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67910-12-7,MFCD00036966
Catalog No.:AA005OS9

67910-12-7 | 11-Dehydro-TXB2

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1mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005OS9
Chemical Name:
11-Dehydro-TXB2
CAS Number:
67910-12-7
Molecular Formula:
C20H32O6
Molecular Weight:
368.4645
MDL Number:
MFCD00036966
SMILES:
CCCCCC(C=CC1OC(=O)CC(C1CC=CCCCC(=O)O)O)O
Properties
Properties
 
Storage:
-20 ℃;Inert atmosphere;Light sensitive;  

Computed Properties
 
Complexity:
485  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
12  
XLogP3:
2.6  

Literature

Title: Endogenous secretory RAGE in obese women: association with platelet activation and oxidative stress.

Journal: The Journal of clinical endocrinology and metabolism 20120901

Title: Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism.

Journal: Thrombosis and haemostasis 20120901

Title: Urinary 11-dehydro-thromboxane B₂ and 2,3-dinor-6-keto-prostaglandin-F₁α in healthy post-menopausal and pre-menopausal women receiving aspirin 100 mg.

Journal: Journal of thrombosis and thrombolysis 20120701

Title: Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20120601

Title: The influence of aspirin dose and glycemic control on platelet inhibition in patients with type 2 diabetes mellitus.

Journal: Journal of thrombosis and haemostasis : JTH 20120401

Title: Reversal of the anti-platelet effects of aspirin and clopidogrel.

Journal: Journal of thrombosis and haemostasis : JTH 20120401

Title: Effects of carprofen, meloxicam and deracoxib on platelet function in dogs.

Journal: Veterinary anaesthesia and analgesia 20120301

Title: Aspirin resistance in off-pump coronary artery bypass grafting.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20120101

Title: The purification step is not crucial in EIA measurements of thromboxane B2 and 11-dehydrothromboxane B2 in human plasma.

Journal: Clinical laboratory 20120101

Title: Dietary fish oil alters the lysophospholipid metabolomic profile and decreases urinary 11-dehydro thromboxane B₂ concentration in healthy Beagles.

Journal: Veterinary immunology and immunopathology 20111215

Title: Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis.

Journal: Thrombosis research 20111001

Title: Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications.

Journal: Thrombosis and haemostasis 20110901

Title: Aspirin failure in patients presenting with acute cerebrovascular ischaemia.

Journal: Thrombosis and haemostasis 20110801

Title: The role of thromboxane A(2) in the pathogenesis of intrauterine growth restriction associated with maternal smoking in pregnancy.

Journal: Prostaglandins & other lipid mediators 20110801

Title: Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs.

Journal: American journal of veterinary research 20110801

Title: Urinary 11-dehydro thromboxane B₂ levels in type 2 diabetic patients before and during aspirin intake.

Journal: Clinica chimica acta; international journal of clinical chemistry 20110715

Title: Effect of polymorphism and type II diabetes on aspirin resistance in patients with unstable coronary artery disease.

Journal: Chinese medical journal 20110601

Title: Stress-induced salivary cortisol secretion during hypobaric hypoxia challenge and in vivo urinary thromboxane production in healthy male subjects.

Journal: Stress (Amsterdam, Netherlands) 20110501

Title: In vivo oxidation, platelet activation and simultaneous occurrence of natural immunity in atherosclerosis-prone mice.

Journal: The Israel Medical Association journal : IMAJ 20110501

Title: Comparison of UHPLC and HPLC methods for the assay of prostanoids: 'are the methods equivalent in terms of accuracy and precision?'.

Journal: Bioanalysis 20110401

Title: Biomarkers of potential harm among adult smokers and nonsmokers in the total exposure study.

Journal: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20110301

Title: Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of iloprost.

Journal: Thrombosis and haemostasis 20110201

Title: Comparison of methods to evaluate aspirin-mediated platelet inhibition after percutaneous intervention with stent implantation.

Journal: Platelets 20110101

Title: The cyclooxygenase-1 C50T polymorphism is not associated with aspirin responsiveness status in stable coronary artery disease in Tunisian patients.

Journal: Genetic testing and molecular biomarkers 20110101

Title: Aspirin resistance may be associated with adverse pregnancy outcomes.

Journal: Neuro endocrinology letters 20110101

Title: Platelet cyclooxygenase expression in normal dogs.

Journal: Journal of veterinary internal medicine 20110101

Title: Antiplatelet effects of aspirin with phytosterols: comparison with non-enteric coated aspirin alone.

