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[1]CurrentPatentAssignee:ZHENGZHOUUNIVERSITYOFINDUSTRYTECHNOLOGY-CN106674220,2017,ALocationinpatent:Paragraph0033;0034;0035;0036;0037
[2]CurrentPatentAssignee:HENANUNIVERSITY-CN106317051,2017,ALocationinpatent:Paragraph0014
[3]Matsumoto;Miyamoto;Minamida;Nishimura;Egawa;Nishimura[JournalofMedicinalChemistry,1984,vol.27,#3,p.292-301]
[4]CurrentPatentAssignee:SumitomoPharma(in:SumitomoChemical);LABORATOIREROGERBELLON;SUMITOMOCHEMICALCOMPANYLIMITED;BELLONLABORROGER;SumitomoChemical(w/oDongwooFine-Chem)-US4352803,1982,A
[1]Matsumoto;Miyamoto;Minamida;Nishimura;Egawa;Nishimura[JournalofMedicinalChemistry,1984,vol.27,#3,p.292-301]
[1]Domagala,JohnM.;Hanna,LoriDoyle;Heifetz,CarlL.;Hutt,MarlandP.;Mich,ThomasF.;etal.[JournalofMedicinalChemistry,1986,vol.29,#3,p.394-404]
[1]Matsumoto;Miyamoto;Minamida;etal.[JournalofHeterocyclicChemistry,1984,vol.21,#3,p.673-679]
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Title: 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents.
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Title: Natural history of small gallbladder polyps is benign: evidence from a clinical and pathogenetic study.
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Title: Rapid determination of 19 quinolone residues in spiked fish and pig muscle by high-performance liquid chromatography (HPLC) tandem mass spectrometry.
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Title: Trace analysis of quinolone and fluoroquinolone antibiotics from wastewaters by liquid chromatography-electrospray tandem mass spectrometry.
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Title: Effects of treatment with antimicrobial agents on the human colonic microflora.
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Title: Enhancement of RNAi by a small molecule antibiotic enoxacin.
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Title: Formation of secondary triplet species after excitation of fluoroquinolones in the presence of relatively strong bases.
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Title: Determination of enoxacin using Tb composite nanoparticles sensitized luminescence method.
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Title: Development of an immunochromatography strip for the rapid detection of 12 fluoroquinolones in chicken muscle and liver.
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Title: Drug resistance mechanism of the fish-pathogenic bacterium Lactococcus garvieae.
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Title: Synthesis and antibacterial activity of quinolone-based compounds containing a coumarin moiety.
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Title: Development of an HPLC multi-residue method for the determination of ten quinolones in bovine liver and porcine kidney according to the European Union Decision 2002/657/EC.
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Title: Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling.
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Title: Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants.
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Title: Development and validation of an HPLC confirmatory method for residue analysis of ten quinolones in tissues of various food-producing animals, according to the European Union Decision 2002/657/EC.
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Title: A rapid CE-potential gradient detection method for determination of quinolones.
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Title: In vitro cytotoxicity and phototoxicity of N-piperazinyl quinolone derivatives with a 2-thienyl group.
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Title: Leishmania panamensis: comparative inhibition of nuclear DNA topoisomerase II enzymes from promastigotes and human macrophages reveals anti-parasite selectivity of fluoroquinolones, flavonoids and pentamidine.
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Title: In vitro availability studies of enoxacin in presence of H2 receptor antagonists.
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Title: Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi.
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Title: [Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry].
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Title: Triplet excited fluoroquinolones as mediators for thymine cyclobutane dimer formation in DNA.
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Title: Effective separation and simultaneous determination of seven fluoroquinolones by capillary electrophoresis with diode-array detector.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601
Title: Separation of fifteen quinolones by high performance liquid chromatography: application to pharmaceuticals and ofloxacin determination in urine.
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Title: Determination of fluorinated quinolone antibacterials by ion chromatography with fluorescence detection.
Journal: Journal of Zhejiang University. Science. B 20070501
Title: Enoxacin-Tb3+ complex as an environmentally friendly fluorescence probe for DNA and its application.
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Title: Interaction between fluoroquinolones and bovine serum albumin studied by affinity capillary electrophoresis.
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Title: Micro- and nanofabrication methods in nanotechnological medical and pharmaceutical devices.
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Title: A new approach to quantitative NMR: fluoroquinolones analysis by evaluating the chemical shift displacements.
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Title: Investigation on sensitized chemiluminescence systems and their mechanism for five fluoroquinolones.
