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50-33-9,MFCD00005500
Catalog No.:AA006UMA

50-33-9 | 4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine

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10mg
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$6.00   $4.00
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50mg
97%
in stock  
$7.00   $5.00
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10g
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100g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006UMA
Chemical Name:
4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine
CAS Number:
50-33-9
Molecular Formula:
C19H20N2O2
Molecular Weight:
308.3743
MDL Number:
MFCD00005500
SMILES:
CCCCC1C(=O)N(N(C1=O)c1ccccc1)c1ccccc1
UN Number:
2811
Properties
Properties
 
BP:
424.9°C at 760 mmHg  
Form:
Solid  
MP:
104-107 °C  
Refractive Index:
1.6140 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
389  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.2  

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Title: Efficacy of single-dose intravenous phenylbutazone and flunixin meglumine before, during and after exercise in an experimental reversible model of foot lameness in horses.

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Title: A comparative study on the adverse effects of flunixin, ketoprofen and phenylbutazone in miniature donkeys: haematological, biochemical and pathological findings.

Journal: New Zealand veterinary journal 20101001

Title: Surveillance study of novobiocin and phenylbutazone residues in raw bovine milk using liquid chromatography-tandem mass spectrometry.

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Title: Determination of non-steroidal anti-inflammatory drugs residues in animal muscles by liquid chromatography-tandem mass spectrometry.

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Title: Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity.

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Title: Effect of an endurance-like exercise on the disposition and detection time of phenylbutazone and dexamethasone in the horse: application to medication control.

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Title: Antemortem diagnosis of a distal axonopathy causing severe stringhalt in a horse.

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Title: Cutaneous and tendon sheath mastocytomas with eosinophilic joint and tendon sheath effusions in a horse.

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Title: Analgesic effects of butorphanol tartrate and phenylbutazone administered alone and in combination in young horses undergoing routine castration.

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Title: Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database.

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Title: Enhancement of transdermal delivery of phenylbutazone from liposomal gel formulations through deer skin.

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Title: Evaluation of topically administered diclofenac liposomal cream for treatment of horses with experimentally induced osteoarthritis.

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Title: Effects of single-dose intravenous phenylbutazone on experimentally induced, reversible lameness in the horse.

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Title: Effectiveness of administration of phenylbutazone alone or concurrent administration of phenylbutazone and flunixin meglumine to alleviate lameness in horses.

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Title: The effects of chiropractic, massage and phenylbutazone on spinal mechanical nociceptive thresholds in horses without clinical signs.

Journal: Equine veterinary journal 20080101

Title: Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis.

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Title: Rapid characterization of drug-drug interaction in plasma protein binding using a surface plasmon resonance biosensor.

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Title: Effects of continuous oral administration of phenylbutazone on biomarkers of cartilage and bone metabolism in horses.

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Title: Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone.

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Title: Vitex negundo Linn (VN) leaf extract as an adjuvant therapy to standard anti-inflammatory drugs.

Journal: The Indian journal of medical research 20061001

Title: Inactivation of alpha1-antiproteinase induced by phenylbutazone: participation of peroxyl radicals and hydroperoxide.

Journal: Basic & clinical pharmacology & toxicology 20060901

Title: Evaluation of anti-inflammatory activity of Calotropis gigantea (AKANDA) in various biological system.

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Title: Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis.

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Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Simultaneous and minimally invasive assessment of muscle tolerance and bioavailability of different volumes of an intramuscular formulation in the same animals.

Journal: Journal of animal science 20060501

Title: ['Tübinger bomb' is now personally mixed].

Journal: MMW Fortschritte der Medizin 20060406

Title: Involvement of opioidergic and alpha2-adrenergic mechanisms in the central analgesic effects of non-steroidal anti-inflammatory drugs in sheep.

Journal: Research in veterinary science 20060401

Title: Intra-abdominal abscess and peritonitis in an Appaloosa gelding.

