Name: Name:MRS 2578
Brand: AABLOCKS
SKU: AA005OD3
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA005OD3

Chemical Name: MRS 2578

CAS Number: 711019-86-2

Molecular Formula: C20H20N6S4

Molecular Weight: 472.6730

MDL Number: MFCD07370141

SMILES: S=C=Nc1cccc(c1)NC(=S)NCCCCNC(=S)Nc1cccc(c1)N=C=S

Properties

Form: Solid

MP: 170 - 173°C

Storage: Inert atmosphere;2-8℃;

Complexity: 604

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 30

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 4

Isotope Atom Count: 0

Rotatable Bond Count: 9

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 6.3

Literature fold

Title: P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals.

Journal: Journal of immunology (Baltimore, Md. : 1950)20170101

Title: Purine receptor P2Y6 mediates cellular response to γ-ray-induced DNA damage.

Journal: The Journal of toxicological sciences20140201

Title: Rotenone induces neuronal death by microglial phagocytosis of neurons.

Journal: The FEBS journal20131001

Title: Autocrine regulation of γ-irradiation-induced DNA damage response via extracellular nucleotides-mediated activation of P2Y6 and P2Y12 receptors.

Journal: DNA repair20120801

Title: P2Y receptors regulate proliferation of human pancreatic duct epithelial cells.

Journal: Pancreas20120701

Title: Involvement of P2Y receptors in the protective effect of ATP towards the cell damage in HaCaT cells exposed to H₂O₂.

Journal: The Journal of toxicological sciences20110101

Title: Blockade of murine T cell activation by antagonists of P2Y6 and P2X7 receptors.

Journal: Biochemical and biophysical research communications20090710

Title: Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors.

Journal: Biochemical pharmacology20040501

Title: Mamedova LK, et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol, 2004, 67(9), 1763-1770.

Title: Nishida M, et al. P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiacfibrosis. EMBO J. 2008 Dec 3;27(23):3104-15.

Title: Riegel AK, et al. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood, 2011, 117(8), 2548-2555.

Title: Vieira RP, et al. Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation. Am J Respir Crit Care Med, 2011, 184(2), 215-223.

711019-86-2 | MRS 2578