20070101

Title: Proarrhythmic potential of reverse use-dependent drugs.

Journal: Journal of electrocardiology20070101

Title: Elevation of intracellular ca(2+) concentration induced by hypoxia in retinal ganglion cells.

Journal: Japanese journal of ophthalmology20070101

Title: Evaluation of the guinea pig monophasic action potential (MAP) assay in predicting drug-induced delay of ventricular repolarisation using 12 clinically documented drugs.

Journal: Journal of pharmacological and toxicological methods20070101

Title: [Cardioversion of amiodarone-insensitive atrial fibrillation by bepridil in heart failure: two case reports].

Journal: Journal of cardiology20061201

Title: The influence of sodium-calcium exchange inhibitors on rabbit lens ion balance and transparency.

Journal: Experimental eye research20061101

Title: Studies of the effect of ionomycin on the KCNQ4 channel expressed in Xenopus oocytes.

Journal: Biochemical and biophysical research communications20060915

Title: Pharmacological activation and inhibition of Slack (Slo2.2) channels.

Journal: Neuropharmacology20060901

Title: Pharmacological cardioversion of persistent atrial fibrillation with and without a history of drug-resistant paroxysmal atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society20060901

Title: Iron ions derived from the nitric oxide donor sodium nitroprusside inhibit mineralization.

Journal: European journal of pharmacology20060807

Title: Clinical evaluation of adverse effects during bepridil administration for atrial fibrillation and flutter.

Journal: Circulation journal : official journal of the Japanese Circulation Society20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Chronic hypoxia inhibits Na+/Ca2+ exchanger expression in cortical astrocytes.

Journal: Neuroreport20060424

Title: [Strategy for cardiac arrhythmias in acute coronary syndrome].

Journal: Nihon rinsho. Japanese journal of clinical medicine20060401

Title: Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias.

Journal: Biological & pharmaceutical bulletin20060301

Title: [Present status in and prospects for anti-arrhythmic drug therapy: How to use type III anti-arrhythmic agents].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine20060210

Title: [Clinical care for patients with possible Brugada syndrome].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine20060210

Title: Role of the Na+/Ca2+ exchanger in calcium homeostasis and human sperm motility regulation.

Journal: Cell motility and the cytoskeleton20060201

Title: Bepridil inhibits sub-acute phase of atrial electrical remodeling in canine rapid atrial stimulation model.

Journal: Circulation journal : official journal of the Japanese Circulation Society20060201

Title: Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection.

Journal: The Journal of pharmacology and experimental therapeutics20060101

Title: [A case of drug-induced pneumonitis due to bepridil].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society20060101

Title: Recurrence of atrial fibrillation after internal cardioversion of persistent atrial fibrillation: prognostic importance of electrophysiologic parameters.

Journal: Circulation journal : official journal of the Japanese Circulation Society20051201

Title: Involvement of Na+-Ca2+ exchanger in intracellular Ca2+ increase and neuronal injury induced by polychlorinated biphenyls in human neuroblastoma SH-SY5Y cells.

Journal: The Journal of pharmacology and experimental therapeutics20051001

Title: Practical application of guinea pig telemetry system for QT evaluation.

Journal: The Journal of toxicological sciences20050801

Title: Voltage-dependent and frequency-independent inhibition of recombinant Cav3.2 T-type Ca2+ channel by bepridil.

Journal: Pharmacology20050701

Title: Repolarization dynamics in patients with idiopathic ventricular fibrillation: pharmacological therapy with bepridil and disopyramide.

Journal: Journal of cardiovascular pharmacology20050601

Title: Fibrillation cycle length and fibrillatory rate obtained from peak frequency of fibrillation waves.

Journal: The American journal of cardiology20050415

Title: Conversion and maintenance of sinus rhythm by bepridil in patients with persistent atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society20050101

Title: Effects of Na+-Ca2+ exchanger activity on the alpha-amino-3-hydroxy-5-methyl-4-isoxazolone-propionate-induced Ca2+ influx in cerebellar Purkinje neurons.

