Title: [Homoharringtonine combined arsenic trioxide induced apoptosis in human multiple myeloma cell line RPMI 8226: an experimental research].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine20130601
Title: [Clinical investigation of homoharringtonine in combination with all-transretinoic acid and arsenic trioxide for acute promyelocytic leukemia].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20130201
Title: Over-expression of RPL23 in myelodysplastic syndromes is associated with apoptosis resistance of CD34+ cells and predicts poor prognosis and distinct response to CHG chemotherapy or decitabine.
Journal: Annals of hematology20121001
Title: [Cytotoxicity of homoharringtonine on leukemic stem-like cells in AML cell line KG-1].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences20120901
Title: Omacetaxine mepesuccinate prevents cytokine-dependent resistance to nilotinib in vitro: potential role of the common β-subunit c of cytokine receptors.
Journal: Leukemia20120601
Title: [Establishment of human homoharringtonine-resistant SKM-1 cell line and its biological characteristics].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20120601
Title: Investigation into omacetaxine solution stability for in vitro study.
Journal: Biomedical chromatography : BMC20120501
Title: Effect of homoharringtonine on bone marrow CD34 + CD117 + cells in patients with chronic myelogenous leukemia.
Journal: Leukemia & lymphoma20120501
Title: Undetectable molecular residual disease after omacetaxine and nilotinib combination therapy in an imatinib-resistant chronic myeloid leukaemia patient harbouring the BCR-ABL1 T315I gatekeeper mutation.
Journal: British journal of haematology20120501
Title: High-dose homoharringtonine versus standard-dose daunorubicin is effective and safe as induction and post-induction chemotherapy for elderly patients with acute myeloid leukemia: a multicenter experience from China.
Journal: Medical oncology (Northwood, London, England)20120301
Title: Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival.
Journal: Cancer research20120201
Title: [Effects of interferon-α combined with homoharringtonine on K562 cell proliferation and β-catenin expression].
Journal: Zhongguo shi yan xue ye xue za zhi20120201
Title: Salvage therapy with endostatin, low-dose homoharringtonine, and cytarabine in combination with granulocyte-colony stimulating factor for elderly patients with primary refractory acute myeloid leukemia.
Journal: American journal of hematology20120101
Title: Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines.
Journal: BMC medical genomics20120101
Title: [Outcome of acute promyelocytic leukemia with homoharringtonine (HHT) and ATRA].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20111101
Title: Efficacy and safety of CHG regimen (low-dose cytarabine, homoharringtonine with G-CSF priming) as induction chemotherapy for elderly patients with high-risk MDS or AML transformed from MDS.
Journal: Journal of cancer research and clinical oncology20111001
Title: Omacetaxine mepesuccinate for the treatment of leukemia.
Journal: Expert opinion on pharmacotherapy20111001
Title: [Effect of homoharringtonine combined with AG490 on JAK2-STAT5 associated signal pathway in HEL cells].
Journal: Zhongguo shi yan xue ye xue za zhi20111001
Title: [Clinical study on combination of homoharringtonine, Ara-C and idarubicin induction for treatment of newly diagnosed acute myeloid leukemia patients].
Journal: Zhongguo shi yan xue ye xue za zhi20111001
Title: Successful treatment of childhood Philadelphia chromosome-positive acute myeloid leukemia.
Journal: Pediatrics international : official journal of the Japan Pediatric Society20110801
Title: Low dose of homoharringtonine and cytarabine combined with granulocyte colony-stimulating factor priming on the outcome of relapsed or refractory acute myeloid leukemia.
Journal: Journal of cancer research and clinical oncology20110601
Title: Bcl-xL is a dominant antiapoptotic protein that inhibits homoharringtonine-induced apoptosis in leukemia cells.
Journal: Molecular pharmacology20110601
Title: Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells.
Journal: Leukemia20110601
Title: Homoharringtonine as a backbone drug for the treatment of newly diagnosed pediatric acute myeloid leukemia: a report from a single institution in China.
Journal: International journal of hematology20110501
Title: Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia.
Journal: Blood20110106
Title: Omacetaxine as an anticancer therapeutic: what is old is new again.
Journal: Current pharmaceutical design20110101
Title: Omacetaxine: the FDA decision.
Journal: Clinical advances in hematology & oncology : H&O20110101
Title: [The efficacy and safety of HAA regimen as induction chemotherapy in 150 newly diagnosed acute myeloid leukemia].
Journal: Zhonghua nei ke za zhi20110101
Title: Standard-dose imatinib plus low-dose homoharringtonine and granulocyte colony-stimulating factor is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis who have failed prior single-agent therapy with imatinib.
