Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry20121115
Title: Suppression of inflammation in a mouse model of rheumatoid arthritis using targeted lipase-labile fumagillin prodrug nanoparticles.
Journal: Biomaterials20121101
Title: Impact of Nosema (Microsporidia) infection and fumagillin treatment on Lygus lineolaris (Hemiptera: Miridae).
Journal: Journal of invertebrate pathology20121001
Title: The effect of induced queen replacement on Nosema spp. infection in honey bee (Apis mellifera iberiensis) colonies.
Journal: Environmental microbiology20120401
Title: The development of MetAP-2 inhibitors in cancer treatment.
Journal: Current medicinal chemistry20120101
Title: Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.
Journal: PloS one20120101
Title: Anti-angiogenic treatment strategies for the therapy of endometriosis.
Journal: Human reproduction update20120101
Title: Methionine aminopeptidase 2 is required for HSC initiation and proliferation.
Journal: Blood20111117
Title: Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37.
Journal: Chemistry & biology20111028
Title: Local inhibition of angiogenesis results in an atrophic non-union in a rat osteotomy model.
Journal: European cells & materials20110706
Title: The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes.
Journal: Microbiology (Reading, England)20110501
Title: Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells.
Journal: European journal of medicinal chemistry20110401
Title: Rapid determination of fumagillin residues in honey by liquid chromatography-tandem mass spectrometry using the QuEChERS method.
Journal: Journal of AOAC International20110101
Title: Fumagillin reduces adipose tissue formation in murine models of nutritionally induced obesity.
Journal: Obesity (Silver Spring, Md.)20101201
Title: Design, synthesis and discovery of 5-hydroxyaurone derivatives as growth inhibitors against HUVEC and some cancer cell lines.
Journal: European journal of medicinal chemistry20101201
Title: p67/MetAP2 suppresses K-RasV12-mediated transformation of NIH3T3 mouse fibroblasts in culture and in athymic mice.
Journal: Biochemistry20101130
Title: Concise synthesis and antiangiogenic activity of artemisinin-glycolipid hybrids on chorioallantoic membranes.
Journal: Bioorganic & medicinal chemistry letters20101115
Title: Methionine aminopeptidases as potential targets for treatment of gastrointestinal cancers and other tumours.
Journal: Current drug targets20101101
Title: Fumagillin for treatment of intestinal microsporidiosis in renal transplant recipients.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20100801
Title: A novel angiogenesis model for screening anti-angiogenic compounds: the chorioallantoic membrane/feather bud assay.
Journal: International journal of oncology20100701
Title: Inhibition of neutrophil function following exposure to the Aspergillus fumigatus toxin fumagillin.
Journal: Journal of medical microbiology20100601
Title: Specificity in the interaction of natural products with their target proteins--a biochemical and structural insight.
Journal: Mini reviews in medicinal chemistry20100601
Title: Syntheses of fumagillin and ovalicin.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany)20100406
Title: Effect of fumagillin on adipocyte differentiation and adipogenesis.
Journal: Biochimica et biophysica acta20100401
Title: Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
Journal: Bioorganic & medicinal chemistry letters20100201
Title: Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.
Journal: Journal of medicinal chemistry20091224
Title: Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470.
Journal: Molecular and biochemical parasitology20091201
Title: Roles of P67/MetAP2 as a tumor suppressor.
Journal: Biochimica et biophysica acta20091201
Title: Emerging prevalence of microsporidial keratitis in Singapore: epidemiology, clinical features, and management.
Journal: Ophthalmology20091201
Title: Paracrine induction of endothelium by tumor exosomes.
Journal: Laboratory investigation; a journal of technical methods and pathology20091101
Title: Alphavbeta3-targeted nanotherapy suppresses inflammatory arthritis in mice.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20090901
Title: Antiparasitic activities of novel, orally available fumagillin analogs.
Journal: Bioorganic & medicinal chemistry letters20090901
Title: Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis.
Journal: Pathology international20090701
Title: Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo.
Journal: Chemistry & biology20090227
Title: Microsporidiosis in solid organ transplant recipients: two Enterocytozoon bieneusi cases and review.
Journal: Transplant infectious disease : an official journal of the Transplantation Society20090201
Title: Testing intra-hemocelic injection of antimicrobials against Encephalitozoon sp. (Microsporidia) in an insect host.