Journal: The Veterinary clinics of North America. Equine practice 20060401

Title: Actinobacillus pleuritis and peritonitis in a quarter horse mare.

Journal: The Veterinary clinics of North America. Equine practice 20060401

Title: Postpartum hemoperitoneum and septic peritonitis in a Thoroughbred mare.

Journal: The Veterinary clinics of North America. Equine practice 20060401

Title: Left otitis media/interna and right maxillary sinusitis in a Percheron mare.

Journal: The Veterinary clinics of North America. Equine practice 20060401

Title: Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses.

Journal: American journal of veterinary research 20060301

Title: [Hyperammonemia type II as an example of urea cycle disorder].

Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20060101

Title: Glucuronidation of DRF-6574, hydroxy metabolite of DRF-4367 (a novel COX-2 inhibitor) by pooled human liver, intestinal microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT1A1, 1A3 and 1A8.

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Title: Synthesis and antiinflammatory activity of coumarin derivatives.

Journal: Journal of medicinal chemistry 20051006

Title: COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.

Journal: Pharmacological research 20051001

Title: Chip fractures from the distal lateral trochlear ridge of the talus of a quarter horse gelding: a veterinary medicine clinical report.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20050905

Title: Micronization of phenylbutazone by rapid expansion of supercritical CO2 solution.

Journal: Chemical & pharmaceutical bulletin 20050801

Title: Evaluation of electroacupuncture treatment of horses with signs of chronic thoracolumbar pain.

Journal: Journal of the American Veterinary Medical Association 20050715

Title: Protein binding characteristics of 2'-benzoyloxycinnamaldehyde.

Journal: Drug development and industrial pharmacy 20050701

Title: ['Buta': is it or is it not allowed?].

Journal: Tijdschrift voor diergeneeskunde 20050701

Title: Quantitative comparison of three commonly used treatments for navicular syndrome in horses.

Journal: American journal of veterinary research 20050701

Title: Agranulocytosis and citrobacter infection associated with jamu, a herbal remedy containing phenylbutazone.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050615

Title: Septic arthritis and granulomatous synovitis caused by infection with Mycobacterium avium complex in a horse.

Journal: Journal of the American Veterinary Medical Association 20050615

Title: Phenylbutazone and equine research.

Journal: The Veterinary record 20050423

Title: Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis.

Journal: Research in veterinary science 20050401

Title: UDP-glucuronosyltransferases and clinical drug-drug interactions.

Journal: Pharmacology & therapeutics 20050401

Title: High-performance frontal analysis of the binding of thyroxine enantiomers to human serum albumin.

Journal: Pharmaceutical research 20050401

Title: Phenylbutazone and equine research.

Journal: The Veterinary record 20050305

Title: Evaluation of the analgesic effects of phenylbutazone administered at a high or low dosage in horses with chronic lameness.

Journal: Journal of the American Veterinary Medical Association 20050201

Title: Use of force plate analysis to compare the analgesic effects of intravenous administration of phenylbutazone and flunixin meglumine in horses with navicular syndrome.

Journal: American journal of veterinary research 20050201

Title: Comparison of the effect of Sporobolus virginicus and Rhodes (Chloris gayana) hay diets on the absorption pattern of phenylbutazone in the camel (Camelus dromedarius).

Journal: Veterinary journal (London, England : 1997) 20050101

Title: Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation.

Journal: Oncogene 20041209

Title: Synthesis of some newer analogues of substituted dibenzoyl phenol as potent anti-inflammatory agents.

Journal: Bioorganic & medicinal chemistry letters 20041101

Title: Effects of phenylbutazone, indomethacin, prostaglandin E2, butyrate, and glutamine on restitution of oxidant-injured right dorsal colon of horses in vitro.

Journal: American journal of veterinary research 20041101

Title: Influence of thiamphenicol on the primary functions of human polymorphonuclear leucocytes against Streptococcus pyogenes.

Journal: International journal of antimicrobial agents 20041001

Title: Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.

