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90038-01-0,MFCD18783094
Catalog No.:AA006LEQ

90038-01-0 | Detomidine HCl

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Purity
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10mg
98%
in stock  
$7.00   $5.00
- +
100mg
98%
in stock  
$12.00   $8.00
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250mg
98%
in stock  
$15.00   $11.00
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1g
98%
in stock  
$26.00   $18.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006LEQ
Chemical Name:
Detomidine HCl
CAS Number:
90038-01-0
Molecular Formula:
C12H15ClN2
Molecular Weight:
222.7139
MDL Number:
MFCD18783094
SMILES:
Cc1cccc(c1C)Cc1cnc[nH]1.Cl
Properties
Properties
 
BP:
386.5°C at 760 mmHg  
Form:
Solid  
MP:
160°C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
181  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  

Literature

Title: Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse.

Journal: Veterinary anaesthesia and analgesia 20121101

Title: A controlled study evaluating a novel surgical treatment for kissing spines in standing sedated horses.

Journal: Veterinary surgery : VS 20121001

Title: Chemical immobilization of chimpanzees (Pan troglodytes) using a combination of detomidine and ketamine.

Journal: Veterinary anaesthesia and analgesia 20120901

Title: Evaluation of a butorphanol, detomidine, and midazolam combination for immobilization of captive Nile lechwe antelopes (Kobus magaceros).

Journal: Journal of wildlife diseases 20120701

Title: The effects of yohimbine on the pharmacokinetic parameters of detomidine in the horse.

Journal: Veterinary anaesthesia and analgesia 20120501

Title: Effect of sedation with detomidine on intraocular pressure with and without topical anesthesia in clinically normal horses.

Journal: Journal of the American Veterinary Medical Association 20120201

Title: Qualitative and quantitative characteristics of the electroencephalogram in normal horses after sedation.

Journal: Journal of veterinary internal medicine 20120101

Title: Effects of a constant rate infusion of detomidine on cardiovascular function, isoflurane requirements and recovery quality in horses.

Journal: Veterinary anaesthesia and analgesia 20111101

Title: Dehydration of detomidine hydrochloride monohydrate.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20111009

Title: Chemical restraint and anaesthetic effects of a tiletamine-zolazepam/ketamine/detomidine combination in cattle.

Journal: Veterinary journal (London, England : 1997) 20111001

Title: Atipamezole antagonism of an ACTH stimulation test in ponies sedated with detomidine.

Journal: Journal of veterinary pharmacology and therapeutics 20111001

Title: Pharmacokinetics and pharmacodynamics of detomidine following sublingual administration to horses.

Journal: American journal of veterinary research 20111001

Title: Clinical evaluation of detomidine-butorphanol-guaifenesin-ketamine as short term TIVA in Spiti ponies.

Journal: Pakistan journal of biological sciences : PJBS 20110601

Title: Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses.

Journal: Equine veterinary journal 20110501

Title: Assessment of the sedative effects of buprenorphine administered with 20 microg/kg detomidine in horses.

Journal: The Veterinary record 20110416

Title: Assessment of the sedative effects of buprenorphine administered with 10 μg/kg detomidine in horses.

Journal: The Veterinary record 20110409

Title: Bioavailability of detomidine administered sublingually to horses as an oromucosal gel.

Journal: Journal of veterinary pharmacology and therapeutics 20110201

Title: Efficacy of sublingual administration of detomidine gel for sedation of horses undergoing veterinary and husbandry procedures under field conditions.

Journal: Journal of the American Veterinary Medical Association 20101215

Title: Total intravenous anesthesia with midazolam, ketamine, and xylazine or detomidine following induction with tiletamine, zolazepam, and xylazine in red deer (Cervus elaphus hippelaphus) undergoing surgery.

Journal: Journal of wildlife diseases 20101001

Title: Accidental poisoning with detomidine and butorphanol.

Journal: Occupational medicine (Oxford, England) 20100901

Title: Comparison of intraoperative behavioral and hormonal responses to noxious stimuli between mares sedated with caudal epidural detomidine hydrochloride or a continuous intravenous infusion of detomidine hydrochloride for standing laparoscopic ovariectomy.

Journal: Veterinary surgery : VS 20100801

Title: Anesthetic management of a white rhinoceros (Ceratotherium simum) undergoing an emergency exploratory celiotomy for colic.

Journal: Veterinary anaesthesia and analgesia 20100501

Title: Tachypnea and antipyresis in febrile horses after sedation with alpha-agonists.