Journal: Thrombosis research 20101101

Title: Effects of different doses, enteric-coated preparation of aspirin, and sex on urinary 11-dehydrothromboxane B2 in healthy volunteers.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20101001

Title: Clinical determinants of aspirin resistance in diabetes.

Journal: Diabetes research and clinical practice 20101001

Title: Regulation of oxidative stress and inflammation by glycaemic control: evidence for reversible activation of the 5-lipoxygenase pathway in type 1, but not in type 2 diabetes.

Journal: Diabetologia 20100901

Title: Determinants of thromboxane biosynthesis in rheumatoid arthritis: Role of RAGE and oxidant stress.

Journal: Free radical biology & medicine 20100901

Title: Aspirin resistance following pediatric cardiac surgery.

Journal: Thrombosis research 20100901

Title: Aspirin resistance with genetic dyslipidemia: contribution of vascular thromboxane generation.

Journal: Physiological genomics 20100801

Title: Mechanisms underlying early development of pulmonary vascular obstructive disease in Down syndrome: An imbalance in biosynthesis of thromboxane A2 and prostacyclin.

Journal: American journal of medical genetics. Part A 20100801

Title: Platelet function recovery after cessation of aspirin: preliminary study of volunteers and surgical patients.

Journal: European journal of anaesthesiology 20100701

Title: The inhibitory effect of statins on urinary 11-dehydrothromboxane levels.

Journal: International angiology : a journal of the International Union of Angiology 20100601

Title: Post interventional cardiology urinary thromboxane correlates with PlateletMapping detected aspirin resistance.

Journal: Thrombosis research 20100401

Title: Postprandial hyperglycemia is a determinant of platelet activation in early type 2 diabetes mellitus.

Journal: Journal of thrombosis and haemostasis : JTH 20100401

Title: Simultaneous quantification of 8-iso-prostaglandin-F(2alpha) and 11-dehydro thromboxane B(2) in human urine by liquid chromatography-tandem mass spectrometry.

Journal: Analytical biochemistry 20100215

Title: The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy.

Journal: Blood 20100204

Title: Response variability to aspirin and one-year prediction of vascular events in patients with stable coronary artery disease.

Journal: Journal of thrombosis and thrombolysis 20100101

Title: Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT.

Journal: PloS one 20100101

Title: Adaptive regression modeling of biomarkers of potential harm in a population of U.S. adult cigarette smokers and nonsmokers.

Journal: BMC medical research methodology 20100101

Title: [Aspirin resistance in patients with stable ischemic heart disease].

Journal: Kardiologiia 20100101

Title: Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects.

Journal: Journal of clinical pharmacology 20091201

Title: Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study).

Journal: The American journal of cardiology 20090815

Title: Increased urinary leukotriene E4 excretion in obstructive sleep apnea: effects of obesity and hypoxia.

Journal: The Journal of allergy and clinical immunology 20090801

Title: Response to aspirin in healthy individuals. Cross-comparison of light transmission aggregometry, VerifyNow system, platelet count drop, thromboelastography (TEG) and urinary 11-dehydrothromboxane B(2).

Journal: Thrombosis and haemostasis 20090801

Title: Letter by cattaneo regarding article, 'incomplete inhibition of thromboxane biosynthesis by acetylsalicylic Acid: determinants and effect on cardiovascular risk'.

Journal: Circulation 20090623

Title: Cardiovascular biomarkers in groups of established smokers after a decade of smoking.

Journal: Basic & clinical pharmacology & toxicology 20090401

Title: Determinants of platelet activation in hypertensives with microalbuminuria.

Journal: Free radical biology & medicine 20090401

Title: Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin.

Journal: Thrombosis and haemostasis 20090401

Title: Isoprostenes as indicators of oxidative stress in schizophrenia.

Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101

Title: Evaluation of biomarkers of exposure and potential harm in smokers, former smokers and never-smokers.

Journal: Clinical chemistry and laboratory medicine 20090101

Title: Aspirin resistance in Indian patients with coronary artery disease and cardiovascular events.

Journal: Journal of postgraduate medicine 20090101

Title: Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking > or =48 g of alcohol per day.

Journal: Alcoholism, clinical and experimental research 20081101

Title: Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk.

Journal: Circulation 20081021

Title: Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study.

Journal: Pharmacogenetics and genomics 20080701

Title: Aspirin responsiveness in healthy volunteers measured with multiple assay platforms.

Journal: Clinical chemistry 20080601

Title: A 12-month, randomized, controlled study to evaluate exposure and cardiovascular risk factors in adult smokers switching from conventional cigarettes to a second-generation electrically heated cigarette smoking system.

Journal: Journal of clinical pharmacology 20080501

Title: Platelet thromboxane A2 secretion in patients with major depression responsive to electroconvulsive therapy.

