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81846-19-7,MFCD00888847
Catalog No.:AA005HQU

81846-19-7 | Rumodolin

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Purity
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Price(USD)
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1mg
98%
in stock  
$25.00   $18.00
- +
10mg
98%
in stock  
$78.00   $55.00
- +
50mg
95%
in stock  
$311.00   $218.00
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100mg
95%
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$443.00   $310.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA005HQU
Chemical Name:
Rumodolin
CAS Number:
81846-19-7
Molecular Formula:
C23H34O5
Molecular Weight:
390.5131
MDL Number:
MFCD00888847
SMILES:
CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O
Properties
Properties
 
BP:
587.1°C at 760 mmHg  
Form:
Solid  
MP:
>113°C (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
495  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
XLogP3:
4.5  

Downstream Synthesis Route

[1]Patent:CN106831680,2017,A.Locationinpatent:Paragraph0108;0119;0120;0121

[2]JournalofOrganicChemistry,2004,vol.69,p.1890-1902

[3]Patent:US2013/53581,2013,A1.Locationinpatent:Paragraph0187

[4]Patent:EP2581361,2013,A1.Locationinpatent:Paragraph0183;0184

[5]Patent:US2009/163738,2009,A1.Locationinpatent:Page/Pagecolumn5-6

[1]JournalofOrganicChemistry,2004,vol.69,p.1890-1902

[2]OrganicandBiomolecularChemistry,2019,vol.17,p.9489-9501

[1]JournalofOrganicChemistry,2004,vol.69,p.1890-1902

[1]JournalofOrganicChemistry,2004,vol.69,p.1890-1902

[2]Patent:WO2012/9816,2012,A1

[3]Patent:WO2012/88607,2012,A1

[4]Patent:US2013/53581,2013,A1

[5]Patent:EP2581361,2013,A1

[6]Patent:US2013/331593,2013,A1

[7]Patent:WO2014/89385,2014,A2

[8]Patent:WO2015/73314,2015,A1

[9]Patent:WO2016/55819,2016,A1

[10]Patent:US2016/152548,2016,A1

[11]Patent:CN106831680,2017,A

[12]Patent:CN107602376,2018,A

[13]Patent:CN107602376,2018,A

[1]Patent:WO2019/171093,2019,A2.Locationinpatent:Page/Pagecolumn14;15;16;17

[2]Patent:US2009/163738,2009,A1.Locationinpatent:Page/Pagecolumn6-7

[3]Patent:WO2014/89385,2014,A2.Locationinpatent:Paragraph0435-0436

[4]Patent:US2015/259274,2015,A1.Locationinpatent:Paragraph0098

[5]Patent:US2016/152548,2016,A1.Locationinpatent:Paragraph0059;0079;0080

Literature

Title: Novel homozygous BMP9 nonsense mutation causes pulmonary arterial hypertension: a case report.

Journal: BMC pulmonary medicine 20160101

Title: Prostaglandin I(2) analogues enhance already exuberant Th17 cell responses in systemic sclerosis.

Journal: Annals of the rheumatic diseases 20121201

Title: Pathways in pulmonary arterial hypertension: the future is here.

Journal: European respiratory review : an official journal of the European Respiratory Society 20121201

Title: Safety and efficacy of transition from systemic prostanoids to inhaled treprostinil in pulmonary arterial hypertension.

Journal: The American journal of cardiology 20121115

Title: Experiences with treprostinil in the treatment of pulmonary arterial hypertension.

Journal: Therapeutic advances in respiratory disease 20121001

Title: Bloodstream infections in patients with pulmonary arterial hypertension treated with intravenous prostanoids: insights from the REVEAL REGISTRY®.

Journal: Mayo Clinic proceedings 20120901

Title: Baseline NT-proBNP correlates with change in 6-minute walk distance in patients with pulmonary arterial hypertension in the pivotal inhaled treprostinil study TRIUMPH-1.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20120801

Title: Long-term treatment, tolerability, and survival with sub-cutaneous treprostinil for severe pulmonary hypertension.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20120701

Title: Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist.

