226700-81-8,MFCD08141843
Catalog No.:AA006WYL

226700-81-8 | Fosamprenavir calcium

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Purity
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1mg
≥98%
in stock  
$263.00   $184.00
- +
50mg
≥95%
in stock  
$365.00   $255.00
- +
100mg
≥95%
in stock  
$547.00   $383.00
- +
250mg
≥95%
in stock  
$888.00   $622.00
- +
1g
≥95%
in stock  
$2,291.00   $1,604.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA006WYL
Chemical Name:
Fosamprenavir calcium
CAS Number:
226700-81-8
Molecular Formula:
C25H34CaN3O9PS
Molecular Weight:
623.6689
MDL Number:
MFCD08141843
SMILES:
CC(CN(S(=O)(=O)c1ccc(cc1)N)C[C@H]([C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)OP(=O)([O-])[O-])C.[Ca+2]
Properties
Properties
 
Form:
Solid  
MP:
282-284 °C  
Storage:
-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
901  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
13  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Protease inhibitor monotherapy: what is its role?

Journal: Current HIV/AIDS reports 20120601

Title: Long-term efficacy and safety of once-daily fosamprenavir 1400 mg boosted by ritonavir 100 mg: the BOLD100 study.

Journal: International journal of STD & AIDS 20120301

Title: Interactions between buprenorphine and the protease inhibitors darunavir-ritonavir and fosamprenavir-ritonavir.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120201

Title: Hepatic safety profile of fosamprenavir-containing regimens in HIV-1-infected patients with or without hepatitis B or C coinfection.

Journal: HIV clinical trials 20120101

Title: Efficacy and safety of a dual boosted protease inhibitor-based regimen, atazanavir and fosamprenavir/ritonavir, against HIV: experience in a pediatric population.

Journal: BMC infectious diseases 20120101

Title: Viral response in stable patients switching to fosamprenavir/ritonavir monotherapy (the FONT Study).

Journal: HIV medicine 20110801

Title: Liver toxicity of antiretroviral combinations including fosamprenavir plus ritonavir 1400/100 mg once daily in HIV/hepatitis C virus-coinfected patients.

Journal: AIDS patient care and STDs 20110701

Title: The inclusion of historical control data may reduce the power of a confirmatory study.

Journal: Statistics in medicine 20110530

Title: Development and validation of discriminating method of dissolution for fosamprenavir tablets based on in vivo data.

Journal: Journal of pharmaceutical and biomedical analysis 20110220

Title: Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110201

Title: Changes in lipid profiles after switching to a protease inhibitor-containing cART--unfavourable effect of fosamprenavir in obese patients.

Journal: European journal of medical research 20110101

Title: Safety of fosamprenavir in a cohort of HIV-1-infected patients with co-morbidities.

Journal: In vivo (Athens, Greece) 20110101

Title: Avascular necrosis of the talus in a HIV-infected patient.

Journal: Foot & ankle international 20101201

Title: Effect of posaconazole on the pharmacokinetics of fosamprenavir and vice versa in healthy volunteers.

Journal: The Journal of antimicrobial chemotherapy 20101001

Title: Safety and efficacy of fosamprenavir in human immunodeficiency virus-infected pregnant women.

Journal: The Pediatric infectious disease journal 20101001

Title: Impact of individual antiretroviral drugs on the risk of myocardial infarction in human immunodeficiency virus-infected patients: a case-control study nested within the French Hospital Database on HIV ANRS cohort CO4.

Journal: Archives of internal medicine 20100726

Title: Fosamprenavir treatment in a highly active antiretroviral therapy schedule induces a HCV-RNA decrease and a Th1 network boost in HIV/HCV-coinfected patients.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20100601

Title: Long-term efficacy and safety of fosamprenavir in human immunodeficiency virus-infected pediatric patients.

Journal: The Pediatric infectious disease journal 20100601

Title: Electrochemical evaluation and determination of antiretroviral drug fosamprenavir using boron-doped diamond and glassy carbon electrodes.

Journal: Analytical and bioanalytical chemistry 20100501

Title: Impact of low abundance HIV variants on response to ritonavir-boosted atazanavir or fosamprenavir given once daily with tenofovir/emtricitabine in antiretroviral-naive HIV-infected patients.

Journal: AIDS research and human retroviruses 20100401

Title: Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method.

Journal: Bioanalysis 20100401

Title: Steady-state amprenavir and tenofovir pharmacokinetics after coadministration of unboosted or ritonavir-boosted fosamprenavir with tenofovir disoproxil fumarate in healthy volunteers.

Journal: HIV medicine 20100301

Title: Heart attack warning issued.

Journal: AIDS patient care and STDs 20100101

Title: Effects of intermittent IL-2 alone or with peri-cycle antiretroviral therapy in early HIV infection: the STALWART study.

Journal: PloS one 20100101

Title: [Adverse reactions of atazanavir, fosamprenavir and tipranavir in 'real life'].

Journal: Therapie 20100101

Title: Similar virologic and immunologic efficacy with fosamprenavir boosted with 100 mg or 200 mg of ritonavir in HIV-infected patients: results of the LESS trial.

Journal: HIV clinical trials 20100101

Title: Effect of boosted fosamprenavir or lopinavir-based combinations on whole-body insulin sensitivity and lipids in treatment-naive HIV-type-1-positive men.

