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23948-77-8,MFCD01740400
Catalog No.:AA006XOD

23948-77-8 | (3-Phenylphenyl)acetic acid

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250mg
95%
in stock  
$87.00   $61.00
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1g
95%
in stock  
$170.00   $119.00
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5g
95%
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$612.00   $429.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA006XOD
Chemical Name:
(3-Phenylphenyl)acetic acid
CAS Number:
23948-77-8
Molecular Formula:
C14H12O2
Molecular Weight:
212.2439
MDL Number:
MFCD01740400
SMILES:
OC(=O)Cc1cccc(c1)c1ccccc1
Properties
Computed Properties
 
Complexity:
231  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.2  

Downstream Synthesis Route

[1]Turner[JournaloftheAmericanChemicalSociety,1950,vol.72,p.3823]

[2]Sam;Shafik[JournalofPharmaceuticalSciences,1969,vol.58,#8,p.952-955]

[1]Ruechardt,C.;Grundmeier,M.[ChemischeBerichte,1975,vol.108,p.2448-2464]

[2]Kotsikorou,Evangelia;Song,Yongcheng;Chan,JulianM.W.;Faelens,Stephanie;Tovian,Zev;Broderick,Erin;Bakalara,Norbert;Docampo,Roberta;Oldfield,Eric[JournalofMedicinalChemistry,2005,vol.48,#19,p.6128-6139]

[1]Rafferty;Borchardt;Grunewald[JournalofMedicinalChemistry,1982,vol.25,#10,p.1204-1208]

[2]Tikk,I.;Toth,G.;Deak,Gy.[ActaChimicaHungarica,1983,vol.114,#3-4,p.355-360]

[3]Ruechardt,C.;Grundmeier,M.[ChemischeBerichte,1975,vol.108,p.2448-2464]

[4]Pendergast;Johnson;Dickerson;Dev;Duch;Ferone;Hall;Humphreys;Kelly;Wilson[JournalofMedicinalChemistry,1993,vol.36,#16,p.2279-2291]

[5]Kotsikorou,Evangelia;Song,Yongcheng;Chan,JulianM.W.;Faelens,Stephanie;Tovian,Zev;Broderick,Erin;Bakalara,Norbert;Docampo,Roberta;Oldfield,Eric[JournalofMedicinalChemistry,2005,vol.48,#19,p.6128-6139]

[6]Ren,Jie;Li,Yuhang;Ke,Hongwei;Li,Yanting;Yang,Longhe;Yu,Helin;Huang,Rui;Lu,Canzhong;Qiu,Yan[RSCAdvances,2017,vol.7,#21,p.12455-12463]

[1]Tamura,Yasumitsu;Yoshimoto,Yoshihiko;Kunimoto,Katsutoshi;Tada,Shin-ichi;Matsumura,Shingo;etal.[JournalofMedicinalChemistry,1981,vol.24,#1,p.43-47]

[2]Dhanoa;Bagley;Chang;Lotti;Chen;Kivlighn;Zingaro;Siegl;Chakravarty;Patchett;Greenlee[JournalofMedicinalChemistry,1993,vol.36,#23,p.3738-3742]

[1]Pendergast;Johnson;Dickerson;Dev;Duch;Ferone;Hall;Humphreys;Kelly;Wilson[JournalofMedicinalChemistry,1993,vol.36,#16,p.2279-2291]

[2]CurrentPatentAssignee:ASTELLASPHARMAINC.-EP1199307,2002,A1Locationinpatent:Page13

Literature

Title: A novel protocol for the oral administration of test chemicals to adult zebrafish.

Journal: Zebrafish 20111201

Title: Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.

Journal: Bioorganic & medicinal chemistry letters 20111101

Title: Some pharmaceutical and inclusion properties of 2-hydroxybutyl-β-cyclodextrin derivative.

Journal: International journal of pharmaceutics 20111031

Title: Effect of enoxacin, felbinac, and sparfloxacin on fatty acid metabolism and glucose concentrations in rat tissues.

Journal: International journal of toxicology 20110501

Title: Fluorous derivatization and fluorous-phase separation for fluorometric determination of naproxen and felbinac in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20110428

Title: Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110401

Title: Expression and modulation of connexin 30.2, a novel gap junction protein in the mouse retina.

Journal: Visual neuroscience 20100701

Title: Design, synthesis and evaluation of mutual prodrug of 4-biphenylacetic acid and quercetin tetramethyl ether (BPA-QTME) as gastrosparing NSAID.

Journal: European journal of medicinal chemistry 20100601

Title: The suitability of tris(hydroxylmethyl) aminomethane (THAM) as a buffering system for hydroxypropyl methylcellulose (HPMC) hydrophilic matrices containing a weak acid drug.

Journal: International journal of pharmaceutics 20100315

Title: Towards the design of cyclooxygenase (COX) inhibitors based on 4',5 di-substituted biphenyl acetic acid molecules: a QSAR study with a new DFT based descriptor - nucleus independent chemical shift.

Journal: Journal of molecular modeling 20091001

Title: Validated LC-MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat.

Journal: Journal of pharmaceutical and biomedical analysis 20090815

Title: Mechanisms of drug release in citrate buffered HPMC matrices.

Journal: International journal of pharmaceutics 20090331

Title: Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.

Journal: Drug metabolism and pharmacokinetics 20090101

Title: Percutaneous penetration of felbinac after application of transdermal patches: relationship with pharmacological effects in rats.

Journal: The Journal of pharmacy and pharmacology 20080101

Title: Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.

Journal: BMC musculoskeletal disorders 20080101

Title: Synthesis and pharmacological evaluation of some dual-acting amino-alcohol ester derivatives of flurbiprofen and 2-[1,1'-biphenyl-4-yl]acetic acid: a potential approach to reduce local gastrointestinal toxicity.

Journal: Chemistry & biodiversity 20061101

Title: Changes in brain interleukin-1beta following the coadministration of norfloxacin with biphenylacetic acid in rats.

Journal: European journal of pharmacology 20060814

Title: Synthesis, characterization and in vitro evaluation of dimethyl-beta-cyclodextrin-4-biphenylylacetic acid conjugate.

Journal: Journal of drug targeting 20030501

Title: Characterization of the interaction between a novel convulsant agent, norbiphen, and GABA(A) and other ligand-gated ion channels.

Journal: Neuropharmacology 20020901

Title: A pharmacokinetic/pharmacodynamic approach to show that not all fluoroquinolones exhibit similar sensitivity toward the proconvulsant effect of biphenyl acetic acid in rats.

Journal: The Journal of antimicrobial chemotherapy 20011201

Title: Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide.

Journal: Chemical communications (Cambridge, England) 20011121

Title: Biphenylacetic acid enhances the antagonistic action of fluoroquinolones on the GABA(A)-mediated responses of the isolated guinea-pig ileum.

Journal: Pharmacological research 20010901

Title: Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid.

Journal: General pharmacology 19971101

Title: Effect of bile duct ligation and unilateral nephrectomy on brain concentration and convulsant potential of the quinolone antibacterial agent levofloxacin in rats.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19960201

Title: Quantitation of GABAA receptor inhibition required for quinolone-induced convulsions in mice.

Journal: The Journal of antimicrobial chemotherapy 19941101

Title: Biphenylacetate, but not theophylline, lethally interacts with ciprofloxacin in mice.

Journal: Pharmacology & toxicology 19931101

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Tags:23948-77-8 Molecular Formula|23948-77-8 MDL|23948-77-8 SMILES|23948-77-8 (3-Phenylphenyl)acetic acid