Journal: Biochemical pharmacology 20120701

Title: Treatment with sildenafil and treprostinil allows successful liver transplantation of patients with moderate to severe portopulmonary hypertension.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20120601

Title: Inhaled treprostinil for the treatment of pulmonary arterial hypertension.

Journal: Expert review of respiratory medicine 20120601

Title: Cost effectiveness of prostacyclins in pulmonary arterial hypertension.

Journal: Applied health economics and health policy 20120501

Title: Pulmonary arterial hypertension in the setting of pregnancy: a case series and standard treatment approach.

Journal: Lung 20120401

Title: Prognostic factors in severe pulmonary hypertension patients who need parenteral prostanoid therapy: the impact of late referral.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20120401

Title: Peroxisome proliferator-activated receptor-β/δ, the acute signaling factor in prostacyclin-induced pulmonary vasodilation.

Journal: American journal of respiratory cell and molecular biology 20120301

Title: [Progress in pharmacotherapy of pulmonary arterial hypertension in children].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20120301

Title: Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel.

Journal: American journal of physiology. Heart and circulatory physiology 20120201

Title: The effect of diluent pH on bloodstream infection rates in patients receiving IV treprostinil for pulmonary arterial hypertension.

Journal: Chest 20120101

Title: Effect of prostaglandin I2 analogs on cytokine expression in human myeloid dendritic cells via epigenetic regulation.

Journal: Molecular medicine (Cambridge, Mass.) 20120101

Title: Inhaled treprostinil: a therapeutic review.

Journal: Drug design, development and therapy 20120101

Title: Smooth muscle myosin inhibition: a novel therapeutic approach for pulmonary hypertension.

Journal: PloS one 20120101

Title: Long-term effects of inhaled treprostinil in patients with pulmonary arterial hypertension: the Treprostinil Sodium Inhalation Used in the Management of Pulmonary Arterial Hypertension (TRIUMPH) study open-label extension.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20111201

Title: Inhaled treprostinil for the treatment of pulmonary arterial hypertension.

Journal: Critical care nurse 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20111101

Title: Inhaled treprostinil sodium for the treatment of pulmonary arterial hypertension.

Journal: Expert opinion on pharmacotherapy 20111101

Title: Treprostinil inhibits the adhesion and differentiation of fibrocytes via the cyclic adenosine monophosphate-dependent and Ras-proximate protein-dependent inactivation of extracellular regulated kinase.

Journal: American journal of respiratory cell and molecular biology 20111001

Title: Prostaglandin I2 analogs suppress tumor necrosis factor α production and the maturation of human monocyte-derived dendritic cells.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20111001

Title: Cutaneous reaction to inhaled treprostinil.

Journal: Journal of the American Academy of Dermatology 20111001

Title: Prognostic factors associated with increased survival in patients with pulmonary arterial hypertension treated with subcutaneous treprostinil in randomized, placebo-controlled trials.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110901

Title: Differential response to intravenous prostacyclin analog therapy in patients with pulmonary arterial hypertension.

Journal: Pulmonary pharmacology & therapeutics 20110801

Title: Prostaglandin I(2) analogues suppress TNF-α expression in human monocytes via mitogen-activated protein kinase pathway.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110701

Title: [Treatment of idiopathic pulmonary arterial hypertension].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20110701

Title: The potential for inhaled treprostinil in the treatment of pulmonary arterial hypertension.

Journal: Therapeutic advances in respiratory disease 20110601

Title: Add-on therapy with subcutaneous treprostinil for refractory pediatric pulmonary hypertension.

Journal: The Journal of pediatrics 20110401

Title: Constrictive-like physiology in severe pulmonary hypertension: the effect of the Valsalva maneuver.

Journal: Southern medical journal 20110401

Title: Treprostinil increases the number and angiogenic potential of endothelial progenitor cells in children with pulmonary hypertension.

