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75450-34-9,MFCD09055422
Catalog No.:AA005X5B

75450-34-9 | Cgp37157

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5mg
≥99%
in stock  
$154.00   $108.00
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10mg
≥95%
in stock  
$206.00   $144.00
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25mg
≥99%
in stock  
$388.00   $272.00
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50mg
≥99%
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$611.00   $428.00
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100mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005X5B
Chemical Name:
Cgp37157
CAS Number:
75450-34-9
Molecular Formula:
C15H11Cl2NOS
Molecular Weight:
324.2249
MDL Number:
MFCD09055422
SMILES:
O=C1CSC(c2c(N1)ccc(c2)Cl)c1ccccc1Cl
Properties
Properties
 
BP:
479.8°C at 760 mmHg  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
368  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.3  

Literature

Title: Simultaneous mitochondrial Ca(2+) overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells.

Journal: Cancer letters 20121128

Title: Inflammation alters regional mitochondrial Ca²+ in human airway smooth muscle cells.

Journal: American journal of physiology. Cell physiology 20120801

Title: Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.

Journal: ACS chemical neuroscience 20120718

Title: Hyperuricemia induces endothelial dysfunction via mitochondrial Na+/Ca2+ exchanger-mediated mitochondrial calcium overload.

Journal: Cell calcium 20120501

Title: Effect of two intracellular calcium modulators on sperm motility and heparin-induced capacitation in cryopreserved bovine spermatozoa.

Journal: Animal reproduction science 20120401

Title: Small-molecule inhibitors of biofilm formation in laboratory and clinical isolates of Candida albicans.

Journal: Journal of medical microbiology 20120101

Title: Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route.

Journal: ASN neuro 20120101

Title: Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.

Journal: PloS one 20120101

Title: Phospholipase C-η2 is activated by elevated intracellular Ca(2+) levels.

Journal: Cellular signalling 20111101

Title: Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110701

Title: CGP-37157 inhibits the sarcoplasmic reticulum Ca²+ ATPase and activates ryanodine receptor channels in striated muscle.

Journal: Molecular pharmacology 20110101

Title: [Mitochondrial Na+-Ca2+-exchanger inhibitor CGP37157 produces endothelial cell depolarization with membrane potential oscillations].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20110101

Title: HTDP-2, a new synthetic compound, inhibits glutamate release through reduction of voltage-dependent Ca²⁺ influx in rat cerebral cortex nerve terminals.

Journal: Pharmacology 20110101

Title: Role of mitochondrial dysfunction in cardiac glycoside toxicity.

Journal: Journal of molecular and cellular cardiology 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Role of mitochondria in contraction and pacemaking in the mouse uterus.

Journal: British journal of pharmacology 20101101

Title: Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra.

Journal: British journal of pharmacology 20101001

Title: Mitochondrial Na+/Ca2+ exchanger, a new target for neuroprotection in rat hippocampal slices.

Journal: Biochemical and biophysical research communications 20100910

Title: Specific mitochondrial calcium overload induces mitochondrial fission in prostate cancer cells.

Journal: International journal of oncology 20100601

Title: Coupling of mitochondria to store-operated Ca(2+)-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells.

Journal: Cell calcium 20100601

Title: SLP-2 negatively modulates mitochondrial sodium-calcium exchange.

Journal: Cell calcium 20100101

Title: Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy.

Journal: Journal of neurochemistry 20091101

Title: Mitochondrial Na+/Ca2+-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine.

Journal: The Journal of pharmacology and experimental therapeutics 20090901

Title: Inhibition of mitochondrial calcium uptake rather than efflux impedes calcium release by inositol-1,4,5-trisphosphate-sensitive receptors.

Journal: Cell calcium 20090801

Title: Mitochondrial regulation of sarcoplasmic reticulum Ca2+ content in vascular smooth muscle cells.

Journal: Circulation research 20090102

Title: Mitochondrial inhibitors activate influx of external Ca(2+) in sea urchin sperm.

Journal: Biochimica et biophysica acta 20090101

Title: Mitochondria modulate Ca2+-dependent glutamate release from rat cortical astrocytes.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080924

Title: Pulses of extracellular K+ produce two cytosolic Ca2+ transients that display different temperature dependence and carbonyl cyanide m-chlorophenyl sensitivity in SH-SY5Y cells.

Journal: Brain research 20080605

Title: Voltage-gated Ca(2+) influx and insulin secretion in human and mouse beta-cells are impaired by the mitochondrial Na(+)/Ca(2+) exchange inhibitor CGP-37157.

Journal: European journal of pharmacology 20071208

Title: Mechanisms of [(3)H]glycine release from mouse spinal cord synaptosomes selectively labeled through GLYT2 transporters.

Journal: Journal of neurochemistry 20071201

Title: Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line.

Journal: American journal of physiology. Renal physiology 20070801

Title: Modulation of Ca(2+) release and Ca(2+) oscillations in HeLa cells and fibroblasts by mitochondrial Ca(2+) uniporter stimulation.

Journal: The Journal of physiology 20070401

Title: Inhibition of L-type Ca2+ channel by mitochondrial Na+-Ca2+ exchange inhibitor CGP-37157 in rat atrial myocytes.

Journal: European journal of pharmacology 20061215

Title: Therapeutic advantage of combining calcium channel blockers and TRAIL in prostate cancer.

Journal: Molecular cancer therapeutics 20060801

Title: Mitochondria maintain maturation and secretion of lipoprotein lipase in the endoplasmic reticulum.

