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95153-31-4,MFCD00865777
Catalog No.:AA0066AB

95153-31-4 | Perindoprilat

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1mg
≥95%
in stock  
$110.00   $77.00
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5mg
≥95%
in stock  
$356.00   $249.00
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10mg
≥95%
in stock  
$548.00   $383.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0066AB
Chemical Name:
Perindoprilat
CAS Number:
95153-31-4
Molecular Formula:
C17H28N2O5
Molecular Weight:
340.4146
MDL Number:
MFCD00865777
SMILES:
CCC[C@@H](C(=O)O)N[C@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O)C
Properties
Properties
 
Form:
Solid  
MP:
>125C (dec.)  
Storage:
-20 ℃;Keep in dry area;  

Computed Properties
 
Complexity:
495  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
0.2  

Literature

Title: Perindoprilat monohydrate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20121101

Title: Novel pseudopolymorph of the active metabolite of perindopril.

Journal: Acta crystallographica. Section C, Crystal structure communications 20120901

Title: Hydrophilic interaction liquid chromatography/positive ion electrospray ionization mass spectrometry method for the quantification of perindopril and its main metabolite in human plasma.

Journal: Analytical and bioanalytical chemistry 20100701

Title: Angiotensin metabolism in rat stomach wall: prevalence of angiotensin-(1-7) formation.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301

Title: Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE.

Journal: European journal of pharmacology 20071222

Title: Inhibition of neutral endopeptidase by thiorphan does not modify coronary vascular responses to angiotensin I, angiotensin II and bradykinin in the isolated guinea pig heart.

Journal: Pharmacological reports : PR 20070101

Title: Potential deployment of angiotensin I converting enzyme inhibitors and of angiotensin II type 1 and type 2 receptor blockers in cancer chemotherapy.

Journal: Anti-cancer agents in medicinal chemistry 20060901

Title: First LC-MS/MS electrospray ionization validated method for the quantification of perindopril and its metabolite perindoprilat in human plasma and its application to bioequivalence study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060606

Title: The pharmacokinetics of perindoprilat in normal volunteers and patients: influence of age and disease state.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050901

Title: Tgf-beta1 induced by high glucose is controlled by angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker on cultured human peritoneal mesothelial cells.

Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20050101

Title: Effects of the angiotensin-I converting enzyme inhibitor perindopril on tumor growth and angiogenesis in head and neck squamous cell carcinoma cells.

Journal: Journal of cancer research and clinical oncology 20041001

Title: The role of bradykinin in the antifibrotic actions of perindoprilat on human mesangial cells.

Journal: Kidney international 20040401

Title: Elimination kinetics of quinaprilat and perindoprilat in hypertensive patients with renal failure on haemodialysis.

Journal: Biological & pharmaceutical bulletin 20030601

Title: Intraluminal pressure increases vascular neuronal nitric oxide synthase expression.

Journal: Journal of hypertension 20030501

Title: Myocardial uptake and biochemical and hemodynamic effects of ACE inhibitors in humans.

Journal: Hypertension (Dallas, Tex. : 1979) 20030301

Title: Dipyridamole, cold pressor test, and demonstration of endothelial dysfunction: a PET study of myocardial perfusion in diabetes.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030101

Title: Effect of neutral endopeptidase inhibition on vascular response induced by exogenous angiotensin I in the isolated rat lung.

Journal: Polish journal of pharmacology 20030101

Title: Complementary effects of adenosine and angiotensin II in hypoxemia-induced renal dysfunction in the rabbit.

Journal: Life sciences 20020705

Title: Interaction of digoxin with antihypertensive drugs via MDR1.

Journal: Life sciences 20020215

Title: Pharmacokinetic-pharmacodynamic model for perindoprilat regional haemodynamic effects in healthy volunteers and in congestive heart failure patients.

Journal: British journal of clinical pharmacology 20010701

Title: The initial hemodynamic response to newer antihypertensive agents at rest and during exercise: review of visacor, doxazosin, nisoldipine, tiapamil, perindoprilat, pinacidil, dilevalol, and carvedilol.

Journal: Cardiovascular drugs and therapy 19900801

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