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Title: Interference-free determination of fluoroquinolone antibiotics in plasma by using excitation-emission matrix fluorescence coupled with second-order calibration algorithms.
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Title: Quinolones for uncomplicated acute cystitis in women.
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Title: Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety.
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Title: A batch chemiluminescence determination of enoxacin using a tris-(1,10-phenanthroline)ruthenium(II)-cerium(IV) system.
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Title: Electrochemiluminescence of terbium (III)-two fluoroquinolones-sodium sulfite system in aqueous solution.
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Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
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Title: Simultaneous determination of (fluoro)quinolone antibiotics in kidney, marine products, eggs, and muscle by enzyme-linked immunosorbent assay (ELISA).
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Title: Mutagenesis induced by 12 quinolone antibacterial agents in Escherichia coli WP2uvrA/pKM101.
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Title: Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice.
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Journal: Guang pu xue yu guang pu fen xi = Guang pu 20060301
Title: Genotoxic potential of quinolone antimicrobials in the in vitro comet assay and micronucleus test.
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Title: Determination of fluoroquinolones in urine and serum by using high performance liquid chromatography and multiemission scan fluorimetric detection.
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Title: Antimicrobial drug resistance, regulation, and research.
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Title: Photophysics and photochemistry of nalidixic acid.
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Title: T cell-mediated hypersensitivity to quinolones: mechanisms and cross-reactivity.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060101
Title: Effects of Transcutol P on the corneal permeability of drugs and evaluation of its ocular irritation of rabbit eyes.
Journal: The Journal of pharmacy and pharmacology 20060101
Title: Radiation-induced in vitro phototoxic potential of some fluoroquinolones.
Journal: Drug and chemical toxicology 20060101
Title: Preparation and evaluation of sustained ophthalmic gel of enoxacin.
Journal: Drug development and industrial pharmacy 20051201
Title: Validation of a novel HPLC sorbent material for the determination of ten quinolones in human and veterinary pharmaceutical formulations.
Journal: Journal of separation science 20051201
Title: Selective action of fluoroquinolones against intracellular amastigotes of Leishmania (Viannia) panamensis in vitro.
Journal: The Journal of parasitology 20051201
Title: Separation and determination of seven fluoroquinolones by pressurized capillary electrochromatography.
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Title: [Determination of enoxacin in urine by synchronous fluorimetry].
Journal: Guang pu xue yu guang pu fen xi = Guang pu 20051001
Title: HPLC determination of enoxacin, ciprofloxacin, norfloxacin and ofloxacin with photoinduced fluorimetric (PIF) detection and multiemission scanning: application to urine and serum.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050805
Title: Structure-phototoxicity relationship in Balb/c mice treated with fluoroquinolone derivatives, followed by ultraviolet-A irradiation.
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Title: Interaction study between enoxacin and fluvoxamine.
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Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.
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Title: Vibrational spectroscopic characterization of fluoroquinolones.
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Title: Susceptibility and resistance genes to fluoroquinolones in methicillin-resistant Staphylococcus aureus isolated in 2002.
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Title: Fluoroquinolone-resistant Campylobacter isolates from conventional and antibiotic-free chicken products.
Journal: Environmental health perspectives 20050501
Title: Antimicrosporidial activity of (fluoro)quinolones in vitro and in vivo.
Journal: Folia parasitologica 20050501
Title: Evaluation of phototoxic and photoallergic potentials of 13 compounds by different in vitro and in vivo methods.
Journal: Journal of photochemistry and photobiology. B, Biology 20050404
Title: Determination of fluoroquinolones in edible animal tissue samples by high performance liquid chromatography after solid phase extraction.
Journal: Journal of separation science 20050401
Title: Antibacterial studies, DNA oxidative cleavage, and crystal structures of Cu(II) and Co(II) complexes with two quinolone family members, ciprofloxacin and enoxacin.
Journal: Journal of inorganic biochemistry 20050301
Title: Direct determination of five fluoroquinolones in chicken whole blood and in veterinary drugs by HPLC.
Journal: Journal of separation science 20050301
Title: Celecoxib does not induce convulsions nor does it affect GABAA receptor binding activity in the presence of new quinolones in mice.
Journal: European journal of pharmacology 20050110
Title: Induced and photoinduced DNA damage by quinolones: ciprofloxacin, ofloxacin and nalidixic acid determined by comet assay.
Journal: Photochemistry and photobiology 20050101
Title: Flow-injection electrogenerated chemiluminescence determination of fluoroquinolones based on its sensitizing effect.
