676596-65-9,MFCD09037522
Catalog No.:AA005QU9

676596-65-9 | 1-Azakenpaullone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98% by HPLC
in stock  
$97.00   $68.00
- +
5mg
≥98%
in stock  
$422.00   $295.00
- +
10mg
≥98%
in stock  
$709.00   $496.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA005QU9
Chemical Name:
1-Azakenpaullone
CAS Number:
676596-65-9
Molecular Formula:
C15H10BrN3O
Molecular Weight:
328.1634
MDL Number:
MFCD09037522
SMILES:
O=C1Nc2cccnc2c2c(C1)c1cc(Br)ccc1[nH]2
Properties
Properties
 
Form:
Solid  
MP:
>290°C (dec.)  
Solubility:
DMSO: >10mg/mL  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
405  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.2  

Literature

Title: Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions.

Journal: Toxicology and applied pharmacology 20150415

Title: A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

Journal: Cell stem cell 20130606

Title: Roles of glycogen synthase kinase 3 in Alzheimer's disease.

Journal: Current Alzheimer research 20120901

Title: Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523

Title: Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice.

Journal: Laboratory investigation; a journal of technical methods and pathology 20120401

Title: Neuroprotective effects of the beta-catenin stabilization in an oxygen- and glucose-deprived human neural progenitor cell culture system.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20110801

Title: Regulation of serotonin 1B receptor by glycogen synthase kinase-3.

Journal: Molecular pharmacology 20091201

Title: Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

Journal: Cellular signalling 20090401

Title: Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity.

Journal: Cellular signalling 20090201

Title: Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.

Journal: The Journal of biological chemistry 20081107

Title: Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.

Journal: Human reproduction (Oxford, England) 20080801

Title: 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication.

Journal: Journal of medicinal chemistry 20080410

Title: Glycogen synthase kinases 3alpha and 3beta in cardiac myocytes: regulation and consequences of their inhibition.

Journal: Cellular signalling 20080101

Title: New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells.

Journal: European journal of medicinal chemistry 20050801

Title: Epoxide-containing side chains enhance antiproliferative activity of paullones.

Journal: European journal of medicinal chemistry 20050701

Title: GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons.

Journal: Journal of cell science 20041115

Title: 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.

Journal: Bioorganic & medicinal chemistry letters 20040119

Title: The specificities of protein kinase inhibitors: an update.

Journal: The Biochemical journal 20030401

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

Journal: Diabetes 20000201

Title: Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

Journal: Diabetes 19990801

Title: Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.

Journal: Cancer research 19990601

Title: Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19930815

Title: Kunick C, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.

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Tags:676596-65-9 Molecular Formula|676596-65-9 MDL|676596-65-9 SMILES|676596-65-9 1-Azakenpaullone
Catalog No.: AA005QU9
676596-65-9,MFCD09037522
676596-65-9 | 1-Azakenpaullone
Pack Size: 1mg
Purity: 98% by HPLC
in stock
$97.00 $68.00
Pack Size: 5mg
Purity: ≥98%
in stock
$422.00 $295.00
Pack Size: 10mg
Purity: ≥98%
in stock
$709.00 $496.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA005QU9
Chemical Name: 1-Azakenpaullone
CAS Number: 676596-65-9
Molecular Formula: C15H10BrN3O
Molecular Weight: 328.1634
MDL Number: MFCD09037522
SMILES: O=C1Nc2cccnc2c2c(C1)c1cc(Br)ccc1[nH]2
Properties
Form: Solid  
MP: >290°C (dec.)  
Solubility: DMSO: >10mg/mL  
Storage: Keep in dry area;2-8℃;  
Complexity: 405  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.2  
Literature fold

Title: Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions.

Journal: Toxicology and applied pharmacology20150415

Title: A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

Journal: Cell stem cell20130606

Title: Roles of glycogen synthase kinase 3 in Alzheimer's disease.

Journal: Current Alzheimer research20120901

Title: Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20120523

Title: Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice.

Journal: Laboratory investigation; a journal of technical methods and pathology20120401

Title: Neuroprotective effects of the beta-catenin stabilization in an oxygen- and glucose-deprived human neural progenitor cell culture system.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience20110801

Title: Regulation of serotonin 1B receptor by glycogen synthase kinase-3.

Journal: Molecular pharmacology20091201

Title: Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

Journal: Cellular signalling20090401

Title: Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity.

Journal: Cellular signalling20090201

Title: Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.

Journal: The Journal of biological chemistry20081107

Title: Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.

Journal: Human reproduction (Oxford, England)20080801

Title: 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication.

Journal: Journal of medicinal chemistry20080410

Title: Glycogen synthase kinases 3alpha and 3beta in cardiac myocytes: regulation and consequences of their inhibition.

Journal: Cellular signalling20080101

Title: New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells.

Journal: European journal of medicinal chemistry20050801

Title: Epoxide-containing side chains enhance antiproliferative activity of paullones.

Journal: European journal of medicinal chemistry20050701

Title: GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons.

Journal: Journal of cell science20041115

Title: 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.

Journal: Bioorganic & medicinal chemistry letters20040119

Title: The specificities of protein kinase inhibitors: an update.

Journal: The Biochemical journal20030401

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

Journal: Diabetes20000201

Title: Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

Journal: Diabetes19990801

Title: Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.

Journal: Cancer research19990601

Title: Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Journal: Proceedings of the National Academy of Sciences of the United States of America19930815

Title: Kunick C, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.

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