Journal: Psychosomatic medicine 20080401

Title: Aspirin resistance in children with heart disease at risk for thromboembolism: prevalence and possible mechanisms.

Journal: Pediatric cardiology 20080301

Title: Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study.

Journal: Clinical pharmacology and therapeutics 20080101

Title: AspirinWorks: a new immunologic diagnostic test for monitoring aspirin effect.

Journal: Molecular diagnosis & therapy 20080101

Title: Platelet aggregation and recruitment with aspirin-clopidogrel therapy.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20080101

Title: Biochemical evaluation of the antiplatelet effect of aspirin in patients at different levels of cardiovascular risk.

Journal: Bratislavske lekarske listy 20080101

Title: Effects of etoricoxib and comparator nonsteroidal anti-inflammatory drugs on urinary sodium excretion, blood pressure, and other renal function indicators in elderly subjects consuming a controlled sodium diet.

Journal: Journal of clinical pharmacology 20071201

Title: Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites.

Journal: Journal of the American College of Nutrition 20071001

Title: Variable platelet response to aspirin and clopidogrel in atherothrombotic disease.

Journal: Circulation 20070424

Title: Determinants of platelet activation in Alzheimer's disease.

Journal: Neurobiology of aging 20070301

Title: Screening for aspirin resistance in stable coronary artery patients by three different tests.

Journal: Thrombosis research 20070101

Title: Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population.

Journal: The American journal of cardiology 20060915

Title: Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease.

Journal: Clinical pharmacology and therapeutics 20060901

Title: Aspirin resistance detected with aggregometry cannot be explained by cyclooxygenase activity: involvement of other signaling pathway(s) in cardiovascular events of aspirin-treated patients.

Journal: Journal of thrombosis and haemostasis : JTH 20060601

Title: Reduced blood platelet sensitivity to aspirin in coronary artery disease: are dyslipidaemia and inflammatory states possible factors predisposing to sub-optimal platelet response to aspirin?

Journal: Basic & clinical pharmacology & toxicology 20060501

Title: A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited.

Journal: European journal of clinical investigation 20060401

Title: Thromboxane-dependent CD40 ligand release in type 2 diabetes mellitus.

Journal: Journal of the American College of Cardiology 20060117

Title: Measurement of urinary 11-dehydro-thromboxane B2 excretion in dogs with gastric dilatation-volvulus.

Journal: American journal of veterinary research 20060101

Title: A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension.

Journal: American journal of respiratory and critical care medicine 20051215

Title: Inhibition of thromboxane biosynthesis by triflusal in type 2 diabetes mellitus.

Journal: Atherosclerosis 20051201

Title: Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotype.

Journal: British journal of haematology 20051001

Title: Cigarette smoking is associated with increased circulating proinflammatory and procoagulant markers in patients with chronic coronary artery disease: effects of aspirin treatment.

Journal: American heart journal 20050501

Title: Abnormal pH-sensing of platelet Na+/H+ exchanger in patients with cardiac syndrome X.

Journal: International journal of cardiology 20050428

Title: Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure?

Journal: Stroke 20050201

Title: Platelet activation in patients with colorectal cancer.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20050201

Title: Helicobacter pylori infection causes persistent platelet activation in vivo through enhanced lipid peroxidation.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050101

Title: Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage.

Journal: Thrombosis research 20050101

Title: Can platelet function tests predict the clinical efficacy of aspirin?

Journal: Seminars in thrombosis and hemostasis 20050101

Title: Prostacyclin, thromboxane A and the effect of low-dose ASA in pregnancies at high risk for hypertensive disorders.

Journal: Acta obstetricia et gynecologica Scandinavica 20041201

Title: Terms and conditions: semantic complexity and aspirin resistance.

Journal: Circulation 20040921

Title: Platelet activation in type 2 diabetes mellitus.

Journal: Journal of thrombosis and haemostasis : JTH 20040801

Title: Reduction of daily life ischaemia by aspirin in patients with angina: underlying link between thromboxane A2 and macrophage colony stimulating factor.

Journal: Heart (British Cardiac Society) 20040401

Title: Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects.

Journal: Circulation 20040330

Title: Serial urinary 11-dehydrothromboxane B2, aspirin dose, and vascular events in blacks after recent cerebral infarction.

Journal: Stroke 20040301

Title: 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.

Journal: The Journal of biological chemistry 20040227

Title: Determinants of platelet activation in human essential hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 20040101

Title: What is the lowest dose of aspirin for maximum suppression of in vivo thromboxane production after a transient ischemic attack or ischemic stroke?