Journal: Neuroscience20050101

Title: Influence of different calcic antagonists on the Caco-2 cell monolayer integrity or 'TEER, a measurement of toxicity?'.

Journal: European journal of drug metabolism and pharmacokinetics20050101

Title: Drug-induced changes in fibrillation cycle length and organization index can predict chemical cardioversion of long-lasting atrial fibrillation with bepridil alone or in combination with aprindine.

Journal: Circulation journal : official journal of the Japanese Circulation Society20041201

Title: Effects of blockers of Ca2+ channels and other ion channels on in vitro excystment of Paragonimus ohirai metacercariae induced by sodium cholate.

Journal: Parasitology research20041101

Title: Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis.

Journal: Experimental neurology20040901

Title: Maintenance of sinus rhythm and recovery of atrial mechanical function after cardioversion with bepridil or in combination with aprindine in long-lasting persistent atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society20040901

Title: Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists.

Journal: Bioorganic & medicinal chemistry letters20040716

Title: Atrial fibrillatory frequency, atrial fibrillatory rate, or atrial cycle length--does it matter?

Journal: The American journal of cardiology20040701

Title: Evidence for a protective role played by the Na+/Ca2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats.

Journal: Neuropharmacology20040301

Title: Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.

Journal: European journal of pharmacology20040220

Title: Bepridil block of recombinant human cardiac IKs current shows a time-dependent unblock.

Journal: Journal of cardiovascular pharmacology20040201

Title: A case of bepridil induced interstitial pneumonitis.

Journal: Heart (British Cardiac Society)20031201

Title: Sodium-calcium exchange influences the response to endothelin-1 in lens epithelium.

Journal: Cell calcium20030901

Title: A case of sick sinus syndrome that developed torsades de pointes, pacing failure and sensing failure during administration of bepridil.

Journal: Japanese heart journal20030901

Title: Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm.

Journal: The American journal of cardiology20030815

Title: Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration.

Journal: Annals of neurology20030201

Title: Evaluation of the effect of bepridil on paroxysmal atrial fibrillation: relationship between efficacy and the f-f interval in surface ECG recordings.

Journal: Circulation journal : official journal of the Japanese Circulation Society20030101

Title: Bepridil prevents paroxysmal atrial fibrillation by a class III antiarrhythmic drug effect.

Journal: Pacing and clinical electrophysiology : PACE20030101

Title: Transepithelial transport of bepridil in the human intestinal cell line, Caco-2, using a 'dynamic model'.

Journal: European journal of drug metabolism and pharmacokinetics20030101

Title: Beta-blocker decreases the increase in QT dispersion and transmural dispersion of repolarization induced by bepridil.

Journal: Circulation journal : official journal of the Japanese Circulation Society20021101

Title: Na+/Ca2+ exchanger in Na+ efflux-Ca2+ influx mode of operation exerts a neuroprotective role in cellular models of in vitro anoxia and in vivo cerebral ischemia.

Journal: Annals of the New York Academy of Sciences20021101

Title: Na(+)/Ca(2+) exchanger in porcine oocytes.

Journal: Biology of reproduction20021001

Title: Possible role of calcium ions, calcium channels and calmodulin in excystation and metacystic development of Entamoeba invadens.

Journal: Parasitology research20020901

Title: [Successful hybrid therapy combined with oral bepridil and ICD in a patient with amiodarone refractory life-threatening ventricular tachyarrhythmia associated with ischemic cardiomyopathy].

Journal: Journal of UOEH20020901

Title: Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil.

Journal: The Journal of biological chemistry20020823

Title: Assessment of pro-oxidant activity of foods by kinetic analysis of crocin bleaching.

Journal: Journal of agricultural and food chemistry20020508

Title: Identification of radical scavengers in sweet grass (Hierochloe odorata).

Journal: Journal of agricultural and food chemistry20020508

Title: On-line HPLC-DPPH screening method for evaluation of radical scavenging phenols extracted from apples (Malus domestica L.).

Journal: Journal of agricultural and food chemistry20020424

Title: Antioxidant functions of selected allium thiosulfinates and S-alk(en)yl-L-cysteine sulfoxides.