Journal: Angiogenesis 20110301

Title: Cathodal iontophoresis of treprostinil and iloprost induces a sustained increase in cutaneous flux in rats.

Journal: British journal of pharmacology 20110201

Title: Portopulmonary hypertension as an indication for combined heart, lung, and liver or lung and liver transplantation: literature review and case presentation.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20110201

Title: Effects of PGI2 analogues on Th1- and Th2-related chemokines in monocytes via epigenetic regulation.

Journal: Journal of molecular medicine (Berlin, Germany) 20110101

Title: Overview of current therapeutic approaches for pulmonary hypertension.

Journal: Pulmonary circulation 20110101

Title: [The man from the kingdom of the near-dead - modern treatment of pulmonary hypertension].

Journal: Kardiologia polska 20110101

Title: Pulmonary thromboendarterectomy after treatment with treprostenil in a chronic thromboembolic pulmonary hypertension patient: a case report.

Journal: International journal of general medicine 20110101

Title: Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension.

Journal: The European respiratory journal 20101201

Title: Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension.

Journal: American journal of respiratory and critical care medicine 20101101

Title: Subcutaneous treprostinil in pulmonary arterial hypertension: Practical considerations.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20101101

Title: The Adult Patient with Eisenmenger Syndrome: A Medical Update after Dana Point Part II: Medical Treatment - Study Results.

Journal: Current cardiology reviews 20101101

Title: Prostaglandin I(2) analogues enhance growth-related oncogene-alpha expression in human monocyte-derived dendritic cells.

Journal: Inflammation 20101001

Title: Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function.

Journal: The Journal of pharmacology and experimental therapeutics 20101001

Title: Prostacyclin administration errors in pulmonary arterial hypertension patients admitted to hospitals in the United States: a national survey.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20100801

Title: Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.

Journal: Circulation research 20100723

Title: Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers.

Journal: Journal of clinical pharmacology 20100701

Title: Stability and antimicrobial effectiveness of treprostinil sodium in Sterile Diluent for Flolan.

Journal: International journal of clinical practice 20100601

Title: Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial.

Journal: Journal of the American College of Cardiology 20100504

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100501

Title: Targeting of the prostacyclin specific IP1 receptor in lungs with molecular conjugates comprising prostaglandin I2 analogues.

Journal: Biomaterials 20100401

Title: Prostacyclin in the intensive care setting.

Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100301

Title: Exercise improvement and plasma biomarker changes with intravenous treprostinil therapy for pulmonary arterial hypertension: a placebo-controlled trial.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20100201

Title: The globalization of clinical trials in pulmonary arterial hypertension.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20100201

Title: Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis.

Journal: Respiratory research 20100101

Title: Hemodynamics in pulmonary arterial hypertension (PAH): do they explain long-term clinical outcomes with PAH-specific therapy?

Journal: BMC cardiovascular disorders 20100101

Title: The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension.

Journal: PloS one 20100101

Title: Inhaled treprostinil and pulmonary arterial hypertension.

Journal: Vascular health and risk management 20100101

Title: Closed-hub systems with protected connections and the reduction of risk of catheter-related bloodstream infection in pediatric patients receiving intravenous prostanoid therapy for pulmonary hypertension.

Journal: Infection control and hospital epidemiology 20090901

Title: Treprostinil to reverse pulmonary hypertension associated with idiopathic pulmonary fibrosis as a bridge to single-lung transplantation.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090901

Title: Initial experience using continuous intravenous treprostinil to manage pulmonary arterial hypertension in patients with end-stage liver disease.

Journal: Transplant international : official journal of the European Society for Organ Transplantation 20090501

Title: Primary pulmonary hypertension as a manifestation of adult multi-system mitochondrial disorder.

Journal: Yonsei medical journal 20090430

Title: Addition of prostanoids in pulmonary hypertension deteriorating on oral therapy.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090301

Title: A pediatric case study of treprostinil overdose.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090301

Title: Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension.

