482-45-1,MFCD00272155
Catalog No.:AA006WVM

482-45-1 | Isoimperatorin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$43.00   $30.00
- +
25mg
98%
in stock  
$107.00   $75.00
- +
100mg
98%
in stock  
$207.00   $145.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA006WVM
Chemical Name:
Isoimperatorin
CAS Number:
482-45-1
Molecular Formula:
C16H14O4
Molecular Weight:
270.2800
MDL Number:
MFCD00272155
SMILES:
CC(=CCOc1c2ccoc2cc2c1ccc(=O)o2)C
Properties
Properties
 
BP:
448.3°C at 760 mmHg  
Form:
Solid  
MP:
107-111°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
436  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.8  

Literature

Title: Mechanism-based inactivation of cytochrome P450 2B6 by isoimperatorin.

Journal: Chemico-biological interactions 20150125

Title: Study on pharmacokinetics and tissue distribution of pteryxin in mice by ultra-pressure liquid chromatography with tandem mass spectrometry.

Journal: Biomedical chromatography : BMC 20120701

Title: [Fingerprint of Angelica polymorpha by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120301

Title: Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice.

Journal: Toxicology letters 20120225

Title: [Fingerprint analysis of Glehniae Radix by TLC].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120201

Title: Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.

Journal: Bioorganic & medicinal chemistry 20120115

Title: Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.

Journal: Journal of natural products 20110624

Title: [Determination of supermolecular inclusion constants of hydroxylpropyl-beta-cylcodextrin with imperatorin and isoimperatorin by phase solubility method].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110601

Title: [Determination of imperatorin and isoimperatorin in cosmetics by high performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20110501

Title: Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.

Journal: PloS one 20110101

Title: Citrusosides A-D and furanocoumarins with cholinesterase inhibitory activity from the fruit peels of Citrus hystrix.

Journal: Journal of natural products 20101129

Title: [Fast determination of active components in Angelica dahurica extract using capillary electrochromatography with methacrylate ester-based monolithic columns].

Journal: Se pu = Chinese journal of chromatography 20100301

Title: Biotransformation of isoimperatorin and imperatorin by Glomerella cingulata and beta-secretase inhibitory activity.

Journal: Bioorganic & medicinal chemistry 20100101

Title: Imperatorin is responsible for the vasodilatation activity of Angelica Dahurica var. Formosana regulated by nitric oxide in an endothelium-dependent manner.

Journal: Chinese journal of integrative medicine 20091201

Title: Simultaneous determination of five coumarins in Angelicae dahuricae Radix by HPLC/UV and LC-ESI-MS/MS.

Journal: Biomedical chromatography : BMC 20091001

Title: Notopterygium forbesii Boiss extract and its active constituent phenethyl ferulate attenuate pro-inflammatory responses to lipopolysaccharide in RAW 264.7 macrophages. A 'protective' role for oxidative stress?

Journal: Chemical research in toxicology 20090801

Title: Coumarins from Angelica lucida L.--antibacterial activities.

Journal: Molecules (Basel, Switzerland) 20090727

Title: [Chemical constituents of antibacterial activity fraction of Angelica polymorpha].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801

Title: The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.

Journal: Archives of pharmacal research 20080201

Title: [Studies on chemical constituents in fruit of Gardenia jasminoides].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

Title: Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages.

Journal: Pharmacological research 20070401

Title: Potent protective effect of isoimperatorin against aflatoxin B1-inducible cytotoxicity in H4IIE cells: bifunctional effects on glutathione S-transferase and CYP1A.

Journal: Carcinogenesis 20061201

Title: Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061101

Title: Preparative isolation of imperatorin, oxypeucedanin and isoimperatorin from traditional Chinese herb 'bai zhi'Angelica dahurica (Fisch. ex Hoffm) Benth. et Hook using multidimensional high-speed counter-current chromatography.

Journal: Journal of chromatography. A 20060519

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Studies on chemical constituents in roots of Heracleum rapula].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

Title: New cosmetic agents for skin whitening from Angelica dahurica.

Journal: Journal of cosmetic science 20060101

Title: Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants.

Journal: Pharmacogenetics and genomics 20050301

Title: 2D NMR spectroscopic analyses of archangelicin from the seeds of Angelica archangelica.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20041201

Title: [Determination of coumarins content in Radix Angelicae dahuricae by HPLC and UV].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20041101

Title: [Determination of isoimperatorin and osthol in ganmao yixiaoshi capsule by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041001

Title: [Study on coumarin compounds from Exocarpium Citri Grandis].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040801

Title: [Studies on quality standards of radix Angelicae dahuricae].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040701

Title: [Extraction of coumarins from Angelica dahurica by supercritical extraction and GC-MS analysis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040301

Title: Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.

Journal: Archives of pharmacal research 20030901

Title: Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.

Journal: Planta medica 20020501

Title: Inhibitors of 5alpha -reductase type I in LNCaP cells from the roots of Angelica koreana.

Journal: Planta medica 20020201

Title: Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.

Journal: Journal of natural products 20010501

Title: Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.

Journal: Bioorganic & medicinal chemistry 19941001

Title: Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25(6):856-9.

Title: Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21(10). pii: E1276.

Title: Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11(7):e0158796.

Title: Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62.