Journal: Journal of agricultural and food chemistry20020424

Title: Antioxidative activity and safety of the 50 ethanolic extract from red bean fermented by Bacillus subtilis IMR-NK1.

Journal: Journal of agricultural and food chemistry20020410

Title: Comparison of radical scavenging effect, inhibition of microsomal oxygen free radical generation, and serum lipoprotein oxidation of several natural antioxidants.

Journal: Journal of agricultural and food chemistry20020410

Title: Antioxidant properties of ferulic acid and its related compounds.

Journal: Journal of agricultural and food chemistry20020327

Title: Free radical studies of ellagic acid, a natural phenolic antioxidant.

Journal: Journal of agricultural and food chemistry20020327

Title: Free radical scavenging activity of red ginseng aqueous extracts.

Journal: Toxicology20020320

Title: Free radical scavenging properties of wheat extracts.

Journal: Journal of agricultural and food chemistry20020313

Title: Antioxidants from the bark of Burkea africana, an African medicinal plant.

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Title: Antioxidant capacities of ten edible North American plants.

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Title: Antioxidant enzymes and DPPH-radical scavenging activity in chilled and heat-shocked rice (Oryza sativa L.) seedlings radicles.

Journal: Journal of agricultural and food chemistry20020130

Title: Antioxidant effects of 1,5-anhydro-D-fructose, a new natural sugar, in vitro.

Journal: Planta medica20020101

Title: Role of Na(+)-Ca(2+) exchanger after traumatic or hypoxic/ischemic injury to spinal cord white matter.

Journal: The spine journal : official journal of the North American Spine Society20020101

Title: A quinolone alkaloid with antioxidant activity from the aleurone layer of anthocyanin-pigmented rice.

Journal: Journal of natural products20011201

Title: Inhibitory effect of bepridil on hKv1.5 channel current: comparison with amiodarone and E-4031.

Journal: European journal of pharmacology20011102

Title: Antioxidant properties of methanolic extracts from several ear mushrooms.

Journal: Journal of agricultural and food chemistry20011101

Title: Synthesis and in vitro studies of pyrone derivatives as scavengers of active oxygen species.

Journal: Arzneimittel-Forschung20011101

Title: Scavenging of reactive oxygen species by chlorophyllin: an ESR study.

Journal: Free radical research20011101

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Journal: Planta medica20011001

Title: Identification and antioxidant activity of novel chlorogenic acid derivatives from bamboo (Phyllostachys edulis).

Journal: Journal of agricultural and food chemistry20011001

Title: Antioxidant activities of dioscorin, the storage protein of yam (Dioscorea batatas Decne) tuber.

Journal: Journal of agricultural and food chemistry20011001

Title: Scavenging of free radicals, antimicrobial, and cytotoxic activities of the Maillard reaction products of beta-lactoglobulin glycated with several sugars.

Journal: Journal of agricultural and food chemistry20011001

Title: DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity of flavonoids obtained from some medicinal plants.

Journal: Biological & pharmaceutical bulletin20011001

Title: Antioxidative components from the aerial parts of Lactuca scariola L.

Journal: Archives of pharmacal research20011001

Title: Superoxide- and 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activities of soyasaponin beta g related to gallic acid.

Journal: Bioscience, biotechnology, and biochemistry20011001

Title: Sorbicillinol, a key intermediate of bisorbicillinoid biosynthesis in Trichoderma sp. USF-2690.

Journal: Bioscience, biotechnology, and biochemistry20011001

Title: Interaction of bepridil with the cardiac troponin C/troponin I complex.

Journal: FEBS letters20010928

Title: Antiradical and antilipoperoxidative effects of some plant extracts used by Sri Lankan traditional medical practitioners for cardioprotection.

Journal: Phytotherapy research : PTR20010901

Title: Two new diterpenoids from Plectranthus nummularius Briq.

Journal: Chemical & pharmaceutical bulletin20010901

Title: Inhibition of Na+/Ca2+ exchange with KB-R7943 or bepridil diminished mineral deposition by osteoblasts.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research20010801

Title: Phenolic constituents and antioxidant activity of an extract of Anthuriumversicolor leaves.

Journal: Journal of natural products20010801

Title: Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia.

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Title: Antioxidant principles from Bauhinia tarapotensis.

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Title: [Bepridil inhibition on the delayed rectifier K+ currents in thyroxine induced hypertrophied guinea pig ventricular myocytes].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20010701

Title: Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata.

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Title: 2,2-Diphenyl-1-picrylhydrazyl hydrate, a stable free radical, is an alpha-glucosidase inhibitor.

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Title: Isolation and antioxidant activity of galloyl flavonol glycosides from the seashore plant, Pemphis acidula.

Journal: Bioscience, biotechnology, and biochemistry20010601

Title: Effect of the antianginal drug bepridil on intracellular Ca2+ release and extracellular Ca2+ influx in human neutrophils.

Journal: International immunopharmacology20010501

Title: A novel series of thromboxane A2 synthetase inhibitors with free radical scavenging and anti-peroxidative activities.

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Title: Radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl of ascorbic acid 2-glucoside (AA-2G) and 6-acyl-AA-2G.

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Title: Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages.

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Title: Ionic mechanisms of aglycemic axon injury in mammalian central white matter.

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Title: A new antioxidant monoterpene glycoside, alpha-benzoyloxypaeoniflorin from Paeonia suffruticosa.

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Title: 1,1-Diphenyl-2-picrylhydrazyl radical-scavenging active compounds from greater cardamom (Amomum subulatum Roxb.).

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Title: Expression and functional behavior of troponin C in soleus muscle fibers of rat after hindlimb unloading.

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Title: Relationship between effects of phenolic compounds on the generation of free radicals from lactoperoxidase-catalyzed oxidation of NAD(P)H or GSH and their DPPH scavenging ability.

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Title: Antioxidant activities of buckwheat hull extract toward various oxidative stress in vitro and in vivo.

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Title: The antioxidant activity of the essential oils of Artemisia afra, Artemisia abyssinica and Juniperus procera.

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Title: Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method.

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Title: Activation of Na(+), K(+), Cl(-)-cotransport mediates intracellular Ca(2+) increase and apoptosis induced by Pinacidil in HepG2 human hepatoblastoma cells.

Journal: Biochemical and biophysical research communications20010223

Title: In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G.

Journal: Life sciences20010209

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Journal: Atherosclerosis20010101

Title: Antioxidant benzoylated flavan-3-ol glycoside from Celastrus orbiculatus.

Journal: Journal of natural products20010101

Title: Effect of nilvadipine in weak acidic medium by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.

Journal: Arzneimittel-Forschung20010101

Title: Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone.

Journal: Journal of Asian natural products research20010101

Title: Screening of chemiluminescence constituents of cereals and DPPH radical scavenging activity of gamma-oryzanol.

Journal: Luminescence : the journal of biological and chemical luminescence20010101

Title: Antioxidant activity of 5-alkoxymethyl-6-chromanols.

Journal: Redox report : communications in free radical research20010101

Title: Assessment of antioxidant activity of some antileprotic drugs.

Journal: Arzneimittel-Forschung20010101

Title: Electron spin resonance assessment of the antioxidant potential of medicinal plants. Part I. Contribution of anthocyanosides and flavonoids to the radical scavenging ability of fruit and herbal teas.

Journal: Acta poloniae pharmaceutica20010101

Title: Evaluation of the absorption, excretion, and metabolism of the antihypertensive agent RWJ-26899 in male and female CR Wistar rats and Beagle dogs.

Journal: European journal of drug metabolism and pharmacokinetics20010101

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Journal: Anticancer research20010101

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Journal: Presse medicale (Paris, France : 1983)20000401

Title: Propranolol and bepridil attenuating levothyroxine-induced rat cardiac hypertrophy and mitochondrial Ca2+ Mg(2+)-ATPase activity elevation.

Journal: Zhongguo yao li xue bao = Acta pharmacologica Sinica19961101

Title: Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs.

Journal: JAMA19931201

Title: Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance.

Journal: Arzneimittel-Forschung19930301

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Journal: The American journal of cardiology19920409

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