Journal: Journal of medicinal chemistry 20040923

Title: Synthesis of chloro and bromo substituted 5-(indan-1'-yl)tetrazoles and 5-(indan-1'-yl)methyltetrazoles as possible analgesic agents.

Journal: Die Pharmazie 20040601

Title: Lower gastric ulcerogenic effect of suxibuzone compared to phenylbutazone when administered orally to horses.

Journal: Research in veterinary science 20040401

Title: Evaluation of the protein binding ratio of drugs by a micro-scale ultracentrifugation method.

Journal: Journal of pharmaceutical sciences 20040401

Title: [Two cases of anaphylactic shock after metamizol given during postoperative recovery].

Journal: Revista espanola de anestesiologia y reanimacion 20040301

Title: Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.

Journal: Immunopharmacology and immunotoxicology 20040201

Title: Multi-residue liquid chromatography/tandem mass spectrometry method for the detection of non-steroidal anti-inflammatory drugs in bovine muscle: optimisation of ion trap parameters.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Interleukin-1beta inhibits paw oedema induced by local administration of latex of Calotropis procera extracts.

Journal: Inflammopharmacology 20040101

Title: Effect of 14-deoxyandrographolide on calcium-mediated rat uterine smooth muscle contractility.

Journal: Phytotherapy research : PTR 20031101

Title: Antiinflammatory and antiulcer activities of Bambusa arundinacea.

Journal: Journal of ethnopharmacology 20031001

Title: [Contribution of diabetic research to versatile strategies for the treatment of diabetes mellitus].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030901

Title: Effects of lipopolysaccharide and phenylbutazone on gastric contents in the horse.

Journal: Equine veterinary journal 20030701

Title: Ultrasonographic findings in horses with right dorsal colitis: five cases (2000-2001).

Journal: Journal of the American Veterinary Medical Association 20030501

Title: The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz.

Journal: Journal of ethnopharmacology 20030401

Title: Preliminary studies of offspring exposure to phenylbutazone and ivermectin during the perinatal period in a Holstein cow-calf model.

Journal: Toxicology and applied pharmacology 20030315

Title: Analysis of adulterants in a traditional herbal medicinal product using liquid chromatography-mass spectrometry-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20030226

Title: Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B.

Journal: American journal of veterinary research 20030201

Title: Anti-inflammatory activity of some novel alpha-amino naphthalene derivatives.

Journal: Arzneimittel-Forschung 20030101

Title: [Clinical problems with oral anticoagulation -- 3 case reports].

Journal: Therapeutische Umschau. Revue therapeutique 20030101

Title: Molecular basis of sulindac competition with specific markers for the major binding sites on human serum albumin.

Journal: Arzneimittel-Forschung 20030101

Title: Ornithine transcarbamylase deficiency: a urea cycle defect.

Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20030101

Title: Role of laboratory in the management of phenylbutazone poisoning.

Journal: Journal of toxicology. Clinical toxicology 20030101

Title: Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs.

Journal: The Journal of biological chemistry 20021011

Title: Cortisol responses to dehorning of calves given a 5-h local anaesthetic regimen plus phenylbutazone, ketoprofen, or adrenocorticotropic hormone prior to dehorning.

Journal: Research in veterinary science 20021001

Title: Characterization of methotrexate transport and its drug interactions with human organic anion transporters.

Journal: The Journal of pharmacology and experimental therapeutics 20020801

Title: Effects of anti-arthritis preparations on gene expression and enzyme activity of cyclooxygenase-2 in cultured equine chondrocytes.

Journal: American journal of veterinary research 20020801

Title: Pharmacodynamics and pharmacokinetics of phenylbutazone in calves.

Journal: Journal of veterinary pharmacology and therapeutics 20020801

Title: Questioning the treatment of venous thromboembolism.

Journal: Annals of internal medicine 20020716

Title: In vitro anion transport alterations and apoptosis induced by phenylbutazone in the right dorsal colon of ponies.