Journal: Annals of hematology20101101
Title: Enrichment of N-Cadherin and Tie2-bearing CD34+/CD38-/CD123+ leukemic stem cells by chemotherapy-resistance.
Journal: Cancer letters20101001
Title: The durable clearance of the T315I BCR-ABL mutated clone in chronic phase chronic myelogenous leukemia patients on omacetaxine allows tyrosine kinase inhibitor rechallenge.
Journal: Clinical lymphoma, myeloma & leukemia20101001
Title: Retrospective robustness of the continual reassessment method.
Journal: Journal of biopharmaceutical statistics20100901
Title: Successful treatment using omacetaxine for a patient with CML and BCR-ABL1 [corrected] 35INS.
Journal: Blood20100506
Title: [Efficiency of GHA priming therapy on patients with acute monocytic leukemia and its mechanism].
Journal: Zhongguo shi yan xue ye xue za zhi20100201
Title: Novel therapeutic agents against cancer stem cells of chronic myeloid leukemia.
Journal: Anti-cancer agents in medicinal chemistry20100201
Title: Homoharringtonine in combination with cytarabine and aclarubicin as induction therapy improves remission and survival of patients with higher risk myelodysplastic syndromes.
Journal: Chinese medical journal20100105
Title: The antitumor activity of homoharringtonine against human mast cells harboring the KIT D816V mutation.
Journal: Molecular cancer therapeutics20100101
Title: Novel screening method for potential skin-whitening compounds by a luciferase reporter assay.
Journal: Bioscience, biotechnology, and biochemistry20100101
Title: Homoharringtonine, omacetaxine mepesuccinate, and chronic myeloid leukemia circa 2009.
Journal: Cancer20091201
Title: Homoharringtonine acts synergistically with SG235-TRAIL, a conditionally replicating adenovirus, in human leukemia cell lines.
Journal: Acta pharmacologica Sinica20091101
Title: The effect of homoharringtonine in patients with chronic myeloid leukemia who have failed or responded suboptimally to imatinib therapy.
Journal: Leukemia & lymphoma20091101
Title: Effect of low-dose cytarabine, homoharringtonine and granulocyte colony-stimulating factor priming regimen on patients with advanced myelodysplastic syndrome or acute myeloid leukemia transformed from myelodysplastic syndrome.
Journal: Leukemia & lymphoma20090901
Title: Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice.
Journal: Leukemia20090801
Title: Prolonged chronic phase in chronic myelogenous leukemia after homoharringtonine therapy.
Journal: Chinese medical journal20090620
Title: [Changes of gene expression profile in homoharringtonine-induced leukemia multi-drug resistant cell line K562/HHT].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20090601
Title: U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
Journal: Journal of molecular biology20090529
Title: A phase II study of continuous infusion homoharringtonine and cytarabine in newly diagnosed patients with chronic myeloid leukemia: CALGB study 19804.
Journal: Cancer chemotherapy and pharmacology20090401
Title: Complexity of BCR-ABL kinase domain mutations during the course of therapy with tyrosine kinase inhibitors in chronic myeloid leukemia.
Journal: American journal of hematology20090401
Title: [Expression and function of Ahi-1 gene in Jurkat cells].
Journal: Zhongguo shi yan xue ye xue za zhi20090401
Title: [Efficacy of induction chemotherapy for patients with high-risk myelodysplastic syndrome (MDS) or MDS-transformed acute myeloid leukemia with CHG regimen and its comparison with regimen GAG and HA].
Journal: Zhongguo shi yan xue ye xue za zhi20090401
Title: Separation and detection of isoquinoline alkaloids using MEEKC coupled with field-amplified sample injection induced by ACN.
Journal: Electrophoresis20090201
Title: [A clinical trial for homoharringtonine and low-dose cytosine arabinoside combined with G-CSF or GM-CSF to treat the relapsed or refractory acute myeloid leukemia (AML), geriatric AML and advanced myelodysplastic syndromes].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition20090101
Title: Altering chemosensitivity by modulating translation elongation.
Journal: PloS one20090101
Title: A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China.
Journal: Journal of hematology & oncology20090101
Title: Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells.
Journal: European journal of haematology20081001
Title: Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.
Journal: Bioorganic & medicinal chemistry letters20081001
Title: [Efficiency of GHA priming chemotherapy on patients with refractory acute myeloid leukemia and myelodysplastic syndrome and its relationship with expression of costimulatory molecule B7.1].
Journal: Zhongguo shi yan xue ye xue za zhi20081001
Title: Homoharringtonine inhibits the AKT pathway and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells.