Journal: Antiviral therapy 20100101

Title: Fosamprenavir/ritonavir in advanced HIV disease (TRIAD): a randomized study of high-dose, dual-boosted or standard dose fosamprenavir/ritonavir in HIV-1-infected patients with antiretroviral resistance.

Journal: The Journal of antimicrobial chemotherapy 20090801

Title: Pharmacokinetics of concurrent administration of fosamprenavir and atazanavir without ritonavir in human immunodeficiency virus-negative subjects.

Journal: Pharmacotherapy 20090801

Title: Comment on: Unboosted fosamprenavir is associated with low drug exposure in HIV-infected patients with mild-moderate liver impairment resulting from HCV-related cirrhosis.

Journal: The Journal of antimicrobial chemotherapy 20090701

Title: Efficacy and safety of ritonavir-boosted dual protease inhibitor therapy in antiretroviral-naive HIV-1-infected patients: the 2IP ANRS 127 study.

Journal: The Journal of antimicrobial chemotherapy 20090701

Title: Favourable use of non-boosted fosamprenavir in patients treated with warfarin.

Journal: International journal of STD & AIDS 20090601

Title: Comparison of once-daily fosamprenavir boosted with either 100 or 200 mg of ritonavir, in combination with abacavir/lamivudine: 96-week results from COL100758.

Journal: AIDS research and human retroviruses 20090401

Title: Unboosted fosamprenavir is associated with low drug exposure in HIV-infected patients with mild-moderate liver impairment resulting from HCV-related cirrhosis.

Journal: The Journal of antimicrobial chemotherapy 20090301

Title: Highly active antiretroviral therapy-associated ptosis in patients with human immunodeficiency virus.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20090301

Title: Fosamprenavir (GW433908)/ritonavir in HIV-infected patients: efficacy and safety results from the Spanish Expanded Access Program.

Journal: Enfermedades infecciosas y microbiologia clinica 20090101

Title: Virologic response and safety of the abacavir/lamivudine fixed-dose formulation as part of highly active antiretroviral therapy: analyses of six clinical studies.

Journal: HIV clinical trials 20090101

Title: Long-term efficacy and safety of fosamprenavir plus ritonavir versus lopinavir/ritonavir in combination with abacavir/lamivudine over 144 weeks.

Journal: HIV clinical trials 20090101

Title: Occurrence of selective ritonavir nonadherence and dose-staggering in recipients of boosted HIV-1 protease inhibitor therapy.

Journal: HIV clinical trials 20090101

Title: Steady-state amprenavir, tenofovir, and emtricitabine pharmacokinetics before and after reducing ritonavir boosting of a fosamprenavir/tenofovir/emtricitabine regimen from 200 mg to 100 mg once daily (TELEX II).

Journal: HIV clinical trials 20090101

Title: Study of once-daily versus twice-daily fosamprenavir plus ritonavir administered with abacavir/lamivudine once daily in antiretroviral-naïve HIV-1-infected adult subjects.

Journal: HIV clinical trials 20090101

Title: Optimal fosamprenavir regimen to prevent lipid abnormalities.

Journal: Acta bio-medica : Atenei Parmensis 20090101

Title: Four posters add to our knowledge of Lexiva.

Journal: Project Inform perspective 20081201

Title: Tolerability of fosamprenavir/ritonavir associated with zidovudine-lamivudine used as postexposure prophylaxis for HIV infection.

Journal: Journal of acquired immune deficiency syndromes (1999) 20081101

Title: Doxorubicin-induced hyperpigmentation.

Journal: Dermatology online journal 20081015

Title: Efficacy and tolerability of a fosamprenavir-ritonavir-based versus a lopinavir-ritonavir-based antiretroviral treatment in 82 therapy-naïve patients with HIV-1 infection.

Journal: International journal of STD & AIDS 20080801

Title: Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with fosamprenavir-ritonavir in opioid-dependent subjects.

Journal: Pharmacotherapy 20080701

Title: Quality control of protease inhibitors.

Journal: Journal of pharmaceutical sciences 20080601

Title: Clinically validated mutation scores for HIV-1 resistance to fosamprenavir/ritonavir.

Journal: The Journal of antimicrobial chemotherapy 20080601

Title: Effects of atazanavir/ritonavir or fosamprenavir/ritonavir on the pharmacokinetics of rosuvastatin.

Journal: Journal of cardiovascular pharmacology 20080601

Title: [Individualized therapy with fosamprenavir/r. A PI suitable in liver problems].

Journal: MMW Fortschritte der Medizin 20080428

Title: [Plasma levels following the switch from amprenavir to fosamprenavir in HIV-infected patients under antiretroviral treatment with lopinavir/ritonavir].

Journal: Enfermedades infecciosas y microbiologia clinica 20080301

Title: Impact of nevirapine or efavirenz co-administration on ritonavir-boosted amprenavir pharmacokinetics in HIV-infected patients.

Journal: Fundamental & clinical pharmacology 20080201

Title: FDA notifications. Fosamprenavir label is updated.

Journal: AIDS alert 20080201

Title: Pharmacokinetics of an indinavir-ritonavir-fosamprenavir regimen in patients with human immunodeficiency virus.

Journal: Pharmacotherapy 20080101

Title: Randomized study of dual versus single ritonavir-enhanced protease inhibitors for protease inhibitor-experienced patients with HIV.