Journal: Pulmonary pharmacology & therapeutics 20090201

Title: Portopulmonary hypertension.

Journal: Current gastroenterology reports 20090201

Title: Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.

Journal: Pulmonary pharmacology & therapeutics 20081001

Title: Treprostinil-based therapy in the treatment of moderate-to-severe pulmonary arterial hypertension: long-term efficacy and combination with bosentan.

Journal: Chest 20080701

Title: Prostacyclin analogs stimulate receptor-mediated cAMP synthesis and ATP release from rabbit and human erythrocytes.

Journal: Microcirculation (New York, N.Y. : 1994) 20080701

Title: Treprostinil for the treatment of pulmonary hypertension.

Journal: Expert opinion on pharmacotherapy 20080601

Title: Treprostinil for pulmonary hypertension.

Journal: Vascular health and risk management 20080601

Title: Long-term experience after transition from parenteral prostanoids to oral agents in patients with pulmonary hypertension.

Journal: Respiratory medicine 20080501

Title: Treatment of a nonhealing saphenous vein harvest graft with treprostinil sodium.

Journal: The Annals of thoracic surgery 20080401

Title: Bloodstream infections in patients given treatment with intravenous prostanoids.

Journal: Infection control and hospital epidemiology 20080401

Title: Patient safety challenges in treprostinil therapy.

Journal: Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 20080401

Title: Advances in diagnosis and treatment in patients with pulmonary arterial hypertension.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20080201

Title: [Treprostinil therapy for distal chronic thromboembolic pulmonary hypertension].

Journal: Kardiologia polska 20080201

Title: Dose proportionality of treprostinil sodium administered by continuous subcutaneous and intravenous infusion.

Journal: Journal of clinical pharmacology 20080101

Title: A novel catheter system for totally implantable intravenous drug therapy: assessment of catheter function and patency with trepostinil therapy.

Journal: The journal of vascular access 20080101

Title: The role of treprostinil in the management of pulmonary hypertension.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101

Title: A clinical comparison of slow- and rapid-escalation treprostinil dosing regimens in patients with pulmonary hypertension.

Journal: Clinical pharmacokinetics 20080101

Title: Advances in prostanoid infusion therapy for pulmonary arterial hypertension.

Journal: Journal of infusion nursing : the official publication of the Infusion Nurses Society 20080101

Title: Nebulized milrinone use in a pulmonary hypertensive crisis.

Journal: Pharmacotherapy 20071201

Title: Safety and efficacy of transition from subcutaneous treprostinil to oral sildenafil in patients with pulmonary arterial hypertension.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20071101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20071101

Title: IP receptor-dependent activation of PPARgamma by stable prostacyclin analogues.

Journal: Biochemical and biophysical research communications 20070907

Title: Transition from IV epoprostenol to subcutaneous treprostinil in pulmonary arterial hypertension: a controlled trial.

Journal: Chest 20070901

Title: Transition from IV to subcutaneous prostacyclin: premature withdrawal?

Journal: Chest 20070901

Title: Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes.

Journal: British journal of pharmacology 20070701

Title: Practical aspects of continuous intravenous treprostinil therapy.

Journal: Critical care nurse 20070401

Title: Long-term outcome in a patient with pulmonary hypertension and hereditary hemorrhagic telangiectasia.

Journal: Chest 20070401

Title: [Long-term experience with trerpostinil infusion treatment in patients with pulmonary arterial hypertension in the Czech Republic].

Journal: Vnitrni lekarstvi 20070401

Title: Bloodstream infections among patients treated with intravenous epoprostenol or intravenous treprostinil for pulmonary arterial hypertension--seven sites, United States, 2003-2006.

Journal: MMWR. Morbidity and mortality weekly report 20070302

Title: Transition of stable pediatric patients with pulmonary arterial hypertension from intravenous epoprostenol to intravenous treprostinil.

Journal: The American journal of cardiology 20070301

Title: Treprostinil for severe inoperable chronic thromboembolic pulmonary hypertension.