Journal: The Biochemical journal 20060515

Title: Involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity.

Journal: World journal of gastroenterology 20060207

Title: Involvement of glutamate receptors of the NMDA type in the modulation of acetylcholine and glutamate overflow from the guinea pig ileum during in vitro hypoxia and hypoglycaemia.

Journal: Neurochemistry international 20060201

Title: Na+-dependent sources of intra-axonal Ca2+ release in rat optic nerve during in vitro chemical ischemia.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20051026

Title: Role of sodium in mitochondrial membrane depolarization induced by P2X7 receptor activation in submandibular glands.

Journal: FEBS letters 20051010

Title: Hyposmolarity evokes norepinephrine efflux from synaptosomes by a depolarization- and Ca2+ -dependent exocytotic mechanism.

Journal: The European journal of neuroscience 20051001

Title: Mitochondrial nitric oxide mediates decreased vulnerability of hippocampal neurons from immature animals to NMDA.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713

Title: Probing the endogenous Ca2+ buffers at the presynaptic terminals of the crayfish neuromuscular junction.

Journal: Journal of neurophysiology 20050701

Title: Mitochondrial dysfunction is related to necrosis-like programmed cell death induced by A23187 in CEM cells.

Journal: European journal of pharmacology 20050615

Title: Mitochondrial calcium ion and membrane potential transients follow the pattern of epileptiform discharges in hippocampal slice cultures.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050427

Title: The role of mitochondria for Ca2+ refilling of the endoplasmic reticulum.

Journal: The Journal of biological chemistry 20050401

Title: Extracellular pH modifies mitochondrial control of capacitative calcium entry in Jurkat cells.

Journal: The Journal of biological chemistry 20050204

Title: Fowl (Gallus domesticus) sperm motility depends upon mitochondrial calcium cycling driven by extracellular sodium.

Journal: Biology of reproduction 20050101

Title: Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency.

Journal: The Journal of biological chemistry 20040924

Title: A novel mechanism of regulation of cardiac contractility by mitochondrial functional state.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801

Title: Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries.

Journal: The Journal of physiology 20040501

Title: Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures.

Journal: Neuroscience 20040101

Title: Inhibition of plasmalemmal Na(+)/Ca(2+) exchange by mitochondrial Na(+)/Ca(2+) exchange inhibitor 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP-37157) in cerebellar granule cells.

Journal: Biochemical pharmacology 20031215

Title: Sustained Ca2+ transfer across mitochondria is Essential for mitochondrial Ca2+ buffering, sore-operated Ca2+ entry, and Ca2+ store refilling.

Journal: The Journal of biological chemistry 20031107

Title: Inhibition of canine (NCX1.1) and Drosophila (CALX1.1) Na(+)-Ca(2+) exchangers by 7-chloro-3,5-dihydro-5-phenyl-1H-4,1-benzothiazepine-2-one (CGP-37157).

Journal: The Journal of pharmacology and experimental therapeutics 20030901

Title: Mitochondrial and myoplasmic [Ca2+] in single fibres from mouse limb muscles during repeated tetanic contractions.

Journal: The Journal of physiology 20030815

Title: Characterization of the intracellular calcium store at the base of the sperm flagellum that regulates hyperactivated motility.

Journal: Biology of reproduction 20030501

Title: Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets.

Journal: Diabetes 20030401

Title: Cellular mechanisms of the acute increase of glutamate release induced by nerve growth factor in rat cerebral cortex.

Journal: Neuropharmacology 20030301

Title: Pacemaker frequency is increased by sodium nitroprusside in the guinea pig gastric antrum.

Journal: The Journal of physiology 20030101

Title: Mitochondrial Ca2+ in mouse soleus single muscle fibres in response to repeated tetanic contractions.

Journal: Advances in experimental medicine and biology 20030101

Title: Inhibition of mitochondrial Na(+)/Ca(2+) exchange by 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury.

Journal: Neuroscience letters 20020315

Title: NMDA-induced calcium loads recycle across the mitochondrial inner membrane of hippocampal neurons in culture.

Journal: Journal of neurophysiology 20020201

Title: Multiple mechanisms of transmitter release evoked by 'pathologically' elevated extracellular [K+]: involvement of transporter reversal and mitochondrial calcium.

Journal: Journal of neurochemistry 20020201

Title: Mitochondria regulate Ca2+ wave initiation and inositol trisphosphate signal transduction in oligodendrocyte progenitors.

Journal: Journal of neurochemistry 20020201

Title: Roles for mitochondrial and reverse mode Na+/Ca2+ exchange and the plasmalemma Ca2+ ATPase in post-tetanic potentiation at crayfish neuromuscular junctions.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20011215

Title: Selective, high-resolution fluorescence imaging of mitochondrial Ca2+ concentration.

Journal: Cell calcium 20011101

Title: Mitochondria recycle Ca(2+) to the endoplasmic reticulum and prevent the depletion of neighboring endoplasmic reticulum regions.

Journal: The Journal of biological chemistry 20010803

Title: Chiesi M, et al. Structural dependency of the inhibitory action of benzodiazepines and related compounds on the mitochondrial Na+-Ca2+ exchanger. Biochem Pharmacol. 1988 Nov 15;37(22):4399-403.

Title: Ruiz A, et al. CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels. Cell Death Dis. 2014 Apr 10;5:e1156.

Title: Scherzed A, et al. Effects of salinomycin and CGP37157 on head and neck squamous cell carcinoma cell lines in vitro. Mol Med Rep. 2015 Sep;12(3):4455-61.

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