Journal: American journal of veterinary research 20020701

Title: Evaluation of the influence of prostaglandin E2 on recombinant equine interleukin-1beta-stimulated matrix metalloproteinases 1, 3, and 13 and tissue inhibitor of matrix metalloproteinase 1 expression in equine chondrocyte cultures.

Journal: American journal of veterinary research 20020701

Title: Pharmacokinetics of phenylbutazone in beef steers.

Journal: Journal of veterinary pharmacology and therapeutics 20020601

Title: Pharmacokinetic/pharmacodynamic approach to assess irrelevant plasma or urine drug concentrations in postcompetition samples for drug control in the horse.

Journal: Equine veterinary journal 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Lipid peroxidation induced by phenylbutazone radicals.

Journal: Life sciences 20020419

Title: Significant omission in antithrombotic supplement.

Journal: Chest 20020401

Title: Determination by high-performance liquid chromatography of phenylbutazone in samples of plasma from fighting bulls.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020325

Title: Drug-plasma protein binding assay by electrokinetic chromatography-frontal analysis.

Journal: Electrophoresis 20020301

Title: Reconsidering anticoagulant therapy in venous thromboembolism.

Journal: Blood 20020115

Title: Sperm-zona pellucida interaction involves a carbonyl reductase activity in the hamster.

Journal: Molecular reproduction and development 20020101

Title: Inducible nitric oxide expression in equine articular chondrocytes: effects of antiinflammatory compounds.

Journal: Osteoarthritis and cartilage 20020101

Title: Late diagnosis of ornithine transcarbamylase defect in three related female patients: polymorphic presentations.

Journal: Critical care medicine 20020101

Title: [Phenylbutazone-induced sialadenitis fever simulating angioedema].

Journal: Annales de dermatologie et de venereologie 20020101

Title: Confirmation of phenylbutazone residues in bovine kidney by liquid chromatography/mass spectrometry.

Journal: Journal of AOAC International 20020101

Title: Renal papillary necrosis.

Journal: Toxicologic pathology 20020101

Title: Effects of oral administration of phenylbutazone to horses on in vitro articular cartilage metabolism.

Journal: American journal of veterinary research 20011201

Title: Synthesis and antiinflammatory, analgesic activity of 3,3'-(1,2-ethanediyl)-bis[2-aryl-4-thiazolidinone] chiral compounds. Part 10.

Journal: Bioorganic & medicinal chemistry letters 20011105

Title: In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats.

Journal: American journal of veterinary research 20011101

Title: Osteomyelitis of the sustentaculum tali in horses: 10 cases (1992-1998).

Journal: Journal of the American Veterinary Medical Association 20010801

Title: Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats.

Journal: Fitoterapia 20010601

Title: Pharmacokinetics of phenylbutazone in llamas following single intravenous and oral doses.

Journal: Journal of veterinary pharmacology and therapeutics 20010601

Title: [Effect of anti-inflammatory drugs, alone and combined with ofloxacin, on the respiratory burst of human polymorphonuclear leukocytes].

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20010601

Title: Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in miniature donkeys.

Journal: American journal of veterinary research 20010501

Title: Identification and reactivity of the major metabolite (beta-1-glucuronide) of the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20010501

Title: Fistulation of the auditory tube diverticulum (guttural pouch) with a neodymium:yttrium-aluminum-garnet laser for treatment of chronic empyema in two horses.

Journal: Journal of the American Veterinary Medical Association 20010201

Title: Phenylbutazone radicals inactivate creatine kinase.

Journal: Free radical research 20010201

Title: Effects of anti-inflammatory drugs on lipopolysaccharide-challenged and -unchallenged equine synovial explants.

Journal: American journal of veterinary research 20010101

Title: Synthesis and anti-inflammatory activity of 1-acetyl-5-substituted aryl-3-(beta-aminonaphthyl)-2-pyrazolines and beta-(substituted aminoethyl) amidonaphthalenes.

Journal: European journal of medicinal chemistry 20010101

Title: Cytotoxicity and mode of action of 1-(1-cyclohexenyl) and 1-unsubstituted 3,5-pyrazolidinediones in human Molt4 T cell leukemia.