Journal: Leukemia & lymphoma20081001
Title: [Effects of RNA interference targeting hypoxia-inducible factor-1alpha (HIF-1alpha) on chemosensitivity of leukemia K562 cells towards homoharringtonine].
Journal: Ai zheng = Aizheng = Chinese journal of cancer20080701
Title: Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin.
Journal: International journal of hematology20080601
Title: New Bcr-Abl inhibitors in chronic myeloid leukemia: keeping resistance in check.
Journal: Expert opinion on investigational drugs20080601
Title: Omacetaxine mepesuccinate--a semisynthetic formulation of the natural antitumoral alkaloid homoharringtonine, for chronic myelocytic leukemia and other myeloid malignancies.
Journal: IDrugs : the investigational drugs journal20080501
Title: Homoharringtonine for the treatment of chronic myelogenous leukemia.
Journal: Expert opinion on pharmacotherapy20080401
Title: The prognostic significance of leukemic cells clearance kinetics evaluation during the initial course of induction therapy with HAD (homoharringtonine, cytosine arabinoside, daunorubicin) in patients with de novo acute myeloid leukemia.
Journal: American journal of hematology20080301
Title: Combination chemotherapy with low-dose cytarabine, homoharringtonine, and granulocyte colony-stimulating factor priming in patients with relapsed or refractory acute myeloid leukemia.
Journal: American journal of hematology20080301
Title: Therapeutic experience of adult acute myeloid leukemia in a single institution of China and its relationship with chromosome karyotype.
Journal: Leukemia & lymphoma20080301
Title: ABT-737 is a useful component of combinatory chemotherapies for chronic myeloid leukaemias with diverse drug-resistance mechanisms.
Journal: British journal of haematology20080101
Title: [HAA regimen as induction chemotherapy for newly diagnosed acute myelogenous leukemia].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20080101
Title: Novel agents in CML therapy: tyrosine kinase inhibitors and beyond.
Journal: Hematology. American Society of Hematology. Education Program20080101
Title: Refractory multiple myeloma treated with homoharringtonine: report of two cases.
Journal: Annals of hematology20071201
Title: Gene expression profiling in apoptotic k562 cells treated by homoharringtonine.
Journal: Acta biochimica et biophysica Sinica20071201
Title: BCR-ABL(T315I) transcript disappearance in an imatinib-resistant CML patient treated with homoharringtonine: a new therapeutic challenge?
Journal: Leukemia20071001
Title: Interferon-alpha or homoharringtonine as salvage treatment for chronic myeloid leukemia patients who acquire the T315I BCR-ABL mutation.
Journal: Blood20071001
Title: Chronic myeloid leukaemia in India.
Journal: Lancet (London, England)20070929
Title: TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade.
Journal: FEBS letters20070807
Title: Homoharringtonine induces apoptosis and growth arrest in human myeloma cells.
Journal: Leukemia & lymphoma20070701
Title: [Role of Bid protein in the mitochondria and Endoplasmic Reticulum associated apoptotic pathway].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20070701
Title: Effect of cantharidin, cephalotaxine and homoharringtonine on 'in vitro' models of hepatitis B virus (HBV) and bovine viral diarrhoea virus (BVDV) replication.
Journal: Planta medica20070601
Title: Gene expression pattern in apoptotic QGY-7703 cells induced by homoharringtonine.
Journal: Acta pharmacologica Sinica20070601
Title: Homoharringtonine-induced apoptosis of MDS cell line MUTZ-1 cells is mediated by the endoplasmic reticulum stress pathway.
Journal: Leukemia & lymphoma20070501
Title: Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy.
Journal: Cancer20070115
Title: Recent developments in adaptive designs for Phase I/II dose-finding studies.
Journal: Journal of biopharmaceutical statistics20070101
Title: A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia.
Journal: British journal of cancer20060807
Title: Homoharringtonine in combination with cytarabine and aclarubicin resulted in high complete remission rate after the first induction therapy in patients with de novo acute myeloid leukemia.
Journal: Leukemia20060801
Title: [Effect of several anti-tumor drugs on apoptosis induction in Jurkat cell line].
Journal: Zhongguo shi yan xue ye xue za zhi20060801
Title: Imatinib activity in vitro in tumor cells from patients with chronic myeloid leukemia in chronic phase and blast crisis.
Journal: Anti-cancer drugs20060701
Title: Quantitative real-time RT-PCR monitoring of BCR-ABL in chronic myelogenous leukemia shows lack of agreement in blood and bone marrow samples.
Journal: International journal of oncology20060501
Title: New strategies in chronic myeloid leukemia.
Journal: International journal of hematology20060501
Title: Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia-1 down-regulation in myeloid leukemia cells.