Journal: Journal of veterinary internal medicine 20100101

Title: Plasma concentrations, behavioural and physiological effects following intravenous and intramuscular detomidine in horses.

Journal: Equine veterinary journal 20091101

Title: Comparison of the effects of the alpha-2 agonists detomidine, romifidine and xylazine on nociceptive withdrawal reflex and temporal summation in horses.

Journal: Veterinary anaesthesia and analgesia 20090701

Title: Pharmacokinetics of detomidine administered to horses at rest and after maximal exercise.

Journal: Equine veterinary journal 20090501

Title: Pharmacokinetics of detomidine and its metabolites following intravenous and intramuscular administration in horses.

Journal: Equine veterinary journal 20090401

Title: Comparison of azaperone-detomidine-butorphanol-ketamine and azaperone-tiletamine-zolazepam for anaesthesia in piglets.

Journal: Veterinary anaesthesia and analgesia 20090301

Title: Effect of detomidine on visceral and somatic nociception and duodenal motility in conscious adult horses.

Journal: Veterinary anaesthesia and analgesia 20090301

Title: Vascular perfusion of reproductive organs in pony mares and heifers during sedation with detomidine or xylazine.

Journal: American journal of veterinary research 20090101

Title: A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy.

Journal: Veterinary anaesthesia and analgesia 20090101

Title: Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse.

Journal: Acta veterinaria Scandinavica 20090101

Title: Reversible immobilization of asiatic black bear (Ursus thibetanus) with detomidine-tiletamine-zolazepam and atipamezole.

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20081201

Title: Use of multichannel electrointestinography for noninvasive assessment of myoelectrical activity in the cecum and large colon of horses.

Journal: American journal of veterinary research 20080601

Title: Sedation with detomidine and acepromazine influences the endoscopic evaluation of laryngeal function in horses.

Journal: Equine veterinary journal 20071101

Title: The cardiopulmonary effects of etorphine, azaperone, detomidine, and butorphanol in field-anesthetized white rhinoceroses (Ceratotherium simum).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20070901

Title: The use of alpha-2 agonists in the equine practice: comparison between three molecules.

Journal: Veterinary research communications 20070801

Title: The effects of detomidine, romifidine or acepromazine on echocardiographic measurements and cardiac function in normal horses.

Journal: Veterinary anaesthesia and analgesia 20070101

Title: Atipamezole in the management of detomidine overdose in a pony.

Journal: Veterinary anaesthesia and analgesia 20070101

Title: Comparison of intraoperative pain responses following intratesticular or mesorchial injection of lidocaine in standing horses undergoing laparoscopic cryptorchidectomy.

Journal: Journal of the American Veterinary Medical Association 20061201

Title: Adrenergic stimulation and blocking of hormonal secretion activity of cultured cow granulosa cells.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101

Title: The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101

Title: Serial chemical restraint for treatment of decubitus ulcers in two neonatal white rhinoceroses (Ceratotherium simum).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20060901

Title: The stress caused by laparoscopy in sheep and its alleviation.

Journal: New Zealand veterinary journal 20060601

Title: Effects of xylazine, medetomidine, detomidine, and diazepam on sedation, heart and respiratory rates, and cloacal temperature in rock partridges (Alectoris graeca).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20060601

Title: Clinical evaluation of intranasal benzodiazepines, alpha-agonists and their antagonists in canaries.

Journal: Veterinary anaesthesia and analgesia 20060501

Title: Antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole.

Journal: Equine veterinary journal 20060501

Title: Electroencephalographic and electromyographic changes during the use of detomidine and detomidine-butorphanol combination in standing horses.

Journal: Acta veterinaria Hungarica 20060301

Title: Sedative effects of midazolam and xylazine with or without ketamine and detomidine alone following intranasal administration in Ring-necked Parakeets.

Journal: Journal of the American Veterinary Medical Association 20060201

Title: Chemical immobilisation of wild banteng (Bos javanicus) in northern Australia using detomidine, tiletamine and zolazepam.

Journal: Australian veterinary journal 20051001

Title: The analgesic effects of intrathecal xylazine and detomidine in sheep and their antagonism with systemic atipamezole.

Journal: Veterinary anaesthesia and analgesia 20050901

Title: Accidental human poisoning with a veterinary tranquilliser.

Journal: Emergency medicine journal : EMJ 20050701

Title: Standing sedation in African elephants (Loxodonta africana) using detomidine-butorphanol combinations.

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20050601

Title: Overdose during chemical restraint in a black rhinoceros (Diceros bicornis).