Journal: HIV clinical trials 20080101

Title: Drop in trough blood concentrations of tacrolimus after switching from nelfinavir to fosamprenavir in four HIV-infected liver transplant patients.

Journal: Antiviral therapy 20080101

Title: Low rate of adverse hepatic events associated with fosamprenavir/ritonavir-based antiretroviral regimens.

Journal: HIV clinical trials 20080101

Title: Lower dose of ritonavir approved for use with fosamprenavir.

Journal: AIDS clinical care 20071201

Title: FDA notifications. FDA approves NDA for Lexiva.

Journal: AIDS alert 20071201

Title: Parallel monitoring of plasma and intraluminal drug concentrations in man after oral administration of fosamprenavir in the fasted and fed state.

Journal: Pharmaceutical research 20071001

Title: Amprenavir and ritonavir plasma concentrations in HIV-infected patients treated with fosamprenavir/ritonavir with various degrees of liver impairment.

Journal: The Journal of antimicrobial chemotherapy 20071001

Title: Steady-state pharmacokinetics of once-daily fosamprenavir/ritonavir and atazanavir/ritonavir alone and in combination with 20 mg omeprazole in healthy volunteers.

Journal: HIV medicine 20071001

Title: Development and evaluation of an immunoassay for the monitoring of the anti-HIV drug amprenavir.

Journal: Journal of immunological methods 20070831

Title: FDA notifications. FDA approves new formulation of Lexiva.

Journal: AIDS alert 20070801

Title: Fosamprenavir/ritonavir plus tenofovir does not affect amprenavir pharmacokinetics: no effect of tenofovir.

Journal: AIDS (London, England) 20070619

Title: Pharmacokinetics of once-daily tenofovir, emtricitabine, ritonavir and fosamprenavir in HIV-infected subjects.

Journal: AIDS (London, England) 20070619

Title: Fosamprenavir calcium plus ritonavir for HIV infection.

Journal: Expert review of anti-infective therapy 20070601

Title: In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: illustration of intraluminal supersaturation.

Journal: International journal of pharmaceutics 20070524

Title: Use of fosamprenavir, a sulfa-containing protease inhibitor, in HIV-infected patients with glucose-6-phosphate dehydrogenase deficiency.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070315

Title: [Two year use of Telzir: what are the perspectives?].

Journal: Medecine et maladies infectieuses 20070301

Title: Genotypic resistance to lopinavir and fosamprenavir with or without ritonavir of clinical isolates from patients failing protease inhibitors-containing HAART regimens: prevalence and predictors.

Journal: Scandinavian journal of infectious diseases 20070101

Title: Amprenavir and lopinavir pharmacokinetics following coadministration of amprenavir or fosamprenavir with lopinavir/ritonavir, with or without efavirenz.

Journal: Antiviral therapy 20070101

Title: Evaluation of sex differences of fosamprenavir (with and without ritonavir) in HIV-infected men and women.

Journal: HIV clinical trials 20070101

Title: Meeting report. Report from ICAAC.

Journal: AIDS clinical care 20061201

Title: Clinically relevant pharmacology of neuropsychiatric drugs approved over the last three years: Part II.

Journal: Journal of psychiatric practice 20060901

Title: The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection over 48 weeks: a randomised non-inferiority trial.

Journal: Lancet (London, England) 20060805

Title: An update and review of antiretroviral therapy.

Journal: Pharmacotherapy 20060801

Title: Coadministration of esomeprazole with fosamprenavir has no impact on steady-state plasma amprenavir pharmacokinetics.

Journal: Journal of acquired immune deficiency syndromes (1999) 20060501

Title: Pharmacokinetic interaction between Amprenavir/Ritonavir and FosAmprenavir on cyclosporine in two patients with human immunodeficiency virus infection undergoing orthotopic liver transplantation.

Journal: Transplantation proceedings 20060501

Title: Long-term (120-Week) antiviral efficacy and tolerability of fosamprenavir/ritonavir once daily in therapy-naive patients with HIV-1 infection: an uncontrolled, open-label, single-arm follow-on study.

Journal: Clinical therapeutics 20060501

Title: Effects of esomeprazole on the pharmacokinetics of atazanavir and fosamprenavir in a patient with human immunodeficiency virus infection.

Journal: Pharmacotherapy 20060401

Title: Evolution of resistance during first-line treatment with boosted fosamprenavir is associated with baseline mutations.

Journal: AIDS (London, England) 20060102

Title: Interaction between atazanavir and fosamprenavir in the treatment of HIV-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20060101

Title: Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug.

Journal: Clinical pharmacokinetics 20060101

Title: Fosamprenavir: drug development for adherence.

Journal: The Annals of pharmacotherapy 20060101

Title: Fosamprenavir clinical study meta-analysis in ART-naïve subjects: rare occurrence of virologic failure and selection of protease-associated mutations.

Journal: HIV clinical trials 20060101

Title: [The treatment of HIV infection].

Journal: Presse medicale (Paris, France : 1983) 20051119

Title: [Multicentre clinical trials: degree of homogeneity in the ethical-scientific review performed by research ethics committees].

Journal: Medicina clinica 20050917

Title: Lexiva: blood levels not lowered when taken simultaneously with Nexium.