Journal: Anticancer research 20010101

Title: [Preventive effect of carotene-containing preparations in acute gastritis model].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101

Title: Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes.

Journal: Cytokine 19990501

Title: A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 19990301

Title: Cancer chemopreventive activity of resveratrol.

Journal: Drugs under experimental and clinical research 19990101

Title: Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies.

Journal: Acta tropica 19970415

Title: Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.

Journal: Science (New York, N.Y.) 19970110

Title: Development of an in vitro reporter gene assay to assess xenobiotic induction of the human CYP3A4 gene.

Journal: European journal of drug metabolism and pharmacokinetics 19970101

Title: Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 19961201

Title: Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.

Journal: Journal of medicinal chemistry 19950929

Title: Misuse of veterinary phenylbutazone.

Journal: Archives of internal medicine 19950612

Title: Long-term exposure to the anti-inflammatory agent phenylbutazone induces kidney tumors in rats and liver tumors in mice.

Journal: Japanese journal of cancer research : Gann 19950301

Title: Aplastic anemia induced by an adulterated herbal medication.

Journal: Journal of toxicology. Clinical toxicology 19950101

Title: Anti-inflammatory activity and sub-acute toxicity of artemetin.

Journal: Planta medica 19900201

Title: Neurosensory adverse effects after phenylbutazone and misoprostol combined treatment.

Journal: Lancet (London, England) 19891125

Title: Agranulocytosis and liver damage associated with pyrazinobutazone with evidence for an immunological mechanism.

Journal: The Journal of rheumatology 19891101

Title: Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats.

Journal: Brain research 19881018

Title: Diagnosis of antibody-mediated drug allergy. Pyrazolinone and pyrazolidinedione cross-reactivity relationships.

Journal: Allergy 19871101

Title: Long-term studies on carcinogenicity and promoting effect of phenylbutazone in DONRYU rats.

Journal: Journal of the National Cancer Institute 19870901

Title: Promotion of hepatocarcinogenesis by suxibuzone in rats initiated with 3'-methyl-4-dimethylaminoazobenzene.

Journal: Cancer letters 19870701

Title: Dermatomyositis-like syndrome associated with phenylbutazone therapy.

Journal: The Journal of rheumatology 19870401

Title: [Hepatic lesions induced by drugs. Report of 26 cases].

Journal: Acta gastroenterologica Latinoamericana 19870101

Title: Risks of agranulocytosis and aplastic anemia. A first report of their relation to drug use with special reference to analgesics. The International Agranulocytosis and Aplastic Anemia Study.

Journal: JAMA 19861003

Title: Morphological changes in the liver due to phenazone and its derivatives.

Journal: Agents and actions. Supplements 19860101

Title: Strain-related susceptibility to nephrotoxicity induced by aspirin and phenylbutazone in rats.

Journal: Toxicologic pathology 19860101

Title: [Hypokalemic periodic paralysis provoked by 'Ambene'].

Journal: Der Nervenarzt 19851201

Title: [Nephrotic syndrome and acute interstitial nephritis after phenylbutazone].

Journal: Schweizerische medizinische Wochenschrift 19851102

Title: Phenylbutazone-induced systemic vasculitis with crescentic glomerulonephritis.

Journal: Archives of internal medicine 19850401

Title: Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies.

Journal: Hepatology (Baltimore, Md.) 19850101

Title: Antrafenine: anti-inflammatory activity with respect to oedema and leucocyte infiltration in the rat.

Journal: Agents and actions 19840201

Title: Phenylbutazone nephrotoxicity--a light and electron microscopic study.

Journal: Irish journal of medical science 19831201

Title: [Kidney damage after treatment with butapyrazole].

Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 19831115

Title: Renal medullary crest necrosis associated with phenylbutazone therapy in horses.

Journal: Veterinary pathology 19831101

Title: Effects of large doses of phenylbutazone administration to horses.

