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704888-90-4,MFCD09971105
Catalog No.:AA006822

704888-90-4 | ARP 100

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$42.00   $29.00
- +
5mg
≥98%
in stock  
$149.00   $104.00
- +
10mg
≥98%
in stock  
$266.00   $186.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA006822
Chemical Name:
ARP 100
CAS Number:
704888-90-4
Molecular Formula:
C17H20N2O5S
Molecular Weight:
364.4161
MDL Number:
MFCD09971105
SMILES:
ONC(=O)CN(S(=O)(=O)c1ccc(cc1)c1ccccc1)OC(C)C
Properties
Properties
 
Form:
Solid  

Computed Properties
 
Complexity:
518  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.4  

Literature

Title: Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.

Journal: Journal of medicinal chemistry 20100325

Title: Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.

Journal: Bioorganic & medicinal chemistry 20081001

Title: Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides.

Journal: Bioorganic & medicinal chemistry 20060615

Title: Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg Med Chem. 2004 May 1;12(9):2441-50.

Title: Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14(12):4260-76.

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SDS
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Tags:704888-90-4 Molecular Formula|704888-90-4 MDL|704888-90-4 SMILES|704888-90-4 ARP 100
Catalog No.: AA006822
704888-90-4,MFCD09971105
704888-90-4 | ARP 100
Pack Size： 1mg
Purity： ≥98%
in stock
$42.00 $29.00
Pack Size： 5mg
Purity： ≥98%
in stock
$149.00 $104.00
Pack Size： 10mg
Purity： ≥98%
in stock
$266.00 $186.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA006822
Chemical Name: ARP 100
CAS Number: 704888-90-4
Molecular Formula: C17H20N2O5S
Molecular Weight: 364.4161
MDL Number: MFCD09971105
SMILES: ONC(=O)CN(S(=O)(=O)c1ccc(cc1)c1ccccc1)OC(C)C
Properties
Form: Solid  
Complexity: 518  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 25  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.4  
Literature fold

Title: Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.

Journal: Journal of medicinal chemistry20100325

Title: Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.

Journal: Bioorganic & medicinal chemistry20081001

Title: Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides.

Journal: Bioorganic & medicinal chemistry20060615

Title: Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg Med Chem. 2004 May 1;12(9):2441-50.

Title: Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14(12):4260-76.

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