Journal: AIDS treatment news 20050527

Title: [Long-term virus suppression. Expanding therapy options with protease inhibitor].

Journal: MMW Fortschritte der Medizin 20050425

Title: Combining fosamprenavir with lopinavir/ritonavir substantially reduces amprenavir and lopinavir exposure: ACTG protocol A5143 results.

Journal: AIDS (London, England) 20050128

Title: Amprenavir or fosamprenavir plus ritonavir in HIV infection: pharmacology, efficacy and tolerability profile.

Journal: Drugs 20050101

Title: Salvage therapy with ritonavir-boosted amprenavir/fosamprenavir: virological and immunological response in two years follow-up.

Journal: HIV clinical trials 20050101

Title: Steady-State pharmacokinetics of saquinavir hard-gel/ritonavir/fosamprenavir in HIV-1-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20041101

Title: Pharmacokinetics of Telzir (fosamprenavir).

Journal: Journal of HIV therapy 20041101

Title: Fosamprenavir: advancing HIV protease inhibitor treatment options.

Journal: Expert opinion on pharmacotherapy 20040901

Title: SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir /ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients.

Journal: AIDS (London, England) 20040723

Title: New approaches to the industrial synthesis of HIV protease inhibitors.

Journal: Organic & biomolecular chemistry 20040721

Title: [Maintaining independence. New protease inhibitor receives drug approval recommendation].

Journal: MMW Fortschritte der Medizin 20040426

Title: [FPV plus SQV plus a mini-dose ritonavir. 'Double boosting with compatible partners].

Journal: MMW Fortschritte der Medizin 20040426

Title: Pharmacokinetics and safety of GW433908 and ritonavir, with and without efavirenz, in healthy volunteers.

Journal: AIDS (London, England) 20040409

Title: GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients: absence of protease resistance at 48 weeks.

Journal: AIDS (London, England) 20040305

Title: Preclinical pharmacology and pharmacokinetics of GW433908, a water-soluble prodrug of the human immunodeficiency virus protease inhibitor amprenavir.

Journal: Antimicrobial agents and chemotherapy 20040301

Title: Fosamprenavir: a new PI option. Interview by Craig Sterritt.

Journal: IAPAC monthly 20040201

Title: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients.

Journal: Antimicrobial agents and chemotherapy 20040101

Title: The NEAT study: a 48-week open-label study to compare the antiviral efficacy and safety of GW433908 versus nelfinavir in antiretroviral therapy-naive HIV-1-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20040101

Title: FDA grants approval to fosamprenavir calcium.

Journal: AIDS alert 20040101

Title: Initial therapy for human immunodeficiency virus: broadening the options.

Journal: HIV clinical trials 20040101

Title: Peptidomimetic inhibitors of HIV protease.

Journal: Current topics in medicinal chemistry 20040101

Title: Fosamprenavir: a review of its use in the management of antiretroviral therapy-naive patients with HIV infection.

Journal: Drugs 20040101

Title: Anti-HIV agents. Saquinavir with fosamprenavir.

Journal: TreatmentUpdate 20040101

Title: [Are all boosted protease inhibitors the same? Previously treated patients profit too from lopinavir/r].

Journal: MMW Fortschritte der Medizin 20031211

Title: The continuing evolution of HIV therapy.

Journal: The AIDS reader 20031201

Title: Drug profile: fosamprenavir (Lexiva).

Journal: The Hopkins HIV report : a bimonthly newsletter for healthcare providers 20031101

Title: FDA approves Lexiva.

Journal: IAPAC monthly 20031101

Title: Lexiva (fosamprenavir) approved.

Journal: AIDS treatment news 20031031

Title: Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage.

Journal: Journal of medicinal chemistry 20030911

Title: Viral patterns of unboosted 908 identified.

Journal: AIDS patient care and STDs 20030801

Title: Reviving protease inhibitors: new data and more options.

Journal: Journal of acquired immune deficiency syndromes (1999) 20030601

Title: [Potent new protease inhibitor. Boostered protease inhibitors--a separate class of drugs].

Journal: MMW Fortschritte der Medizin 20030428

Title: [No selection of mutations. 908 raises genetic resistance barrier].

Journal: MMW Fortschritte der Medizin 20030428

Title: SOLO trial results released.

Journal: AIDS patient care and STDs 20030201

Title: Five new drugs enter the homestretch.

Journal: GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20021201

Title: NEAT trial releases results.

Journal: AIDS patient care and STDs 20021201

Title: Effects of formulation and dosing strategy on amprenavir concentrations in the seminal plasma of human immunodeficiency virus type 1-infected men.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020915

Title: Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers.

Journal: Journal of clinical pharmacology 20020801

Title: Fosamprenavir. Vertex Pharmaceuticals/GlaxoSmithKline.

Journal: Current opinion in investigational drugs (London, England : 2000) 20020301

Title: From amprenavir to GW433908.

Journal: Journal of HIV therapy 20011101

Title: Phase III trials for new PI.

Journal: AIDS patient care and STDs 20010301

Title: New antiretroviral agents.

Journal: The Hopkins HIV report : a bimonthly newsletter for healthcare providers 20010301

Title: Falcoz C, et al. Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J Clin Pharmacol. 2002 Aug;42(8):887-98.