Journal: Parasitology research20090101
Title: Three-dimensional MR mapping of angiogenesis with alpha5beta1(alpha nu beta3)-targeted theranostic nanoparticles in the MDA-MB-435 xenograft mouse model.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20081201
Title: Magnetic circular dichroism study of a dicobalt(II) methionine aminopeptidase/fumagillin complex and dicobalt II-II and II-III model complexes.
Journal: Inorganic chemistry20081117
Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Journal: Journal of medicinal chemistry20081113
Title: Does fumagillin control the recently detected invasive parasite Nosema ceranae in western honey bees (Apis mellifera)?
Journal: Journal of invertebrate pathology20081101
Title: In vitro evaluation of the clastogenicity of fumagillin.
Journal: Environmental and molecular mutagenesis20081001
Title: How natural infection by Nosema ceranae causes honeybee colony collapse.
Journal: Environmental microbiology20081001
Title: Effect of four antimicrobials against an Encephalitozoon sp. (Microsporidia) in a grasshopper host.
Journal: Parasitology international20080901
Title: Antiangiogenic synergism of integrin-targeted fumagillin nanoparticles and atorvastatin in atherosclerosis.
Journal: JACC. Cardiovascular imaging20080901
Title: Theranostic strategy against plaque angiogenesis.
Journal: JACC. Cardiovascular imaging20080901
Title: Minute dosages of alpha(nu)beta3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20080801
Title: [New antiparasitic drugs].
Journal: La Revue de medecine interne20080601
Title: Trace analysis of fumagillin in honey by liquid chromatography-diode array-electrospray ionization mass spectrometry.
Journal: Journal of chromatography. A20080509
Title: Evaluation of the antiangiogenic potential of AQ4N.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20080301
Title: New insect system for testing antibiotics.
Journal: The Journal of parasitology20071201
Title: FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470).
Journal: Journal of cellular biochemistry20070815
Title: Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis.
Journal: American journal of respiratory cell and molecular biology20070801
Title: Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis.
Journal: Nature clinical practice. Rheumatology20070801
Title: Microsporidium stromal keratitis: in vivo confocal findings.
Journal: Cornea20070801
Title: Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors.
Journal: Expert review of anti-infective therapy20070801
Title: Design, synthesis, and antiangiogenic effects of a series of potent novel fumagillin analogues.
Journal: Chemical & pharmaceutical bulletin20070701
Title: Evaluation of genotoxic effects of fumagillin by cytogenetic tests in vivo.
Journal: Mutation research20070330
Title: Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: potential for drug target.
Journal: Acta oncologica (Stockholm, Sweden)20070101
Title: [On chance discovery in rational drug design. Aspergillus fumigatus and angiogenesis].
Journal: Pharmazie in unserer Zeit20070101
Title: Fumagillin, a new P-glycoprotein-interfering agent able to modulate moxidectin efflux in rat hepatocytes.
Journal: Journal of veterinary pharmacology and therapeutics20061201
Title: In vitro cytotoxicity of Phortress against colorectal cancer.
Journal: International journal of oncology20061101
Title: Stromelysin-1 expression is activated in vivo by Ets-1 through palindromic head-to-head Ets binding sites present in the promoter.
Journal: Oncogene20060921
Title: Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo.
Journal: Journal of medicinal chemistry20060921
Title: Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis.
Journal: Arteriosclerosis, thrombosis, and vascular biology20060901
Title: A noncanonical path to mechanism of action.
Journal: Chemistry & biology20060901
Title: A chemical and genetic approach to the mode of action of fumagillin.
Journal: Chemistry & biology20060901
Title: Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.
Journal: FEBS letters20060515
Title: Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane.
Journal: Bioorganic & medicinal chemistry letters20060301
Title: Interaction between tacrolimus and fumagillin in two kidney transplant recipients.
Journal: Transplantation20060115
Title: Advances in understanding angiogenesis through molecular studies.
Journal: International journal of radiation oncology, biology, physics20060101
Title: Antiparasitic and immunomodulatory effect of innovative treatments against Myxobolus sp. infection in Diplodus puntazzo.
Journal: Veterinary parasitology20051210
Title: Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.
Journal: Cancer research20051101
Title: Keratitis caused by Trachipleistophora anthropopthera.
Journal: The Journal of infection20051101
Title: 4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.
Journal: Journal of medicinal chemistry20050908
Title: Oxocarbenium ion cyclizations for C-branched cyclitols: synthesis of a relay intermediate for fumagillin analogues.
Journal: The Journal of organic chemistry20050819
Title: Methionine aminopeptidases type I and type II are essential to control cell proliferation.
Journal: Journal of cellular biochemistry20050815
Title: Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol.
Journal: Bioorganic & medicinal chemistry letters20050801
Title: Synthesis and biological evaluation of novel fumagillin and ovalicin analogues.
Journal: Organic & biomolecular chemistry20050607
Title: Phylogenetic relationships of methionine aminopeptidase 2 among Encephalitozoon species and genotypes of microsporidia.
Journal: Molecular and biochemical parasitology20050401
Title: Microsporidiosis: an emerging and opportunistic infection in humans and animals.
Journal: Acta tropica20050401
Title: Enantioselective approaches to potential MetAP-2 reversible inhibitors.
Journal: The Journal of organic chemistry20050318
Title: Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model.
Journal: International journal of cancer20050310
Title: Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis.
Journal: World journal of gastroenterology20050214
Title: Characterization of the active site and insight into the binding mode of the anti-angiogenesis agent fumagillin to the manganese(II)-loaded methionyl aminopeptidase from Escherichia coli.
Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry20050101
Title: Octosporea bayeri: fumidil B inhibits vertical transmission in Daphnia magna.
Journal: Experimental parasitology20050101
Title: The parasitophorous vacuole membrane of Encephalitozoon cuniculi lacks host cell membrane proteins immediately after invasion.
Journal: Eukaryotic cell20050101
Title: Antiangiogenic agents: studies on fumagillin and curcumin analogs.
Journal: Current pharmaceutical design20050101
Title: Treatment of cells with the angiogenic inhibitor fumagillin results in increased stability of eukaryotic initiation factor 2-associated glycoprotein, p67, and reduced phosphorylation of extracellular signal-regulated kinases.
Journal: Biochemistry20041123
Title: The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.
Journal: FEBS letters20041008
Title: Occurrence of Cystosporogenes sp. (Protozoa, Microsporidia) in a multi-species insect production facility and its elimination from a colony of the eastern spruce budworm, Choristoneura fumiferana (Clem.) (Lepidoptera: Tortricidae).
Journal: Journal of invertebrate pathology20040901
Title: Early genetic mechanisms underlying the inhibitory effects of endostatin and fumagillin on human endothelial cells.
Journal: Genome research20040801
Title: Fumagiringillin, a new fumagillin derivative from a strain of the fungus Aspergillus fumigatus.
Journal: Journal of natural products20040801
Title: Depletion of methionine aminopeptidase 2 does not alter cell response to fumagillin or bengamides.
Journal: Cancer research20040501
Title: Inhibitory effects of 9-(4-thio-beta-D-ribo-pentofuranosyl)guanine on tumor growth and angiogenesis.
Journal: Biological & pharmaceutical bulletin20040401
Title: Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs.
Journal: Archives of pharmacal research20040201
Title: MetAP-2 inhibitors based on the fumagillin structure. Side-chain modification and ring-substituted analogues.
Journal: The Journal of organic chemistry20040123
Title: Investigation of novel fumagillin analogues as angiogenesis inhibitors.
Journal: Bioorganic & medicinal chemistry letters20040105
Title: Small molecule inhibitors of methionine aminopeptidase type 2 (MetAP-2).
Journal: Angiogenesis20040101
Title: Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors.
Journal: The Journal of biological chemistry20031226
Title: Protonation states of methionine aminopeptidase and their relevance for inhibitor binding and catalytic activity.
Journal: The Journal of biological chemistry20031128
Title: Design, synthesis and evaluation of a series of novel fumagillin analogues.
Journal: Bioorganic & medicinal chemistry20031117
Title: Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin.
Journal: Cancer research20031001
Title: Effects of Nosema bombi and its treatment fumagillin on bumble bee (Bombus occidentalis) colonies.
Journal: Journal of invertebrate pathology20030901
Title: Homology modeling and calculation of the cobalt cluster charges of the Encephazlitozoon cuniculi methionine aminopeptidase, a potential target for drug design.
Journal: Biophysical chemistry20030801
Title: Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis.
Journal: Journal of medicinal chemistry20030731
Title: Microsporidial keratoconjunctivitis in healthy individuals: a case series.
Journal: Ophthalmology20030701
Title: Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae.