Journal: Veterinary anaesthesia and analgesia 20050101

Title: Chemical immobilization of captive aardvark (Orycteropus afer).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20041201

Title: Effects of alpha2-adrenergic receptor agonists on urine production in horses deprived of food and water.

Journal: American journal of veterinary research 20041001

Title: [Influence of detomidine on echocardiographic function parameters and cardiac hemodynamics in horses with and without heart murmur].

Journal: Schweizer Archiv fur Tierheilkunde 20040301

Title: Serial immobilization of a Brazilian tapir (Tapirus terrestrus) with oral detomidine and oral carfentanil.

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20031201

Title: Comparison of etorphine-detomidine and medetomidine-ketamine anesthesia in captive addax (Addax nasomaculatus).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030901

Title: A comparison of the antinociceptive effects of xylazine, detomidine and romifidine on experimental pain in horses.

Journal: Veterinary anaesthesia and analgesia 20030701

Title: Interactions of xylazine and detomidine with alpha2-adrenoceptors in brain tissue from cattle, swine and rats.

Journal: Journal of veterinary pharmacology and therapeutics 20030601

Title: Influence of detomidine and buprenorphine on motor-evoked potentials in horses.

Journal: The Veterinary record 20030426

Title: Hormonal, metabolic and physiological effects of laparoscopic surgery using a detomidine-buprenorphine combination in standing horses.

Journal: Veterinary anaesthesia and analgesia 20030401

Title: Effects of alpha-2 adrenoceptor agonists during recovery from isoflurane anaesthesia in horses.

Journal: Equine veterinary journal 20030301

Title: Flash electroretinography in standing horses using the DTL microfiber electrode.

Journal: Veterinary ophthalmology 20030301

Title: Preliminary study of the effects of xylazine or detomidine with or without butorphanol for standing sedation in dairy cattle.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20030101

Title: In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus.

Journal: American journal of veterinary research 20021201

Title: Effects of treatment with oxytocin, xylazine butorphanol, guaifenesin, acepromazine, and detomidine on esophageal manometric pressure in conscious horses.

Journal: American journal of veterinary research 20021201

Title: Different contractile effects of alpha1- and alpha2-adrenergic agonists on horse isolated common digital artery smooth muscle ring preparations in vitro.

Journal: Pharmacological research 20021001

Title: Aberrations in uterine contractile patterns in mares with delayed uterine clearance after administration of detomidine and oxytocin.

Journal: Theriogenology 20020901

Title: Incorrect dose of detomidine.

Journal: Journal of the American Veterinary Medical Association 20020715

Title: The effects of xylazine, detomidine, acepromazine and butorphanol on equine solid phase gastric emptying rate.

Journal: Equine veterinary journal 20020701

Title: Repeated chemical immobilization of a captive greater one-horned rhinoceros (Rhinoceros unicornis), using combinations of etorphine, detomidine, and ketamine.

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020601

Title: N-Glucuronidation of some 4-arylalkyl-1H-imidazoles by rat, dog, and human liver microsomes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020301

Title: Evaluation of the bispectral index as an indicator of degree of central nervous system depression in isoflurane-anesthetized horses.

Journal: American journal of veterinary research 20020301

Title: Epidural morphine and detomidine decreases postoperative hindlimb lameness in horses after bilateral stifle arthroscopy.

Journal: Veterinary surgery : VS 20020101

Title: Analgesic effect of butorphanol and levomethadone in detomidine sedated horses.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20010801

Title: High-performance liquid chromatographic method combining radiochemical and ultraviolet detection for determination of low activities of uridine 5'-diphosphate-glucuronosyltransferase.

Journal: Analytical biochemistry 20010515

Title: Equine thoracoscopy: normal anatomy and surgical technique.

Journal: Equine veterinary journal 20010501

Title: Severe pruritus associated with epidural morphine and detomidine in a horse.

Journal: Australian veterinary journal 20010401

Title: Comparison of detomidine and romifidine as premedicants before ketamine and halothane anesthesia in horses undergoing elective surgery.

Journal: American journal of veterinary research 20010301

Title: Standing laparoscopic herniorrhaphy in stallions using cylindrical polypropylene mesh prosthesis.

Journal: Equine veterinary journal 20010101

Title: Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7.

Title: J Still, et al. Cardiovascular and respiratory effects of detomidine in isoflurane-anaesthetised horses. J S Afr Vet Assoc. 1996 Dec;67(4):199-203.

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Tags:90038-01-0 Molecular Formula|90038-01-0 MDL|90038-01-0 SMILES|90038-01-0 Detomidine HCl