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Related Products of 226700-81-8
Tags:226700-81-8 Molecular Formula|226700-81-8 MDL|226700-81-8 SMILES|226700-81-8 Fosamprenavir calcium
Catalog No.: AA006WYL
226700-81-8,MFCD08141843
226700-81-8 | Fosamprenavir calcium
Pack Size: 1mg
Purity: ≥98%
in stock
$263.00 $184.00
Pack Size: 50mg
Purity: ≥95%
in stock
$365.00 $255.00
Pack Size: 100mg
Purity: ≥95%
in stock
$547.00 $383.00
Pack Size: 250mg
Purity: ≥95%
in stock
$888.00 $622.00
Pack Size: 1g
Purity: ≥95%
in stock
$2,291.00 $1,604.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA006WYL
Chemical Name: Fosamprenavir calcium
CAS Number: 226700-81-8
Molecular Formula: C25H34CaN3O9PS
Molecular Weight: 623.6689
MDL Number: MFCD08141843
SMILES: CC(CN(S(=O)(=O)c1ccc(cc1)N)C[C@H]([C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)OP(=O)([O-])[O-])C.[Ca+2]
Properties
Form: Solid  
MP: 282-284 °C  
Storage: -20 ℃;Inert atmosphere;  
Complexity: 901  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 3  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 40  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 13  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Protease inhibitor monotherapy: what is its role?

Journal: Current HIV/AIDS reports20120601

Title: Long-term efficacy and safety of once-daily fosamprenavir 1400 mg boosted by ritonavir 100 mg: the BOLD100 study.

Journal: International journal of STD & AIDS20120301

Title: Interactions between buprenorphine and the protease inhibitors darunavir-ritonavir and fosamprenavir-ritonavir.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20120201

Title: Hepatic safety profile of fosamprenavir-containing regimens in HIV-1-infected patients with or without hepatitis B or C coinfection.

Journal: HIV clinical trials20120101

Title: Efficacy and safety of a dual boosted protease inhibitor-based regimen, atazanavir and fosamprenavir/ritonavir, against HIV: experience in a pediatric population.

Journal: BMC infectious diseases20120101

Title: Viral response in stable patients switching to fosamprenavir/ritonavir monotherapy (the FONT Study).

Journal: HIV medicine20110801

Title: Liver toxicity of antiretroviral combinations including fosamprenavir plus ritonavir 1400/100 mg once daily in HIV/hepatitis C virus-coinfected patients.

Journal: AIDS patient care and STDs20110701

Title: The inclusion of historical control data may reduce the power of a confirmatory study.

Journal: Statistics in medicine20110530

Title: Development and validation of discriminating method of dissolution for fosamprenavir tablets based on in vivo data.

Journal: Journal of pharmaceutical and biomedical analysis20110220

Title: Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20110201

Title: Changes in lipid profiles after switching to a protease inhibitor-containing cART--unfavourable effect of fosamprenavir in obese patients.

Journal: European journal of medical research20110101

Title: Safety of fosamprenavir in a cohort of HIV-1-infected patients with co-morbidities.

Journal: In vivo (Athens, Greece)20110101

Title: Avascular necrosis of the talus in a HIV-infected patient.

Journal: Foot & ankle international20101201

Title: Effect of posaconazole on the pharmacokinetics of fosamprenavir and vice versa in healthy volunteers.

Journal: The Journal of antimicrobial chemotherapy20101001

Title: Safety and efficacy of fosamprenavir in human immunodeficiency virus-infected pregnant women.

Journal: The Pediatric infectious disease journal20101001

Title: Impact of individual antiretroviral drugs on the risk of myocardial infarction in human immunodeficiency virus-infected patients: a case-control study nested within the French Hospital Database on HIV ANRS cohort CO4.

Journal: Archives of internal medicine20100726

Title: Fosamprenavir treatment in a highly active antiretroviral therapy schedule induces a HCV-RNA decrease and a Th1 network boost in HIV/HCV-coinfected patients.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases20100601

Title: Long-term efficacy and safety of fosamprenavir in human immunodeficiency virus-infected pediatric patients.

Journal: The Pediatric infectious disease journal20100601

Title: Electrochemical evaluation and determination of antiretroviral drug fosamprenavir using boron-doped diamond and glassy carbon electrodes.

Journal: Analytical and bioanalytical chemistry20100501

Title: Impact of low abundance HIV variants on response to ritonavir-boosted atazanavir or fosamprenavir given once daily with tenofovir/emtricitabine in antiretroviral-naive HIV-infected patients.

Journal: AIDS research and human retroviruses20100401

Title: Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method.

Journal: Bioanalysis20100401

Title: Steady-state amprenavir and tenofovir pharmacokinetics after coadministration of unboosted or ritonavir-boosted fosamprenavir with tenofovir disoproxil fumarate in healthy volunteers.

Journal: HIV medicine20100301

Title: Heart attack warning issued.

Journal: AIDS patient care and STDs20100101

Title: Effects of intermittent IL-2 alone or with peri-cycle antiretroviral therapy in early HIV infection: the STALWART study.

Journal: PloS one20100101

Title: [Adverse reactions of atazanavir, fosamprenavir and tipranavir in 'real life'].

Journal: Therapie20100101

Title: Similar virologic and immunologic efficacy with fosamprenavir boosted with 100 mg or 200 mg of ritonavir in HIV-infected patients: results of the LESS trial.