Journal: Luminescence : the journal of biological and chemical luminescence 20050101
Title: A novel approach to estimate in vitro antibacterial potency of Chinese medicine using a concentration-killing curve method.
Journal: The American journal of Chinese medicine 20050101
Title: Bench-to-bedside review: antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unit.
Journal: Critical care (London, England) 20050101
Title: Validation of HPLC method for determination of six fluoroquinolones: cinoxacin, ciprofloxacin, enoxacin, lomefloxacin, norfloxacin and ofloxacin.
Journal: Acta poloniae pharmaceutica 20041201
Title: [Simultaneous determination of quinolones in foods by LC/MS/MS].
Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20041001
Title: Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.
Journal: Antimicrobial agents and chemotherapy 20040401
Title: Enoxacin trihydrate.
Journal: Acta crystallographica. Section C, Crystal structure communications 20040401
Title: Partial least squares multicomponent fluorimetric determination of fluoroquinolones in human urine samples.
Journal: Talanta 20040310
Title: Sensitivity and spectrum of bacterial isolates in infectious otitis externa.
Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20040301
Title: Effects of eight antibacterial agents on cell survival and expression of epithelial-cell- or cell-adhesion-related genes in human gingival epithelial cells.
Journal: Journal of periodontal research 20040201
Title: Comparative evaluation of antiproliferative activity and induction of apoptosis by some fluoroquinolones with a human non-small cell lung cancer cell line in culture.
Journal: Asian Pacific journal of cancer prevention : APJCP 20040101
Title: Cotransport of macrolide and fluoroquinolones, a beneficial interaction reversing P-glycoprotein efflux.
Journal: American journal of therapeutics 20040101
Title: Spectroscopic properties of various quinolone antibiotics in aqueous-organic solvent mixtures.
Journal: Photochemistry and photobiology 20040101
Title: A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity.
Journal: The British journal of dermatology 20031201
Title: Effects of anti-inflammatory drugs on convulsant activity of quinolones: a comparative study of drug interaction between quinolones and anti-inflammatory drugs.
Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20031201
Title: Corneal and scleral permeability of quinolones--a pharmacokinetics study.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201
Title: Flow-injection analysis of two fluoquinolones by the sensitizing effect of terbium(III) on chemiluminescence of the potassium permanganate-sodium sulfite system.
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Title: Relationship between extent of inhibition and inhibitor dose: literature evaluation based on the metabolism and transport drug interaction database.
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Title: Synthesis and in vitro antibacterial evaluation of N-[5-(5-nitro-2-thienyl)-1,3,4-thiadiazole-2-yl] piperazinyl quinolones.
Journal: European journal of medicinal chemistry 20030901
Title: [Analysis of the response factors of different quinolones detected by evaporative light-scattering detector].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030901
Title: Binding characteristics of fluoroquinolones to synthetic levodopa melanin.
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Title: [Surveillance on concurrent administration of quinolones and anti-inflammatory drugs in a community hospital].
Journal: The Japanese journal of antibiotics 20030801
Title: Interference-free analysis using three-way fluorescence data and the parallel factor model. Determination of fluoroquinolone antibiotics in human serum.
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Title: [Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol].
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Title: Direct determination of four fluoroquinolones, enoxacin, norfloxacin, ofloxacin, and ciprofloxacin, in pharmaceuticals and blood serum by HPLC.
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Title: Pharmacological evaluation of garenoxacin, a novel des-F(6)-quinolone antimicrobial agent: effects on the central nervous system.
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Title: Laser flash photolysis study of photoionization in fluoroquinolones.
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Journal: The American journal of medicine 20020708
Title: Spectrophotometric determination of enoxacin as ion-pairs with bromophenol blue and bromocresol purple in bulk and pharmaceutical dosage form.
Journal: Journal of pharmaceutical and biomedical analysis 20020701
Title: [Phototoxicity studies of pazufloxacin mesilate, a novel parenteral quinolone antimicrobial agent--in vitro and in vivo studies].
Journal: The Japanese journal of antibiotics 20020601
Title: [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration].
Journal: The Japanese journal of antibiotics 20020601
Title: In vitro photochemical clastogenicity of quinolone antibacterial agents studied by a chromosomal aberration test with light irradiation.
Journal: Mutation research 20020527
Title: Osteoadsorptive bisphosphonate derivatives of fluoroquinolone antibacterials.