Journal: Molecular cancer therapeutics20060301
Title: Homoharringtonine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of telomerase.
Journal: The American journal of Chinese medicine20060101
Title: Phase I/II trial of adding semisynthetic homoharringtonine in chronic myeloid leukemia patients who have achieved partial or complete cytogenetic response on imatinib.
Journal: Cancer20050501
Title: Correlation between survivin mRNA expression and homoharringtonine induced apoptosis of malignant hematopoietic cells.
Journal: Chinese medical journal20050405
Title: Induction of apoptosis by homoharringtonine in G1 phase human chronic myeloid leukemic cells.
Journal: Chinese medical journal20050320
Title: [Protection of mdr1 transfected cord blood mononuclear cell graft against anticancer agents in vivo].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20050201
Title: Effect of Homoharringtonine on corneal haze after excimer laser photorefractive keratectomy in rabbits.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban20050101
Title: Homoharringtonine: a new treatment option for myeloid leukemia.
Journal: Hematology (Amsterdam, Netherlands)20040801
Title: Homoharringtonine mediates myeloid cell apoptosis via upregulation of pro-apoptotic bax and inducing caspase-3-mediated cleavage of poly(ADP-ribose) polymerase (PARP).
Journal: American journal of hematology20040701
Title: Investigational strategies in chronic myelogenous leukemia.
Journal: Hematology/oncology clinics of North America20040601
Title: Identification of genes responsive to apoptosis in HL-60 cells.
Journal: Acta pharmacologica Sinica20040301
Title: Homoharringtonine induces apoptosis of endothelium and down-regulates VEGF expression of K562 cells.
Journal: Journal of Zhejiang University. Science20040201
Title: [Expression and significance of apoptosis protein inhibitor survivin and XIAP, in patients with myelodysplastic syndromes and in the cell line MUTZ-1].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20040101
Title: [Comparative proteomics research of apoptosis initiation induced by homoharringtonine in HL-60 cells].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20031201
Title: New agents in chronic myelogenous leukemia.
Journal: Journal of the National Comprehensive Cancer Network : JNCCN20031001
Title: Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase.
Journal: Cancer20030901
Title: [Glivec in combination with HA regimen for treatment of 20 patients with Ph chromosome positive acute leukemia].
Journal: Ai zheng = Aizheng = Chinese journal of cancer20030801
Title: A homoharringtonine-based regimen for childhood acute myelogenous leukemia.
Journal: Medical and pediatric oncology20030701
Title: [Inhibition of activation of nuclear factor-kappaB enhanced apoptosis of leukemic cells induced by homoharringtonine].
Journal: Zhonghua nei ke za zhi20030501
Title: [Effect of homoharringtonine on expression of human telomerase reverse transcriptase mRNA in HL-60 cells].
Journal: Zhongguo shi yan xue ye xue za zhi20030401
Title: Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines.
Journal: Naunyn-Schmiedeberg's archives of pharmacology20030101
Title: Metabolism of homoharringtonine, a cytotoxic component of the evergreen plant Cephalotaxus harringtonia.
Journal: Journal of experimental therapeutics & oncology20030101
Title: In vitro effects of STI 571-containing drug combinations on the growth of Philadelphia-positive chronic myelogenous leukemia cells.
Journal: Cancer20020515
Title: Homoharringtonine effective in CML patients.
Journal: The Lancet. Oncology20020501
Title: Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia.
Journal: Cancer20020401
Title: [Chemotherapy and radiation therapy].
Journal: Nihon rinsho. Japanese journal of clinical medicine20011201
Title: Homoharringtonine: history, current research, and future direction.
Journal: Cancer20010915
Title: A phase II study of Homoharringtonine for the treatment of children with refractory or recurrent acute myelogenous leukemia: a pediatric oncology group study.
Journal: Medical and pediatric oncology20010801
Title: [Involvement of mitochondrial membrane potential in the homoharringtonine induced apoptosis of leukemic T-cells].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20010501
Title: In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents.
Journal: Blood20010401
Title: Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation.
Journal: Leukemia20010401
Title: [Severe side effects of the treatment of acute promyelocytic leukemia with all-trans retinoic acid].
Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University20000628
Title: Homoharringtonine: an effective new natural product in cancer chemotherapy.
Journal: Bulletin du cancer19951201
Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
Journal: Journal of natural products19910101
Title: Inhibition of translation in eukaryotic systems by harringtonine.
Journal: European journal of biochemistry19770101
Title: Inhibition of protein synthesis in intact HeLa cells.
Journal: Antimicrobial agents and chemotherapy19751001
Title: Cao W, et al. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Sci Rep. 2015 Jul 13;5:8477