Journal: HIV clinical trials20100101

Title: Effect of boosted fosamprenavir or lopinavir-based combinations on whole-body insulin sensitivity and lipids in treatment-naive HIV-type-1-positive men.

Journal: Antiviral therapy20100101

Title: Fosamprenavir/ritonavir in advanced HIV disease (TRIAD): a randomized study of high-dose, dual-boosted or standard dose fosamprenavir/ritonavir in HIV-1-infected patients with antiretroviral resistance.

Journal: The Journal of antimicrobial chemotherapy20090801

Title: Pharmacokinetics of concurrent administration of fosamprenavir and atazanavir without ritonavir in human immunodeficiency virus-negative subjects.

Journal: Pharmacotherapy20090801

Title: Comment on: Unboosted fosamprenavir is associated with low drug exposure in HIV-infected patients with mild-moderate liver impairment resulting from HCV-related cirrhosis.

Journal: The Journal of antimicrobial chemotherapy20090701

Title: Efficacy and safety of ritonavir-boosted dual protease inhibitor therapy in antiretroviral-naive HIV-1-infected patients: the 2IP ANRS 127 study.

Journal: The Journal of antimicrobial chemotherapy20090701

Title: Favourable use of non-boosted fosamprenavir in patients treated with warfarin.

Journal: International journal of STD & AIDS20090601

Title: Comparison of once-daily fosamprenavir boosted with either 100 or 200 mg of ritonavir, in combination with abacavir/lamivudine: 96-week results from COL100758.

Journal: AIDS research and human retroviruses20090401

Title: Unboosted fosamprenavir is associated with low drug exposure in HIV-infected patients with mild-moderate liver impairment resulting from HCV-related cirrhosis.

Journal: The Journal of antimicrobial chemotherapy20090301

Title: Highly active antiretroviral therapy-associated ptosis in patients with human immunodeficiency virus.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960)20090301

Title: Fosamprenavir (GW433908)/ritonavir in HIV-infected patients: efficacy and safety results from the Spanish Expanded Access Program.

Journal: Enfermedades infecciosas y microbiologia clinica20090101

Title: Virologic response and safety of the abacavir/lamivudine fixed-dose formulation as part of highly active antiretroviral therapy: analyses of six clinical studies.

Journal: HIV clinical trials20090101

Title: Long-term efficacy and safety of fosamprenavir plus ritonavir versus lopinavir/ritonavir in combination with abacavir/lamivudine over 144 weeks.

Journal: HIV clinical trials20090101

Title: Occurrence of selective ritonavir nonadherence and dose-staggering in recipients of boosted HIV-1 protease inhibitor therapy.

Journal: HIV clinical trials20090101

Title: Steady-state amprenavir, tenofovir, and emtricitabine pharmacokinetics before and after reducing ritonavir boosting of a fosamprenavir/tenofovir/emtricitabine regimen from 200 mg to 100 mg once daily (TELEX II).

Journal: HIV clinical trials20090101

Title: Study of once-daily versus twice-daily fosamprenavir plus ritonavir administered with abacavir/lamivudine once daily in antiretroviral-naïve HIV-1-infected adult subjects.

Journal: HIV clinical trials20090101

Title: Optimal fosamprenavir regimen to prevent lipid abnormalities.

Journal: Acta bio-medica : Atenei Parmensis20090101

Title: Four posters add to our knowledge of Lexiva.

Journal: Project Inform perspective20081201

Title: Tolerability of fosamprenavir/ritonavir associated with zidovudine-lamivudine used as postexposure prophylaxis for HIV infection.

Journal: Journal of acquired immune deficiency syndromes (1999)20081101

Title: Doxorubicin-induced hyperpigmentation.

Journal: Dermatology online journal20081015

Title: Efficacy and tolerability of a fosamprenavir-ritonavir-based versus a lopinavir-ritonavir-based antiretroviral treatment in 82 therapy-naïve patients with HIV-1 infection.

Journal: International journal of STD & AIDS20080801

Title: Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with fosamprenavir-ritonavir in opioid-dependent subjects.

Journal: Pharmacotherapy20080701

Title: Quality control of protease inhibitors.

Journal: Journal of pharmaceutical sciences20080601

Title: Clinically validated mutation scores for HIV-1 resistance to fosamprenavir/ritonavir.

Journal: The Journal of antimicrobial chemotherapy20080601

Title: Effects of atazanavir/ritonavir or fosamprenavir/ritonavir on the pharmacokinetics of rosuvastatin.

Journal: Journal of cardiovascular pharmacology20080601

Title: [Individualized therapy with fosamprenavir/r. A PI suitable in liver problems].

Journal: MMW Fortschritte der Medizin20080428

Title: [Plasma levels following the switch from amprenavir to fosamprenavir in HIV-infected patients under antiretroviral treatment with lopinavir/ritonavir].

Journal: Enfermedades infecciosas y microbiologia clinica20080301

Title: Impact of nevirapine or efavirenz co-administration on ritonavir-boosted amprenavir pharmacokinetics in HIV-infected patients.

Journal: Fundamental & clinical pharmacology20080201

Title: FDA notifications. Fosamprenavir label is updated.