Journal: Journal of medicinal chemistry 20020523
Title: Multiresidue determination of (fluoro)quinolone antibiotics in swine kidney using liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. A 20020405
Title: Possible involvement of P-glycoprotein in the biliary excretion of grepafloxacin.
Journal: Clinical and experimental pharmacology & physiology 20020301
Title: Possible gatifloxacin-induced fulminant hepatic failure.
Journal: The Annals of pharmacotherapy 20020101
Title: Antituberculosis agents. III. In vitro evaluation of antimycobacterial activity and cytotoxicity of some N-piperazinyl quinolone derivatives.
Journal: Bollettino chimico farmaceutico 20020101
Title: Quinolones and false-positive urine screening for opiates by immunoassay technology.
Journal: JAMA 20011226
Title: In vitro method for prediction of the phototoxic potentials of fluoroquinolones.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20011201
Title: A pharmacokinetic/pharmacodynamic approach to show that not all fluoroquinolones exhibit similar sensitivity toward the proconvulsant effect of biphenyl acetic acid in rats.
Journal: The Journal of antimicrobial chemotherapy 20011201
Title: Biphenylacetic acid enhances the antagonistic action of fluoroquinolones on the GABA(A)-mediated responses of the isolated guinea-pig ileum.
Journal: Pharmacological research 20010901
Title: Is more than one quinolone needed in clinical practice?
Journal: The Annals of pharmacotherapy 20010901
Title: Inhibitory effect of quinolone antimicrobial and nonsteroidal anti-inflammatory drugs on a medium chain acyl-CoA synthetase.
Journal: Biochemical pharmacology 20010801
Title: [Terbium sensitized chemiluminescence of enoxacin].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010801
Title: Polysaccharide synthesis as a carbon dissipation mechanism in metabolically uncoupled Xanthomonas campestris cells.
Journal: Journal of biotechnology 20010726
Title: Effect of liposomes and niosomes on skin permeation of enoxacin.
Journal: International journal of pharmaceutics 20010521
Title: [Convulsion following the combination of single preoperative oral administration of enoxacine and single postoperative intravenous administration of flurbiprofen axetil].
Journal: Masui. The Japanese journal of anesthesiology 20010401
Title: Analysis of fluoroquinolone-mediated photosensitization of 2'-deoxyguanosine, calf thymus and cellular DNA: determination of type-I, type-II and triplet-triplet energy transfer mechanism contribution.
Journal: Photochemistry and photobiology 20010301
Title: [Effect of subinhibitory levels of aminoglycosides and fluoroquinolines on hydrophobicity and motility of Serratia marcescens].
Journal: Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne 20010201
Title: Selective separation and simultaneous determination of trace levels of five types of fluorinated quinolone drugs by thin-layer chromatography/fluorescence densitometry.
Journal: Journal of AOAC International 20010101
Title: History of quinolones and their side effects.
Journal: Chemotherapy 20010101
Title: Comparison of side effects of levofloxacin versus other fluoroquinolones.
Journal: Chemotherapy 20010101
Title: Evidence of different profiles of side effects and drug-drug interactions among the quinolones--the pharmacokinetic standpoint.
Journal: Chemotherapy 20010101
Title: Pharmacokinetic aspects of treating infections in the intensive care unit: focus on drug interactions.
Journal: Clinical pharmacokinetics 20010101
Title: Profiles of hepatic and dysrhythmic cardiovascular events following use of fluoroquinolone antibacterials: experience from large cohorts from the Drug Safety Research Unit Prescription-Event Monitoring database.
Journal: Drug safety 20010101
Title: Synthesis and antibacterial activity of some novel N-substituted piperazinyl-quinolones.
Journal: Bollettino chimico farmaceutico 20010101
Title: Pharmacokinetics of enoxacin and its oxometabolite after multiple oral dosing and penetration into prostatic tissue.
Journal: The Journal of antimicrobial chemotherapy 20001201
Title: Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening.
Journal: Antimicrobial agents and chemotherapy 20001001
Title: Anti-toxoplasma activities of 24 quinolones and fluoroquinolones in vitro: prediction of activity by molecular topology and virtual computational techniques.
Journal: Antimicrobial agents and chemotherapy 20001001
Title: A new fluoroquinolone derivative exhibits inhibitory activity against human immunodeficiency virus type 1 replication.
Journal: Chemotherapy 19990101
Title: Cross-reactivity in murine fluoroquinolone photoallergy: exclusive usage of TCR Vbeta13 by immune T cells that recognize fluoroquinolone-photomodified cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 19980415
Title: Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice.
