Home Pyridines 6839-91-4
6839-91-4,MFCD26097263
Catalog No.:AA0063XK

6839-91-4 | Di(2-pyridyl) ketone thiosemicarbazone

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250mg
97%
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$70.00   $49.00
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1g
97%
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$122.00   $85.00
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  • Technical Information
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Technical Information
Catalog Number:
AA0063XK
Chemical Name:
Di(2-pyridyl) ketone thiosemicarbazone
CAS Number:
6839-91-4
Molecular Formula:
C12H11N5S
Molecular Weight:
257.3142
MDL Number:
MFCD26097263
SMILES:
NC(=S)NN=C(c1ccccn1)c1ccccn1
Properties
Computed Properties
 
Complexity:
298  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
1.6  

Literature

Title: Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones.

Journal: Biochemical pharmacology 20120615

Title: Bis{μ-2-[bis-(pyridin-2-yl)methyl-idene]hydrazinecarbothio-amidato}bis-[bromido-copper(II)] methanol disolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20120301

Title: Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes.

Journal: Cancer research 20110901

Title: Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9.

Journal: Molecular pharmacology 20110101

Title: The medicinal chemistry of novel iron chelators for the treatment of cancer.

Journal: Current topics in medicinal chemistry 20110101

Title: Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents.

Journal: Biochimica et biophysica acta 20090701

Title: 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.

Journal: Journal of medicinal chemistry 20090312

Title: Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.

Journal: Journal of medicinal chemistry 20090122

Title: Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.

Journal: Journal of medicinal chemistry 20070726

Title: Future of toxicology--iron chelators and differing modes of action and toxicity: the changing face of iron chelation therapy.

Journal: Chemical research in toxicology 20070501

Title: Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity.

Journal: Journal of medicinal chemistry 20061102

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