Journal: American journal of veterinary research 19830501

Title: Phenylbutazone associated glomerulonephritis. Glomerulonephritis and fever.

Journal: IMJ. Illinois medical journal 19821201

Title: Sialadenitis and systemic reaction associated with phenylbutazone.

Journal: Australian and New Zealand journal of medicine 19820601

Title: Animal experiments on the safety pharmacology of lofexidine.

Journal: Arzneimittel-Forschung 19820101

Title: Acute nephrotic syndrome with reversible renal failure after phenylbutazone.

Journal: British medical journal (Clinical research ed.) 19810321

Title: Phenylbutazone liver injury: a clinical-pathologic survey of 23 cases and review of the literature.

Journal: Hepatology (Baltimore, Md.) 19810101

Title: Intrahepatic cholestasis induced by phenylbutazone.

Journal: Digestion 19810101

Title: Phenylbutazone-induced blood dyscrasias suspected in three dogs.

Journal: The Veterinary record 19800913

Title: Use of phenylbutazone in sports medicine: understanding the risks.

Journal: The American journal of sports medicine 19800101

Title: Confusion associated with cimetidine.

Journal: British medical journal 19791201

Title: Antiinflammatory agents. 1. Synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid.

Journal: Journal of medicinal chemistry 19790901

Title: Exacerbation of phenylbutazone-related renal failure by indomethacin.

Journal: Archives of internal medicine 19781101

Title: Interstitial nephritis in a case of phenylbutazone hypersensitivity.

Journal: British medical journal 19780520

Title: [Acute interstitial nephritis with oliguric renal failure following phenylbutazone medication].

Journal: Schweizerische medizinische Wochenschrift 19780401

Title: Renal papillary necrosis associated with indomethacin and phenylbutazone treated rheumatoid arthritis.

Journal: Australian and New Zealand journal of medicine 19780401

Title: Drug-related gustatory disorders.

Journal: The Annals of otology, rhinology, and laryngology 19780101

Title: [Macroscopic hematuria during treatment with phenylbutazone derivatives. Positive lymphocyte transformation test for these drugs. Two cases in children].

Journal: Annales de pediatrie 19771001

Title: Phenylbutazone and the horse--a review.

Journal: Equine veterinary journal 19770701

Title: Development of a lymphocytic lymphoma during immunosuppressive therapy with azathioprine for systemic lupus erythematosus with renal involvement induced by phenylbutazone.

Journal: Clinical nephrology 19770701

Title: Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases.

Journal: The American journal of digestive diseases 19770701

Title: Aspirin, phenacetin, and the kidney: a rheumatism clinic study.

Journal: The Medical journal of Australia 19770625

Title: Study of fatal bone marrow depression with special reference to phenylbutazone and oxyphenbutazone.

Journal: British medical journal 19770611

Title: Association of renal papillary necrosis and ankylosing spondylitis.

Journal: Arthritis and rheumatism 19770501

Title: [Current aspects of iatrogenic lesions of the bone marrow].

Journal: Minerva medica 19761114

Title: Aplastic anemia from veterinary phenylbutazone.

Journal: JAMA 19760830

Title: [Evaluation of the effects of some non-steroid anti-inflammatory agents on the gastric mucosa].

Journal: Minerva medica 19760707

Title: Further studies of the acute effects of phenylbutazone, oxyphenbutazone and indomethacin on the rat kidney.

Journal: Pathology 19760401

Title: Polycythaemia in androgen-dependent aplastic anaemia.

Journal: British medical journal 19760124

Title: Clinical evaluation of ketoprofen (Orudis) in rheumatoid arthritis. Results of a multi-centre, double-blind, cross-over trial against phenylbutazone.

Journal: Scandinavian journal of rheumatology. Supplement 19760101

Title: Long-term treatment with ketoprofen in rheumatoid arthritis. A clinical trial with special reference to side-effects.

Journal: Scandinavian journal of rheumatology. Supplement 19760101

Title: Phenylbutazone and hepatitis.