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SDS
Tags:482-45-1 Molecular Formula|482-45-1 MDL|482-45-1 SMILES|482-45-1 Isoimperatorin
Catalog No.: AA006WVM
482-45-1,MFCD00272155
482-45-1 | Isoimperatorin
Pack Size: 5mg
Purity: 98%
in stock
$43.00 $30.00
Pack Size: 25mg
Purity: 98%
in stock
$107.00 $75.00
Pack Size: 100mg
Purity: 98%
in stock
$207.00 $145.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA006WVM
Chemical Name: Isoimperatorin
CAS Number: 482-45-1
Molecular Formula: C16H14O4
Molecular Weight: 270.2800
MDL Number: MFCD00272155
SMILES: CC(=CCOc1c2ccoc2cc2c1ccc(=O)o2)C
Properties
BP: 448.3°C at 760 mmHg  
Form: Solid  
MP: 107-111°C  
Storage: Keep in dry area;2-8℃;  
Complexity: 436  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.8  
Literature fold

Title: Mechanism-based inactivation of cytochrome P450 2B6 by isoimperatorin.

Journal: Chemico-biological interactions20150125

Title: Study on pharmacokinetics and tissue distribution of pteryxin in mice by ultra-pressure liquid chromatography with tandem mass spectrometry.

Journal: Biomedical chromatography : BMC20120701

Title: [Fingerprint of Angelica polymorpha by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20120301

Title: Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice.

Journal: Toxicology letters20120225

Title: [Fingerprint analysis of Glehniae Radix by TLC].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20120201

Title: Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.

Journal: Bioorganic & medicinal chemistry20120115

Title: Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.

Journal: Journal of natural products20110624

Title: [Determination of supermolecular inclusion constants of hydroxylpropyl-beta-cylcodextrin with imperatorin and isoimperatorin by phase solubility method].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20110601

Title: [Determination of imperatorin and isoimperatorin in cosmetics by high performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography20110501

Title: Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.

Journal: PloS one20110101

Title: Citrusosides A-D and furanocoumarins with cholinesterase inhibitory activity from the fruit peels of Citrus hystrix.

Journal: Journal of natural products20101129

Title: [Fast determination of active components in Angelica dahurica extract using capillary electrochromatography with methacrylate ester-based monolithic columns].

Journal: Se pu = Chinese journal of chromatography20100301

Title: Biotransformation of isoimperatorin and imperatorin by Glomerella cingulata and beta-secretase inhibitory activity.

Journal: Bioorganic & medicinal chemistry20100101

Title: Imperatorin is responsible for the vasodilatation activity of Angelica Dahurica var. Formosana regulated by nitric oxide in an endothelium-dependent manner.

Journal: Chinese journal of integrative medicine20091201

Title: Simultaneous determination of five coumarins in Angelicae dahuricae Radix by HPLC/UV and LC-ESI-MS/MS.

Journal: Biomedical chromatography : BMC20091001

Title: Notopterygium forbesii Boiss extract and its active constituent phenethyl ferulate attenuate pro-inflammatory responses to lipopolysaccharide in RAW 264.7 macrophages. A 'protective' role for oxidative stress?

Journal: Chemical research in toxicology20090801

Title: Coumarins from Angelica lucida L.--antibacterial activities.

Journal: Molecules (Basel, Switzerland)20090727

Title: [Chemical constituents of antibacterial activity fraction of Angelica polymorpha].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20080801

Title: The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.

Journal: Archives of pharmacal research20080201

Title: [Studies on chemical constituents in fruit of Gardenia jasminoides].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20070601

Title: Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages.

Journal: Pharmacological research20070401

Title: Potent protective effect of isoimperatorin against aflatoxin B1-inducible cytotoxicity in H4IIE cells: bifunctional effects on glutathione S-transferase and CYP1A.

Journal: Carcinogenesis20061201

Title: Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20061101

Title: Preparative isolation of imperatorin, oxypeucedanin and isoimperatorin from traditional Chinese herb 'bai zhi'Angelica dahurica (Fisch. ex Hoffm) Benth. et Hook using multidimensional high-speed counter-current chromatography.

Journal: Journal of chromatography. A20060519

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: [Studies on chemical constituents in roots of Heracleum rapula].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20060201

Title: New cosmetic agents for skin whitening from Angelica dahurica.

Journal: Journal of cosmetic science20060101

Title: Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants.

Journal: Pharmacogenetics and genomics20050301

Title: 2D NMR spectroscopic analyses of archangelicin from the seeds of Angelica archangelica.

Journal: Acta pharmaceutica (Zagreb, Croatia)20041201

Title: [Determination of coumarins content in Radix Angelicae dahuricae by HPLC and UV].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20041101

Title: [Determination of isoimperatorin and osthol in ganmao yixiaoshi capsule by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20041001

Title: [Study on coumarin compounds from Exocarpium Citri Grandis].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20040801

Title: [Studies on quality standards of radix Angelicae dahuricae].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20040701

Title: [Extraction of coumarins from Angelica dahurica by supercritical extraction and GC-MS analysis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20040301

Title: Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.

Journal: Archives of pharmacal research20030901

Title: Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.

Journal: Planta medica20020501

Title: Inhibitors of 5alpha -reductase type I in LNCaP cells from the roots of Angelica koreana.

Journal: Planta medica20020201

Title: Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.

Journal: Journal of natural products20010501

Title: Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.

Journal: Bioorganic & medicinal chemistry19941001

Title: Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25(6):856-9.

Title: Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21(10). pii: E1276.

Title: Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11(7):e0158796.

Title: Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62.

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