Journal: AIDS alert20080201

Title: Pharmacokinetics of an indinavir-ritonavir-fosamprenavir regimen in patients with human immunodeficiency virus.

Journal: Pharmacotherapy20080101

Title: Randomized study of dual versus single ritonavir-enhanced protease inhibitors for protease inhibitor-experienced patients with HIV.

Journal: HIV clinical trials20080101

Title: Drop in trough blood concentrations of tacrolimus after switching from nelfinavir to fosamprenavir in four HIV-infected liver transplant patients.

Journal: Antiviral therapy20080101

Title: Low rate of adverse hepatic events associated with fosamprenavir/ritonavir-based antiretroviral regimens.

Journal: HIV clinical trials20080101

Title: Lower dose of ritonavir approved for use with fosamprenavir.

Journal: AIDS clinical care20071201

Title: FDA notifications. FDA approves NDA for Lexiva.

Journal: AIDS alert20071201

Title: Parallel monitoring of plasma and intraluminal drug concentrations in man after oral administration of fosamprenavir in the fasted and fed state.

Journal: Pharmaceutical research20071001

Title: Amprenavir and ritonavir plasma concentrations in HIV-infected patients treated with fosamprenavir/ritonavir with various degrees of liver impairment.

Journal: The Journal of antimicrobial chemotherapy20071001

Title: Steady-state pharmacokinetics of once-daily fosamprenavir/ritonavir and atazanavir/ritonavir alone and in combination with 20 mg omeprazole in healthy volunteers.

Journal: HIV medicine20071001

Title: Development and evaluation of an immunoassay for the monitoring of the anti-HIV drug amprenavir.

Journal: Journal of immunological methods20070831

Title: FDA notifications. FDA approves new formulation of Lexiva.

Journal: AIDS alert20070801

Title: Fosamprenavir/ritonavir plus tenofovir does not affect amprenavir pharmacokinetics: no effect of tenofovir.

Journal: AIDS (London, England)20070619

Title: Pharmacokinetics of once-daily tenofovir, emtricitabine, ritonavir and fosamprenavir in HIV-infected subjects.

Journal: AIDS (London, England)20070619

Title: Fosamprenavir calcium plus ritonavir for HIV infection.

Journal: Expert review of anti-infective therapy20070601

Title: In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: illustration of intraluminal supersaturation.

Journal: International journal of pharmaceutics20070524

Title: Use of fosamprenavir, a sulfa-containing protease inhibitor, in HIV-infected patients with glucose-6-phosphate dehydrogenase deficiency.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20070315

Title: [Two year use of Telzir: what are the perspectives?].

Journal: Medecine et maladies infectieuses20070301

Title: Genotypic resistance to lopinavir and fosamprenavir with or without ritonavir of clinical isolates from patients failing protease inhibitors-containing HAART regimens: prevalence and predictors.

Journal: Scandinavian journal of infectious diseases20070101

Title: Amprenavir and lopinavir pharmacokinetics following coadministration of amprenavir or fosamprenavir with lopinavir/ritonavir, with or without efavirenz.

Journal: Antiviral therapy20070101

Title: Evaluation of sex differences of fosamprenavir (with and without ritonavir) in HIV-infected men and women.

Journal: HIV clinical trials20070101

Title: Meeting report. Report from ICAAC.

Journal: AIDS clinical care20061201

Title: Clinically relevant pharmacology of neuropsychiatric drugs approved over the last three years: Part II.

Journal: Journal of psychiatric practice20060901

Title: The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection over 48 weeks: a randomised non-inferiority trial.

Journal: Lancet (London, England)20060805

Title: An update and review of antiretroviral therapy.

Journal: Pharmacotherapy20060801

Title: Coadministration of esomeprazole with fosamprenavir has no impact on steady-state plasma amprenavir pharmacokinetics.

Journal: Journal of acquired immune deficiency syndromes (1999)20060501

Title: Pharmacokinetic interaction between Amprenavir/Ritonavir and FosAmprenavir on cyclosporine in two patients with human immunodeficiency virus infection undergoing orthotopic liver transplantation.

Journal: Transplantation proceedings20060501

Title: Long-term (120-Week) antiviral efficacy and tolerability of fosamprenavir/ritonavir once daily in therapy-naive patients with HIV-1 infection: an uncontrolled, open-label, single-arm follow-on study.

Journal: Clinical therapeutics20060501

Title: Effects of esomeprazole on the pharmacokinetics of atazanavir and fosamprenavir in a patient with human immunodeficiency virus infection.

Journal: Pharmacotherapy20060401

Title: Evolution of resistance during first-line treatment with boosted fosamprenavir is associated with baseline mutations.

Journal: AIDS (London, England)20060102

Title: Interaction between atazanavir and fosamprenavir in the treatment of HIV-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999)20060101

Title: Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug.

Journal: Clinical pharmacokinetics20060101

Title: Fosamprenavir: drug development for adherence.

Journal: The Annals of pharmacotherapy20060101

Title: Fosamprenavir clinical study meta-analysis in ART-naïve subjects: rare occurrence of virologic failure and selection of protease-associated mutations.

Journal: HIV clinical trials20060101

Title: [The treatment of HIV infection].

Journal: Presse medicale (Paris, France : 1983)20051119

Title: [Multicentre clinical trials: degree of homogeneity in the ethical-scientific review performed by research ethics committees].

