+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
958852-01-2,MFCD18074517
Catalog No.:AA005WVA

958852-01-2 | Gsk1059615

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$133.00   $93.00
- +
10mg
≥98%
in stock  
$159.00   $111.00
- +
25mg
≥98%
in stock  
$360.00   $252.00
- +
50mg
≥98%
in stock  
$652.00   $456.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA005WVA
Chemical Name:
Gsk1059615
CAS Number:
958852-01-2
Molecular Formula:
C18H11N3O2S
Molecular Weight:
333.3638
MDL Number:
MFCD18074517
SMILES:
O=C1NC(=O)/C(=C/c2ccc3c(c2)c(ccn3)c2ccncc2)/S1
Properties
Properties
 
Form:
Solid  
MP:
>290℃ (dec.)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
544  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/136940,2007,A2Locationinpatent:Page/Pagecolumn41

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/136940,2007,A2

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/136940,2007,A2

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/136940,2007,A2

Literature

Title: GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway.

Journal: Oncotarget 20170801

Title: Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.

Journal: ACS medicinal chemistry letters 20100408

Title: Carnero A. Novel inhibitors of the PI3K family. Expert Opin Investig Drugs. 2009 Sep;18(9):1265-77.

Title: Maira SM, et al. From the bench to the bed side: PI3K pathway inhibitors in clinical development. Curr Top Microbiol Immunol, 2010, 347, 209-239.

Title: Takashi Kei Kishimoto, et al. Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses. US 20160074531 A1.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 958852-01-2
648450-29-7

648450-29-7

 1287651-14-2

1287651-14-2
Building Blocks
More >
Tags:958852-01-2 Molecular Formula|958852-01-2 MDL|958852-01-2 SMILES|958852-01-2 Gsk1059615
Catalog No.: AA005WVA
958852-01-2,MFCD18074517
958852-01-2 | Gsk1059615
Pack Size： 5mg
Purity： ≥98%
in stock
$133.00 $93.00
Pack Size： 10mg
Purity： ≥98%
in stock
$159.00 $111.00
Pack Size： 25mg
Purity： ≥98%
in stock
$360.00 $252.00
Pack Size： 50mg
Purity： ≥98%
in stock
$652.00 $456.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA005WVA
Chemical Name: Gsk1059615
CAS Number: 958852-01-2
Molecular Formula: C18H11N3O2S
Molecular Weight: 333.3638
MDL Number: MFCD18074517
SMILES: O=C1NC(=O)/C(=C/c2ccc3c(c2)c(ccn3)c2ccncc2)/S1
Properties
Form: Solid  
MP: >290℃ (dec.)  
Storage: Keep in dry area;2-8℃;  
Complexity: 544  
Covalently-Bonded Unit Count: 1  
Defined Bond Stereocenter Count: 1  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 1  
Rotatable Bond Count: 2  
XLogP3: 3  
Downstream Synthesis Route
2295-31-0    958852-13-6    958852-01-2 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/136940,2007,A2Locationinpatent:Page/Pagecolumn41

676256-25-0    1692-15-5    958852-01-2 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/136940,2007,A2

65340-70-7    958852-01-2 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/136940,2007,A2

916811-99-9    958852-01-2 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2007/136940,2007,A2

Literature fold

Title: GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway.

Journal: Oncotarget20170801

Title: Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.

Journal: ACS medicinal chemistry letters20100408

Title: Carnero A. Novel inhibitors of the PI3K family. Expert Opin Investig Drugs. 2009 Sep;18(9):1265-77.

Title: Maira SM, et al. From the bench to the bed side: PI3K pathway inhibitors in clinical development. Curr Top Microbiol Immunol, 2010, 347, 209-239.

Title: Takashi Kei Kishimoto, et al. Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses. US 20160074531 A1.

Related Products of of 958852-01-2
648450-29-7
648450-29-7
1287651-14-2
1287651-14-2
Building Blocks More >
6950-43-2
6950-43-2
5-Bromo-2-nitrobenzoic acid
AA005XI2 | MFCD00093013
73101-65-2
73101-65-2
Benzo[d]isoxazol-3-yl-methanesulfonyl chloride
AA005Y5I | MFCD07367669
97614-41-0
97614-41-0
1,3,5-Tri-O-benzoyl-2-O-(trifluoromethanesulfonyl)-a-D-ribofuranose
AA005YS0 | MFCD18643133
741709-65-9
741709-65-9
2,3-Dimethylpyridine-5-boronic acid pinacol ester
AA005ZG1 | MFCD12405444
954233-05-7
954233-05-7
2-Cyclopropyl-4-methylpyrimidine-5-carboxylic acid
AA00607U | MFCD09750211
67482-48-8
67482-48-8
3-Chlorothiophene-2-carbaldehyde
AA00611B | MFCD01764973
70978-93-7
70978-93-7
4-(2-Ethoxyethoxy)piperidine
AA0061TE | MFCD08687707
73217-31-9
73217-31-9
3-(Chloromethyl)-5-(4-methoxyphenyl)-1,2,4-oxadiazole
AA0062P0 | MFCD00084967
72615-78-2
72615-78-2
Piperazine,3-methyl-1-phenyl-
AA0063EO | MFCD06804051
72534-45-3
72534-45-3
2-Hydroxy-3-(trifluoromethyl)aniline
AA006495 | MFCD08532490
Submit
© 2017 AA BLOCKS, INC. All rights reserved.