Journal: Rheumatology and rehabilitation 19750501

Title: The chemical and biological background to alclofenac.

Journal: Current medical research and opinion 19750101

Title: Double-bind cross-over tiral of flurbiprofen and phenylbutazone in ankylosing spondylitis.

Journal: British medical journal 19741130

Title: Letter: Idiosyncrasy to phenothiazines in phenylbutazone-associated aplastic anaemia.

Journal: British medical journal 19741005

Title: Renal and gastric lesions after phenylbutazone and indomethacin in the rat.

Journal: Pathology 19741001

Title: Proceedings: A pharmacokinetic study of phenylbutazone-associated hypoplastic anaemia.

Journal: British journal of haematology 19740901

Title: Acetanilide oxidation in phenylbutazone-associated hypoplastic anaemia.

Journal: British medical journal 19740803

Title: Aspirin and the kidney. New Zealand Rheumatism Association Study.

Journal: British medical journal 19740330

Title: [Primary cardiac involvement and painful salivary gland enlargement due to phenylbutazone].

Journal: Harefuah 19740301

Title: Femoral neuropathy due to retroperitoneal bleeding. An unusual complication of heparin therapy.

Journal: Archives of internal medicine 19730701

Title: [Acute renal insufficiency following butapyrazole treatment in the course of plasmatic cell leukemia (author's transl)].

Journal: Przeglad lekarski 19730101

Title: Effects of anti-inflammatory drugs on prostaglandin biosynthesis.

Journal: Nature: New biology 19720726

Title: Papillary necrosis following phenylbutazone ingestion.

Journal: Archives of surgery (Chicago, Ill. : 1960) 19710901

Title: [Allergo-toxic disturbances of the heart muscle with congestive heart failure as a result of parenteral treatment with phenylbutazone].

Journal: Vnitrni lekarstvi 19710201

Title: Treatment of aplastic anemia with nandrolone decanoate.

Journal: Blood 19701201

Title: Mefanamic acid-induced haemolytic anaemia.

Journal: British medical journal 19700502

Title: Therapeutic activity of 4-allyloxy-3-chlorophenylacetic acid.

Journal: Arzneimittel-Forschung 19700401

Title: Rheumatoid arthritis: comparison of treatment with monophenylbutazone and phenylbutazone.

Journal: Canadian Medical Association journal 19691227

Title: [A fatal pathological condition with hyperglobulinemic purpura and polymyositis after phenylbutazone].

Journal: Munchener medizinische Wochenschrift (1950) 19681115

Title: Probenecid, nephrotic syndrome, and renal failure.

Journal: Annals of the rheumatic diseases 19680501

Title: Phenylbutazone anuria.

Journal: Southern medical journal 19671201

Title: Bone marrow depression induced by chloramphenicol or phenylbutazone. Leukemia and other sequelae.

Journal: JAMA 19670911

Title: [Bilateral renal cortical necrosis following pyrazolone treatment].

Journal: Deutsche medizinische Wochenschrift (1946) 19670609

Title: Evaluation of indomethacin by a controlled, cross-over technique in 30 patients with ankylosing spondylitis.

Journal: Canadian Medical Association journal 19670603

Title: Nephrotic syndrome caused by probenecid.

Journal: JAMA 19670102

Title: [The renal incidents of phenylbutazone].

Journal: La Presse medicale 19661203

Title: [Renal complications following phenylbutazone treatment].

Journal: Das Deutsche Gesundheitswesen 19660519

Title: [Vasculitis allergica cutis caused by phenylbutazone].

Journal: Dermatologica 19660101

Title: Phenylbutazone-induced pericarditis.

Journal: British medical journal 19651002

Title: G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14.

Title: Guiying Chen, et al. Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Sci Rep. 2016 Apr 29;6:25317.

Title: Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6.

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Tags:50-33-9 Molecular Formula|50-33-9 MDL|50-33-9 SMILES|50-33-9 4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine