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479-18-5,MFCD00005759
Catalog No.:AA006YC7

479-18-5 | Diphylline

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Purity
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100mg
98%
in stock  
$6.00   $4.00
- +
25g
98%
in stock  
$23.00   $16.00
- +
100g
98%
in stock  
$74.00   $52.00
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500g
98%
in stock  
$130.00   $91.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006YC7
Chemical Name:
Diphylline
CAS Number:
479-18-5
Molecular Formula:
C10H14N4O4
Molecular Weight:
254.2426
MDL Number:
MFCD00005759
SMILES:
OCC(Cn1cnc2c1c(=O)n(C)c(=O)n2C)O
Properties
Computed Properties
 
Complexity:
364  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-1.8  

Literature

Title: Application of artificial neural networks (ANNs) and genetic programming (GP) for prediction of drug release from solid lipid matrices.

Journal: International journal of pharmaceutics 20121015

Title: Prediction of dissolution time and coating thickness of sustained release formulations using Raman spectroscopy and terahertz pulsed imaging.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120401

Title: Xanthines down-regulate the drug transporter ABCG2 and reverse multidrug resistance.

Journal: Molecular pharmacology 20120301

Title: Drug release from extruded solid lipid matrices: theoretical predictions and independent experiments.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120101

Title: Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy.

Journal: Malaria journal 20120101

Title: Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.

Journal: PloS one 20120101

Title: Dissolution from solid lipid extrudates containing release modifiers.

Journal: International journal of pharmaceutics 20110630

Title: Validation of Raman spectroscopic procedures in agreement with ICH guideline Q2 with considering the transfer to real time monitoring of an active coating process.

Journal: Journal of pharmaceutical and biomedical analysis 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds.

Journal: FEBS letters 20100219

Title: Feasibility of Raman spectroscopy as PAT tool in active coating.

Journal: Drug development and industrial pharmacy 20100201

Title: Modeling drug release from PVAc/PVP matrix tablets.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20100125

Title: Spectrophotometric and reversed-phase high-performance liquid chromatographic method for the determination of doxophylline in pharmaceutical formulations.

Journal: Journal of young pharmacists : JYP 20100101

Title: Accuracy of Veterans Affairs databases for diagnoses of chronic diseases.

Journal: Preventing chronic disease 20091001

Title: Expression and purification of human mPGES-1 in E. coli and identification of inhibitory compounds from a drug-library.

Journal: BMB reports 20081130

Title: Hydroxypropyl methylcellulose acetate succinate: potential drug-excipient incompatibility.

Journal: AAPS PharmSciTech 20080901

Title: Synthesis, pharmacological activity and nitric oxide generation by nitrate derivatives of theophylline.

Journal: The Journal of pharmacy and pharmacology 20080501

Title: Synthesis and activity against HBV of novel Tetra-seconucleoside analogues of dyphlline having the acyclic chains of ACV and HBG.

Journal: Nucleosides, nucleotides & nucleic acids 20080301

Title: A comparison of the stability of ertapenem and meropenem in pharmaceutical preparations in solid state.

Journal: Journal of pharmaceutical and biomedical analysis 20080107

Title: New validated liquid chromatographic and chemometrics-assisted UV spectroscopic methods for the determination of two multicomponent cough mixtures in syrup.

Journal: Journal of AOAC International 20080101

Title: [Combining LABA and ICS in patients with severe COPD].

Journal: Polskie Archiwum Medycyny Wewnetrznej 20070101

Title: Extruded and spheronized beads containing Carbopol 974P to deliver nonelectrolytes and salts of weakly basic drugs.

Journal: International journal of pharmaceutics 20060914

Title: [Clinical observation on shufei granule in improving right ventricular function of patients with chronic pulmonary heart disease].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060801

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Rapid determination of acyclovir in plasma and cerebrospinal fluid by micellar electrokinetic chromatography with direct sample injection and its clinical application.

Journal: Electrophoresis 20060201

Title: HPLC and chemometric assisted spectrophotometric methods for simultaneous determination of diprophylline, phenobarbitone and papaverine hydrochloride.

Journal: Farmaco (Societa chimica italiana : 1989) 20050901

Title: Optimization and characterization of controlled release multi-particulate beads coated with starch acetate.

Journal: International journal of pharmaceutics 20050427

Title: Modeling of drug release from partially coated matrices made of a high viscosity HPMC.

Journal: International journal of pharmaceutics 20040519

Title: Simultaneous determination of theophylline and dyphylline by micellar electrokinetic chromatography and application in drug formulations.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031005

Title: Wet granulation fine particle ethylcellulose tablets: effect of production variables and mathematical modeling of drug release.

Journal: AAPS pharmSci 20030601

Title: Kinetic-spectrophotometric determination of theophylline, dyphylline, and proxyphylline by use of partial least-squares regression.

Journal: Analytical and bioanalytical chemistry 20020901

Title: Electrophoretic behaviour of pharmacologically active alkylxanthines.

Journal: Journal of chromatography. A 20020315

Title: Application of micellar electrokinetic chromatography to the quality control of a pharmaceutical preparation containing three bronchodilators.

Journal: Electrophoresis 20020201

Title: Multi-component kinetic-spectrophotometric analysis. Selection of wavelength and time ranges.

Journal: The Analyst 20010701

Title: Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.

Title: Yosry El-said, et al. In-vitro evaluation of sustained-release dyphylline tablets. Drug Development and Industrial Pharmacy. Volume 17, 1991 - Issue 2

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