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69056-38-8,MFCD00891665
Catalog No.:AA005LPE

69056-38-8 | (6R)-5,6,7,8-Tetrahydro-l-biopterin diHCl

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$26.00   $18.00
- +
5mg
≥99%
in stock  
$53.00   $37.00
- +
10mg
≥99%
in stock  
$93.00   $65.00
- +
50mg
≥99%
in stock  
$155.00   $108.00
- +
100mg
≥99%
in stock  
$203.00   $142.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA005LPE
Chemical Name:
(6R)-5,6,7,8-Tetrahydro-l-biopterin diHCl
CAS Number:
69056-38-8
Molecular Formula:
C9H17Cl2N5O3
Molecular Weight:
314.1690
MDL Number:
MFCD00891665
SMILES:
C[C@@H]([C@@H]([C@H]1CNc2c(N1)c(=O)[nH]c(n2)N)O)O.Cl.Cl
Properties
Properties
 
Form:
Solid  
MP:
>202°C (dec.)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
405  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
2  

Downstream Synthesis Route

[1]TetrahedronLetters,1986,vol.27,p.585-588

108-24-7    69056-38-8   
(6R)-2-acetamido-5,8-diacetyl-6-(1R,2S)-1,2-bis(acetyloxy)propyl-5,6,7,8-tetrahydropteridin-4(3H)-one 

[1]HelveticaChimicaActa,2001,vol.84,p.918-927

22150-76-1   
(6S)-tetrahydrobiopterindihydrochloride 
  69056-38-8 

[1]Patent:WO2005/49614,2005,A2.Locationinpatent:Page/Pagecolumn28-29

[1]CurrentPatentAssignee:MERCKKGAA-US2006/35900,2006,A1Locationinpatent:Page/Pagecolumn16

[2]CurrentPatentAssignee:MERCKKGAA-US2006/35900,2006,A1Locationinpatent:Page/Pagecolumn18;19

[3]CurrentPatentAssignee:MERCKKGAA-US2006/35900,2006,A1Locationinpatent:Page/Pagecolumn17

[4]CurrentPatentAssignee:MERCKKGAA-US2006/35900,2006,A1Locationinpatent:Page/Pagecolumn16;17

[5]CurrentPatentAssignee:MERCKKGAA-US2006/35900,2006,A1Locationinpatent:Page/Pagecolumn17

[6]CurrentPatentAssignee:MERCKKGAA-US2006/35900,2006,A1Locationinpatent:Page/Pagecolumn18

Literature

Title: Winn SR et al. High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU). Mol Genet Metab. 2016 Jan;117(1):5-11.

Title: Somaraju UR et al. Sapropterin dihydrochloride for phenylketonuria. Cochrane Database Syst Rev. 2015 Mar 27

Title: Jurecki ER et al. Sapropterin Dihydrochloride Mixed With Common Foods and Beverages. Top Clin Nutr. 2014 Oct;29(4):325-331.

Title: Grange DK et al. Sapropterin dihydrochloride use in pregnant women with phenylketonuria: an interim report of the PKU MOMS sub-registry. Mol Genet Metab. 2014 May;112(1):9-16

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SDS
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Tags:69056-38-8 Molecular Formula|69056-38-8 MDL|69056-38-8 SMILES|69056-38-8 (6R)-5,6,7,8-Tetrahydro-l-biopterin diHCl