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141430-65-1,MFCD00910291
Catalog No.:AA006Y8H

141430-65-1 | Abt-751

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$12.00   $8.00
- +
5mg
98%
in stock  
$27.00   $19.00
- +
10mg
98%
in stock  
$39.00   $28.00
- +
25mg
98%
in stock  
$65.00   $46.00
- +
50mg
98%
in stock  
$110.00   $77.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006Y8H
Chemical Name:
Abt-751
CAS Number:
141430-65-1
Molecular Formula:
C18H17N3O4S
Molecular Weight:
371.4103
MDL Number:
MFCD00910291
SMILES:
COc1ccc(cc1)S(=O)(=O)Nc1cccnc1Nc1ccc(cc1)O
NSC Number:
742134
Properties
Computed Properties
 
Complexity:
523  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
2.8  

Literature

Title: Huang SM et al.,Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling., Nature. 2009 Oct 1;461(7264):614-20.

Title: Elizabeth Fox et al. A Phase I Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 21 Days Every 28 Days in Pediatric Patients with Solid Tumors Clin Cancer Res February 15, 2008 14; 1111

Title: Aggarwal C, Somaiah N, Simon G.,Antiangiogenic agents in the management of non-small cell lung cancer: where do we stand now and where are we headed?,Cancer Biol Ther. 2012 Mar;13(5):247-63.

Title: Silver M, Rusk A, Phillips B, Beck E, Jankowski M, Philibert J, Hahn K, Hershey E, McKeegan E, Bauch J, Krivoshik A, Khanna C.,Evaluation of the oral antimitotic agent (ABT-751) in dogs with lymphoma.,J Vet Intern Med. 2012 Mar-Apr;26(2):349-54. doi: 10.1111/j.1939-1676.2012.00892.x. Epub 2012 Feb 28.

Title: Gaynon PS, Harned TM; for the Therapeutic Advances in Childhood LeukemiaLymphoma (TACL) Consortium.

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SDS
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Tags:141430-65-1 Molecular Formula|141430-65-1 MDL|141430-65-1 SMILES|141430-65-1 Abt-751