Journal: Journal of thrombosis and haemostasis : JTH 20070301

Title: Prostanoid therapy for pulmonary arterial hypertension.

Journal: Clinics in chest medicine 20070301

Title: [Pulmonary hypertension treatment: future prospects].

Journal: Archivos de bronconeumologia 20070301

Title: Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20070201

Title: Assessment and treatment of pulmonary arterial hypertension: an Australian perspective in 2006.

Journal: Internal medicine journal 20070101

Title: Rapid switch from intravenous epoprostenol to intravenous treprostinil in patients with pulmonary arterial hypertension.

Journal: Journal of cardiovascular pharmacology 20070101

Title: The role of peroxisome proliferator-activated receptors in pulmonary vascular disease.

Journal: PPAR research 20070101

Title: The Role of PPARs in Lung Fibrosis.

Journal: PPAR research 20070101

Title: Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil.

Journal: The European respiratory journal 20061201

Title: Long-term treprostinil in pulmonary arterial hypertension: Is the glass half full or half empty?

Journal: The European respiratory journal 20061201

Title: [Pulmonary arterial hypertension and systemic sclerosis].

Journal: Presse medicale (Paris, France : 1983) 20061201

Title: Conversion to bosentan from prostacyclin infusion therapy in pulmonary arterial hypertension: a pilot study.

Journal: Chest 20061101

Title: Treprostinil in advanced experimental pulmonary hypertension: beneficial outcome without reversed pulmonary vascular remodeling.

Journal: Journal of cardiovascular pharmacology 20061101

Title: Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies.

Journal: Journal of the American College of Cardiology 20061017

Title: Safety and efficacy of inhaled treprostinil as add-on therapy to bosentan in pulmonary arterial hypertension.

Journal: Journal of the American College of Cardiology 20061003

Title: Current treatment options in children with pulmonary arterial hypertension and experiences with oral bosentan.

Journal: European journal of clinical investigation 20060901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060901

Title: Treprostinil for the treatment of pulmonary arterial hypertension in patients with New York Heart Association class II-IV symptoms.

Journal: Pharmacotherapy 20060801

Title: Systemic sclerosis associated pulmonary hypertension: improved survival in the current era.

Journal: Heart (British Cardiac Society) 20060701

Title: An evidence-based approach to the management of pulmonary arterial hypertension.

Journal: Current opinion in cardiology 20060701

Title: [Update in the diagnosis and therapy for pulmonary arterial hypertension].

Journal: Revista medica de Chile 20060701

Title: Efficacy of long-term subcutaneous treprostinil sodium therapy in pulmonary hypertension.

Journal: Chest 20060601

Title: A pilot trial of treprostinil for the treatment and prevention of digital ulcers in patients with systemic sclerosis.

Journal: Journal of the American Academy of Dermatology 20060501

Title: Safety and efficacy of IV treprostinil for pulmonary arterial hypertension: a prospective, multicenter, open-label, 12-week trial.

Journal: Chest 20060301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060301

Title: Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts.

Journal: American journal of respiratory cell and molecular biology 20060201

Title: Digital ulcers in patients with systemic sclerosis.

Journal: Autoimmunity reviews 20060201

Title: Inhaled treprostinil [corrected] for treatment of chronic pulmonary arterial hypertension.

Journal: Annals of internal medicine 20060117

Title: The prostacyclin analog, treprostinil sodium, provides symptom relief in severe Buerger's disease--a case report and review of literature.

Journal: Angiology 20060101

Title: [The best of clinical cardiovascular pharmacology in 2005].

Journal: Archives des maladies du coeur et des vaisseaux 20060101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060101

Title: [Clinical implications and prognostic significance of the study on the circadian variation of heart rate variability in patients with severe pulmonary hypertension].

Journal: Gaceta medica de Mexico 20060101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060101

Title: Treprostinil sodium (Remodulin), a prostacyclin analog, in the treatment of critical limb ischemia: open-label study.