Journal: Medicina clinica20050917

Title: Lexiva: blood levels not lowered when taken simultaneously with Nexium.

Journal: AIDS treatment news20050527

Title: [Long-term virus suppression. Expanding therapy options with protease inhibitor].

Journal: MMW Fortschritte der Medizin20050425

Title: Combining fosamprenavir with lopinavir/ritonavir substantially reduces amprenavir and lopinavir exposure: ACTG protocol A5143 results.

Journal: AIDS (London, England)20050128

Title: Amprenavir or fosamprenavir plus ritonavir in HIV infection: pharmacology, efficacy and tolerability profile.

Journal: Drugs20050101

Title: Salvage therapy with ritonavir-boosted amprenavir/fosamprenavir: virological and immunological response in two years follow-up.

Journal: HIV clinical trials20050101

Title: Steady-State pharmacokinetics of saquinavir hard-gel/ritonavir/fosamprenavir in HIV-1-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999)20041101

Title: Pharmacokinetics of Telzir (fosamprenavir).

Journal: Journal of HIV therapy20041101

Title: Fosamprenavir: advancing HIV protease inhibitor treatment options.

Journal: Expert opinion on pharmacotherapy20040901

Title: SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir /ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients.

Journal: AIDS (London, England)20040723

Title: New approaches to the industrial synthesis of HIV protease inhibitors.

Journal: Organic & biomolecular chemistry20040721

Title: [Maintaining independence. New protease inhibitor receives drug approval recommendation].

Journal: MMW Fortschritte der Medizin20040426

Title: [FPV plus SQV plus a mini-dose ritonavir. 'Double boosting with compatible partners].

Journal: MMW Fortschritte der Medizin20040426

Title: Pharmacokinetics and safety of GW433908 and ritonavir, with and without efavirenz, in healthy volunteers.

Journal: AIDS (London, England)20040409

Title: GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients: absence of protease resistance at 48 weeks.

Journal: AIDS (London, England)20040305

Title: Preclinical pharmacology and pharmacokinetics of GW433908, a water-soluble prodrug of the human immunodeficiency virus protease inhibitor amprenavir.

Journal: Antimicrobial agents and chemotherapy20040301

Title: Fosamprenavir: a new PI option. Interview by Craig Sterritt.

Journal: IAPAC monthly20040201

Title: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients.

Journal: Antimicrobial agents and chemotherapy20040101

Title: The NEAT study: a 48-week open-label study to compare the antiviral efficacy and safety of GW433908 versus nelfinavir in antiretroviral therapy-naive HIV-1-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999)20040101

Title: FDA grants approval to fosamprenavir calcium.

Journal: AIDS alert20040101

Title: Initial therapy for human immunodeficiency virus: broadening the options.

Journal: HIV clinical trials20040101

Title: Peptidomimetic inhibitors of HIV protease.

Journal: Current topics in medicinal chemistry20040101

Title: Fosamprenavir: a review of its use in the management of antiretroviral therapy-naive patients with HIV infection.

Journal: Drugs20040101

Title: Anti-HIV agents. Saquinavir with fosamprenavir.

Journal: TreatmentUpdate20040101

Title: [Are all boosted protease inhibitors the same? Previously treated patients profit too from lopinavir/r].

Journal: MMW Fortschritte der Medizin20031211

Title: The continuing evolution of HIV therapy.

Journal: The AIDS reader20031201

Title: Drug profile: fosamprenavir (Lexiva).

Journal: The Hopkins HIV report : a bimonthly newsletter for healthcare providers20031101

Title: FDA approves Lexiva.

Journal: IAPAC monthly20031101

Title: Lexiva (fosamprenavir) approved.

Journal: AIDS treatment news20031031

Title: Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage.

Journal: Journal of medicinal chemistry20030911

Title: Viral patterns of unboosted 908 identified.

Journal: AIDS patient care and STDs20030801

Title: Reviving protease inhibitors: new data and more options.

Journal: Journal of acquired immune deficiency syndromes (1999)20030601

Title: [Potent new protease inhibitor. Boostered protease inhibitors--a separate class of drugs].

Journal: MMW Fortschritte der Medizin20030428

Title: [No selection of mutations. 908 raises genetic resistance barrier].

Journal: MMW Fortschritte der Medizin20030428

Title: SOLO trial results released.

Journal: AIDS patient care and STDs20030201

Title: Five new drugs enter the homestretch.

Journal: GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies20021201

Title: NEAT trial releases results.

Journal: AIDS patient care and STDs20021201

Title: Effects of formulation and dosing strategy on amprenavir concentrations in the seminal plasma of human immunodeficiency virus type 1-infected men.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20020915

Title: Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers.

Journal: Journal of clinical pharmacology20020801

Title: Fosamprenavir. Vertex Pharmaceuticals/GlaxoSmithKline.

Journal: Current opinion in investigational drugs (London, England : 2000)20020301

Title: From amprenavir to GW433908.

Journal: Journal of HIV therapy20011101

Title: Phase III trials for new PI.

Journal: AIDS patient care and STDs20010301

Title: New antiretroviral agents.

Journal: The Hopkins HIV report : a bimonthly newsletter for healthcare providers20010301

Title: Falcoz C, et al. Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J Clin Pharmacol. 2002 Aug;42(8):887-98.

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