Journal: Cerebrovascular diseases (Basel, Switzerland) 20040101

Title: Quantitative liquid chromatography-tandem mass spectrometric analysis of 11-dehydro TXB2 in urine.

Journal: Prostaglandins & other lipid mediators 20040101

Title: Prothrombotic responses to exercise are little influenced by clopidogrel treatment.

Journal: Thrombosis research 20040101

Title: Diet rich in saturated fat decreases the ratio of thromboxane/prostacyclin in healthy men.

Journal: Biomedical and environmental sciences : BES 20031201

Title: High dose of inhaled fluticasone reduces high levels of urinary leukotriene E4 in the early morning in mild and moderate nocturnal asthma.

Journal: Chest 20031101

Title: Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration.

Journal: Circulation 20030701

Title: Daily prickly pear consumption improves platelet function.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20030701

Title: Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain.

Journal: Journal of neurochemistry 20030501

Title: Aspirin dosage and thromboxane synthesis in patients with vascular disease.

Journal: Pharmacotherapy 20030501

Title: Characterization of 11-dehydro-thromboxane B2 recombinant antibody obtained by phage display technology.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20030401

Title: Lipid and protein oxidation contribute to a prothrombotic state in patients with type 2 diabetes mellitus.

Journal: Journal of thrombosis and haemostasis : JTH 20030201

Title: Modulation of aspirin-insensitive eicosanoid biosynthesis by 6-methylprednisolone in unstable angina.

Journal: Circulation 20030107

Title: NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide.

Journal: Circulation 20021210

Title: Aspirin resistance.

Journal: Circulation 20021210

Title: Increased oxidative stress and platelet activation in patients with hypertension and renovascular disease.

Journal: Circulation 20021126

Title: Comments on 'Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications'.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20021101

Title: Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects.

Journal: Thrombosis research 20021101

Title: Platelet activation in obese women: role of inflammation and oxidant stress.

Journal: JAMA 20021001

Title: Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy.

Journal: Circulation 20020723

Title: Opposite effects of nicotinic acid and pyridoxine on systemic prostacyclin, thromboxane and leukotriene production in man.

Journal: Pharmacology & toxicology 20020601

Title: Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events.

Journal: Circulation 20020409

Title: The levels of five markers of hemostasis and endothelial status at different stages of normotensive pregnancy.

Journal: Acta obstetricia et gynecologica Scandinavica 20020301

Title: Aspirin and urinary 11-dehydrothromboxane B(2) in African American stroke patients.

Journal: Stroke 20020101

Title: Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients.

Journal: Chest 20020101

Title: Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre-eclampsia.

Journal: European journal of haematology 20020101

Title: Circadian characteristics of urinary leukotriene E(4) in healthy subjects and nocturnal asthmatic patients.

Journal: Chest 20011201

Title: Urinary 11-dehydro-thromboxane B(2) and coagulation activation markers measured within 24 h of human acute ischemic stroke.

Journal: Neuroscience letters 20011102

Title: Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine.

Journal: American journal of physiology. Renal physiology 20011101

Title: Possible involvement of mast-cell activation in aspirin provocation of aspirin-induced asthma.

Journal: Allergy 20011101

Title: Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide.

Journal: Clinical pharmacology and therapeutics 20011001

Title: Comparative study of platelet activation markers in diabetes mellitus patients complicated by cerebrovascular disease.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20011001

Title: Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20011001

Title: Oxidative stress and platelet activation in homozygous homocystinuria.

Journal: Circulation 20010904

Title: Increased lipid peroxidation correlates with platelet activation but not with markers of endothelial cell and blood coagulation activation in patients with antiphospholipid antibodies.

Journal: British journal of haematology 20010901

Title: [Correlation between the clinical effects of Seratrodast and the level of 11-dehydrothromboxane B2 in urine/sputum in bronchial asthma patients].

Journal: Arerugi = [Allergy] 20010601

Title: Enhanced in vivo lipid peroxidation in scleroderma spectrum disorders.

Journal: Arthritis and rheumatism 20010501

Title: Monitoring the antiplatelet action of aspirin.

Journal: JAAPA : official journal of the American Academy of Physician Assistants 20010501

Title: Difference in urinary 11-dehydro TXB2 and LTE4 excretion in patients with rheumatoid arthritis.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20010101

Title: Systemic and pulmonary hypertension after abrupt cessation of prostacyclin: role of thromboxane A2.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 19960101

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Tags:67910-12-7 Molecular Formula|67910-12-7 MDL|67910-12-7 SMILES|67910-12-7 11-Dehydro-TXB2