Journal: Journal of medicinal chemistry20030619
Title: Development of a real-time polymerase-chain-reaction assay for quantitative detection of Enterocytozoon bieneusi DNA in stool specimens from immunocompromised patients with intestinal microsporidiosis.
Journal: The Journal of infectious diseases20030501
Title: Bilateral microsporidial keratoconjunctivitis in an immunocompetent non-contact lens wearer.
Journal: Cornea20030501
Title: Microsporidial keratoconjunctivitis in a healthy patient with a history of LASIK surgery.
Journal: Cornea20030401
Title: Carbon and nitrogen source nutrition of fumagillin biosynthesis by Aspergillus fumigatus.
Journal: Current microbiology20030401
Title: Electrochemical desorption of self-assembled monolayers noninvasively releases patterned cells from geometrical confinements.
Journal: Journal of the American Chemical Society20030305
Title: A novel early chorioallantoic membrane assay demonstrates quantitative and qualitative changes caused by antiangiogenic substances.
Journal: The Journal of laboratory and clinical medicine20030301
Title: Concise stereocontrolled routes to fumagillol, fumagillin, and TNP-470.
Journal: Chirality20030201
Title: Effects of carboxymethylcellulose and carboxypolymethylene on morphology of Aspergillus fumigatus NRRL 2346 and fumagillin production.
Journal: Current microbiology20030101
Title: [Light- and temperature-induced degradation of fumagillin].
Journal: Acta pharmaceutica Hungarica20030101
Title: Understanding the selectivity of fumagillin for the methionine aminopeptidase type II.
Journal: Oncology research20030101
Title: Fumagillin for intestinal microsporidiosis.
Journal: The New England journal of medicine20021024
Title: Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4.
Journal: The Journal of biological chemistry20020719
Title: Fumagillin treatment of intestinal microsporidiosis.
Journal: The New England journal of medicine20020620
Title: Novel bicyclic oxazolone derivatives as anti-angiogenic agents.
Journal: Bioorganic & medicinal chemistry letters20020603
Title: Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis.
Journal: Journal of biomedical science20020101
Title: Effect of vaginally administered fumagillin on immunohistochemical distribution of leukemia inhibitory factor, interleukin 6, transforming growth factor beta and vascular endothelial growth factor in implantation stage endometrium of the rhesus monkey.
Journal: Indian journal of physiology and pharmacology20020101
Title: [Human microsporidiosis].
Journal: Klinische Padiatrie20020101
Title: The identification of in vitro metabolites of CKD-732 by liquid chromatography/tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM20020101
Title: Structure of Sch 528647: a new antitumor antibiotic related to fumagillin.
Journal: The Journal of antibiotics20011201
Title: Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity.
Journal: The American journal of pathology20010801
Title: Microsporidial keratoconjunctivitis in a healthy contact lens wearer without human immunodeficiency virus infection.
Journal: Ophthalmology20010501
Title: General aspects of anti-angiogenesis and cancer therapy.
Journal: Expert opinion on biological therapy20010301
Title: Effect of vaginally administered fumagillin on the morphology of implantation stage endometrium in the rhesus monkey.
Journal: Contraception20010201
Title: Regulation and action of angiogenic factors in the primate ovary.
Journal: Archives of medical research20010101
Title: A re-evaluation of fumagillin selectivity towards endothelial cells.
Journal: Anticancer research20010101
Title: Microsporidian methionine aminopeptidase type 2.
Journal: The Journal of eukaryotic microbiology20010101
Title: In vitro and in vivo evaluation of aminopeptidase inhibitors as antimicrosporidial therapies.
Journal: The Journal of eukaryotic microbiology20010101
Title: Screening of compounds for antimicrosporidial activity in vitro.
Journal: Folia parasitologica19980101
Title: Effects of albendazole, fumagillin, and TNP-470 on microsporidial replication in vitro.
Journal: Antimicrobial agents and chemotherapy19970701
Title: Susceptibility of Encephalitozoon cuniculi to several drugs in vitro.
Journal: Antimicrobial agents and chemotherapy19950601
Title: Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth.
Journal: Nature19901206
Title: Lefkove, B., B. Govindarajan, and J.L. Arbiser, Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. Expert Rev Anti Infect Ther, 2007. 5(4): p. 573-9.
Title: Watanabe N, et al. Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity. FEBS Lett. 2006 May 15;580(11):2598-602.