Journal: Japanese journal of pharmacology 19980401
Title: Neurotoxicodynamics of the interaction between ciprofloxacin and foscarnet in mice.
Journal: Antimicrobial agents and chemotherapy 19980301
Title: Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid.
Journal: General pharmacology 19971101
Title: Circadian variation in enoxacin-induced convulsions in mice coadministered with fenbufen.
Journal: Japanese journal of pharmacology 19970201
Title: N-1-tert-butyl-substituted quinolones: in vitro anti-Mycobacterium avium activities and structure-activity relationship studies.
Journal: Antimicrobial agents and chemotherapy 19961101
Title: Epileptogenic activity induced by combined treatment with antiinflammatory drugs and enoxacin and its inhibition by a calcium antagonist, nicardipine.
Journal: Methods and findings in experimental and clinical pharmacology 19961101
Title: Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position.
Journal: Antimicrobial agents and chemotherapy 19961001
Title: Intermolecular interactions of antimicrobial fluoroquinolones with purified rat liver CYP1A2 studied by proton nuclear magnetic resonance spectroscopy.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 19961001
Title: [In vitro anti-MAC activities of new quinolones in focus (2)].
Journal: Kekkaku : [Tuberculosis] 19960901
Title: Interaction between enoxacin, a new antimicrobial, and nimesulide, a new non-steroidal anti-inflammatory agent in mice.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19960801
Title: Effects of some quinolones on imipenem-induced seizures in DBA/2 mice.
Journal: General pharmacology 19940301
Title: In-vitro activities of quinolones against mycobacteria.
Journal: The Journal of antimicrobial chemotherapy 19931201
Title: Acute cholestatic liver injury induced by enoxacin.
Journal: Journal of hepatology 19930401
Title: [Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19921001
Title: Repeated treatment with quinolones potentiates the seizures induced by aminophylline in genetically epilepsy-prone rats.
Journal: General pharmacology 19920901
Title: Enoxacin acute liver injury.
Journal: Journal of hepatology 19920501
Title: Interaction of the new quinolone antibacterial agent levofloxacin with fenbufen in mice.
Journal: Arzneimittel-Forschung 19920301
Title: Assessment of temafloxacin neurotoxicity in rodents.
Journal: The American journal of medicine 19911230
Title: Hippocampus and frontal cortex are the potential mediatory sites for convulsions induced by new quinolones and non-steroidal anti-inflammatory drugs.
Journal: International journal of clinical pharmacology, therapy, and toxicology 19910601
Title: Responsiveness of genetically epilepsy-prone rats to aminophylline-induced seizures and interactions with quinolones.
Journal: Neuropharmacology 19910201
Title: Fluoroquinolones protect the human lymphocyte CEM cell line from HIV-1-mediated cytotoxicity.
Journal: Cell structure and function 19901001
Title: Comparative in-vitro activities of ten fluoroquinolones and fusidic acid against Mycobacterium spp.
Journal: The Journal of antimicrobial chemotherapy 19900901
Title: In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone.
Journal: Antimicrobial agents and chemotherapy 19890801
Title: Comparative antimycobacterial activities of difloxacin, temafloxacin, enoxacin, pefloxacin, reference fluoroquinolones, and a new macrolide, clarithromycin.
Journal: Antimicrobial agents and chemotherapy 19890401
Title: Effect of enoxacin on theophylline neurotoxicity.
Journal: Life sciences 19890101
Title: Norfloxacin and seizures.
Journal: Annals of internal medicine 19880715
Title: Enoxacin in acute exacerbations of chronic bronchitis: a comparison with amoxycillin.
Journal: The Journal of antimicrobial chemotherapy 19880201
Title: Enoxacin in the treatment of lower respiratory tract infections.
Journal: The Journal of antimicrobial chemotherapy 19880201
Title: Activity of five fluoroquinolones against Mycobacterium avium-intracellulare complex and M. xenopi.
Journal: Annales de l'Institut Pasteur. Microbiology 19880101
Title: Comparative in-vitro activity of five fluoroquinolones against mycobacteria.
Journal: The Journal of antimicrobial chemotherapy 19870501
Title: In-vitro activity of six fluorinated quinolones against Mycobacterium tuberculosis.
Journal: The Journal of antimicrobial chemotherapy 19870501
Title: Activity of ciprofloxacin and other fluorinated quinolones against mycobacteria.
Journal: The American journal of medicine 19870427
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