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Title: MicroRNA-375 Is Induced in Cisplatin Nephrotoxicity to Repress Hepatocyte Nuclear Factor 1-β.
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Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
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Title: Inhibition of type I interferon-mediated antiviral action in human glioma cells by the IKK inhibitors BMS-345541 and TPCA-1.
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Title: NF-κB signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells.
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Title: Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.
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Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
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Title: Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
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Title: Identification of new inhibitors of protein kinase R guided by statistical modeling.
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Title: IKK-2 inhibitor TPCA-1 represses nasal epithelial inflammation in vitro.
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Title: Identification of angular naphthopyrones from the Philippine echinoderm Comanthus species as inhibitors of the NF-κB signaling pathway.
Journal: European journal of pharmacology 20110425
Title: 3,5-Disubstituted-indole-7-carboxamides: the discovery of a novel series of potent, selective inhibitors of IKK-β.
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Title: Pancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis.
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Title: Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.
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Title: Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes.
Journal: Clinical and experimental immunology 20101201
Title: Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione.
Journal: Molecular pharmacology 20100501
Title: Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1.
Journal: British journal of pharmacology 20090601
Title: IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening.
Journal: Bioorganic & medicinal chemistry 20090401
Title: Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.
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Title: Inhibition by a selective IkappaB kinase-2 inhibitor of interleukin-1-induced collagen degradation by corneal fibroblasts in three-dimensional culture.
Journal: Investigative ophthalmology & visual science 20081101
Title: The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20071101
Title: BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway.
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Title: Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model.
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Title: IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic.
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Title: Multiple Toll-like receptor ligands induce an IL-6 transcriptional response in skeletal myocytes.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060301
Title: Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma.
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Title: Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation.
Journal: The Journal of pharmacology and experimental therapeutics 20050101