Journal: Vascular 20060101

Title: Delivery of intravenous treprostinil at low infusion rates using a miniaturized infusion pump in patients with pulmonary arterial hypertension.

Journal: The journal of vascular access 20060101

Title: Transition from intravenous epoprostenol to intravenous treprostinil in pulmonary hypertension.

Journal: American journal of respiratory and critical care medicine 20051215

Title: Potent effects of aerosol compared with intravenous treprostinil on the pulmonary circulation.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20051201

Title: New therapeutic agents for pulmonary vascular disease.

Journal: Paediatric respiratory reviews 20051201

Title: Cost-minimization analysis of treprostinil vs. epoprostenol as an alternate to oral therapy non-responders for the treatment of pulmonary arterial hypertension.

Journal: Current medical research and opinion 20051201

Title: Effects of aerosol vs IV UT-15 on prostaglandin H2 analog-induced pulmonary hypertension in sheep.

Journal: Chest 20051201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20051201

Title: Combining treprostinil and sildenafil in the treatment of pulmonary hypertension.

Journal: Internal medicine journal 20051101

Title: Efficacy and safety of sildenafil added to treprostinil in pulmonary hypertension.

Journal: The American journal of cardiology 20051101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20050901

Title: Prostacyclin therapy for pulmonary arterial hypertension: new directions.

Journal: Seminars in respiratory and critical care medicine 20050801

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20050601

Title: Prostacyclin for pulmonary hypertension in adults.

Journal: The Cochrane database of systematic reviews 20050418

Title: Staggered transition to epoprostenol from treprostinil in pulmonary arterial hypertension.

Journal: The Annals of pharmacotherapy 20050401

Title: Treprostinil for the treatment of severe digital necrosis in systemic sclerosis.

Journal: Vascular medicine (London, England) 20050201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20050101

Title: Cost-effectiveness of treprostinil versus epoprostenol in patients with pulmonary arterial hypertension: a Canadian analysis.

Journal: Canadian respiratory journal 20050101

Title: Transition from epoprostenol and treprostinil to the oral endothelin receptor antagonist bosentan in patients with pulmonary hypertension.

Journal: Chest 20040901

Title: Pharmacokinetics and steady-state bioequivalence of treprostinil sodium (Remodulin) administered by the intravenous and subcutaneous route to normal volunteers.

Journal: Journal of cardiovascular pharmacology 20040801

Title: Treprostinil, a prostacyclin analogue, in pulmonary arterial hypertension associated with connective tissue disease.

Journal: Chest 20040801

Title: Prostanoid therapy for pulmonary arterial hypertension.

Journal: Journal of the American College of Cardiology 20040616

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040601

Title: Pharmacokinetics of treprostinil sodium administered by 28-day chronic continuous subcutaneous infusion.

Journal: Journal of clinical pharmacology 20040501

Title: Advances in prostacyclin therapy for pulmonary arterial hypertension.

Journal: Critical care nurse 20040401

Title: The intramolecular asymmetric Pauson-Khand cyclization as a novel and general stereoselective route to benzindene prostacyclins: synthesis of UT-15 (treprostinil).

Journal: The Journal of organic chemistry 20040319

Title: Current medical treatment of pulmonary arterial hypertension.

Journal: The Mount Sinai journal of medicine, New York 20040301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040301

Title: Overview of treprostinil sodium for the treatment of pulmonary arterial hypertension.

Journal: Drugs of today (Barcelona, Spain : 1998) 20040301

Title: Treprostinil for pulmonary hypertension.

Journal: Expert review of cardiovascular therapy 20040301

Title: Absolute bioavailability and pharmacokinetics of treprostinil sodium administered by acute subcutaneous infusion.

Journal: Journal of clinical pharmacology 20040101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040101

Title: Drug therapy for pulmonary arterial hypertension: what's on the menu today?

Journal: Chest 20031201

Title: Treatment of pulmonary arterial hypertension: a preliminary decision analysis.

Journal: Chest 20031201

Title: [Sildenafil as a substitute for subcutaneous prostacyclin in pulmonary hypertension].

Journal: Archivos de bronconeumologia 20031001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20030901

Title: [Transition from intravenous to subcutaneous prostacyclin in pulmonary hypertension].

Journal: Revista espanola de cardiologia 20030801

Title: New drugs 2003, part II.

Journal: Nursing 20030701

Title: Effect of continuous subcutaneous treprostinil therapy on the pharmacodynamics and pharmacokinetics of warfarin.

Journal: Journal of cardiovascular pharmacology 20030601

Title: Clinical value of prostacyclin and its analogs in the management of pulmonary arterial hypertension.

Journal: Current vascular pharmacology 20030601

Title: Stability and preservative effectiveness of treprostinil sodium after dilution in common intravenous diluents.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030501

Title: [Treatment of HIV-associated pulmonary hypertension with treprostinil].

Journal: Revista espanola de cardiologia 20030401

Title: Treatments and strategies to optimize the comprehensive management of patients with pulmonary arterial hypertension.

Journal: Cleveland Clinic journal of medicine 20030401

Title: Advances in the treatment of secondary pulmonary hypertension.

Journal: Current opinion in pulmonary medicine 20030301

Title: Efficacy and safety of treprostinil: an epoprostenol analog for primary pulmonary hypertension.

Journal: Journal of cardiovascular pharmacology 20030201

Title: Understanding primary pulmonary hypertension.

Journal: Critical care nursing quarterly 20030101

Title: [Role of prostacyclin and its derivatives in the treatment of pulmonary arterial hypertension].

Journal: Medicina 20030101

Title: [What is new in the treatment of pulmonary artery hypertension?].

Journal: Archivos de cardiologia de Mexico 20030101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20021201

Title: Treprostinil therapy for pulmonary artery hypertension.

Journal: Expert opinion on investigational drugs 20021101

Title: The new clinical trials on pharmacological treatment in pulmonary arterial hypertension.

Journal: The European respiratory journal 20021001

Title: Treprostinil (Remodulin) for pulmonary arterial hypertension.

Journal: The Medical letter on drugs and therapeutics 20020916

Title: The prostacyclin analogue treprostinil blocks NFkappaB nuclear translocation in human alveolar macrophages.

Journal: The Journal of biological chemistry 20020906

Title: From the Food and Drug Administration.

Journal: JAMA 20020703

Title: Treprostinil sodium Pharmacia.

Journal: Current opinion in investigational drugs (London, England : 2000) 20020401

Title: Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery.

Journal: American journal of respiratory cell and molecular biology 20020201

Title: Effects of tapering neonatal dexamethasone on rat growth, neurodevelopment, and stress response.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020101

Title: Emerging medical therapies for pulmonary arterial hypertension.

Journal: Progress in cardiovascular diseases 20020101

Title: Report from the 93rd Cardiovascular and Renal Drugs Advisory Committee Meeting, August 9-10, 2001.

Journal: Circulation 20011009

Title: Medical therapy of pulmonary hypertension. The prostacyclins.

Journal: Clinics in chest medicine 20010901

Title: New and experimental therapies for pulmonary hypertension.

Journal: Clinics in chest medicine 20010901

Title: Whittle BJ, et al. Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. Biochem Pharmacol. 2012 Jul 1;84(1):68-75.

Title: Ferrantino M, et al. Inhaled treprostinil sodium for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2011 Nov;12(16):2583-93.

Title: Ghonem N, et al. Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. 2011 Nov;11(11):2508-16.

Title: Smadja DM, et al. Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells. Thromb Haemost. 2015 Oct;114(4):735-47.

Title: Kazemi Z, et al. Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation. Mol Pharmacol. 2016 Jun;89(6):630-44.

Title: Nikam VS, et al. Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension. Eur Respir J. 2010 Dec;36(6):1302-14.

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Tags:81846-19-7 Molecular Formula|81846-19-7 MDL|81846-19-7 SMILES|81846-19-7 Rumodolin